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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
NFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSP
KVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNTLIARSLGKYN
IICMEDLIHEIYTVGKHFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN

The query sequence (length=225) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8fkp:SD 239 225 0.9867 0.9289 0.9867 1.57e-163 7a01:U2, 8a3d:m, 5aj0:AF, 8b5l:F, 8b6c:F, 9bdl:AL07, 9bdn:AL07, 9bdp:AL07, 7bhp:LF, 8bhf:o3, 8bpo:F2, 8btk:BF, 7cpu:LF, 7cpv:LF, 4d5y:F, 4d67:F, 6d90:F, 6d9j:F, 9f1b:BF, 9f1c:BF, 9f1d:BF, 7f5s:LF, 8fkq:SD, 8fkr:SD, 8fks:SD, 8fkt:SD, 8fku:SD, 8fkv:SD, 8fkw:SD, 8fkx:SD, 8fky:SD, 8fkz:SD, 8fl0:SD, 8fl2:SD, 8fl3:SD, 8fl4:SD, 8fl6:SD, 8fl7:SD, 8fl9:SD, 8fla:SD, 8flb:SD, 8flc:SD, 8fld:SD, 8fle:SD, 8flf:SD, 6frk:F, 6ftg:F, 6fti:F, 6ftj:F, 8g5y:LF, 8g5z:LF, 8g60:LF, 8g61:LF, 8g6j:LF, 8glp:LF, 6gz3:AF, 6gz4:AF, 6gz5:AF, 6hcf:F3, 6hcj:F3, 6hcm:F3, 6hcq:F3, 8idt:p, 8idy:p, 8ie3:p, 8ifd:2A, 8ife:2A, 8ine:p, 8inf:p, 8ink:p, 6ip5:2A, 6ip6:2A, 6ip8:2A, 8ipd:p, 8ipx:p, 8ipy:p, 8ir1:p, 8ir3:p, 3j7o:F, 3j7p:F, 3j7q:F, 3j7r:F, 3j92:F, 3jag:F, 3jah:F, 3jai:F, 3jaj:F, 3jan:F, 8jdj:L, 8jdk:L, 8jdl:L, 8jdm:L, 8k2c:LF, 5lks:LF, 6lqm:w, 6lsr:w, 6lss:p, 7ls1:A1, 7ls2:A1, 6lu8:p, 5lzs:F, 5lzt:F, 5lzu:F, 5lzv:F, 5lzw:F, 5lzx:F, 5lzy:F, 5lzz:F, 7mdz:F, 6mtb:F, 6mtc:F, 6mtd:F, 6mte:F, 7nfx:F, 7nwg:F3, 7nwh:F, 7nwi:F, 7o7y:BF, 7o7z:BF, 7o80:BF, 7o81:BF, 7obr:F, 8ohd:LF, 8oj0:LF, 8oj5:LF, 8oj8:LF, 6ole:H, 6olf:H, 6olg:AF, 6oli:H, 6olz:AF, 6om0:H, 6om7:H, 7ow7:m, 7oyd:F, 8p2k:BF, 6p5i:AF, 6p5j:AF, 6p5k:AF, 6p5n:AF, 8qfd:F, 7qgg:H, 8qoi:LF, 7qvp:LF, 7qvp:MF, 7qwq:F, 7qwr:F, 7qws:F, 6qzp:LF, 6r5q:F, 6r6g:F, 6r6p:F, 6r7q:F, 8rjb:F, 8rjc:F, 8rjd:F, 8scb:F, 6sgc:F2, 6swa:F, 5t2c:m, 6t59:F3, 7tm3:F, 7toq:AL07, 7tor:AL07, 7tut:F, 7ucj:F, 7uck:F, 4ug0:LF, 4ujc:BF, 4ujd:AF, 4uje:CF, 4v5z:Bw, 4v6x:CF, 6w6l:H, 6xa1:LF, 7xnx:LF, 7xny:LF, 8xsx:LF, 8xsy:LF, 8xsz:LF, 6y0g:LF, 8y0w:LF, 8y0x:LF, 6y2l:LF, 6y57:LF, 6y6x:LF, 8yoo:LF, 8yop:LF, 6z6l:LF, 6z6m:LF, 6z6n:LF, 7zjw:LI, 7zjx:LI, 6zm7:LF, 6zme:LF, 6zmi:LF, 6zmo:LF, 6zvk:U2
2 8q7z:BF 234 224 0.8622 0.8291 0.8661 2.25e-142 8q87:BF
3 7oyc:F1 227 224 0.7911 0.7841 0.7946 8.86e-133
4 7oya:F1 222 202 0.7733 0.7838 0.8614 6.64e-131 7oyb:F1
5 7qiw:I 239 202 0.6000 0.5649 0.6683 2.07e-100 8azw:q, 8b2l:q3, 7qiz:I
6 4v3p:Le 244 215 0.6000 0.5533 0.6279 1.70e-97 8ip8:CB, 8ipa:CB, 8ipb:CB, 8jiv:CF, 4v7e:CF
7 8pv1:LF 248 210 0.5911 0.5363 0.6333 2.22e-97 8i9p:LF, 8i9p:CM, 8i9r:LF, 8i9r:CM, 8i9t:LF, 8i9t:CM, 8i9v:LF, 8i9v:CM, 8i9w:LF, 8i9w:CM, 8i9x:CM, 8i9x:LF, 8i9y:CM, 8i9y:LF, 8i9z:CM, 8i9z:LF, 8ia0:CM, 8ia0:LF, 7olc:LF, 7old:LF, 8oo0:LF, 8pv1:CM, 8pv2:LF, 8pv3:CM, 8pv3:LF, 8pv4:LF, 8pv4:CM, 8pv5:LF, 8pv6:CM, 8pv6:LF, 8pv7:CM, 8pv7:LF, 8pv8:LF, 8pvk:CM, 8pvk:LF, 8pvl:CM, 8pvl:LF, 7z3n:LF, 7z3o:LF
8 9bh5:CF 213 204 0.5600 0.5915 0.6176 3.72e-96 9cai:CF
9 4v6w:CF 229 196 0.5689 0.5590 0.6531 2.58e-92 6xu6:CF, 6xu7:CF, 6xu8:CF
10 8euy:F 240 210 0.5556 0.5208 0.5952 1.82e-90 8esq:F, 8esr:F, 8etc:F, 8etg:F, 8eth:F, 8eti:F, 8etj:F, 8eug:F, 8eui:F, 8eup:F, 8ev3:F
11 7r81:I1 247 203 0.5778 0.5263 0.6404 1.42e-87
12 8c3a:o 234 204 0.5022 0.4829 0.5539 1.67e-86 8c3a:BB, 8cq7:o, 8cq7:BB, 8cqw:o, 8cqw:BB, 8cre:o, 8cre:BB, 8oeq:o, 8oeq:BB, 7pzy:o, 7q08:o, 7q0f:o, 7q0p:o, 7q0r:o, 8q5i:o
13 5it7:FF 222 214 0.5200 0.5270 0.5467 4.53e-83 6uz7:AF
14 6c0f:F 242 207 0.5022 0.4669 0.5459 1.30e-82 8aaf:o, 8agt:o, 8agu:o, 8agv:o, 8agw:o, 8agx:o, 8agz:o, 5apn:F, 5apo:F, 7azy:C, 7b7d:LI, 8bip:LF, 8bjq:LF, 8bn3:L7, 8bqd:BO, 8bqx:BO, 7bt6:F, 7btb:F, 6cb1:F, 8ccs:JJ, 8cdl:JJ, 8cdr:JJ, 8ceh:JJ, 8cf5:JJ, 8cg8:JJ, 8cgn:JJ, 8civ:JJ, 8cku:JJ, 8cmj:JJ, 5dat:L7, 5dat:l7, 5dc3:L7, 5dc3:l7, 5dge:L7, 5dge:l7, 5dgf:L7, 5dgf:l7, 5dgv:L7, 5dgv:l7, 8e5t:F, 6elz:F, 6em1:F, 6em3:F, 6em4:F, 6em5:F, 8eub:AF, 8evp:AF, 8evq:AF, 8evr:AF, 8evs:AF, 8evt:AF, 8ewb:AF, 8ewc:AF, 5fci:L7, 5fci:l7, 5fcj:L7, 5fcj:l7, 6ft6:F, 5gak:J, 6gq1:F, 6gqb:F, 6gqv:F, 5h4p:F, 6hd7:J, 8hfr:Gu, 6hhq:o, 6hhq:CI, 5i4l:L7, 5i4l:l7, 6i7o:BO, 6i7o:YO, 3j6x:L7, 3j6y:L7, 3j77:L7, 3j78:L7, 3jct:F, 5jcs:F, 5juo:K, 5jup:K, 5jus:K, 5jut:K, 5juu:K, 8k2d:LF, 8k82:LF, 5lyb:L7, 5lyb:l7, 5m1j:F5, 6m62:F, 5mc6:BO, 5mei:o, 5mei:CI, 7mpi:AF, 7mpj:AF, 6n8j:F, 6n8k:F, 6n8l:F, 6n8m:I, 6n8n:I, 6n8o:I, 7n8b:AF, 7nac:F, 5ndg:L7, 5ndg:l7, 5ndv:L7, 5ndv:l7, 5ndw:L7, 5ndw:l7, 7nrc:LI, 7nrd:LI, 5obm:L7, 5obm:l7, 7of1:F, 7oh3:F, 7ohp:F, 7ohq:F, 7ohr:F, 7ohs:F, 7oht:F, 7ohu:F, 7ohv:F, 7ohw:F, 7ohx:F, 7ohy:F, 6oig:F, 5on6:o, 5on6:CI, 7osa:uL30, 7osm:uL30, 8p8m:LK, 8p8n:LK, 8p8u:LK, 8pfr:LK, 6q8y:BO, 6qik:b, 6qt0:b, 6qtz:b, 7r7a:F, 6r84:J, 6r86:J, 6r87:J, 6ri5:b, 7rr5:LF, 6rzz:b, 6s05:b, 6s47:AI, 6snt:m, 6sv4:BO, 6sv4:YO, 6sv4:ZO, 6t4q:LF, 5t62:I, 5t6r:I, 6t7i:LF, 6t7t:LF, 6t83:Fy, 6t83:Ia, 5tbw:o, 5tbw:CI, 6tb3:BO, 5tga:L7, 5tga:l7, 5tgm:L7, 5tgm:l7, 6tnu:BO, 7too:AL07, 7top:AL07, 7u0h:F, 4u3m:L7, 4u3m:l7, 4u3n:L7, 4u3n:l7, 4u3u:L7, 4u3u:l7, 4u4n:L7, 4u4n:l7, 4u4o:L7, 4u4o:l7, 4u4q:L7, 4u4q:l7, 4u4r:L7, 4u4r:l7, 4u4u:L7, 4u4u:l7, 4u4y:L7, 4u4y:l7, 4u4z:L7, 4u4z:l7, 4u50:L7, 4u50:l7, 4u51:L7, 4u51:l7, 4u52:L7, 4u52:l7, 4u53:L7, 4u53:l7, 4u55:L7, 4u55:l7, 4u56:L7, 4u56:l7, 4u6f:L7, 4u6f:l7, 7ug6:F, 7uoo:F, 7uqb:F, 7uqz:F, 7v08:F, 4v4b:BF, 4v6i:Be, 4v7r:BG, 4v7r:DG, 4v88:BF, 4v88:DF, 4v8t:F, 4v8y:BF, 4v8z:BF, 8v83:F, 8v84:F, 8v87:F, 4v91:F, 6woo:F, 6xiq:F, 6xir:F, 8y0u:LF, 6ylg:F, 6ylh:F, 6ylx:F, 6yly:F, 5z3g:J, 7z34:F, 6z6j:LF, 6z6k:LF, 7zpq:BF, 7zrs:BF, 7zs5:BH, 7zuw:BF, 7zux:EF, 7zw0:LJ
15 4v8p:BV 234 204 0.4978 0.4786 0.5490 3.04e-80 4v8p:CV, 4v8p:EV, 4v8p:GV
16 5t5h:w 215 210 0.4978 0.5209 0.5333 1.23e-78
17 6zj3:Lr 218 175 0.4667 0.4817 0.6000 1.19e-77
18 8ovj:c 229 197 0.4711 0.4629 0.5381 3.79e-76 8a3w:c, 8a98:c, 6az3:c, 3jcs:c, 8rxh:Lc, 8rxx:Lc, 5t2a:u
19 8esq:t 235 217 0.5067 0.4851 0.5253 1.05e-74 8esr:t, 8etg:t, 8eth:t, 8eti:t, 8ev3:t
20 4v8m:Bw 257 197 0.4711 0.4125 0.5381 5.36e-74 8ova:Bw, 8ove:Bw
21 4v7h:BF 213 162 0.4222 0.4460 0.5864 7.98e-70
22 8fru:F 221 195 0.4356 0.4434 0.5026 2.08e-67 8br8:LH, 8brm:LH, 8bsi:LH, 8bsj:LH, 8btd:LH, 8btr:LH, 7pwg:F, 7pwo:F2
23 5xy3:F 231 215 0.4756 0.4632 0.4977 6.32e-65
24 5xxb:F 250 225 0.4622 0.4160 0.4622 1.19e-64
25 8fl2:SI 234 191 0.4178 0.4017 0.4921 9.25e-60 8fkp:SI, 8fkq:SI, 8fkr:SI, 8fks:SI, 8fkt:SI, 8fku:SI, 8fkv:SI, 8fkw:SI, 8fkx:SI, 8fky:SI, 8fkz:SI, 8fl3:SI, 8fl6:SI, 8fl7:SI, 8fla:SI, 8flb:SI, 8fld:SI, 8fle:SI, 8ine:3, 8inf:3, 8ipx:1, 8ipy:1, 8ir3:3
26 3j79:5 223 185 0.4267 0.4305 0.5189 1.41e-59 3jbn:A5, 3jbo:A5, 3jbp:A5, 8tpu:A5, 5umd:5
27 6zu5:LF0 247 212 0.3556 0.3239 0.3774 1.63e-39
28 7qep:L7 231 181 0.3200 0.3117 0.3978 9.50e-37
29 8p5d:LF0 231 227 0.3600 0.3506 0.3568 1.81e-36 8p60:LF0, 8p60:KF0, 7qca:LF0
30 6cb1:t 282 184 0.2933 0.2340 0.3587 2.72e-29
31 6elz:t 290 184 0.2889 0.2241 0.3533 4.06e-29 7btb:t, 6c0f:t, 8e5t:t, 6em1:t, 6em3:t, 6em4:t, 6em5:t, 3jct:t, 6m62:t, 7nac:t, 7ohp:t, 7ohq:t, 7ohr:t, 7ohs:t, 7ohv:t, 7ohw:t, 7r6q:t, 7r7a:t, 7u0h:t, 7uoo:t, 7uqb:t, 7uqz:t, 7v08:t, 8v83:t, 8v84:t, 8v87:t, 6ylx:t, 6yly:t, 5z3g:D
32 6rm3:LF0 230 182 0.2844 0.2783 0.3516 1.80e-26
33 7ohx:t 202 126 0.2311 0.2574 0.4127 4.46e-20
34 4v4n:AY 155 161 0.2533 0.3677 0.3540 4.83e-15 4v6u:BY
35 8hku:L30P 155 166 0.2178 0.3161 0.2952 4.64e-11 8hkv:L30P, 8hky:L30P, 8hkz:L30P, 8hl1:L30P, 8hl2:L30P, 8hl3:L30P, 8hl4:L30P, 8hl5:L30P
36 6skf:Ba 154 161 0.2311 0.3377 0.3230 5.04e-11 6skg:Ba, 6th6:Ba
37 6i3p:C 630 101 0.1156 0.0413 0.2574 0.39 6i3p:A, 6i3p:B, 6i3p:D, 6qic:A, 6qic:B, 6qic:C, 6qic:D
38 7yym:A 1281 151 0.1556 0.0273 0.2318 2.3 4ngb:A, 4ngc:A, 4ngg:A, 4nh3:A, 4nh5:A, 4nh6:A, 7yyn:A, 7zpi:A, 7zpj:A, 7zpk:A
39 6vxe:A 789 33 0.0578 0.0165 0.3939 2.4 6vxe:B, 6vxe:C, 6vxe:D, 6vxe:E, 6vxe:F, 6vxe:G, 6vxe:H
40 4ykn:A 1205 53 0.0800 0.0149 0.3396 6.2 4a55:A, 8am0:A, 8exl:A, 8exo:A, 8exu:A, 8exv:A, 5fi4:A, 8gub:A, 6gvf:A, 6gvg:A, 6gvi:A, 3hhm:A, 7jiu:A, 4jps:A, 4l23:A, 4l2y:A, 7mlk:A, 7myo:A, 4ovv:A, 8ow2:A, 7pg6:A, 6pys:A, 5sx9:A, 5sxj:A, 8tdu:A, 8tdu:C, 8tgd:A, 8tgd:C, 8ts9:A, 8tsa:A, 8tsb:A, 8tsc:A, 8tsd:A, 4tv3:A, 5uk8:A, 5ukj:A, 5ul1:A, 8v8h:A, 8v8h:C, 8v8i:A, 8v8i:C, 8v8j:A, 8v8j:C, 8v8v:A, 8v8v:C, 8w9a:A, 8w9b:A, 4waf:A, 5xgh:A, 5xgi:A, 3zim:A, 4zop:A
41 6cgu:A 207 56 0.0756 0.0821 0.3036 6.2 6cgu:B, 6cgu:C, 6cgu:D, 3lnd:A, 3lnd:B, 3lnd:C, 3lnd:D
42 2lvj:A 77 57 0.0756 0.2208 0.2982 7.7 1k9u:A, 1k9u:B, 2lvk:A, 5otj:D, 5otj:C
43 6cgs:A 207 21 0.0489 0.0531 0.5238 8.8 6cgs:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218