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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
LDSKPASAITAAKNAEVLKNLPFADREEFEAAKRGLIAPFSGQIKNAEGQVVWDMGAYQFLNDKDAADTVNPSLWRQAQL
NNIAGLFEVMPKLYQVRGLDPANMTIIEGDSGLVLIDTLTTAETARAALDLYFQHRPKKPIVAVVYSHSHIDHFGGARGI
IDEADVKAGKVKVFAPSGFMEHAVSENILAGTAMARRGQYQSGVMVPRGAQAQVDSGLFKTTATNATNTLVAPNVLIEKP
YERHTVDGVELEFQLTLGSEAPSDMNIYLPQFKVLNTADNAPPAMHNLLTPRGAEVRDAKAWAGYIDASLEKYGDRTDVL
IQQHNWPVWGGDKVRTYLADQRDMYAFLNNRALNLMNKGLTLHEIAAEVSKLPGELDRKWYLRSYYGALSTNLRAVYQRY
LGFYDGNPANLDPFPPVEAGKRYVEAMGGADAVLKQMRAAIDKGDYRWAVQLGNHLVFADPANKDARALQADAMEQLGYQ
TENALWRNMYMTGAMELRHGVPTYDSRGKSEMGRALTPDMFFDLLAIRLDTDKAVGHDMTLNWVFEDLKQDIALTLRNGV
LTQRVGSLNPKADVTVKLTKPTLDQIAARKLDLPTAIKQGTVKLDGDGKKLGEFFGLLDSFSPKFNIVELE

The query sequence (length=631) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 2yhe:A 639 631 1.0000 0.9875 1.0000 0.0 4av7:A, 4av7:B, 4av7:C, 4av7:D, 4av7:E, 4av7:F, 4axh:A, 4axh:B, 2yhe:B, 2yhe:C, 2yhe:D, 2yhe:E, 2yhe:F
2 4nur:A 633 631 0.4865 0.4850 0.4865 0.0 4nur:B
3 5aij:A 630 626 0.4548 0.4556 0.4585 0.0 5a23:A, 5a23:B, 5a23:C, 5a23:D, 5ajl:A, 5ajl:B, 2cfu:A, 2cfz:A, 2cg2:A, 2cg3:A
4 5i0p:B 323 126 0.0555 0.1084 0.2778 2.17e-05 5i0p:A
5 7l0b:A 202 69 0.0365 0.1139 0.3333 4.37e-04 7l0b:B, 7l0b:C, 7l0b:D
6 5u8o:B 360 102 0.0428 0.0750 0.2647 0.001 5i0p:C, 5i0p:D, 5u8o:A, 5u8o:C, 5u8o:D
7 6ao1:A 354 119 0.0491 0.0876 0.2605 0.006 6ao1:B, 6ao1:C, 6ao1:D
8 2i7t:A 404 232 0.0745 0.1163 0.2026 0.23
9 2m5c:A 227 68 0.0269 0.0749 0.2500 0.37 1bc2:A, 1bc2:B, 2bc2:A, 2bc2:B, 3bc2:A, 2bfk:A, 2bfk:B, 2bfl:A, 2bfl:B, 2bfz:A, 2bfz:B, 2bg2:A, 2bg2:B, 2bg6:A, 2bg6:B, 2bg7:A, 2bg7:B, 2bg8:A, 2bg8:B, 2bga:A, 2bga:B, 1bmc:A, 1bvt:A, 4c09:A, 4c1c:A, 4c1h:A, 6dja:A, 1dxk:A, 6eum:A, 6ewe:A, 6f2n:A, 3fcz:A, 3fcz:B, 5fqa:A, 5fqb:A, 3i11:A, 3i13:A, 3i14:A, 3i15:A, 5jmx:A, 3knr:A, 3knr:B, 3knr:C, 3knr:D, 3kns:A, 3kns:B, 3kns:C, 3kns:D, 2m5d:A, 4nq4:A, 4nq5:A, 4nq6:A, 2nxa:A, 2nyp:A, 2nze:A, 2nze:B, 2nzf:A, 4tyt:A, 2uyx:A, 5w8w:A
10 8uhe:K 593 54 0.0301 0.0320 0.3519 0.48
11 2p4z:B 276 119 0.0428 0.0978 0.2269 0.51 2p4z:A
12 8d2z:A 306 87 0.0491 0.1013 0.3563 0.61 8d2z:B
13 2i7v:A 433 235 0.0777 0.1132 0.2085 1.1 8t1q:A, 8t1r:A
14 6mfi:A 264 70 0.0349 0.0833 0.3143 1.2
15 5ngg:A 274 70 0.0301 0.0693 0.2714 1.3 2gmn:A, 2gmn:B, 3lvz:A, 3lvz:B, 5ngg:B, 5njw:A, 5njw:B, 5wcm:A, 5wcm:B
16 6v5m:A 221 74 0.0396 0.1131 0.3378 1.6 6v54:A, 6v61:A, 6v71:A
17 8gyg:B 305 117 0.0475 0.0984 0.2564 1.7 8gyg:A
18 4r4x:A 544 49 0.0285 0.0331 0.3673 2.2
19 6xfr:B 216 60 0.0285 0.0833 0.3000 2.3 6xfr:A
20 7o85:A 332 159 0.0586 0.1114 0.2327 2.5 7o85:D, 7o85:G, 7o85:J, 7o85:M, 7o85:P, 7o85:S
21 3bdq:B 110 112 0.0523 0.3000 0.2946 3.5 3bdq:A, 2qzt:A, 2qzt:B
22 6gej:S 208 32 0.0158 0.0481 0.3125 3.7 6gen:S
23 2okx:A 954 58 0.0285 0.0189 0.3103 5.4 2okx:B
24 5ek0:A 250 80 0.0317 0.0800 0.2500 5.4 5ek0:B, 5ek0:C, 5ek0:D
25 7mjr:A 899 48 0.0238 0.0167 0.3125 5.5
26 2zwr:B 207 65 0.0301 0.0918 0.2923 6.2 2zwr:A, 2zzi:A, 2zzi:B
27 3n0t:A 452 88 0.0396 0.0553 0.2841 6.5 4ebb:A, 3n0t:B, 3n0t:C, 3n0t:D
28 4a2i:P 82 31 0.0222 0.1707 0.4516 6.6 8a3l:P, 7abz:u, 7ac7:u, 7acj:u, 7acr:u, 4adv:P, 5afi:p, 7afi:P, 7afl:P, 7afo:P, 8akn:Q, 8am9:Q, 6awb:S, 6awc:S, 6awd:S, 9ax7:P, 9ax8:p, 8aye:P, 8b0x:P, 7b5k:p, 8b7y:u, 8bf7:t, 8bge:t, 8bgh:t, 8bh4:t, 8bhj:t, 8bhl:t, 8bhn:t, 8bhp:t, 8bil:t, 8bim:t, 7bod:P, 7boe:P, 7bof:P, 7bog:P, 7boh:P, 7boi:P, 6bu8:P, 6by1:AP, 6by1:BP, 6c4i:p, 8cai:P, 8cep:P, 8cgj:P, 8cgr:P, 8cgu:P, 9cg5:P, 9cg6:P, 9cg7:P, 7cpj:p, 7d6z:w, 7d80:Q, 6dnc:CB, 8eiu:P, 8ekc:p, 8emm:P, 6enf:p, 6enj:p, 6enu:p, 8eyq:P, 8eyt:P, 9fbv:P, 8fiz:AO, 8fto:P, 8fzd:p, 8fze:p, 8fzf:p, 8fzg:p, 8fzh:p, 8fzi:p, 8fzj:p, 8g2u:o, 8g31:o, 8g34:o, 8g38:o, 8g6w:P, 8g7p:p, 8g7q:p, 8g7r:p, 8g7s:p, 8ghu:p, 6gwt:p, 6gxm:p, 6gxn:p, 6gxo:p, 6gxp:p, 6h4n:p, 5h5u:w, 6h58:p, 6h58:pp, 6hrm:u, 8hsp:P, 8htz:P, 8hu1:P, 6i7v:AP, 6i7v:BP, 8ifb:P, 8ifc:P, 5iqr:u, 5it8:AP, 5it8:BP, 5j5b:AP, 5j5b:BP, 5j7l:AP, 5j7l:BP, 5j88:AP, 5j88:BP, 5j8a:AP, 5j8a:BP, 3j9y:p, 3j9z:SP, 5j91:AP, 5j91:BP, 3ja1:SP, 3jbu:P, 3jbv:P, 3jcd:p, 3jce:p, 3jcj:y, 3jcn:s, 5jc9:AP, 5jc9:BP, 7jss:U, 7jsw:U, 7jsz:U, 8jsg:y, 8jsh:y, 5jte:AP, 7jt1:U, 7jt2:U, 7jt3:U, 5ju8:AP, 7k00:P, 8k3o:P, 8k4e:P, 7k50:U, 7k51:U, 7k52:U, 7k53:U, 7k54:U, 7k55:U, 5kcr:1p, 5kcs:1p, 5kps:21, 5kpv:20, 5kpw:20, 5kpx:20, 5l3p:p, 6lkq:O, 7lv0:U, 5lza:p, 5lzb:p, 5lzc:p, 5lzd:p, 5lze:p, 5lzf:p, 7m5d:u, 5mdv:u, 5mdw:u, 5mdy:u, 5mdz:u, 5me0:P, 5me1:P, 5mgp:p, 5my1:P, 7n1p:SP, 7n2c:SP, 7n2u:SP, 7n2v:SP, 7n30:SP, 7n31:SP, 7nar:P, 7nas:P, 7nat:P, 7nau:P, 7nav:P, 7nax:P, 7nbu:P, 5no2:P, 5no3:P, 5no4:P, 5np6:S, 6nqb:P, 7nso:p, 7nsp:p, 7nsq:p, 5nwy:F, 7nwt:u, 7nww:t, 7o19:AP, 7o1a:AP, 7o1c:AP, 5o2r:p, 7o5h:P, 6o7k:y, 6o9j:p, 6o9k:p, 7oe0:P, 7oe1:P, 6ofx:U, 6og7:U, 6ogf:U, 6ogg:U, 6ogi:U, 7oi0:P, 7oif:t, 7oig:t, 7oii:t, 7oiz:P, 7oj0:P, 6om6:u, 6ore:u, 6orl:u, 6osk:u, 6osq:u, 6ost:u, 6ot3:u, 7ot5:t, 7otc:p, 6ouo:u, 8p16:u, 8p17:u, 8p18:u, 7p3k:P, 8peg:P, 8phj:P, 7pjs:p, 7pjt:p, 7pju:p, 7pjv:p, 7pjw:p, 7pjx:p, 7pjy:p, 7pjz:p, 8pkl:P, 8pva:P, 7q4k:AP, 8q4f:P, 6q97:u, 6q98:u, 6q9a:u, 7qg8:I, 7qgh:G, 7qgn:I, 7qgr:G, 8qk7:u, 8qoa:P, 8r3v:P1, 8r6c:P, 8r8m:P, 8rcl:P1, 8rcm:P1, 8rcs:P1, 8rct:P1, 7s1g:x, 7s1h:x, 7s1i:x, 7s1j:x, 7s1k:x, 7sa4:u, 7ss9:U, 7ssd:U, 7ssl:U, 7ssn:U, 7sso:U, 7ssw:U, 7st2:U, 7st6:U, 7st7:U, 8syl:p, 6szs:p, 8t5d:o, 8t5h:o, 6tbv:S161, 6tc3:S161, 7tos:S16, 4u1u:AP, 4u1u:CP, 4u1v:AP, 4u1v:CP, 4u20:AP, 4u20:CP, 4u24:AP, 4u24:CP, 4u25:AP, 4u25:CP, 4u26:AP, 4u26:CP, 4u27:AP, 4u27:CP, 5u4i:p, 5u9f:P, 5u9g:P, 7ug7:SP, 7uph:C, 8upo:U, 8upr:U, 8uql:U, 8uqm:U, 8uqp:U, 8ur0:U, 8urh:U, 8uri:U, 8urx:U, 8ury:U, 5uyk:P, 5uyl:P, 5uym:P, 5uyn:P, 5uyp:P, 5uyq:P, 5uz4:P, 4v4h:AP, 4v4h:CP, 4v4q:AP, 4v4q:CP, 4v4v:AP, 4v4w:AP, 4v50:AP, 4v50:CP, 4v52:AP, 4v52:CP, 4v53:AP, 4v53:CP, 4v54:AP, 4v54:CP, 4v55:AP, 4v55:CP, 4v56:AP, 4v56:CP, 4v57:AP, 4v57:CP, 4v5b:BP, 4v5b:DP, 4v5h:AP, 4v5y:AP, 4v5y:CP, 4v64:AP, 4v64:CP, 4v65:AI, 4v66:AI, 4v69:AP, 4v6c:AP, 4v6c:CP, 4v6d:AP, 4v6d:CP, 4v6e:AP, 4v6e:CP, 4v6k:BT, 4v6l:AT, 4v6m:AP, 4v6n:BS, 4v6o:AS, 4v6p:AS, 4v6q:AS, 4v6r:AS, 4v6s:BR, 4v6t:AP, 4v6v:AP, 4v6y:AP, 4v6z:AP, 4v70:AP, 4v71:AP, 4v72:AP, 4v73:AP, 4v74:AP, 4v75:AP, 4v76:AP, 4v77:AP, 4v78:AP, 4v79:AP, 4v7a:AP, 4v7b:AP, 4v7c:AP, 4v7d:BP, 4v7i:BP, 4v7s:AP, 4v7s:CP, 4v7t:AP, 4v7t:CP, 4v7u:AP, 4v7u:CP, 4v7v:AP, 4v7v:CP, 4v85:AP, 4v89:AP, 4v9c:AP, 4v9c:CP, 4v9d:AP, 4v9d:BP, 4v9o:BP, 4v9o:DP, 4v9o:FP, 4v9o:HP, 4v9p:BP, 4v9p:DP, 4v9p:FP, 4v9p:HP, 8vs9:S16, 8vsa:S16, 6vu3:U, 6vwl:o, 6vwm:o, 6vwn:o, 6vyq:U, 6vyr:U, 6vys:U, 6vyt:U, 6vyu:U, 6vyw:U, 6vyx:U, 6vyy:U, 6vyz:U, 6vz2:U, 6vz3:U, 6vz5:U, 6vz7:U, 6vzj:U, 6w6k:P, 6w77:P, 6w7m:P, 6w7n:P, 6w7w:O, 5wdt:p, 6wd0:U, 6wd1:U, 6wd2:U, 6wd3:U, 6wd4:U, 6wd5:U, 6wd6:U, 6wd7:U, 6wd8:U, 6wd9:U, 6wda:U, 6wdb:U, 6wdc:U, 6wdd:U, 6wde:U, 6wdf:U, 6wdg:U, 6wdh:U, 6wdi:U, 6wdj:U, 6wdk:U, 6wdl:U, 6wdm:U, 5we4:p, 5we6:p, 4wf1:AP, 4wf1:CP, 5wf0:p, 5wfk:p, 5wfs:p, 6wnv:U, 6wnw:U, 4woi:AP, 4woi:DP, 4www:QP, 4www:XP, 6x6t:U, 6x7f:U, 6x7k:U, 6x9q:U, 6xdq:U, 6xdr:U, 6xe0:P, 6xgf:U, 6xii:U, 6xij:U, 6xza:P1, 6xzb:P1, 6y69:p, 7y7c:P, 7y7d:P, 7y7e:P, 7y7f:P, 7y7g:P, 7y7h:P, 4ybb:AP, 4ybb:BP, 2ykr:P, 6ysr:p, 6yss:p, 6yst:p, 6ysu:p, 6ztj:AP, 6ztl:AP, 6ztm:AP, 6ztn:AP, 6zto:AP, 6ztp:AP, 7zta:S161, 6zu1:AP
29 4awy:B 270 51 0.0238 0.0556 0.2941 6.9 4awz:A, 4awz:B, 4awz:C, 4ax0:B, 4ax1:B, 4p62:A
30 6v3q:A 226 63 0.0333 0.0929 0.3333 6.9 6v3q:B
31 1m2x:A 219 55 0.0269 0.0776 0.3091 7.6 1m2x:B, 1m2x:C, 1m2x:D
32 7dck:A 246 81 0.0333 0.0854 0.2593 8.7 7dck:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218