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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKG
HSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRK
PLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQ

The query sequence (length=227) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8ppk:G 240 227 1.0000 0.9458 1.0000 7.55e-167 7a01:b3, 7a09:r, 5a2q:G, 5aj0:BG, 9bdl:AS06, 9bdn:AS06, 9bdp:AS06, 8bhf:H3, 9bkd:S, 9bln:S, 8btk:Af, 7cpu:SG, 7cpv:SG, 4d5l:G, 4d61:G, 6d90:HH, 6d9j:HH, 9f1b:Af, 9f1c:Af, 9f1d:Af, 6fec:q, 5flx:G, 6g18:G, 6g4s:G, 6g4w:G, 6g51:G, 6g53:G, 6g5h:G, 6g5i:G, 8g5y:SG, 8g5z:SG, 8g60:SG, 8g61:SG, 8g6j:SG, 8glp:SG, 6gz3:BG, 6gz4:BG, 6gz5:BG, 6hcf:H1, 6hcj:H2, 6hcm:H1, 6hcq:H2, 8ifd:3H, 8ife:3H, 6ip5:3H, 6ip6:3H, 6ip8:3H, 3j7p:SG, 3j7r:SG, 3jag:GG, 3jah:GG, 3jai:GG, 3jaj:SG, 3jan:SG, 8jdj:3, 8jdk:3, 8jdl:3, 8jdm:3, 7jqb:H, 7jqc:H, 5k0y:q, 8k2c:SG, 7k5i:G, 4kzx:G, 4kzy:G, 4kzz:G, 5lks:SG, 7ls1:K3, 7ls2:K3, 5lzs:GG, 5lzt:GG, 5lzu:GG, 5lzv:GG, 5lzw:GG, 5lzx:GG, 5lzy:GG, 5lzz:GG, 7mdz:GG, 7mq8:L6, 7mq9:L6, 7mqa:L6, 6mtb:GG, 6mtc:GG, 6mtd:GG, 6mte:GG, 7nwg:H2, 7nwh:GG, 7nwi:GG, 7o7y:Af, 7o7z:Af, 7o80:Af, 7o81:Af, 5oa3:G, 6ole:SG, 6olf:SG, 6olg:BG, 6oli:SG, 6olz:BG, 6om0:SG, 6om7:SG, 7oya:G2, 7oyb:G2, 7oyc:G2, 7oyd:GG, 8oz0:S, 8p03:I, 8p09:I, 8p2k:Af, 6p4g:H, 6p4h:H, 6p5i:H, 6p5j:H, 6p5k:H, 6p5n:H, 8pj1:S, 8pj2:S, 8pj3:S, 8pj4:S, 8pj5:S, 8pj6:S, 8ppl:AG, 8q7z:Af, 8q87:Af, 7qgg:SG, 8qoi:SG, 7qp6:S, 7qp7:S, 7qvp:SG, 7qvp:RG, 6qzp:SG, 7r4x:G, 6r5q:z, 6r6g:z, 6r6p:z, 6r7q:z, 8scb:GG, 6sgc:H1, 7syg:H, 7syh:H, 7syi:H, 7syj:H, 7syk:H, 7syl:H, 7sym:H, 7syn:H, 7syo:H, 7syp:H, 7syq:H, 7syr:H, 7sys:H, 7syt:H, 7syu:H, 7syv:H, 7syw:H, 7syx:H, 5t2c:AK, 8t4s:G, 7toq:AS06, 7tor:AS06, 7tql:G, 7ucj:GG, 7uck:GG, 4ug0:SG, 4ujc:CG, 4ujd:CG, 4uje:BG, 4v6x:AG, 5vyc:G1, 5vyc:G2, 5vyc:G3, 5vyc:G4, 5vyc:G5, 5vyc:G6, 6w2s:H, 6w2t:H, 7wts:G, 7wtt:G, 7wtu:G, 7wtv:G, 7wtw:G, 7wtx:G, 7wtz:G, 7wu0:G, 6xa1:SG, 7xnx:SG, 7xny:SG, 8xsx:SG, 8xsy:SG, 8xsz:SG, 8xxl:SG, 8xxm:SG, 8xxn:SG, 6y0g:SG, 8y0w:SG, 8y0x:SG, 6y2l:SG, 6y57:SG, 6yal:I, 6yam:I, 6yan:I, 6ybw:S, 8yoo:SG, 8yop:SG, 6z6l:SG, 6z6m:SG, 6z6n:SG, 7zjw:SR, 7zjx:SR, 6zlw:G, 6zm7:SG, 6zme:SG, 6zmi:SG, 6zmo:SG, 6zmt:G, 6zmw:S, 6zn5:G, 6zoj:G, 6zok:G, 6zon:r, 6zp4:r, 6zuo:G, 6zv6:G, 6zvh:G, 6zvj:r, 6zvk:b3, 6zxd:G, 6zxe:G, 6zxf:G, 6zxg:G, 6zxh:G
2 4v6w:AG 231 227 0.7753 0.7619 0.7753 2.95e-127 6xu6:AG, 6xu7:AG, 6xu8:AG
3 5oql:o 237 228 0.7137 0.6835 0.7105 2.30e-116 7olc:SG, 7old:SG, 8oo0:SG, 7r81:H2, 6rxu:Cd, 6rxv:Cd, 6rxx:Cd, 6rxz:Cd, 7z3n:SG, 7z3o:SG
4 8c3a:CT 236 226 0.6740 0.6483 0.6770 1.50e-107 8c3a:I, 8cq7:I, 8cq7:CT, 8cqw:I, 8cqw:CT, 8cre:I, 8cre:CT, 8oeq:I, 8oeq:CT, 7pzy:H, 7q08:H, 7q0f:H, 7q0p:H, 7q0r:H, 8q5i:H
5 7qix:P 237 230 0.6740 0.6456 0.6652 7.39e-103 8auv:k, 8b2l:k1, 7qiz:FA, 4v7e:BG
6 9bh5:AG 228 219 0.6211 0.6184 0.6438 3.02e-99 9cai:AG
7 8r6f:G 230 231 0.6784 0.6696 0.6667 1.78e-98 8jiw:BG
8 6fyx:G 230 226 0.6256 0.6174 0.6283 8.51e-96 6fyy:G, 6gsm:G, 6gsn:G, 8i7j:G, 5it7:G, 5it9:G, 3j80:G, 3j81:G, 3jam:G, 3jap:G, 8rw1:G, 8s8d:G, 8s8e:G, 8s8f:G, 8s8g:G, 8s8h:G, 8s8i:G, 8s8j:G, 6uz7:G
9 8cbj:G 232 226 0.6344 0.6207 0.6372 1.22e-95 7a1g:T, 7ajt:DG, 7aju:DG, 7b7d:T, 8bn3:S6, 8bqd:T, 8bqx:T, 8c00:T, 8c01:T, 8c83:T, 8cah:T, 8cas:T, 8ccs:j, 8cdl:j, 8cdr:j, 8ceh:j, 8cf5:j, 8cg8:j, 8cgn:j, 8civ:j, 8cku:j, 8cmj:j, 5dat:S6, 5dat:s6, 5dc3:S6, 5dc3:s6, 5dge:S6, 5dge:s6, 5dgf:S6, 5dgf:s6, 5dgv:S6, 5dgv:s6, 6eml:T, 8eub:BG, 8evp:BG, 8evq:BG, 8evr:BG, 8evs:BG, 8evt:BG, 8ewb:BG, 8ewc:BG, 6fai:G, 5fci:S6, 5fci:s6, 5fcj:S6, 5fcj:s6, 6gq1:w, 6gqb:w, 6gqv:w, 6hhq:H, 6hhq:s6, 5i4l:S6, 5i4l:s6, 6i7o:T, 6i7o:Tb, 3j16:C, 3j6x:S6, 3j6y:S6, 3j77:S6, 3j78:S6, 5juo:DB, 5jup:DB, 5jus:DB, 5jut:DB, 5juu:DB, 8k2d:SG, 8k82:SG, 5ll6:T, 5lyb:S6, 5lyb:s6, 5m1j:G2, 5mc6:T, 5mei:s6, 5mei:H, 7mpi:BG, 7mpj:BG, 7n8b:BG, 5ndg:S6, 5ndg:s6, 5ndv:s6, 5ndw:S6, 5ndw:s6, 7nrc:ST, 7nrd:ST, 5obm:S6, 5obm:s6, 5on6:s6, 5on6:H, 7osa:eS6, 7osm:eS6, 6q8y:T, 6rbd:G, 6rbe:G, 7rr5:SG, 6s47:BH, 6snt:G, 6sv4:T, 6sv4:Tb, 6sv4:Tc, 6t4q:SG, 6t7i:SG, 6t7t:SG, 6t83:Gb, 6t83:h, 5tbw:H, 5tbw:s6, 6tb3:T, 5tga:S6, 5tga:s6, 5tgm:S6, 5tgm:s6, 6tnu:T, 5tzs:3, 4u3m:S6, 4u3m:s6, 4u3n:S6, 4u3n:s6, 4u3u:S6, 4u3u:s6, 4u4n:S6, 4u4n:s6, 4u4o:S6, 4u4o:s6, 4u4q:S6, 4u4q:s6, 4u4r:S6, 4u4r:s6, 4u4u:S6, 4u4u:s6, 4u4y:S6, 4u4y:s6, 4u4z:S6, 4u4z:s6, 4u50:S6, 4u50:s6, 4u51:S6, 4u51:s6, 4u52:S6, 4u52:s6, 4u53:S6, 4u53:s6, 4u55:S6, 4u55:s6, 4u56:S6, 4u56:s6, 4u6f:S6, 4u6f:s6, 4uer:Y, 4v88:AG, 4v88:CG, 4v8y:AG, 4v8z:AG, 4v92:BG, 6wdr:G, 5wlc:L6, 6woo:GG, 7wtl:SG, 7wtm:SG, 7wtn:SG, 7wto:SG, 7wtp:SG, 7wtq:SG, 7wtr:SG, 6xiq:w, 6xir:w, 8y0u:SG, 6y7c:G, 6z6j:SG, 6z6k:SG, 6zce:H, 7zpq:AG, 6zqb:DG, 6zqc:DG, 6zqd:DG, 6zqe:DG, 6zqf:DG, 6zqg:DG, 7zrs:AG, 6zu9:T, 7zuw:AG, 7zux:DG, 6zvi:o, 7zw0:sT
10 5xxu:G 220 224 0.6035 0.6227 0.6116 1.05e-87
11 3j7a:H 204 213 0.5551 0.6176 0.5915 5.08e-82 3jbn:H, 3jbo:H, 3jbp:H, 6okk:H, 8tpu:SH
12 5jpq:r 235 222 0.5419 0.5234 0.5541 9.04e-81 4bts:AY, 4bts:BY, 4bts:CY, 4bts:DY, 4v5o:AY, 4v5o:BY
13 5ndv:S6 200 221 0.5639 0.6400 0.5792 3.17e-78
14 6zj3:SG 248 222 0.5463 0.5000 0.5586 1.44e-74
15 7d4i:SH 182 219 0.5066 0.6319 0.5251 2.50e-68 7d5t:SH, 6lqs:SH, 6lqt:SH
16 7ase:P 249 226 0.4670 0.4257 0.4690 5.62e-67 5opt:P
17 4v8m:A3 250 217 0.4405 0.4000 0.4608 1.18e-63 8ova:A3, 8ove:A3
18 5wyj:SH 174 146 0.4097 0.5345 0.6370 1.86e-61 7d63:SH, 6lqp:SH, 6lqq:SH, 6lqr:SH, 6lqu:SH, 6lqv:SH, 7suk:L6
19 8btd:SG 238 227 0.4758 0.4538 0.4758 2.08e-61 8brm:SG, 8bsi:SG, 8bsj:SG, 8btr:SG
20 5t2a:3 249 217 0.4581 0.4177 0.4793 1.46e-57 8a3w:SG, 8a98:SG, 6az1:G, 5osg:P, 8ovj:SG, 8rxh:SG, 8rxx:SG
21 6zu5:SG0 218 213 0.4097 0.4266 0.4366 1.50e-57
22 8fvy:G 216 218 0.4581 0.4815 0.4771 1.33e-56 8br8:SG, 8g4s:G, 7pwf:G, 7pwo:G1
23 8ip8:gb 151 119 0.3568 0.5364 0.6807 1.02e-53 8ip9:gb, 8ipa:gb, 8ipb:gb
24 8ip8:gb 151 32 0.0925 0.1391 0.6562 1.2 8ip9:gb, 8ipa:gb, 8ipb:gb
25 6ke6:SH 112 125 0.3172 0.6429 0.5760 3.91e-45
26 6rm3:SG0 201 161 0.3084 0.3483 0.4348 1.52e-42
27 7qep:S6 204 158 0.3128 0.3480 0.4494 7.80e-36
28 8p5d:SG0 229 154 0.2555 0.2533 0.3766 1.98e-20 8p60:SG0, 8p60:RG0, 7qca:SG0
29 6skf:Ah 123 122 0.1982 0.3659 0.3689 4.44e-14 6skg:Ah, 6th6:Ah
30 6tmf:H 125 123 0.1894 0.3440 0.3496 8.08e-13
31 5jb3:G 125 123 0.1894 0.3440 0.3496 2.38e-12 5jbh:G, 6sw9:G, 6swc:G, 6swd:G, 4v4n:BG, 4v6u:AG, 7zag:G, 7zah:G, 7zai:G, 7zhg:G
32 8hkx:AS6E 105 96 0.1101 0.2381 0.2604 2.13e-05 8hky:AS6E, 8hkz:AS6E, 8hl1:AS6E, 8hl2:AS6E, 8hl3:AS6E, 8hl4:AS6E, 8hl5:AS6E, 8wkp:AS6E, 8wq2:AS6E, 8wq4:AS6E
33 7pbg:A 525 36 0.0573 0.0248 0.3611 1.9 7pbg:B, 7pbi:A, 7pbi:B, 7pbi:C, 7pbi:D, 7pbi:E, 7pbi:F, 7pbi:G, 7pbi:H
34 6yxx:ET 101 37 0.0617 0.1386 0.3784 2.3 7aoi:XT, 6yxy:ET
35 6h8s:A 291 133 0.1366 0.1065 0.2331 3.3 2cjz:A, 6h8r:A, 5ovr:A, 5ovx:A, 5ow1:A
36 2vgr:C 213 35 0.0573 0.0610 0.3714 3.5 2vck:A, 2vck:B, 2vck:C, 2vck:D, 2vgr:A, 2vgr:B, 2vgr:D, 2x9i:A, 2x9i:B, 2x9i:C, 2x9i:D, 2x9j:A, 2x9j:B
37 8hi6:A 534 55 0.0749 0.0318 0.3091 7.1

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218