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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
KLHIVTRIKSTKRRPYWEKDIIKMLGLEKAHTPQVHKNIPSVNAKLKVVKHLIRIKPLK

The query sequence (length=59) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8any:Z 122 59 0.9831 0.4754 0.9831 1.18e-35 7a5f:Z3, 7a5g:Z3, 7a5h:Z, 7a5i:Z3, 7a5j:Z, 7a5k:Z3, 5aj4:B3, 4ce4:3, 6gaw:B3, 6gb2:B3, 6i9r:Z, 3j7y:Z, 3j9m:Z, 8k2a:Ld, 8k2b:Ld, 7l08:Z, 7l20:Z, 7nqh:B3, 7nql:B3, 7nsh:B3, 7nsi:B3, 7nsj:B3, 6nu2:Z, 6nu3:Z, 7o9k:Z, 7o9m:Z, 7odr:Z, 7ods:Z, 7odt:Z, 7of0:Z, 7of2:Z, 7of3:Z, 7of4:Z, 7of5:Z, 7of6:Z, 7of7:Z, 7og4:XZ, 7oi6:Z, 7oi7:Z, 7oi8:Z, 7oi9:Z, 7oia:Z, 7oib:Z, 7oic:Z, 7oid:Z, 7oie:Z, 8oin:BG, 8oiq:BG, 8oir:BG, 8oit:BG, 5ool:Z, 5oom:Z, 7pd3:Z, 8pk0:Z, 7po4:Z, 7qh6:Z, 7qh7:Z, 7qi4:Z, 7qi5:Z, 7qi6:Z, 8qsj:Z, 8qu1:Z, 8qu5:Z, 4v19:3, 6vlz:Z, 6vmi:Z, 8xt0:Ld, 8xt1:Ld, 8xt2:Ld, 8xt3:Ld, 6ydp:B3, 6ydw:B3, 6zm5:Z, 6zm6:Z, 6zs9:XZ, 6zsa:XZ, 6zsb:XZ, 6zsc:XZ, 6zsd:XZ, 6zse:XZ, 6zsg:XZ
2 7asm:X 58 52 0.2373 0.2414 0.2692 0.004 7asn:X, 7aso:f, 7asp:1, 6ddd:M, 6ddg:M, 6fxc:AX, 6fxc:BX, 5hkv:W, 5hl7:W, 6hma:X, 5li0:2, 5nd8:2, 5nd9:2, 5ngm:AX, 7nhl:3, 7nhm:3, 5nrg:W, 8p2f:3, 8p2g:3, 8p2h:3, 7p48:X, 6s0x:X, 6s0z:X, 6s12:X, 6s13:X, 6sj6:2, 5t7v:LD, 5tcu:LD, 7ttu:M, 7ttw:M, 4wce:W, 4wf9:W, 4wfa:W, 4wfb:W, 6wqn:M, 6wqq:M, 6wrs:M, 6wru:M, 8y36:X, 8y37:X, 8y38:X, 8y39:X, 6yef:2
3 6b4v:AA 60 49 0.2373 0.2333 0.2857 0.031 5a9z:AZ, 5aa0:AZ, 7azo:L30A, 7azo:L30B, 7azs:L30A, 7azs:L30B, 9b00:13, 9b00:23, 6b4v:EC, 6boh:AA, 6boh:FC, 6bok:AA, 6bok:DC, 6buw:R3, 6buw:Y3, 6bz6:R3, 6bz6:Y3, 6bz7:R3, 6bz7:Y3, 6bz8:R3, 6bz8:Y3, 6c5l:B3, 6c5l:D3, 6cae:13, 6cae:23, 6cfj:13, 6cfj:23, 6cfk:13, 6cfk:23, 6cfl:13, 6cfl:23, 8cvj:13, 8cvj:23, 8cvk:13, 8cvk:23, 8cvl:13, 8cvl:23, 5czp:Y3, 5czp:R3, 6czr:13, 6czr:23, 5d8b:X, 5d8b:TB, 5dfe:Y3, 5dfe:R3, 5dox:13, 5dox:23, 5doy:13, 5doy:23, 5e7k:L8, 5e7k:H5, 5e81:L8, 5e81:H5, 8ekb:13, 8ekb:23, 5el4:L8, 5el4:H5, 5el5:L8, 5el5:H5, 5el6:L8, 5el6:H5, 5el7:L8, 5el7:H5, 8ev6:13, 8ev6:23, 8ev7:13, 8ev7:23, 5f8k:13, 5f8k:23, 8fc1:13, 8fc1:23, 8fc2:13, 8fc2:23, 8fc3:13, 8fc3:23, 8fc4:13, 8fc4:23, 8fc5:13, 8fc5:23, 8fc6:13, 8fc6:23, 5fdu:13, 5fdu:23, 5fdv:13, 5fdv:23, 6fkr:13, 6fkr:23, 8fom:R3, 8fom:Y3, 8fon:R3, 8fon:Y3, 8g29:13, 8g29:23, 8g2a:13, 8g2a:23, 8g2b:13, 8g2b:23, 8g2c:13, 8g2c:23, 8g2d:13, 8g2d:23, 6gsj:L8, 6gsj:H5, 6gsk:L8, 6gsk:H5, 6gsl:L8, 6gsl:H5, 6gzq:Y1, 6gzx:Y1, 6gzx:Y2, 6gzz:Y1, 6gzz:Y2, 5hau:11, 5hau:21, 5hcp:13, 5hcp:23, 5hcq:13, 5hcq:23, 5hcr:13, 5hcr:23, 5hd1:13, 5hd1:23, 5ib7:L8, 5ib7:H5, 5ib8:L8, 5ib8:H5, 5ibb:L8, 5ibb:H5, 5imq:u, 5imr:u, 5j30:R3, 5j30:Y3, 5j3c:R3, 5j3c:Y3, 5j4b:13, 5j4b:23, 5j4c:13, 5j4c:23, 5j4d:AA, 5j4d:FC, 5j8b:3, 7jql:13, 7jql:23, 7jqm:13, 7jqm:23, 4l47:R3, 4l47:Y3, 4l71:R3, 4l71:Y3, 4lel:R3, 4lel:Y3, 4lfz:R3, 4lfz:Y3, 7lh5:B3, 7lh5:D3, 4lnt:R3, 4lnt:Y3, 4lsk:R3, 4lsk:Y3, 4lt8:R3, 4lt8:Y3, 7md7:13, 7md7:23, 1ml5:x, 6n1d:AL30, 6n1d:BL30, 6n9e:13, 6n9e:23, 6n9f:13, 6n9f:23, 5ndj:L8, 5ndj:H5, 5ndk:L8, 5ndk:H5, 6nd5:13, 6nd5:23, 6nd6:13, 6nd6:23, 6ndk:R3, 6ndk:Y3, 6nsh:R3, 6nsh:Y3, 6nta:R3, 6nta:Y3, 6nuo:R3, 6nuo:Y3, 6nwy:R3, 6nwy:Y3, 6o3m:R3, 6o3m:Y3, 6o97:13, 6o97:23, 6of1:13, 6of1:23, 6of6:R3, 6of6:Y3, 6oj2:R3, 6oj2:Y3, 6ope:R3, 6ope:Y3, 6ord:R3, 6ord:Y3, 6osi:R3, 6osi:Y3, 5ot7:Y, 6otr:R3, 6otr:Y3, 6oxa:R3, 6oxa:Y3, 6oxi:R3, 6oxi:Y3, 4p6f:R3, 4p6f:Y3, 4p70:R3, 4p70:Y3, 6q95:Z, 6qnq:L8, 6qnq:H5, 6qnr:L8, 6qnr:H5, 7rq8:13, 7rq8:23, 7rq9:13, 7rq9:23, 7rqa:13, 7rqa:23, 7rqb:13, 7rqb:23, 7rqc:13, 7rqc:23, 7rqd:13, 7rqd:23, 7rqe:13, 7rqe:23, 8t8b:13, 8t8b:23, 8t8c:13, 8t8c:23, 4tua:R3, 4tua:Y3, 4tub:R3, 4tub:Y3, 4tuc:R3, 4tuc:Y3, 4tud:R3, 4tud:Y3, 4tue:R3, 4tue:Y3, 7u2h:13, 7u2h:23, 7u2i:13, 7u2i:23, 7u2j:13, 7u2j:23, 6ucq:13, 6ucq:23, 8ud6:13, 8ud6:23, 8ud7:13, 8ud7:23, 8ud8:13, 8ud8:23, 6uo1:13, 6uo1:23, 5uq7:3, 5uq8:3, 8uvr:13, 8uvr:23, 8uvs:13, 8uvs:23, 4v42:BX, 4v4i:X, 4v4j:X, 4v4p:AX, 4v4r:B3, 4v4s:B3, 4v4t:B3, 4v4x:B2, 4v4y:B2, 4v4z:B2, 4v51:B3, 4v51:D3, 4v5a:B3, 4v5a:D3, 4v5c:B3, 4v5c:D3, 4v5d:B3, 4v5d:D3, 4v5e:B3, 4v5e:D3, 4v5f:B3, 4v5f:D3, 4v5g:B3, 4v5g:D3, 4v5j:B3, 4v5j:D3, 4v5k:B3, 4v5k:D3, 4v5l:B3, 4v5m:B3, 4v5n:B3, 4v5p:B3, 4v5p:D3, 4v5q:B3, 4v5q:D3, 4v5r:B3, 4v5r:D3, 4v5s:B3, 4v5s:D3, 4v63:B3, 4v63:D3, 4v67:B3, 4v67:D3, 4v68:B3, 4v6a:B3, 4v6a:D3, 4v6f:AX, 4v6f:DX, 4v6g:BX, 4v6g:DX, 4v7j:A3, 4v7j:B3, 4v7k:A3, 4v7k:B3, 4v7l:B3, 4v7l:D3, 4v7m:B3, 4v7m:D3, 4v7p:BZ, 4v7p:CZ, 4v7w:B3, 4v7w:D3, 4v7x:B3, 4v7x:D3, 4v7y:B3, 4v7y:D3, 4v7z:B3, 4v7z:D3, 4v83:BZ, 4v83:DZ, 4v84:BZ, 4v84:DZ, 4v87:AX, 4v87:DX, 4v8a:A3, 4v8a:B3, 4v8b:BX, 4v8b:DX, 4v8c:AX, 4v8c:BX, 4v8d:BX, 4v8d:DX, 4v8e:AX, 4v8e:CX, 4v8f:AX, 4v8f:DX, 4v8g:B3, 4v8g:D3, 4v8h:B3, 4v8h:D3, 4v8i:B3, 4v8i:D3, 4v8j:B3, 4v8j:D3, 4v8n:B3, 4v8n:D3, 4v8o:B3, 4v8q:A3, 4v8u:B3, 4v8u:D3, 4v8x:B3, 4v8x:D3, 5v8i:13, 5v8i:23, 4v90:B3, 4v95:B3, 4v95:D3, 4v97:B3, 4v97:D3, 4v9a:BX, 4v9a:DX, 4v9b:BX, 4v9b:DX, 4v9h:B3, 4v9i:B3, 4v9i:D3, 4v9j:B3, 4v9j:D3, 4v9k:B3, 4v9k:D3, 4v9l:B3, 4v9l:D3, 4v9m:B3, 4v9m:D3, 4v9n:B3, 4v9n:D3, 4v9q:AZ, 4v9q:CZ, 4v9r:B3, 4v9r:D3, 4v9s:B3, 4v9s:D3, 5vp2:13, 5vp2:23, 5vpo:R3, 5vpo:Y3, 5vpp:R3, 5vpp:Y3, 8vtu:13, 8vtu:23, 8vtv:13, 8vtv:23, 8vtw:13, 8vtw:23, 8vtx:13, 8vtx:23, 8vty:13, 8vty:23, 1vvj:R3, 1vvj:Y3, 1vy4:B3, 1vy4:D3, 1vy5:B3, 1vy5:D3, 1vy6:B3, 1vy6:D3, 1vy7:B3, 1vy7:D3, 4w29:B3, 4w29:D3, 4w2e:3, 4w2f:B3, 4w2f:D3, 4w2g:B3, 4w2g:D3, 4w2h:B3, 4w2h:D3, 4w2i:B3, 4w2i:D3, 4w4g:R3, 4w4g:Y3, 5w4k:13, 5w4k:23, 5wis:13, 5wis:23, 5wit:13, 5wit:23, 4wpo:A3, 4wpo:C3, 4wq1:L8, 4wq1:H5, 4wqf:A3, 4wqf:C3, 4wqr:L8, 4wqr:H5, 4wqu:A3, 4wqu:C3, 4wqy:A3, 4wqy:C3, 4wr6:L8, 4wr6:H5, 4wra:L8, 4wra:H5, 4wro:L8, 4wsd:L8, 4wsd:H5, 4wsm:L8, 4wsm:H5, 4wt1:L8, 4wt1:H5, 4wt8:CL, 4wt8:DL, 4wu1:L8, 4wu1:H5, 4wzd:L8, 4wzd:H5, 4wzo:L8, 4wzo:H5, 4xej:AL30, 4xej:BL30, 6xhv:13, 6xhv:23, 6xhw:13, 6xhw:23, 6xhx:13, 6xhx:23, 6xhy:13, 6xhy:23, 6xqd:13, 6xqd:23, 6xqe:13, 6xqe:23, 4y4o:13, 4y4o:23, 4y4p:13, 4y4p:23, 4ypb:R3, 4ypb:Y3, 4yzv:R3, 4yzv:Y3, 4z3s:13, 4z3s:23, 4z8c:13, 4z8c:23, 4zer:13, 4zer:23, 5zlu:v, 4zsn:R3, 4zsn:Y3
4 7a0r:W 55 49 0.2373 0.2545 0.2857 0.050 7a0s:W, 7a18:W, 3cf5:W, 3dll:W, 5dm6:W, 5dm7:W, 4io9:W, 4ioa:W, 4ioc:W, 5jvg:W, 5jvh:W, 1nkw:X, 1nwx:X, 1nwy:X, 3pio:W, 3pip:W, 1sm1:X, 4u67:W, 4v49:BX, 4v4a:BX, 4v4g:BZ, 4v4g:DZ, 4v4g:FZ, 4v4g:HZ, 4v4g:JZ, 4wfn:W, 1xbp:X, 2zjp:W, 2zjq:W, 2zjr:W
5 7aqc:Z 58 43 0.2034 0.2069 0.2791 0.075 7aqd:Z, 7as8:d, 7as9:d, 8buu:Z, 6ha1:Z, 6ha8:Z, 6htq:Y, 3j3v:Y, 3j9w:B2, 5njt:w, 7o5b:x, 7ope:d, 6ppf:Z, 6ppk:Z, 8qcq:Z, 7qgu:a, 7qh4:a, 8qpp:x, 7qv1:Z, 7qv2:Z, 7qv3:Z, 8r55:x, 8s1p:Z, 8s1u:Z, 7s9u:Z, 7sae:Z, 6tnn:w, 6tpq:w
6 7f0d:Z 59 55 0.1864 0.1864 0.2000 0.12 7kgb:Z, 7msc:Z, 7msh:Z, 7msm:Z, 7msz:Z, 7mt2:Z, 7mt3:Z, 7mt7:Z, 7sfr:Z, 5v7q:Z, 5v93:Z
7 8a57:3 56 43 0.2034 0.2143 0.2791 0.14 8a5i:3, 8a63:3, 7nhn:3, 8uu4:2, 8uu5:2, 8uu6:2, 8uu7:2, 8uu8:2, 8uu9:2, 8uua:2
8 7jil:Z 56 53 0.2373 0.2500 0.2642 0.79
9 3j6b:U 82 42 0.2373 0.1707 0.3333 0.96 5mrc:U, 5mre:U, 5mrf:U
10 5myj:B2 58 52 0.2034 0.2069 0.2308 0.98
11 1g8t:A 241 36 0.2373 0.0581 0.3889 1.0 1g8t:B
12 8hku:L30P 155 49 0.2034 0.0774 0.2449 1.1 8hkv:L30P, 8hky:L30P, 8hkz:L30P, 8hl1:L30P, 8hl2:L30P, 8hl3:L30P, 8hl4:L30P, 8hl5:L30P
13 8rd8:YW 56 52 0.2542 0.2679 0.2885 1.3 8rdv:YW, 8rdw:YW
14 4aq4:A 418 32 0.1864 0.0263 0.3438 1.5 6x84:B
15 5kjh:B 807 27 0.1695 0.0124 0.3704 2.1 5m5g:B
16 5kkl:B 839 27 0.1695 0.0119 0.3704 2.2
17 4r9f:A 402 39 0.2034 0.0299 0.3077 2.4 4r9g:A, 4r9g:B
18 6z1h:A 382 23 0.1525 0.0236 0.3913 2.5
19 7ml3:7 548 23 0.1864 0.0201 0.4783 2.7
20 4pab:B 824 43 0.2203 0.0158 0.3023 3.1 5l46:A, 5l46:B, 4p9s:A, 4p9s:B, 4paa:A, 4paa:B, 4pab:A
21 8rxh:LB 404 29 0.1864 0.0272 0.3793 3.1 8a3w:B, 8a98:B, 6az3:B, 3jcs:B, 8ovj:B, 8rxx:LB, 5t2a:d
22 7k04:7 638 23 0.1864 0.0172 0.4783 3.2 5fmf:1, 7m2u:7, 7ml0:7, 7ml1:7, 7ml2:7, 5sva:Z
23 7zsa:7 616 23 0.1864 0.0179 0.4783 3.4 8cen:7, 8ceo:7, 7o4i:7, 7o4j:7, 7o4k:7, 7o4l:7, 7o72:7, 7o73:7, 7o75:7, 7zs9:7, 7zsb:7
24 5zeb:1 60 54 0.1864 0.1833 0.2037 3.9 6dzi:a, 6dzp:a, 8fr8:7, 8kab:a, 5o60:a, 5o61:a, 7s0s:b, 8v9j:2, 8v9k:2, 8v9l:2, 8whx:3, 8why:3, 8wi7:3, 8wi8:3, 8wib:3, 8wic:3, 7xam:a, 5xym:Z, 8xz3:a, 7y41:a, 5zep:v, 5zet:1
25 4qrz:A 383 31 0.1864 0.0287 0.3548 5.1 4qsc:A, 4qsd:A
26 3tdh:C 316 32 0.1864 0.0348 0.3438 5.4 3t4n:C, 3te5:C
27 7qep:L3 363 27 0.1864 0.0303 0.4074 6.3
28 7q0s:A 620 31 0.1695 0.0161 0.3226 7.1 8cvx:A, 8cvx:B, 8cvx:D, 8cvx:C, 7q0s:B, 7q0s:C, 7q0s:D, 7q12:A, 7q12:B, 7q12:C, 7q12:D, 7q13:A, 7q13:C, 7q13:B, 7q13:D
29 3abk:C 259 23 0.1356 0.0309 0.3478 7.8 3abk:P, 3abl:C, 3abl:P, 3abm:C, 3abm:P, 3ag1:C, 3ag2:C, 3ag2:P, 3ag3:C, 3ag4:C, 3ag4:P, 5b1a:C, 5b1a:P, 5b1b:C, 5b1b:P, 5b3s:C, 5b3s:P, 7coh:C, 7coh:P, 7cp5:C, 7cp5:P, 8d4t:P, 7d5w:C, 7d5w:P, 7d5x:C, 7d5x:P, 2dyr:C, 2dyr:P, 2dys:C, 2dys:P, 2eij:C, 2eij:P, 2eik:C, 2eik:P, 2eil:C, 2eil:P, 2eim:C, 2eim:P, 2ein:C, 2ein:P, 7ev7:C, 7ev7:P, 8gbt:C, 8gcq:C, 8gvm:C, 8gvm:P, 8h8r:C, 8h8r:P, 8h8s:C, 8h8s:P, 8ijn:C, 8ijn:P, 6j8m:C, 6j8m:P, 6juw:C, 6juw:P, 6jy3:C, 6jy4:C, 6nmf:C, 6nmf:P, 6nmp:C, 7thu:C, 7thu:P, 7tie:C, 7tie:P, 7tih:C, 7tih:P, 7tii:C, 7tii:P, 7vuw:C, 7vuw:P, 7vvr:C, 7vvr:P, 7w3e:C, 7w3e:P, 5wau:C, 5wau:c, 3x2q:C, 3x2q:P, 5xdq:C, 5xdq:P, 5xdx:C, 5xdx:P, 7xma:C, 7xma:P, 7xmb:C, 7xmb:P, 7y44:P, 7ypy:C, 7ypy:P, 5z84:C, 5z84:P, 5z85:C, 5z85:P, 5z86:C, 5z86:P, 5zco:C, 5zco:P, 5zcp:C, 5zcp:P, 5zcq:C, 5zcq:P, 2zxw:C, 2zxw:P

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218