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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
MEYRLKAYYREGEKPSALRRAGKLPGVMYNRHLNRKVYVDLVEFDKVFRQASIHHVIVLELPDGQSLPTLVRQVNLDKRR
RRPEHVDFFVLSDEPVEMYVPLRFRDILVKVSPRNIPEFIEVLPPGVELAVSPEE

The query sequence (length=135) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 9b00:1Z 154 152 1.0000 0.8766 0.8882 1.40e-88 6cae:1Z, 6cfj:1Z, 8cvj:1Z, 8cvk:1Z, 8cvl:1Z, 5doy:1Z, 5e7k:D5, 8ekb:1Z, 5el4:H8, 5el4:D5, 5el5:H8, 5el5:D5, 5el6:D5, 5el7:D5, 8ev6:1Z, 8ev7:1Z, 8g29:1Z, 8g2a:1Z, 8g2b:1Z, 8g2c:1Z, 8g2d:1Z, 5j4b:1Z, 5j4c:1Z, 7jql:1Z, 7jqm:1Z, 6n9e:1Z, 6n9f:1Z, 5ndj:D5, 5ndk:D5, 6nd5:1Z, 6nd6:1Z, 6o97:1Z, 6of1:1Z, 7rq8:1Z, 7rq9:1Z, 7u2h:1Z, 7u2i:1Z, 7u2j:1Z, 8ud6:1Z, 8ud7:1Z, 8ud8:1Z, 6uo1:1Z, 8uvr:1Z, 8uvs:1Z, 5vp2:1Z, 8vtu:1Z, 8vtv:1Z, 8vtx:1Z, 4w2f:BZ, 5w4k:1Z, 5wis:1Z, 5wit:1Z, 4wra:D5, 4wsm:D5, 4wzo:D5, 6xhv:1Z, 6xhw:1Z, 6xhy:1Z, 6xqd:1Z, 6xqe:1Z, 4y4p:1Z, 4z3s:1Z
2 6ucq:1Z 204 169 1.0000 0.6618 0.7988 3.34e-86 5a9z:AW, 5aa0:AW, 7azo:L25A, 7azo:L25B, 7azs:L25A, 7azs:L25B, 9b00:2Z, 6b4v:W, 6b4v:AC, 6boh:W, 6boh:BC, 6bok:W, 6bok:ZB, 6buw:RZ, 6buw:YZ, 6bz6:RZ, 6bz6:YZ, 6bz7:RZ, 6bz7:YZ, 6bz8:RZ, 6bz8:YZ, 6c5l:BZ, 6c5l:DZ, 6cae:2Z, 6cfj:2Z, 6cfk:1Z, 6cfk:2Z, 6cfl:1Z, 6cfl:2Z, 8cvj:2Z, 8cvk:2Z, 8cvl:2Z, 5czp:YZ, 5czp:RZ, 6czr:1Z, 6czr:2Z, 5d8b:T, 5d8b:PB, 5dfe:RZ, 5dfe:YZ, 5dox:1Z, 5dox:2Z, 5doy:2Z, 5e7k:H8, 5e81:H8, 5e81:D5, 8ekb:2Z, 5el6:H8, 5el7:H8, 8ev6:2Z, 8ev7:2Z, 5f8k:1Z, 5f8k:2Z, 8fc1:1Z, 8fc1:2Z, 8fc2:1Z, 8fc2:2Z, 8fc3:1Z, 8fc3:2Z, 8fc4:1Z, 8fc4:2Z, 8fc5:1Z, 8fc5:2Z, 8fc6:1Z, 8fc6:2Z, 5fdu:1Z, 5fdu:2Z, 5fdv:1Z, 5fdv:2Z, 1feu:A, 1feu:D, 6fkr:1Z, 6fkr:2Z, 8fom:RZ, 8fom:YZ, 8fon:RZ, 8fon:YZ, 8g29:2Z, 8g2a:2Z, 8g2b:2Z, 8g2c:2Z, 8g2d:2Z, 6gsj:H8, 6gsj:D5, 6gsk:H8, 6gsk:D5, 6gsl:H8, 6gsl:D5, 6gzq:U1, 6gzx:U1, 6gzx:U2, 6gzz:U1, 6gzz:U2, 5hau:1X, 5hau:2X, 5hcp:1Z, 5hcp:2Z, 5hcq:1Z, 5hcq:2Z, 5hcr:1Z, 5hcr:2Z, 5hd1:1Z, 5hd1:2Z, 5ib7:H8, 5ib7:D5, 5ib8:H8, 5ib8:D5, 5ibb:H8, 5ibb:D5, 5imq:r, 5imr:r, 5j30:RZ, 5j30:YZ, 5j3c:RZ, 5j3c:YZ, 5j4b:2Z, 5j4c:2Z, 5j4d:W, 5j4d:BC, 5j8b:Z, 7jql:2Z, 7jqm:2Z, 4l47:RZ, 4l47:YZ, 4l71:RZ, 4l71:YZ, 4lel:RZ, 4lel:YZ, 4lfz:RZ, 4lfz:YZ, 7lh5:BZ, 7lh5:DZ, 4lnt:RZ, 4lnt:YZ, 4lsk:RZ, 4lsk:YZ, 4lt8:RZ, 4lt8:YZ, 7md7:1Z, 7md7:2Z, 6n1d:AL25, 6n1d:BL25, 6n9e:2Z, 6n9f:2Z, 5ndj:H8, 5ndk:H8, 6nd5:2Z, 6nd6:2Z, 6ndk:RZ, 6ndk:YZ, 6nsh:RZ, 6nsh:YZ, 6nta:RZ, 6nta:YZ, 6nuo:RZ, 6nuo:YZ, 6nwy:RZ, 6nwy:YZ, 6o3m:RZ, 6o3m:YZ, 6o97:2Z, 6of1:2Z, 6of6:RZ, 6of6:YZ, 6oj2:RZ, 6oj2:YZ, 6ope:RZ, 6ope:YZ, 6ord:RZ, 6ord:YZ, 6osi:RZ, 6osi:YZ, 5ot7:6, 6otr:RZ, 6otr:YZ, 6oxa:RZ, 6oxa:YZ, 6oxi:RZ, 6oxi:YZ, 4p6f:RZ, 4p6f:YZ, 4p70:RZ, 4p70:YZ, 6q95:V, 6qnq:H8, 6qnq:D5, 6qnr:H8, 6qnr:D5, 7rq8:2Z, 7rq9:2Z, 7rqa:1Z, 7rqa:2Z, 7rqb:1Z, 7rqb:2Z, 7rqc:1Z, 7rqc:2Z, 7rqd:1Z, 7rqd:2Z, 7rqe:1Z, 7rqe:2Z, 8t8b:1Z, 8t8b:2Z, 8t8c:1Z, 8t8c:2Z, 4tua:RZ, 4tua:YZ, 4tub:RZ, 4tub:YZ, 4tuc:RZ, 4tuc:YZ, 4tud:RZ, 4tud:YZ, 4tue:RZ, 4tue:YZ, 7u2h:2Z, 7u2i:2Z, 7u2j:2Z, 6ucq:2Z, 8ud6:2Z, 8ud7:2Z, 8ud8:2Z, 6uo1:2Z, 5uq7:Z, 5uq8:Z, 8uvr:2Z, 8uvs:2Z, 4v4i:T, 4v4j:T, 4v4x:BY, 4v4y:BY, 4v4z:BY, 4v51:BZ, 4v51:DZ, 4v5a:BZ, 4v5a:DZ, 4v5c:BZ, 4v5c:DZ, 4v5d:BZ, 4v5d:DZ, 4v5e:BZ, 4v5e:DZ, 4v5f:BZ, 4v5f:DZ, 4v5g:BZ, 4v5g:DZ, 4v5j:BZ, 4v5j:DZ, 4v5k:BZ, 4v5k:DZ, 4v5l:BZ, 4v5m:BZ, 4v5n:BZ, 4v5p:BZ, 4v5p:DZ, 4v5q:BZ, 4v5q:DZ, 4v5r:BZ, 4v5r:DZ, 4v5s:BZ, 4v5s:DZ, 4v63:BZ, 4v63:DZ, 4v67:BZ, 4v67:DZ, 4v68:BZ, 4v6a:BZ, 4v6a:DZ, 4v6f:AV, 4v6f:DV, 4v6g:BV, 4v6g:DV, 4v7j:AZ, 4v7j:BZ, 4v7k:AZ, 4v7k:BZ, 4v7l:BZ, 4v7l:DZ, 4v7m:BZ, 4v7m:DZ, 4v7p:BV, 4v7p:CV, 4v7w:BZ, 4v7w:DZ, 4v7x:BZ, 4v7x:DZ, 4v7y:BZ, 4v7y:DZ, 4v7z:BZ, 4v7z:DZ, 4v83:BV, 4v83:DV, 4v84:BV, 4v84:DV, 4v87:AV, 4v87:DV, 4v8a:AZ, 4v8a:BZ, 4v8b:BV, 4v8b:DV, 4v8c:AV, 4v8c:BV, 4v8d:BV, 4v8d:DV, 4v8e:AV, 4v8e:CV, 4v8f:AV, 4v8f:DV, 4v8g:BZ, 4v8g:DZ, 4v8h:BZ, 4v8h:DZ, 4v8i:BZ, 4v8i:DZ, 4v8j:BZ, 4v8j:DZ, 4v8n:BZ, 4v8n:DZ, 4v8o:BZ, 4v8q:AZ, 4v8u:BZ, 4v8u:DZ, 4v8x:BZ, 4v8x:DZ, 5v8i:1Z, 5v8i:2Z, 4v90:BZ, 4v95:BZ, 4v95:DZ, 4v97:BZ, 4v97:DZ, 4v9a:BV, 4v9a:DV, 4v9b:BV, 4v9b:DV, 4v9h:BZ, 4v9i:BZ, 4v9i:DZ, 4v9j:BZ, 4v9j:DZ, 4v9k:BZ, 4v9k:DZ, 4v9l:BZ, 4v9l:DZ, 4v9m:BZ, 4v9m:DZ, 4v9n:BZ, 4v9n:DZ, 4v9q:AV, 4v9q:CV, 4v9r:BZ, 4v9r:DZ, 4v9s:BZ, 4v9s:DZ, 5vp2:2Z, 5vpo:RZ, 5vpo:YZ, 5vpp:RZ, 5vpp:YZ, 8vtu:2Z, 8vtv:2Z, 8vtw:1Z, 8vtw:2Z, 8vtx:2Z, 8vty:1Z, 8vty:2Z, 1vvj:RZ, 1vvj:YZ, 1vy4:BZ, 1vy4:DZ, 1vy5:BZ, 1vy5:DZ, 1vy6:BZ, 1vy6:DZ, 1vy7:BZ, 1vy7:DZ, 4w29:BZ, 4w29:DZ, 4w2e:Z, 4w2f:DZ, 4w2g:BZ, 4w2g:DZ, 4w2h:BZ, 4w2h:DZ, 4w2i:BZ, 4w2i:DZ, 4w4g:RZ, 4w4g:YZ, 5w4k:2Z, 5wis:2Z, 5wit:2Z, 4wpo:AZ, 4wpo:CZ, 4wq1:H8, 4wq1:D5, 4wqf:AZ, 4wqf:CZ, 4wqr:H8, 4wqr:D5, 4wqu:AZ, 4wqu:CZ, 4wqy:AZ, 4wqy:CZ, 4wr6:H8, 4wr6:D5, 4wra:H8, 4wro:H8, 4wsd:H8, 4wsd:D5, 4wsm:H8, 4wt1:H8, 4wt1:D5, 4wt8:CZ, 4wt8:DZ, 4wu1:H8, 4wu1:D5, 4wzd:H8, 4wzd:D5, 4wzo:H8, 4xej:AL25, 4xej:BL25, 6xhv:2Z, 6xhw:2Z, 6xhx:1Z, 6xhx:2Z, 6xhy:2Z, 6xqd:2Z, 6xqe:2Z, 4y4o:1Z, 4y4o:2Z, 4y4p:2Z, 4ypb:RZ, 4ypb:YZ, 4yzv:RZ, 4yzv:YZ, 4z3s:2Z, 4z8c:1Z, 4z8c:2Z, 4zer:1Z, 4zer:2Z, 5zlu:s, 4zsn:RZ, 4zsn:YZ
3 1nwx:T 223 147 0.3185 0.1928 0.2925 2.27e-14 7a0r:S, 7a0s:S, 7a18:S, 3cf5:S, 3dll:S, 5dm6:S, 5dm7:S, 4io9:S, 4ioa:S, 4ioc:S, 5jvg:S, 5jvh:S, 1nwy:T, 3pio:S, 3pip:S, 1sm1:T, 4u67:S, 4v4g:BW, 4v4g:DW, 4v4g:FW, 4v4g:HW, 4v4g:JW, 4v4p:AV, 4v4r:BZ, 4v4s:BZ, 4v4t:BZ, 4wfn:S, 1xbp:T, 2zjp:S, 2zjq:S, 2zjr:S
4 7jil:V 124 106 0.2593 0.2823 0.3302 9.75e-14
5 5nrg:S 174 141 0.3037 0.2356 0.2908 3.72e-08 7asm:T, 7asn:T, 7aso:a, 7asp:T, 6ddd:H, 6ddg:H, 6fxc:AT, 6fxc:BT, 5hkv:S, 5hl7:S, 6hma:T, 5li0:Y, 5nd8:Y, 5nd9:Y, 5ngm:AT, 7nhl:Y, 7nhm:Y, 8p2f:Y, 8p2g:Y, 8p2h:Y, 7p48:T, 6s0x:T, 6s0z:T, 6s12:T, 6s13:T, 5t7v:L8, 5tcu:L8, 7ttu:H, 7ttw:H, 4wce:S, 4wf9:S, 4wfa:S, 4wfb:S, 6wqn:H, 6wqq:H, 6wrs:H, 6wru:H, 8y36:T, 8y37:T, 8y38:T, 8y39:T, 6yef:Y
6 7unr:X 190 156 0.3111 0.2211 0.2692 1.04e-04 8cd1:V, 6spb:V, 6spd:V, 6spf:V, 6spg:V, 7unu:X, 7unv:X, 7unw:X
7 6o8w:W 94 75 0.1481 0.2128 0.2667 5.83e-04 6o8x:W, 6o8y:W, 6o8z:W, 6o90:W
8 7f0d:V 177 75 0.1630 0.1243 0.2933 0.009 7kgb:V, 7msc:V, 7msh:V, 7msm:V, 7msz:V, 7mt2:V, 7mt3:V, 7mt7:V, 7sfr:V, 5v7q:V, 5v93:V
9 9c4g:u 179 146 0.2963 0.2235 0.2740 0.038 8crx:u, 8cvm:u
10 4ho9:A 294 38 0.0889 0.0408 0.3158 0.84 4ho3:A, 4ho4:A, 4ho5:A, 4ho5:B, 4ho6:A, 4ho8:A, 4ho8:B, 4ho8:C, 4ho8:D, 4ho9:B, 4hoc:A, 4hoc:B
11 4kh6:B 596 28 0.1037 0.0235 0.5000 3.5 4a59:A, 4a59:B, 4a59:C, 4a59:D, 4a5a:A, 4a5a:B, 4a5a:C, 4a5a:D, 4kh4:A, 4kh4:B, 4kh5:A, 4kh5:B, 4kh6:A
12 8ag6:B 975 40 0.1037 0.0144 0.3500 4.6 2o8b:B, 2o8c:B, 2o8d:B, 2o8e:B, 2o8f:B
13 1lvw:A 295 37 0.0815 0.0373 0.2973 5.7 1lvw:B, 1lvw:C, 1lvw:D
14 4hnx:B 213 36 0.0889 0.0563 0.3333 5.8 4hnw:B, 6o07:B, 4xnh:B, 4xpd:B, 4y49:B, 4y49:H, 4y49:N
15 3hq2:B 497 58 0.1259 0.0342 0.2931 6.1 3hq2:A
16 7epq:A 296 120 0.2000 0.0912 0.2250 8.4 7epq:B
17 7u1x:A 439 49 0.1259 0.0387 0.3469 9.0 7t7k:B, 7t7k:A, 7t7o:B, 7t7o:A, 7u1v:A, 7u1v:B, 7u1x:B, 7u1y:A
18 5vjp:B 179 41 0.1037 0.0782 0.3415 9.5 1g2p:A, 5vjn:A, 5vjn:B, 5vjp:A

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218