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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
NPFHELEPGPEVPEVVYALIEIPKGSRNKYELDKKTGLLKLDRVLYSPFFYPVDYGIIPQTWYDDGDPFDIMVIMREPVY
PLTIIEARPIGIMKMEDSGDKDWKVLAVPVEDPYFNDWKDISDVPKAFLDEIAHFFQRYKELQGKTTKIEGWGNAEEAKR
EILRAIEMYKEKFG

The query sequence (length=174) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 3q46:A 178 174 0.9943 0.9719 0.9943 1.36e-125 3i98:A, 3i98:B, 3i98:C, 3i98:D, 3i98:E, 3i98:F, 3q3l:A, 3q3l:B, 3q3l:C, 3q3l:D, 3q3l:E, 3q3l:F, 3q4w:A, 3q5v:A, 3q5v:B, 3r5u:A, 3r5u:B, 3r5v:A, 3r5v:B, 3r5v:C, 3r5v:D, 3r5v:E, 3r5v:F, 5ucq:A, 5ucq:B, 5ucq:C
2 1qez:A 169 166 0.4828 0.4970 0.5060 5.35e-53 1qez:F, 1qez:B, 1qez:C, 1qez:D, 1qez:E
3 4z71:B 163 152 0.4310 0.4601 0.4934 3.47e-47 5kde:A, 5kdf:A, 1wcf:A, 4z70:A, 4z70:B, 4z70:C, 4z71:A, 4z71:C, 4z72:A, 4z73:A, 4z73:B, 4z73:C, 4z73:D, 4z73:F, 4z73:G, 4z73:E, 4z73:H, 4z73:I, 4z73:J, 4z73:K, 4z73:L, 4z74:A, 4z74:B, 4z74:C, 4z74:D, 4z74:F, 4z74:G, 4z74:E, 4z74:H, 4z74:I, 4z74:J, 4z74:K, 4z74:L
4 6k21:A 173 172 0.3966 0.3988 0.4012 5.42e-42 6k27:A, 6k27:B, 6k27:C, 6k27:D, 6k27:E, 6k27:F, 6k27:G, 6k27:H, 6ki8:A, 6ki8:B, 6ki8:C
5 2au6:A 175 168 0.4080 0.4057 0.4226 4.53e-41 2au7:A, 2au8:A, 2au9:A, 2auu:A, 1i40:A, 1i6t:A, 1ino:A, 1ipw:A, 1ipw:B, 1jfd:A, 1jfd:B, 1mjw:A, 1mjw:B, 1mjx:A, 1mjx:B, 1obw:A, 1obw:B, 1obw:C, 4um4:A, 4um4:B, 4um4:C
6 3tr4:B 171 158 0.3908 0.3977 0.4304 8.63e-38 3tr4:A, 3tr4:C, 3tr4:D, 3tr4:E, 3tr4:F
7 3ej2:A 182 173 0.4023 0.3846 0.4046 1.27e-37 3eiy:A, 3ej0:A
8 2bqy:A 170 158 0.3736 0.3824 0.4114 1.36e-36
9 5tea:B 174 169 0.3736 0.3736 0.3846 2.07e-36 5tea:A, 5tea:C, 5tea:D, 5tea:E, 5tea:F
10 7btn:A 275 161 0.3161 0.2000 0.3416 1.55e-18
11 2ik0:B 286 151 0.2816 0.1713 0.3245 2.63e-14 117e:A, 117e:B, 1e6a:A, 1e6a:B, 1e9g:A, 1e9g:B, 1huj:A, 1huj:B, 1huk:A, 1huk:B, 2ihp:A, 2ihp:B, 2ik0:A, 2ik1:A, 2ik1:B, 2ik2:A, 2ik2:B, 2ik4:A, 2ik4:B, 2ik6:A, 2ik6:B, 2ik7:A, 2ik7:B, 2ik9:A, 1m38:A, 1m38:B, 8prk:A, 8prk:B, 1wgi:A, 1wgi:B, 1wgj:A, 1wgj:B, 1ypp:A, 1ypp:B
12 5cuy:D 396 147 0.2701 0.1187 0.3197 1.67e-12 5c5v:A, 5c5v:B, 5cuy:A, 5cuy:B, 5cuy:C
13 5cuv:A 382 147 0.2816 0.1283 0.3333 3.02e-12 5cuu:A, 5cuu:B, 5cuv:B, 5cux:A, 5cux:B
14 5wrt:A 235 186 0.3161 0.2340 0.2957 3.48e-12 5wrt:B
15 4qlz:A 284 170 0.3046 0.1866 0.3118 5.45e-12 4qlz:B
16 8qpt:B 289 172 0.2701 0.1626 0.2733 1.30e-11 8qpt:A
17 5wru:B 308 147 0.2241 0.1266 0.2653 1.37e-07
18 8axs:A 573 74 0.1379 0.0419 0.3243 0.70 8axi:A, 8axi:B, 8axs:B, 8axt:A, 8axt:B, 8hls:A, 8hls:B
19 3hkz:A 836 45 0.0862 0.0179 0.3333 2.3 3hkz:I, 2y0s:A, 2y0s:W
20 6hqw:A 395 50 0.0862 0.0380 0.3000 2.5
21 4ayb:A 872 45 0.0862 0.0172 0.3333 2.5 2pmz:A, 2pmz:Q, 4v8s:AW, 4v8s:BA, 2waq:A, 2wb1:A, 2wb1:W
22 6meq:A 416 26 0.0747 0.0312 0.5000 2.8 5k8r:A, 6mer:A
23 8ieo:P 1031 48 0.0805 0.0136 0.2917 4.5 8iem:P
24 6d6q:M 709 41 0.0690 0.0169 0.2927 6.1 6d6r:M, 7z52:B
25 5hwn:B 310 38 0.0747 0.0419 0.3421 7.6 5hwm:A, 5hwm:B, 5hwm:C, 5hwm:D, 5hwn:A, 5hwn:C, 5hwn:D, 4ur8:A, 4ur8:B, 4ur8:C, 4ur8:D
26 7olc:SN 150 70 0.0977 0.1133 0.2429 8.9 7old:SN, 8oo0:SN, 7r81:O2, 6rxx:Ch, 7z3n:SN, 7z3o:SN
27 4u79:A 337 33 0.0747 0.0386 0.3939 9.0 2b1p:A, 8bzp:B, 3cgo:A, 3da6:A, 4e73:A, 6ekd:A, 6emh:C, 6emh:D, 8enj:A, 6eq9:B, 2exc:X, 3fi2:A, 3fi3:A, 3fv8:A, 4g1w:A, 4hys:A, 4hyu:A, 4izy:A, 7ksk:A, 3kvx:A, 2o0u:A, 2o2u:A, 2ok1:A, 3oxi:A, 3oy1:A, 2p33:A, 2r9s:A, 2r9s:B, 3rtp:A, 3ttj:A, 1ukh:A, 4z9l:A, 2zdu:A

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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