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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
MKIIILGAGQVGGTLAENLVGENNDITIVDNNADRLRELQDKYDLRVVNGHASHPDVLHEAGAQDADMLVAVTNTDETNM
AACQVAFTLFNTPNRVARIRSPEYLAEKEALFKSGAIPVDHLIAPEELVTSYIERLIQYPGALQVVSFAEQKVSLVAVKA
YGPLVGNALSALREHDTRVAAIFRQGRPIRPQGTTIIEADDEVFFVAASNHIRSVMSELQRLEKPYRRIMIVGGGNIGAS
LAKRLEQTYSVKLIERDYQRAEKLSEQLENTIVFCGDAADQELLTEENIDQVDVFIALTNEDETNIMSAMLAKRMGAKKV
MVLIQRGAYVDLVQGGVIDVAISPQQATISALLTHVRRADIVNVSSLRRGAAEAIEAVAHGDETTSKVVGRAIGDIKLPP
GTTIGAVVRGEEVLIAHDRTVIEQDDHVVMFLVDKKYVPDVEALFQPSPFF

The query sequence (length=451) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4j9v:A 456 456 0.9978 0.9868 0.9868 0.0 4j9u:H, 4j9u:G, 4j9u:E, 4j9u:F, 4j9v:B, 6v4k:E, 6v4k:F, 6v4k:G, 6v4k:H, 6v4l:C, 6v4l:D
2 1lss:A 132 138 0.1086 0.3712 0.3551 1.34e-16 1lss:B, 1lss:C, 1lss:D
3 1lss:A 132 118 0.0887 0.3030 0.3390 9.86e-13 1lss:B, 1lss:C, 1lss:D
4 2g1u:A 137 135 0.0887 0.2920 0.2963 1.52e-09 3l4b:A, 3l4b:B, 3l4b:E, 3l4b:F
5 2g1u:A 137 90 0.0599 0.1971 0.3000 0.006 3l4b:A, 3l4b:B, 3l4b:E, 3l4b:F
6 4gx2:B 548 322 0.1774 0.1460 0.2484 2.35e-09 4gvl:A, 4gvl:B, 4gvl:D, 4gvl:C, 4gx0:B, 4gx0:C, 4gx1:B, 4gx1:C, 4gx2:C, 4gx5:B, 4gx5:C
7 3l9x:A 336 100 0.0599 0.0804 0.2700 1.17e-05 3l9x:B
8 3l9x:A 336 151 0.0865 0.1161 0.2583 1.2 3l9x:B
9 3l9w:B 357 100 0.0599 0.0756 0.2700 1.47e-05 3eyw:A, 3eyw:B, 3l9w:A
10 3l9w:B 357 151 0.0865 0.1092 0.2583 1.5 3eyw:A, 3eyw:B, 3l9w:A
11 8by2:A 548 99 0.0576 0.0474 0.2626 9.96e-05 8bxg:A, 8bxg:B, 8by2:B, 9emb:A, 9emb:B
12 8by2:A 548 90 0.0554 0.0456 0.2778 2.6 8bxg:A, 8bxg:B, 8by2:B, 9emb:A, 9emb:B
13 8hye:C 371 42 0.0443 0.0539 0.4762 7.36e-04 8hye:A, 8hye:B
14 6i8v:A 216 224 0.1175 0.2454 0.2366 0.002
15 6i8v:A 216 205 0.0953 0.1991 0.2098 0.031
16 4gx0:D 376 87 0.0576 0.0691 0.2989 0.008 4gx0:A, 4gx1:A, 4gx1:D, 4gx2:A, 4gx2:D, 4gx5:A, 4gx5:D
17 5nc8:A 159 96 0.0554 0.1572 0.2604 0.011 5nc8:B
18 8hyh:A 366 52 0.0488 0.0601 0.4231 0.071
19 6smz:C 295 40 0.0333 0.0508 0.3750 0.21 6smy:A, 6smy:B, 6smy:C, 6smy:D, 6smz:A, 6smz:B, 6smz:D
20 6btl:A 492 141 0.0776 0.0711 0.2482 0.48 6btl:B, 6bu7:A, 6bu7:B, 4nev:A, 4nev:B, 7nvp:AAA, 7nvp:BBB, 6oex:B, 6oex:A, 6oey:B, 6oey:A, 6oez:B, 6oez:A, 8pf3:A, 8pf3:B, 8pf3:C, 8pf3:D, 8pf4:A, 8pf4:B, 8pf4:C, 8pf4:D, 8pf5:A, 8pf5:B, 8pf5:C, 8pf5:D, 6rb5:A, 6rb5:B, 5s9s:A, 5s9s:B, 5s9t:A, 5s9t:B, 5s9u:A, 5s9u:B, 5s9v:A, 5s9v:B, 5s9w:A, 5s9w:B, 5s9x:A, 5s9x:B, 5s9y:A, 5s9y:B, 5s9z:A, 5s9z:B, 5sa0:A, 5sa0:B, 5sa1:A, 5sa1:B, 5sa2:A, 5sa2:B, 5sa3:A, 5sa3:B, 5smj:A, 5smj:B, 2wba:A, 2wba:B, 2woi:A, 2woi:B, 2woi:C, 2woi:D, 2wov:A, 2wov:B, 2wov:C, 2wov:D, 2wow:A, 2wow:B, 2wow:C, 2wow:D, 2wp5:A, 2wp5:B, 2wp5:C, 2wp5:D, 2wp6:A, 2wp6:B, 2wp6:C, 2wp6:D, 2wpc:A, 2wpc:B, 2wpc:C, 2wpc:D, 2wpe:A, 2wpe:B, 2wpe:C, 2wpe:D, 2wpf:A, 2wpf:B, 2wpf:C, 2wpf:D
21 2vhw:E 373 68 0.0399 0.0483 0.2647 0.58 4lmp:A, 6o7f:A, 2vhv:A, 2vhv:B, 2vhw:A, 2vhw:B, 2vhw:C, 2vhw:D, 2vhw:F, 2vhx:A, 2vhx:B, 2vhx:C, 2vhx:D, 2vhx:E, 2vhx:F, 2vhz:A, 2vhz:B, 2voj:A, 2voj:C, 2voj:E
22 4ohw:A 399 116 0.0732 0.0827 0.2845 0.66 4ohv:A, 4ohx:A, 4ohy:A, 4ohz:A, 4oi0:A, 4oi1:A, 4oi2:A
23 1bzl:A 486 122 0.0732 0.0679 0.2705 1.1 1aog:A, 1aog:B, 1bzl:B, 1gxf:A, 1gxf:B, 1nda:A, 1nda:B, 1nda:C, 1nda:D, 4new:A
24 1xhc:A 346 30 0.0310 0.0405 0.4667 1.1
25 2pzm:A 316 63 0.0466 0.0665 0.3333 1.2 2pzk:A, 2pzk:B, 2pzl:A, 2pzl:B, 2pzm:B
26 4xr9:A 456 40 0.0310 0.0307 0.3500 1.2
27 6jby:A 521 82 0.0532 0.0461 0.2927 1.3 7bwp:A, 7cgs:A, 5eb4:A, 5eb4:B, 5eb5:A, 5eb5:B, 8jm0:A, 8jm1:A, 8jm2:A, 8jm3:A, 8jm4:A, 8jm5:B, 8jm6:A, 8jm7:A, 8jm8:A, 6lqy:A, 6lr8:A
28 7zp9:B 133 98 0.0532 0.1805 0.2449 1.6 7zp9:H, 7zp9:D, 7zp9:E, 7zp9:F, 7zp9:A, 7zp9:J, 7zp9:L, 7zpo:H, 7zpo:D, 7zpo:E, 7zpo:F, 7zpo:A, 7zpo:B, 7zpo:J, 7zpo:L, 7zpr:H, 7zpr:D, 7zpr:E, 7zpr:F, 7zpr:A, 7zpr:B, 7zpr:J, 7zpr:L
29 1h9m:A 141 55 0.0399 0.1277 0.3273 2.1 1h9m:B
30 3zv5:A 275 38 0.0310 0.0509 0.3684 2.2 2y99:A, 2y99:B, 3zv5:B, 3zv6:A, 3zv6:B
31 3abi:A 349 41 0.0355 0.0458 0.3902 2.5 3abi:B
32 2ftw:A 484 43 0.0377 0.0351 0.3953 2.8
33 3red:A 521 36 0.0355 0.0307 0.4444 3.0 3red:B, 3red:C, 3red:D, 3red:E, 3red:F, 3red:G, 3red:H, 3red:I, 3red:J, 3red:K, 3red:L
34 7epw:A 373 39 0.0310 0.0375 0.3590 3.2 4a6n:A, 4a6n:B, 4a6n:C, 4a6n:D, 4a99:A, 4a99:C, 4a99:B, 4a99:D, 7epv:A, 4guv:A, 4guv:B, 4guv:C, 4guv:D, 3p9u:A, 3p9u:B, 3p9u:C, 3p9u:D, 3v3n:A, 3v3n:B, 3v3n:C, 3v3n:D, 3v3o:A, 3v3o:B, 3v3o:C, 3v3o:D, 2xdo:A, 2xdo:B, 2xdo:C, 2xdo:D, 2xyo:A, 2xyo:B, 2xyo:C, 2xyo:D, 2y6q:A, 2y6q:B, 2y6q:C, 2y6q:D, 2y6r:A, 2y6r:B, 2y6r:C, 2y6r:D
35 3gdn:A 521 35 0.0355 0.0307 0.4571 3.3 3gdn:B, 3gdp:A, 3gdp:B, 1ju2:A, 1ju2:B
36 1nyt:A 271 62 0.0466 0.0775 0.3387 3.6 1nyt:B, 1nyt:C, 1nyt:D
37 3he3:A 366 59 0.0421 0.0519 0.3220 3.6 3hdq:A, 3hdq:B, 3hdq:C, 3hdq:D, 3hdq:E, 3hdq:F, 3hdq:G, 3hdq:H, 3hdq:I, 3hdq:J, 3hdy:A, 3hdy:B, 3hdy:C, 3hdy:D, 3hdy:E, 3hdy:F, 3hdy:G, 3hdy:H, 3hdy:I, 3hdy:J, 3he3:B, 3he3:C, 3he3:D, 3he3:E, 3he3:F, 3he3:G, 3he3:H, 3he3:I, 3he3:J, 3mj4:A, 3mj4:B, 3mj4:C, 3mj4:D, 3mj4:E, 3mj4:F, 3mj4:G, 3mj4:H, 3mj4:I, 3mj4:J
38 1amk:A 250 79 0.0554 0.1000 0.3165 3.8 7abx:A, 7az3:A, 7az4:A, 7az9:A, 7aza:A, 1if2:A, 1n55:A, 1qds:A, 2vxn:A, 2y61:A, 2y62:A, 2y63:A
39 6g9w:B 468 88 0.0510 0.0491 0.2614 4.1 6g9v:B, 6g9w:A, 6tn3:B
40 1pj6:A 828 32 0.0333 0.0181 0.4688 4.9 3gsi:A, 1pj5:A, 1pj7:A
41 2ehd:B 213 47 0.0333 0.0704 0.3191 5.2 2ehd:A
42 3klj:A 378 30 0.0288 0.0344 0.4333 5.7
43 6y1w:A 505 45 0.0421 0.0376 0.4222 6.0 6y1w:B
44 2cvj:A 180 55 0.0355 0.0889 0.2909 6.4 2ywl:A, 2ywl:B
45 2q1w:A 300 51 0.0421 0.0633 0.3725 6.5 2q1w:B, 2q1w:C
46 4n0q:B 345 69 0.0421 0.0551 0.2754 7.6 4n0q:A, 4n0q:C, 4n0q:D
47 1h2a:L 534 51 0.0377 0.0318 0.3333 8.0 1h2r:L, 4u9h:L, 4u9i:L, 1ubh:L, 1ubj:L, 1ubk:L, 1ubl:L, 1ubm:L, 1ubo:L, 1ubr:L, 1ubt:L, 1ubu:L, 8w6x:L, 1wuh:L, 1wui:L, 1wuj:L, 1wuk:L, 1wul:L, 5xle:L, 5xlf:L, 5xlg:L, 5xlh:L, 5y4n:L
48 5er0:A 450 29 0.0244 0.0244 0.3793 9.4 5er0:B, 5er0:C, 5er0:D, 5vn0:A, 5vn0:B, 5vn0:C, 5vn0:D, 5vn0:E, 5vn0:F, 5vn0:G, 5vn0:H, 5voh:A, 5voh:B, 5voh:C, 5voh:D

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218