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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKDLPATSVVITFHNEARSALLRTVVS
VLKKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLL
ERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYF
EELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYA
AVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGG
NQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCREDDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPA
LSQQWKFTLNL

The query sequence (length=491) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4d0t:A 496 495 1.0000 0.9899 0.9919 0.0 5ajn:A, 5ajo:A, 5ajp:A, 4d0t:C, 4d0t:F, 4d0t:B, 4d0t:D, 4d0t:E, 4d0z:B, 4d0z:E, 4d0z:A, 4d0z:C, 4d0z:D, 4d0z:F, 4d11:D, 4d11:E, 4d11:B, 4d11:A, 4d11:F, 6e7i:A, 6egs:A, 6egs:B, 2ffu:A, 2ffv:A, 2ffv:B, 5fv9:A, 5fv9:B, 5fv9:C, 5fv9:D, 5fv9:E, 5fv9:F, 5ndf:A, 5ndf:B, 5ndf:C, 5ndf:D, 5ndf:E, 5ndf:F, 6nqt:A, 6nqt:B, 6nqt:C, 6nqt:D, 6nqt:E, 6nqt:F
2 4d11:C 436 495 0.8778 0.9885 0.8707 0.0
3 8v9q:A 500 477 0.4582 0.4500 0.4717 1.27e-155 1xhb:A
4 6e4q:A 505 491 0.4358 0.4238 0.4358 5.69e-134 6e4q:B, 6e4q:C, 6e4q:D
5 6pxu:B 532 496 0.4379 0.4041 0.4335 1.72e-126 6pxu:A
6 6h0b:B 521 473 0.4155 0.3916 0.4313 7.39e-123
7 6s24:A 537 497 0.4155 0.3799 0.4105 4.41e-115 6s22:A
8 8v9q:B 449 464 0.4196 0.4588 0.4440 2.37e-114
9 2d7i:A 536 496 0.3931 0.3601 0.3891 7.75e-111 2d7r:A
10 6iwq:A 546 460 0.3422 0.3077 0.3652 1.87e-101 6iwq:B, 6iwq:C, 6iwq:D, 6iwq:E, 6iwq:F, 6iwr:A, 6iwr:B, 6iwr:C, 6iwr:D, 6iwr:E, 6iwr:F
11 8ujg:A 530 400 0.3279 0.3038 0.4025 1.52e-83 8uhz:A, 8ui1:A, 8ui6:A, 8uje:A, 8ujf:A, 8ujf:B, 8ujg:B, 8ujh:A
12 8r8a:A 127 111 0.0631 0.2441 0.2793 3.02e-06
13 1knm:A 129 117 0.0713 0.2713 0.2991 1.92e-05 1mc9:A
14 1knm:A 129 76 0.0570 0.2171 0.3684 0.001 1mc9:A
15 2aai:B 262 117 0.0672 0.1260 0.2821 1.50e-04 7kd0:B, 3rti:B, 3rtj:B
16 2aai:B 262 83 0.0448 0.0840 0.2651 0.051 7kd0:B, 3rti:B, 3rtj:B
17 1abr:B 267 87 0.0489 0.0899 0.2759 5.95e-04
18 1abr:B 267 58 0.0407 0.0749 0.3448 0.019
19 1rzo:B 262 117 0.0692 0.1298 0.2906 0.001 1rzo:D
20 1rzo:B 262 81 0.0448 0.0840 0.2716 0.025 1rzo:D
21 6h4f:B 318 123 0.0754 0.1164 0.3008 0.001 6h1j:B, 6h21:A, 6h21:B, 6h21:C, 6h2n:A, 6h2n:B, 6h2n:C, 6h4f:C, 6h4f:F, 6h4f:O, 6h4f:P, 6h4f:E, 6h4f:G, 6h4f:Q, 6h4f:A, 6h4f:D, 6h4f:H, 6h4f:I, 6h4m:B, 6h4m:C, 6h4m:F, 6h4m:O, 6h4m:P, 6h4m:E, 6h4m:G, 6h4m:Q, 6h4m:A, 6h4m:D, 6h4m:H, 6h4m:I, 6hnq:B, 6hnq:C, 6hnq:F, 6hnq:O, 6hnq:P, 6hnq:E, 6hnq:G, 6hnq:Q, 6hnq:A, 6hnq:D, 6hnq:H, 6hnq:I
22 3a22:A 614 103 0.0611 0.0489 0.2913 0.005 3a22:B, 3a23:A, 3a23:B
23 1vcl:A 432 117 0.0570 0.0648 0.2393 0.082 1vcl:B, 3w9t:A, 3w9t:C, 3w9t:G, 3w9t:B, 3w9t:F, 3w9t:E, 3w9t:D, 2z48:A, 2z48:B, 2z49:A, 2z49:B
24 5mlz:A 355 106 0.0591 0.0817 0.2736 0.15 5mm0:A, 5mm1:A
25 1onk:B 263 70 0.0407 0.0760 0.2857 0.17 3d7w:B, 1oql:B, 1pum:B, 1puu:B, 2r9k:B, 2rg9:B, 1sz6:B, 1tfm:B, 1yf8:B
26 1onk:B 263 86 0.0428 0.0798 0.2442 1.7 3d7w:B, 1oql:B, 1pum:B, 1puu:B, 2r9k:B, 2rg9:B, 1sz6:B, 1tfm:B, 1yf8:B
27 4hr6:C 264 114 0.0591 0.1098 0.2544 0.43 5y97:C
28 1hwm:B 264 71 0.0407 0.0758 0.2817 1.1 1hwn:B, 1hwo:B, 1hwp:B
29 4zbv:B 261 116 0.0631 0.1188 0.2672 1.4 4zfw:B, 4zfy:B, 4zgr:B, 4zlb:B
30 4owl:D 137 82 0.0468 0.1679 0.2805 1.5 4owj:A, 4owj:B, 4owj:C, 4owj:D, 4owj:E, 4owj:F, 4owj:G, 4owk:A, 4owk:B, 4owk:C, 4owk:D, 4owk:E, 4owk:F, 4owk:G, 4owl:B, 4owl:C, 4owl:E, 4owl:F, 4owl:A, 4owl:G
31 1unb:A 288 77 0.0407 0.0694 0.2597 5.1 1e5h:A, 1hjf:A, 2jb8:A, 1rxg:A, 1uo9:A, 1uob:A, 1w2a:X, 1w2n:A, 1w2o:A
32 3exs:D 218 76 0.0448 0.1009 0.2895 5.1 3exs:A, 3ext:A
33 8d4c:C 180 100 0.0530 0.1444 0.2600 7.8 8d4c:H, 8d4c:D, 8d4c:F, 8d4d:C, 8d4d:H, 8d4d:D, 8d4d:F, 8d4e:C, 8d4e:H, 8d4e:Z, 8d4f:C, 8d4f:H, 8d4f:Z, 8d4f:D, 8d4f:F, 8d4f:Q, 8d4g:C, 8d4g:H, 8d4g:Z, 8d4g:D, 8d4g:F, 8d4g:Q, 8d9r:C, 8d9r:H, 8d9r:Z, 8d9r:J, 8d9r:X, 8d9r:3, 8d9r:K, 8d9r:a, 8d9r:4, 8d9r:O, 8d9r:b, 8d9r:5, 8d9r:P, 8d9r:c, 8d9r:6, 8d9r:Q, 8d9r:d, 8d9r:7, 8d9s:C, 8d9s:H, 8d9s:Z, 8d9s:J, 8d9s:X, 8d9s:3, 8d9s:K, 8d9s:a, 8d9s:4, 8d9s:O, 8d9s:b, 8d9s:5, 8d9s:P, 8d9s:c, 8d9s:6, 8d9s:Q, 8d9s:d, 8d9s:7, 8d9t:C, 8d9t:H, 8d9t:J, 8d9t:X, 8d9t:K, 8d9t:Z, 8d9t:O, 8d9t:a, 8d9t:P, 8d9t:b, 8d9t:Q, 8d9t:c, 8d9u:C, 8d9u:H, 8d9u:J, 8d9u:X, 8d9u:K, 8d9u:Z, 8d9u:O, 8d9u:a, 8d9u:P, 8d9u:b, 8d9u:Q, 8d9u:c, 8d9v:C, 8d9v:H, 8d9v:D, 8d9v:F, 8d9w:F, 8d9w:I, 1hur:A, 1hur:B, 7ux3:C, 7ux3:H
34 1isv:A 436 44 0.0326 0.0367 0.3636 9.6 2d20:A, 2d20:B, 2d22:A, 2d22:B, 2d23:A, 2d23:B, 2d24:A, 2d24:B, 1e0v:A, 1e0x:A, 1e0x:B, 2g3j:A, 5gqd:A, 5gqd:B, 5gqe:A, 5gqe:B, 1isv:B, 1isw:A, 1isw:B, 1isx:A, 1isx:B, 1isy:A, 1isy:B, 1isz:A, 1isz:B, 1it0:A, 1it0:B, 1od8:A, 1v0k:A, 1v0l:A, 1v0m:A, 1v0n:A, 1v6u:A, 1v6u:B, 1v6v:A, 1v6v:B, 1v6w:A, 1v6w:B, 1v6x:A, 1v6x:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218