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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
MSAQKAPKWYPSEDVAALKKTRKAARPQKLRASLVPGTVLILLAGRFRGKRVVYLKHLEDNTLLISGPFKVNGVPLRRVN
ARYVIATSTKVSVEGVNVEKFNVEYFAKEKLTKKEKKEANLFPEQQNKEIKAERVEDQKVVDKALIAEIKKTPLLKQYLS
ASFSLKNGDKPHMLKF

The query sequence (length=176) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4v6i:BG 176 176 1.0000 1.0000 1.0000 5.13e-127 8aaf:n, 8agt:n, 8agu:n, 8agv:n, 8agw:n, 8agx:n, 8agz:n, 5apn:E, 5apo:E, 7b7d:LH, 8bip:LE, 8bjq:LE, 8bqd:BM, 8bqx:BM, 6c0f:E, 6cb1:E, 8hfr:F8, 5juo:J, 5jup:J, 5jus:J, 5jut:J, 5juu:J, 6n8j:E, 6n8k:E, 6n8l:E, 7nac:E, 7nrc:LH, 7nrd:LH, 7of1:E, 6qik:G, 6qt0:G, 6qtz:G, 7r7a:E, 6ri5:G, 7rr5:LE, 6rzz:G, 6s05:G, 6snt:l, 6t4q:LE, 6t7i:LE, 6t7t:LE, 6t83:Ey, 6tb3:BM, 6tnu:BM, 4v7r:BF, 4v7r:DF, 8y0u:LE, 7z34:E, 7zpq:BE, 7zrs:BE, 7zuw:BE, 7zux:EE, 7zw0:LI
2 5dat:l6 157 175 0.8920 1.0000 0.8971 6.27e-108 7azy:A, 8bn3:L6, 7bt6:E, 7btb:E, 8ccs:II, 8cdl:II, 8cdr:II, 8ceh:II, 8cf5:II, 8cg8:II, 8cgn:II, 8civ:II, 8cku:II, 8cmj:II, 5dat:L6, 5dc3:L6, 5dc3:l6, 5dge:L6, 5dge:l6, 5dgf:L6, 5dgf:l6, 5dgv:L6, 5dgv:l6, 8e5t:E, 6elz:E, 6em1:E, 6em3:E, 6em4:E, 6em5:E, 8eub:AE, 8evp:AE, 8evq:AE, 8evr:AE, 8evs:AE, 8evt:AE, 8ewb:AE, 8ewc:AE, 5fci:L6, 5fci:l6, 5fcj:L6, 5fcj:l6, 6ft6:E, 5gak:I, 6gq1:E, 6gqb:E, 6gqv:E, 5h4p:E, 6hd7:I, 6hhq:n, 6hhq:CH, 5i4l:L6, 5i4l:l6, 6i7o:BM, 6i7o:YM, 3j6x:L6, 3j6y:L6, 3j77:L6, 3j78:L6, 3jct:E, 5jcs:E, 8k2d:LE, 8k82:LE, 5lyb:L6, 5lyb:l6, 5m1j:E5, 6m62:E, 5mc6:BM, 5mei:n, 5mei:CH, 7mpi:AE, 7mpj:AE, 6n8m:H, 6n8n:H, 6n8o:H, 7n8b:AE, 5ndg:L6, 5ndg:l6, 5ndv:L6, 5ndv:l6, 5ndw:L6, 5ndw:l6, 5obm:L6, 5obm:l6, 7oh3:E, 7ohp:E, 7ohq:E, 7ohr:E, 7ohs:E, 7oht:E, 7ohu:E, 7ohv:E, 7ohw:E, 7ohx:E, 7ohy:E, 6oig:E, 5on6:n, 5on6:CH, 7osa:eL6, 7osm:eL6, 8p8m:LJ, 8p8n:LJ, 8p8u:LJ, 8pfr:LJ, 6q8y:BM, 6r84:I, 6r86:I, 6r87:I, 6s47:AH, 6sv4:BM, 6sv4:YM, 6sv4:ZM, 5t62:H, 5t6r:H, 6t83:Ha, 5tbw:n, 5tbw:CH, 5tga:L6, 5tga:l6, 5tgm:L6, 5tgm:l6, 7too:AL06, 7top:AL06, 7u0h:E, 4u3m:L6, 4u3m:l6, 4u3n:L6, 4u3n:l6, 4u3u:L6, 4u3u:l6, 4u4n:L6, 4u4n:l6, 4u4o:L6, 4u4o:l6, 4u4q:L6, 4u4q:l6, 4u4r:L6, 4u4r:l6, 4u4u:L6, 4u4u:l6, 4u4y:L6, 4u4y:l6, 4u4z:L6, 4u4z:l6, 4u50:L6, 4u50:l6, 4u51:L6, 4u51:l6, 4u52:L6, 4u52:l6, 4u53:L6, 4u53:l6, 4u55:L6, 4u55:l6, 4u56:L6, 4u56:l6, 4u6f:L6, 4u6f:l6, 7ug6:E, 7uoo:E, 7uqb:E, 7uqz:E, 7v08:E, 4v88:BE, 4v88:DE, 4v8t:E, 4v8y:BE, 4v8z:BE, 8v83:E, 8v84:E, 8v87:E, 4v91:E, 6woo:E, 6xiq:E, 6xir:E, 6ylg:E, 6ylh:E, 6ylx:E, 6yly:E, 5z3g:I, 6z6j:LE, 6z6k:LE, 7zs5:BG
3 6uz7:AE 164 169 0.7784 0.8354 0.8107 7.95e-99 5it7:EE
4 8c3a:n 157 174 0.7614 0.8535 0.7701 5.99e-92 8c3a:BA, 8cq7:n, 8cq7:BA, 8cqw:n, 8cqw:BA, 8cre:n, 8cre:BA, 8oeq:n, 8oeq:BA, 7pzy:n, 7q08:n, 7q0f:n, 7q0p:n, 7q0r:n, 8q5i:n
5 7r81:H1 194 179 0.5795 0.5258 0.5698 3.44e-65
6 7olc:LE 194 182 0.6023 0.5464 0.5824 4.10e-65 8i9p:LE, 8i9r:LE, 8i9t:LE, 8i9v:LE, 8i9w:LE, 8i9x:LE, 8i9y:LE, 8i9z:LE, 8ia0:LE, 7old:LE, 8oo0:LE, 8pv1:LE, 8pv2:LE, 8pv3:LE, 8pv4:LE, 8pv5:LE, 8pv6:LE, 8pv7:LE, 8pv8:LE, 8pvk:LE, 8pvl:LE, 7z3n:LE, 7z3o:LE
7 8eui:E 183 177 0.5852 0.5628 0.5819 4.13e-65 8esq:E, 8esr:E, 8etc:E, 8eth:E, 8eti:E, 8etj:E, 8eug:E, 8eup:E, 8euy:E, 8ev3:E
8 4v3p:LG 219 172 0.5227 0.4201 0.5349 1.93e-60 8ip8:LB, 8ipa:LB, 8ipb:LB, 4v7e:CE
9 8etg:E 145 159 0.5341 0.6483 0.5912 2.94e-58
10 7qiw:H 201 172 0.5284 0.4627 0.5407 1.31e-55 7qiz:H
11 4v8p:AE 190 178 0.5170 0.4789 0.5112 6.92e-55 4v8p:DE, 4v8p:FE, 4v8p:HE
12 8azw:b 208 168 0.5170 0.4375 0.5417 1.09e-54 8b2l:b3
13 8jiv:CE 175 170 0.4943 0.4971 0.5118 1.40e-54
14 4v6x:CE 262 179 0.4602 0.3092 0.4525 3.86e-44 7a01:T2, 5aj0:AE, 8btk:BE, 7cpu:LE, 7cpv:LE, 4d5y:E, 4d67:E, 9f1b:BE, 9f1c:BE, 9f1d:BE, 8fku:SC, 8fkw:SC, 6frk:E, 6ftg:E, 6fti:E, 6ftj:E, 6gz3:AE, 6gz4:AE, 6gz5:AE, 8idt:o, 8idy:o, 8ie3:o, 8ifd:1H, 8ife:1H, 8ine:o, 8inf:o, 8ink:o, 6ip5:1H, 6ip6:1H, 6ip8:1H, 8ipd:o, 8ipx:o, 8ipy:o, 8ir1:o, 8ir3:o, 3j7o:E, 3j7p:E, 3j7q:E, 3j7r:E, 3j92:E, 3jag:E, 3jah:E, 3jai:E, 3jaj:E, 3jan:E, 5lks:LE, 6lqm:v, 6lsr:v, 6lss:o, 7nfx:E, 7nwi:E, 7o7y:BE, 7o7z:BE, 7o80:BE, 7o81:BE, 7obr:E, 6ole:G, 6olf:G, 6olg:AE, 6oli:G, 6olz:AE, 6om0:G, 6om7:G, 8p2k:BE, 7qgg:G, 8qoi:LE, 7qwq:E, 7qwr:E, 7qws:E, 6qzp:LE, 6r6p:E, 6swa:E, 5t2c:H, 7tm3:E, 7tut:E, 4ug0:LE, 4ujc:BE, 4ujd:AE, 4uje:CE, 6xa1:LE, 8xsx:LE, 8y0w:LE, 6y6x:LE, 6z6l:LE, 6z6m:LE, 6z6n:LE, 7zjx:LH, 6zm7:LE, 6zme:LE, 6zmi:LE, 6zmo:LE, 6zvk:T2
15 8fkp:SC 199 172 0.4375 0.3869 0.4477 8.10e-44 8fkr:SC, 8fkt:SC, 8fkv:SC
16 8q87:BE 225 178 0.4773 0.3733 0.4719 2.40e-42 8q7z:BE
17 7oya:E1 206 180 0.4432 0.3786 0.4333 9.52e-40 7oyb:E1
18 7oyc:E1 214 177 0.4432 0.3645 0.4407 2.61e-39
19 8qfd:E 201 178 0.4318 0.3781 0.4270 4.44e-39 8fl0:SC
20 7zjw:LH 232 178 0.4602 0.3491 0.4551 4.66e-39 7a01:R2, 8a3d:H, 8b5l:E, 8b6c:E, 9bdl:AL06, 9bdn:AL06, 9bdp:AL06, 7bhp:LE, 8bhf:n3, 8bpo:E2, 6d90:E, 6d9j:E, 7f5s:LE, 8fkq:SC, 8fks:SC, 8fkx:SC, 8fky:SC, 8fkz:SC, 8fl2:SC, 8fl3:SC, 8fl4:SC, 8fl6:SC, 8fl7:SC, 8fl9:SC, 8fla:SC, 8flb:SC, 8flc:SC, 8fld:SC, 8fle:SC, 8flf:SC, 9fpz:LE, 9fq0:LE, 8g5y:LE, 8g5z:LE, 8g60:LE, 8g61:LE, 8g6j:LE, 8glp:LE, 6hcf:E3, 6hcj:E3, 6hcm:E3, 6hcq:E3, 8jdj:K, 8jdk:K, 8jdl:K, 8jdm:K, 8k2c:LE, 7ls1:H2, 7ls2:H2, 6lu8:o, 5lzs:E, 5lzt:E, 5lzu:E, 5lzv:E, 5lzw:E, 5lzx:E, 5lzy:E, 5lzz:E, 7mdz:E, 6mtb:E, 6mtc:E, 6mtd:E, 6mte:E, 7nwg:E3, 7nwh:E, 8ohd:LE, 8oj0:LE, 8oj5:LE, 8oj8:LE, 7ow7:H, 7oyd:E, 6p5i:AE, 6p5j:AE, 6p5k:AE, 6p5n:AE, 7qvp:LE, 7qvp:ME, 6r5q:E, 6r6g:E, 6r7q:E, 8rjb:E, 8rjc:E, 8rjd:E, 8scb:E, 6sgc:E2, 6t59:E3, 7toq:AL06, 7tor:AL06, 7ucj:E, 7uck:E, 6w6l:G, 7xnx:LE, 7xny:LE, 8xsy:LE, 8xsz:LE, 6y0g:LE, 8y0x:LE, 6y2l:LE, 6y57:LE, 8yoo:LE, 8yop:LE, 6zvk:R2
21 4v8m:Bv 157 160 0.3920 0.4395 0.4313 6.37e-37 8ova:Bv, 8ove:Bv
22 5xxb:E 124 147 0.3977 0.5645 0.4762 6.60e-35
23 5t5h:v 132 151 0.3750 0.5000 0.4371 2.48e-34
24 4v6w:CE 228 153 0.4091 0.3158 0.4706 3.48e-33 6xu6:CE, 6xu7:CE, 6xu8:CE
25 9bh5:CE 139 152 0.3864 0.4892 0.4474 4.73e-33 9cai:CE
26 8rxh:LF 149 162 0.3807 0.4497 0.4136 6.29e-33 8a3w:F, 8a98:F, 6az3:F, 3jcs:F, 8ovj:F, 8rxx:LF, 5t2a:t
27 6zj3:LU 194 183 0.3864 0.3505 0.3716 4.30e-32
28 6zu5:LE0 179 173 0.2898 0.2849 0.2948 4.29e-18
29 3j79:I 207 174 0.3182 0.2705 0.3218 2.45e-16 3jbn:AI, 3jbo:AI, 3jbp:AI, 8tpu:AI, 5umd:I
30 8p5d:LE0 165 163 0.2614 0.2788 0.2822 2.26e-12 8p60:LE0, 8p60:KE0, 7qca:LE0
31 5xy3:E 135 153 0.2273 0.2963 0.2614 7.29e-07
32 8hku:L141 86 57 0.1136 0.2326 0.3509 4.57e-06 8hku:L142, 8hkv:L141, 8hkv:L142, 8hky:L141, 8hky:L142, 8hkz:L141, 8hkz:L142, 8hl1:L141, 8hl1:L142, 8hl2:L141, 8hl2:L142, 8hl3:L141, 8hl3:L142, 8hl4:L141, 8hl4:L142, 8hl5:L141, 8hl5:L142
33 6rm3:LZ0 125 81 0.1193 0.1680 0.2593 0.011
34 4d5y:Z 136 27 0.0682 0.0882 0.4444 0.013 7a01:22, 8a3d:T, 5aj0:AZ, 8b5l:Z, 8b6c:Z, 9bdl:AL27, 9bdn:AL27, 9bdp:AL27, 7bhp:LZ, 8bhf:M1, 8bpo:Y2, 8btk:BZ, 7cpu:LZ, 7cpv:LZ, 4d67:Z, 6d90:Z, 6d9j:Z, 9f1b:BZ, 9f1c:BZ, 9f1d:BZ, 7f5s:LZ, 8fky:LJ, 8fkz:LJ, 8fl2:LJ, 8fl3:LJ, 8fl4:LJ, 8fl6:LJ, 8fl7:LJ, 8fl9:LJ, 8fla:LJ, 8flb:LJ, 8flc:LJ, 8fld:LJ, 8fle:LJ, 8flf:LJ, 6frk:Z, 6ftg:Z, 6fti:Z, 6ftj:Z, 8g5y:LZ, 8g5z:LZ, 8g60:LZ, 8g61:LZ, 8g6j:LZ, 8glp:LZ, 6gz3:AZ, 6gz4:AZ, 6gz5:AZ, 6hcf:Z3, 6hcj:Z3, 6hcm:Z3, 6hcq:Z3, 8idt:i, 8idy:i, 8ie3:i, 8ifd:2T, 8ife:2T, 8ine:i, 8inf:i, 8ink:i, 6ip5:2T, 6ip6:2T, 6ip8:2T, 8ipd:i, 8ipx:i, 8ipy:i, 8ir1:i, 8ir3:i, 3j7o:Z, 3j7p:Z, 3j7q:Z, 3j7r:Z, 3j92:Z, 3jag:Z, 3jah:Z, 3jai:Z, 3jaj:Z, 3jan:Z, 8jdj:e, 8jdk:e, 8jdl:e, 8jdm:e, 8k2c:LZ, 5lks:LZ, 6lqm:i, 6lsr:i, 6lss:i, 7ls1:T2, 7ls2:T2, 6lu8:i, 5lzs:Z, 5lzt:Z, 5lzu:Z, 5lzv:Z, 5lzw:Z, 5lzx:Z, 5lzy:Z, 5lzz:Z, 7mdz:Z, 6mtb:Z, 6mtc:Z, 6mtd:Z, 6mte:Z, 7nfx:Z, 7nwg:Z3, 7nwh:Z, 7nwi:Z, 7o7y:BZ, 7o7z:BZ, 7o80:BZ, 7o81:BZ, 7obr:Z, 8ohd:LZ, 8oj0:LZ, 8oj5:LZ, 8oj8:LZ, 6ole:a, 6olf:a, 6olg:AZ, 6oli:a, 6olz:AZ, 6om0:a, 6om7:a, 7ow7:T, 7oya:Z1, 7oyb:Z1, 7oyc:Z1, 7oyd:Z, 8p2k:BZ, 6p5i:AZ, 6p5j:AZ, 6p5k:AZ, 6p5n:AZ, 8q7z:BZ, 8q87:BZ, 8qfd:Z, 7qgg:a, 8qoi:LZ, 7qvp:LZ, 7qvp:MZ, 7qwq:Z, 7qwr:Z, 7qws:Z, 6qzp:LZ, 6r5q:Z, 6r6g:Z, 6r6p:Z, 6r7q:Z, 8rjb:Z, 8rjc:Z, 8rjd:Z, 8scb:Z, 6sgc:Z2, 6swa:X, 5t2c:T, 6t59:Z3, 7tm3:Z, 7toq:AL27, 7tor:AL27, 7tut:Z, 7ucj:Z, 7uck:Z, 4ug0:LZ, 4ujc:BZ, 4ujd:AZ, 4uje:CZ, 4v6x:CZ, 6w6l:a, 6xa1:LZ, 7xnx:LZ, 7xny:LZ, 8xsx:LZ, 8xsy:LZ, 8xsz:LZ, 6y0g:LZ, 8y0w:LZ, 8y0x:LZ, 6y2l:LZ, 6y57:LZ, 6y6x:LZ, 8yoo:LZ, 8yop:LZ, 6z6l:LZ, 6z6m:LZ, 6z6n:LZ, 7zjw:Lc, 7zjx:Lc, 6zm7:LZ, 6zme:LZ, 6zmi:LZ, 6zmo:LZ, 6zvk:22
35 4v8p:AN 143 26 0.0852 0.1049 0.5769 0.054 4v8p:DN, 4v8p:FN, 4v8p:HN
36 8ip8:CA 136 29 0.0739 0.0956 0.4483 0.24 8ipa:CA, 8ipb:CA, 8jiv:CZ, 4v3p:La, 4v7e:CZ
37 6zu5:LZ0 127 35 0.0852 0.1181 0.4286 0.91
38 8esq:Z 134 36 0.0852 0.1119 0.4167 1.5 8esr:Z, 8etc:Z, 8eug:Z, 8eui:Z
39 7qep:N7 118 107 0.1420 0.2119 0.2336 2.0
40 3j79:1 140 50 0.1080 0.1357 0.3800 2.5 3jbn:A1, 3jbo:A1, 3jbp:A1, 8tpu:A1, 5umd:1
41 8cd1:U 103 28 0.0682 0.1165 0.4286 2.5 6spb:U, 6spd:U, 6spf:U, 6spg:U, 7unr:W, 7unu:W, 7unv:W, 7unw:W
42 3zby:B 404 58 0.0852 0.0371 0.2586 3.8 4tri:A, 4tri:B, 4uax:A, 2yoo:A, 2yoo:B, 2yoo:C, 2yoo:D, 3zby:A, 3zby:C, 3zby:D, 3zby:E, 3zby:F
43 2cf4:A 330 55 0.0852 0.0455 0.2727 4.0 2wyr:A, 2wyr:B, 2wyr:C, 2wyr:D, 2wyr:E, 2wyr:F, 2wyr:G, 2wyr:H, 2wyr:I, 2wyr:J, 2wyr:K, 2wyr:L
44 4v6w:CZ 134 26 0.0511 0.0672 0.3462 4.2 6xu6:CZ, 6xu7:CZ, 6xu8:CZ
45 8fru:Z 134 26 0.0682 0.0896 0.4615 4.8 8brm:La, 8bsi:La, 8bsj:La, 8btd:La, 8btr:La, 7pwg:Z, 7pwo:Z2
46 8br8:La 119 26 0.0682 0.1008 0.4615 5.6
47 8c3a:AA 135 33 0.0795 0.1037 0.4242 6.9 8c3a:BU, 8cq7:AA, 8cq7:BU, 8cqw:AA, 8cqw:BU, 8cre:AA, 8cre:BU, 8oeq:AA, 8oeq:BU, 7pzy:AA, 7q08:AA, 7q0f:AA, 7q0p:AA, 7q0r:AA, 8q5i:AA
48 8ova:Ba 132 26 0.0568 0.0758 0.3846 9.2 8ove:Ba, 4v8m:Ba

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218