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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
PARKQIETRPEYEMEPEQPGQVYNLWYNKWSGGMRQDPLKSQVKSETRCVISRDSGYTKADKNPGSFFCLYFARGMCSEG
SKCEYLHRLPKDTDFFNANVDCFGREKHADYRDDMGGVGSFLRQNYTLYVGGITPTDDIEEIVSRHFAEWGDIERIRVLN
SRGIAFITYLNEANAQFAKEAMAHQSLECLNVRWATTDPNPASQARNQRRLEERAANAVKKLLPKQFLLDLEETKNGKAA
AAAAAAAAAAAAAAAAAAAAA

The query sequence (length=261) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 3jb9:Y 261 261 1.0000 1.0000 1.0000 0.0
2 7dco:R 261 235 0.3678 0.3678 0.4085 3.90e-54 7b9v:M, 6bk8:G, 6exn:M, 5gm6:R, 5gmk:R, 6j6g:R, 6j6h:R, 6j6n:R, 6j6q:R, 5lj3:M, 5lj5:M, 5mps:M, 5mq0:M, 3tp2:A, 3tp2:B, 3u1l:A, 3u1m:A, 5wsg:R, 5y88:N, 5ylz:N
3 5lqw:F 218 212 0.3563 0.4266 0.4387 6.42e-53
4 7abi:P 237 151 0.1571 0.1730 0.2715 1.48e-07 7aav:P, 7abg:P
5 8ro0:O 342 158 0.1571 0.1199 0.2595 2.28e-07 8ro1:O
6 8ch6:U 295 163 0.1609 0.1424 0.2577 5.59e-06 7a5p:P, 8c6j:M, 6ff4:P, 6ff7:P, 9fmd:O, 8i0p:O, 8i0r:O, 8i0s:O, 8i0t:O, 8i0u:O, 8i0v:O, 8i0w:O, 6icz:O, 6id0:O, 6id1:O, 5mqf:P, 6qdv:M, 7qtt:U, 8ro2:O, 7w59:O, 7w5a:O, 7w5b:O, 5xjc:O, 5yzg:O, 5z56:O, 5z57:O, 6zym:P
7 2fy1:A 108 88 0.0996 0.2407 0.2955 0.001
8 7ohx:o 112 75 0.0881 0.2054 0.3067 0.002
9 6c0f:o 133 75 0.0881 0.1729 0.3067 0.003 7btb:o, 6cb1:o, 8e5t:o, 6elz:o, 6em1:o, 6em3:o, 6em4:o, 6em5:o, 3jct:o, 6m62:o, 7nac:o, 7ohp:o, 7ohq:o, 7ohr:o, 7ohs:o, 7ohv:o, 7ohw:o, 7r6q:o, 7r7a:o, 7u0h:o, 7uoo:o, 7uqb:o, 7uqz:o, 7v08:o, 8v83:o, 8v84:o, 8v87:o, 6ylx:o, 6yly:o, 5z3g:E
10 6g90:B 193 71 0.0766 0.1036 0.2817 0.003
11 6n7p:A 186 71 0.0766 0.1075 0.2817 0.005 6n7r:A, 6n7x:A, 7oqc:B, 7oqe:B, 8w2o:A, 5zwn:Q
12 4lmz:A 176 64 0.0920 0.1364 0.3750 0.009 3nmr:A, 3nna:A, 3nnc:A, 3nnh:A, 3nnh:C, 3nnh:B, 3nnh:D
13 7uj1:B 270 107 0.1111 0.1074 0.2710 0.015 7pu5:B, 7pu5:D, 7pu5:H, 7pu5:J, 7pu5:L, 7sp0:B, 7uj1:A
14 2mb0:B 95 77 0.0881 0.2421 0.2987 0.020
15 7csz:A 175 106 0.0958 0.1429 0.2358 0.13
16 2d9n:A 77 19 0.0345 0.1169 0.4737 0.16 2rhk:C
17 9gpj:A 184 64 0.0690 0.0978 0.2812 0.30 6dcl:A, 6dcl:B, 9f4d:A, 9f4e:A, 9f4f:A, 9f4g:A, 9f4h:A, 9f4j:A, 9f4k:A, 9f4l:A, 9f4m:A, 9f4n:A, 9f4o:A, 9f4p:A, 9f4q:A, 9f4r:A, 9f4s:A, 9f4t:A, 9f4u:A, 9f4v:A, 9f4w:A, 9f4x:A, 9f4y:A, 9f4z:A, 9f50:A, 9f51:A, 9f52:A, 9f53:A, 9f54:A, 9f55:A, 9f5c:A, 9f5d:A, 9f5e:A, 9f5f:A, 9f5g:A, 9f5k:A, 9f7f:A, 9f7h:A, 5mpg:A, 5mpl:A, 1pgz:A, 1po6:A, 8rzv:A, 1u1k:A, 1u1l:A, 1u1m:A, 1u1n:A, 1u1o:A, 1u1p:A, 1u1q:A, 1u1r:A, 2up1:A, 4yoe:A
18 7dco:4 174 62 0.0805 0.1207 0.3387 0.74 6g90:R, 5gm6:e, 5nrl:R, 7oqb:R, 7oqe:R, 5zwm:4
19 3a3c:A 451 51 0.0651 0.0377 0.3333 0.75 2zxt:A
20 6eoj:B 94 19 0.0345 0.0957 0.4737 1.3 7zgp:B, 7zgr:B
21 5elh:A 142 22 0.0421 0.0775 0.5000 1.3 5elh:B
22 2rs2:A 84 87 0.0805 0.2500 0.2414 1.3
23 6dnh:C 117 20 0.0345 0.0769 0.4500 1.8 8e3i:C, 8e3q:C, 6fuw:C, 8r8r:C, 2rhk:D, 6urg:C, 6uro:C
24 8fkp:SH 150 74 0.0805 0.1400 0.2838 1.9 8fkq:SH, 8fkr:SH, 8fks:SH, 8fkt:SH, 8fku:SH, 8fkv:SH, 8fkw:SH, 8fkx:SH, 8fky:SH, 8fkz:SH, 8fl2:SH, 8fl6:SH, 8fla:SH, 8fld:SH, 8ine:t, 8inf:t, 8ipx:t, 8ipy:t, 8ir3:t
25 6ik5:A 705 72 0.0805 0.0298 0.2917 2.1 6ik5:B, 6ik6:A, 6ik6:B, 6ik7:B, 6ik7:A, 6ik8:B, 6ik8:A, 3w5f:A, 3w5g:A, 3w5g:B
26 2xb2:D 89 79 0.0881 0.2584 0.2911 2.1 2xb2:Z
27 2mxy:A 105 59 0.0690 0.1714 0.3051 2.5 2mz1:A
28 8y6o:W 167 70 0.0843 0.1317 0.3143 2.8
29 2w7y:A 389 80 0.0766 0.0514 0.2500 2.9 2w7y:B
30 7c06:A 193 142 0.1226 0.1658 0.2254 3.2 7c06:G, 7c06:D, 7c06:J, 7c06:M, 7c06:P, 7c06:S, 7c06:V, 7c06:Y, 7c07:A, 7c07:G, 7c07:D, 7c07:J, 7c07:M, 7c07:P, 7c07:S, 7c07:V, 7c07:Y, 7c08:A, 7c08:G, 7c08:D, 7c08:J, 7c08:M, 7c08:P, 7c08:S, 7c08:V, 7c08:Y, 4yh8:A
31 5en1:A 184 63 0.0651 0.0924 0.2698 3.5 8hni:A, 8hni:B, 8hni:G, 8hni:I, 8hni:H, 8hni:E, 8hni:K, 8hni:C, 8hni:D, 8hni:J, 8hni:F, 8hni:L, 5ho4:A, 7wm3:A, 7wm3:B, 7wm3:C, 7wm3:D, 5wwe:A, 5wwf:A, 5wwf:C, 5wwg:A
32 2n82:B 104 46 0.0498 0.1250 0.2826 3.7 2err:A, 7vrl:B
33 7k95:A 53 19 0.0268 0.1321 0.3684 5.1 7zyh:A, 7zyh:D, 7zyh:G, 7zyh:J
34 1b8d:A 164 61 0.0843 0.1341 0.3607 8.0 1b8d:K, 5y6p:e2, 5y6p:g2, 5y6p:i2, 5y6p:k2, 5y6p:m2, 5y6p:o2, 5y6p:y2, 5y6p:q2, 5y6p:w2, 5y6p:s2, 5y6p:u2, 5y6p:W2, 5y6p:S2, 5y6p:E2, 5y6p:eE, 5y6p:O2, 5y6p:G2, 5y6p:I2, 5y6p:K2, 5y6p:M2, 5y6p:Q2, 5y6p:U2, 5y6p:Y2, 5y6p:A3, 5y6p:C3, 5y6p:E3, 5y6p:G3, 5y6p:I3, 5y6p:K3, 5y6p:M3, 5y6p:O3, 5y6p:Q3, 5y6p:W3, 5y6p:S3, 5y6p:U3, 5y6p:Y3, 5y6p:u3, 5y6p:s3, 5y6p:e3, 5y6p:eM, 5y6p:o3, 5y6p:g3, 5y6p:i3, 5y6p:k3, 5y6p:m3, 5y6p:q3, 5y6p:A4, 5y6p:w3, 5y6p:y3, 5y6p:C4, 5y6p:E4, 5y6p:K4, 5y6p:G4, 5y6p:I4, 5y6p:M4, 5y6p:O4, 5y6p:Q4, 5y6p:S4, 5y6p:U4, 5y6p:W4, 5y6p:Y4, 5y6p:m4, 5y6p:w4, 5y6p:o4, 5y6p:q4, 5y6p:s4, 5y6p:u4, 5y6p:y4, 5y6p:A5, 5y6p:G5, 5y6p:C5, 5y6p:E5, 5y6p:I5, 5y6p:K5, 5y6p:U5, 5y6p:M5, 5y6p:O5, 5y6p:Q5, 5y6p:S5, 5y6p:m5, 5y6p:w5, 5y6p:o5, 5y6p:q5, 5y6p:s5, 5y6p:u5, 5y6p:y5, 5y6p:i8, 5y6p:j8, 5y6p:aG, 5y6p:k8, 5y6p:l8, 5y6p:m8, 5y6p:A6, 5y6p:C6, 5y6p:E6, 5y6p:G6, 5y6p:I6, 5y6p:K6, 5y6p:M6, 5y6p:O6, 5y6p:Q6, 5y6p:S6, 5y6p:U6, 5y6p:W6, 5y6p:Y6, 5y6p:i6, 5y6p:h6, 5y6p:g6, 5y6p:f6, 5y6p:j6, 5y6p:k6, 5y6p:m6, 5y6p:o6, 5y6p:q6, 5y6p:s6, 5y6p:u6, 5y6p:w6, 5y6p:r8, 5y6p:q8, 5y6p:s8, 5y6p:t8, 5y6p:u8, 5y6p:A7, 5y6p:C7, 5y6p:E7, 5y6p:G7, 5y6p:I7, 5y6p:K7, 5y6p:M7, 5y6p:O7, 5y6p:Q7, 5y6p:S7, 5y6p:U7, 5y6p:W7, 5y6p:Y7, 5y6p:i7, 5y6p:f7, 5y6p:g7, 5y6p:h7, 5y6p:j7, 5y6p:k7, 5y6p:m7, 5y6p:o7, 5y6p:q7, 5y6p:s7, 5y6p:u7, 5y6p:w7, 5y6p:v8, 5y6p:B8, 5y6p:x8, 5y6p:z8, 5y6p:D8, 5y6p:F8, 5y6p:P8, 5y6p:H8, 5y6p:J8, 5y6p:L8, 5y6p:N8, 5y6p:m9, 5y6p:o9, 5y6p:q9, 5y6p:s9, 5y6p:u9, 5y6p:w9, 5y6p:y9, 5y6p:A9, 5y6p:G9, 5y6p:C9, 5y6p:E9, 5y6p:I9, 5y6p:K9, 5y6p:U9, 5y6p:M9, 5y6p:O9, 5y6p:Q9, 5y6p:S9, 5y6p:am, 5y6p:ao, 5y6p:aq, 5y6p:as, 5y6p:au, 5y6p:aw, 5y6p:ay, 5y6p:aA, 5y6p:aC, 5y6p:aE, 5y6p:aI, 5y6p:aK, 5y6p:aM, 5y6p:aO, 5y6p:aQ, 5y6p:aS, 5y6p:aU, 5y6p:bm, 5y6p:bt, 5y6p:bu, 5y6p:bv, 5y6p:bw, 5y6p:bx, 5y6p:by, 5y6p:bA, 5y6p:bC, 5y6p:bE, 5y6p:bG, 5y6p:bI, 5y6p:cy, 5y6p:bK, 5y6p:bM, 5y6p:bO, 5y6p:bQ, 5y6p:bS, 5y6p:bU, 5y6p:cm, 5y6p:ct, 5y6p:cv, 5y6p:cu, 5y6p:cw, 5y6p:cx, 5y6p:cA, 5y6p:cG, 5y6p:cC, 5y6p:dE, 5y6p:cD, 5y6p:cI, 5y6p:cK, 5y6p:cS, 5y6p:cU, 5y6p:cT, 5y6p:cX, 5y6p:cV, 5y6p:dS, 5y6p:cW, 5y6p:cZ, 5y6p:da, 5y6p:db, 5y6p:dc, 5y6p:de, 5y6p:dg, 5y6p:dk, 5y6p:dm, 5y6p:do, 5y6p:dq, 5y6p:ds, 5y6p:du, 5y6p:dA, 5y6p:dC, 5y6p:dG, 5y6p:dI, 5y6p:dJ, 5y6p:dM, 5y6p:dW, 5y6p:dO, 5y6p:dQ, 5y6p:dU, 5y6p:ed, 5y6p:dZ, 5y6p:ea, 5y6p:ej, 5y6p:ef, 5y6p:eh, 5y6p:ek, 5y6p:eu, 5y6p:em, 5y6p:es, 5y6p:eo, 5y6p:eq, 5y6p:eA, 5y6p:eK, 5y6p:eC, 5y6p:eG, 5y6p:eI, 5y6p:eO, 5y6p:eU, 5y6p:eQ, 5y6p:eS, 5y6p:eW, 5y6p:la, 5y6p:lc, 5y6p:le, 5y6p:lg, 5y6p:li, 5y6p:lk, 5y6p:lm, 5y6p:lo, 5y6p:lq, 5y6p:ls, 5y6p:lu, 5y6p:lw, 5y6p:fb, 5y6p:fe, 5y6p:fg, 5y6p:fl, 5y6p:fh, 5y6p:fk, 5y6p:fn, 5y6p:fp, 5y6p:fr, 5y6p:ft, 5y6p:fv, 5y6p:fx, 5y6p:gl, 5y6p:gb, 5y6p:gc, 5y6p:gf, 5y6p:gh, 5y6p:gj, 5y6p:gm, 5y6p:go, 5y6p:gq, 5y6p:gs, 5y6p:gu, 5y6p:gw, 5y6p:hA, 5y6p:hC, 5y6p:hE, 5y6p:hF, 5y6p:hI, 5y6p:hK, 5y6p:hM, 5y6p:hO, 5y6p:hQ, 5y6p:hS, 5y6p:hU, 5y6p:hW, 5y6p:iA, 5y6p:iB
35 4cs7:C 172 19 0.0345 0.0523 0.4737 8.2 4cs7:A, 4cs7:B, 4cs7:E, 4cs8:A, 4cs8:B, 4cs8:C, 4cs8:E, 4cs9:A, 4cs9:B, 4cs9:C, 4cs9:E, 4csa:C, 4csa:A, 4csa:B, 4csa:E
36 4cxv:A 258 24 0.0536 0.0543 0.5833 8.8 4cwm:A, 4cwm:B, 4cxo:A, 4cxp:A, 4cxv:B, 3w52:A
37 6ef8:A 407 59 0.0690 0.0442 0.3051 9.3 6ef8:B, 6ef8:C, 6ef8:D, 6ef8:E, 6ef8:F, 6ef8:G, 6nef:A
38 9fmd:M 224 128 0.1341 0.1562 0.2734 9.9 8c6j:y, 8i0u:M, 8i0v:M, 8i0w:M, 6icz:M, 6id0:M, 6id1:M, 5mqf:N, 6qdv:y, 8ro2:M, 7w59:M, 7w5a:M, 7w5b:M, 5xjc:M, 5yzg:M
39 2rra:A 99 66 0.0690 0.1818 0.2727 9.9 2kxn:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218