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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
LSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVA
VELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGEPAKIEAFRASLSKLGDVYVNDAFGTAHRA
HSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADAIQLINNMLDKVNEMIIGGGMAFTFLKVLNNME
IGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAK
QIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVD
ALSNI

The query sequence (length=405) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4o33:A 417 415 0.9951 0.9664 0.9711 0.0 4axx:A, 3c3a:B, 3c3b:A, 3c3b:B, 3c3c:A, 1hdi:A, 1kf0:A, 5m1r:A, 5m3u:A, 5m6z:A, 5mxm:A, 5np8:A, 4o3f:A, 5o7d:A, 1vjc:A, 1vjd:A, 2wzb:A, 2wzc:A, 2wzd:A, 2x13:A, 2x14:A, 2x15:A, 2xe7:A, 2xe8:A, 2y3i:A, 2y3i:D, 2ybe:A, 2zgv:A, 3zoz:A
2 2paa:A 413 412 0.8543 0.8378 0.8398 0.0
3 3pgk:A 415 412 0.6395 0.6241 0.6286 0.0 1qpg:A
4 1ltk:C 424 415 0.6049 0.5778 0.5904 1.50e-170 1ltk:A, 1ltk:B
5 6yje:A 416 415 0.5877 0.5721 0.5735 2.69e-164 6yjf:A
6 1vpe:A 398 402 0.4938 0.5025 0.4975 2.42e-133
7 1php:A 394 404 0.4790 0.4924 0.4802 5.65e-120
8 13pk:A 415 419 0.4543 0.4434 0.4391 1.69e-113 13pk:B, 13pk:C, 13pk:D, 16pk:A
9 3zlb:A 398 403 0.4642 0.4724 0.4665 9.24e-111
10 4fey:A 392 403 0.4272 0.4413 0.4293 2.76e-102
11 4ng4:B 389 404 0.4123 0.4293 0.4134 2.99e-93 4ng4:A, 4ng4:C
12 1zmr:A 386 401 0.3704 0.3886 0.3741 9.63e-77
13 3fwn:A 467 133 0.0840 0.0728 0.2556 0.016 3fwn:B, 2zya:A, 2zya:B, 2zyd:A, 2zyd:B
14 1nvm:B 312 60 0.0420 0.0545 0.2833 2.0 1nvm:D, 1nvm:H
15 2oo4:A 226 67 0.0494 0.0885 0.2985 3.9 2oo4:B
16 2w90:B 471 148 0.0889 0.0764 0.2432 4.2 2w8z:A, 2w8z:B, 2w90:A
17 6hqv:A 1555 38 0.0346 0.0090 0.3684 4.5 6hqv:B
18 8i4q:A 479 70 0.0519 0.0438 0.3000 5.6 8i4q:B
19 4ha3:A 489 37 0.0346 0.0286 0.3784 6.5 4ha4:A
20 6rm3:LU0 97 47 0.0370 0.1546 0.3191 6.5
21 3zs6:A 506 94 0.0642 0.0514 0.2766 7.2
22 2iz1:B 471 106 0.0617 0.0531 0.2358 8.4 2iyo:A, 2iyp:A, 2iyp:B, 2iyp:C, 2iz0:A, 2iz0:B, 2iz0:C, 2iz1:A, 2iz1:C

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218