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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
IKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNLTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLA
SLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIY
LRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL

The query sequence (length=230) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 2no0:A 242 240 0.9957 0.9463 0.9542 9.86e-171 2a2z:A, 2a2z:C, 2a30:A, 2a30:C, 2a7q:A, 3hp1:A, 3ipx:A, 3ipy:A, 3ipy:B, 4jlj:A, 4jlj:B, 4jlk:A, 4jlk:B, 4jlm:A, 4jlm:B, 4jln:A, 4jln:B, 4kcg:A, 4kcg:B, 3kfx:A, 3kfx:B, 4l5b:A, 4l5b:B, 3mjr:A, 3mjr:B, 3mjr:C, 5mqj:A, 5mqj:B, 5mqj:C, 5mqj:D, 5mql:A, 5mql:B, 5mql:C, 5mql:D, 5mqt:A, 5mqt:B, 5mqt:C, 5mqt:D, 2no0:B, 2no1:A, 2no1:B, 2no6:A, 2no6:B, 2no7:A, 2no7:B, 2no9:A, 2no9:B, 2noa:A, 2noa:B, 8ooj:A, 8ooj:B, 8ooj:C, 8ooj:D, 1p5z:B, 1p60:A, 1p60:B, 1p61:B, 1p62:B, 4q18:A, 4q18:B, 4q19:A, 4q19:B, 4q1a:A, 4q1a:B, 4q1b:A, 4q1b:B, 4q1c:A, 4q1c:B, 4q1d:A, 4q1d:B, 4q1e:A, 4q1e:B, 4q1f:A, 4q1f:B, 3qej:A, 3qej:B, 3qen:A, 3qen:B, 3qeo:A, 3qeo:B, 2qrn:A, 2qrn:B, 2qrn:C, 2qrn:D, 2qro:A, 2qro:B, 2qro:C, 2qro:D, 2zi3:A, 2zi3:B, 2zi4:A, 2zi5:B, 2zi6:B, 2zi9:A, 2zi9:B, 7zi1:A, 7zi2:A, 7zi3:A, 7zi5:A, 7zi6:A, 7zi7:A, 7zi8:A, 7zi9:A, 7zia:A, 7zib:A
2 2a2z:B 221 230 0.9261 0.9638 0.9261 1.62e-156 2a2z:D, 2a30:B, 2a30:D, 3mjr:D, 2zi5:A, 2zi5:C, 2zi5:D, 2zi6:A, 2zi6:C, 2zi6:D, 2zi7:B, 2zi7:A, 2zia:A, 2zia:B
3 2ocp:A 229 232 0.5217 0.5240 0.5172 2.80e-85 2ocp:B, 2ocp:C, 2ocp:D, 2ocp:E, 2ocp:F, 2ocp:G, 2ocp:H
4 6ybh:D 219 211 0.3000 0.3151 0.3270 5.69e-38 1j90:A, 1j90:B, 2jcs:A, 2jcs:B, 2jj8:A, 2jj8:B, 2jj8:C, 2jj8:D, 1oe0:A, 1oe0:B, 1oe0:C, 1oe0:D, 1ot3:A, 1ot3:B, 1ot3:C, 1ot3:D, 1ot3:E, 1ot3:F, 1ot3:G, 1ot3:H, 2vp0:A, 2vp0:B, 2vp2:A, 2vp2:B, 2vp4:A, 2vp4:B, 2vp4:C, 2vp4:D, 2vp5:A, 2vp5:B, 2vp6:A, 2vp6:B, 2vp6:C, 2vp6:D, 2vp6:E, 2vp6:F, 2vp6:G, 2vp6:H, 2vp9:A, 2vp9:B, 2vp9:C, 2vp9:D, 2vp9:E, 2vp9:F, 2vp9:G, 2vp9:H, 2vpp:A, 2vpp:B, 2vqs:A, 2vqs:B, 2vqs:C, 2vqs:D, 6ybh:A, 6ybh:B, 6ybh:C, 6ybh:E, 6ybh:F, 1zm7:A, 1zm7:B, 1zm7:C, 1zm7:D, 1zmx:A, 1zmx:B, 1zmx:C, 1zmx:D, 1zmx:E, 1zmx:F, 1zmx:G, 1zmx:H
5 2jas:C 195 223 0.2739 0.3231 0.2825 8.14e-12 2jaq:A, 2jaq:B, 2jas:A, 2jas:B, 2jas:D, 2jas:E, 2jas:F, 2jat:A, 2jat:B
6 7ak5:O 320 186 0.1826 0.1313 0.2258 0.030 7ak6:O, 7b93:O, 8c2s:O, 8ca3:O, 8ca5:O, 6g2j:O, 6g72:O, 8iao:O, 8iaq:O, 8ib4:O, 8ib6:O, 8ib9:O, 8ibb:O, 8ibd:O, 8ibf:O, 8ic2:O, 8ic4:O, 8olt:O, 8om1:O, 7psa:O, 8pw5:O1, 8pw6:O1, 8pw7:O1, 8rgp:O, 8rgq:O, 8rgr:O, 8rgt:O, 6zr2:O, 6ztq:O
7 8q0a:O 320 123 0.1478 0.1062 0.2764 0.10 8q0f:O, 8q0j:O, 8q0m:O, 8q0o:O, 8q0q:O, 8q1p:O, 8q1u:O, 8q1y:O, 8q25:O, 8q45:O, 8q46:O, 8q47:O, 8q48:O, 8q49:O, 8q4a:O, 7qsd:O, 7qsk:O, 7qsl:O, 7qsm:O, 7qsn:O, 7qso:O, 7r41:O, 7r42:O, 7r43:O, 7r44:O, 7r45:O, 7r46:O, 7r47:O, 7r48:O, 7r4c:O, 7r4d:O, 7r4f:O, 7r4g:O, 7zd6:k, 7zdh:k, 7zdm:k, 7zdp:k, 7zeb:k, 6zka:k, 6zkb:k, 6zkc:k, 6zkd:k, 6zke:k, 6zkf:k, 6zkg:k, 6zkh:k, 6zki:k, 6zkj:k, 6zkk:k, 6zkl:k, 6zkm:k, 6zkn:k, 6zko:k, 6zkp:k, 6zkq:k, 6zkr:k, 6zks:k, 6zkt:k, 6zku:k, 6zkv:k
8 8ud1:1O 320 123 0.1391 0.1000 0.2602 0.12 8ueo:1O, 8uep:1O, 8ueq:1O, 8uer:1O, 8ues:1O, 8uet:1O, 8ueu:1O, 8uev:1O, 8uew:1O, 8uex:1O, 8uey:1O, 8uez:1O, 8ugh:1O, 8ugi:1O, 8ugj:1O, 8ugn:1O, 8ugn:5O, 8ugr:1O, 8ugr:5O, 7v2c:w, 7v2d:w, 7v2e:w, 7v2f:w, 7v2h:w, 7v2k:w, 7v2r:w, 7v30:w, 7v31:w, 7v32:w, 7v33:w, 7v3m:w, 7vbl:w, 7vbp:w, 7vc0:w, 7vwl:w, 7vxs:w, 7vy1:w, 7vy9:w, 7vye:w, 7vyg:w, 7vyi:w, 7vys:w, 7vz8:w, 7vzv:w, 7vzw:w, 7w00:w, 7w0h:w, 7w0r:w, 7w0y:w, 7w1o:w, 7w1p:w, 7w1t:w, 7w1u:w, 7w1v:w, 7w1z:w, 7w20:w, 7w2k:w, 7w2l:w, 7w2r:w, 7w2u:w, 7w2y:w, 7w31:w, 7w32:w, 7w35:w, 7w4c:w, 7w4d:w, 7w4e:w, 7w4f:w, 7w4g:w, 7w4j:w, 7w4k:w, 7w4l:w, 7w4m:w, 7w4n:w, 7w4q:w
9 4tmk:A 210 172 0.2043 0.2238 0.2733 0.14 5tmp:A
10 8b9z:O 368 182 0.1826 0.1141 0.2308 0.74 8ba0:O, 8esw:AL, 8esz:AL
11 8r9b:A 301 35 0.0696 0.0532 0.4571 0.75 7b5o:J, 7b5q:J, 8orm:J, 8p4z:A, 8p4z:B, 8p6v:J, 8p6w:J, 8p6x:J, 8p6y:J, 8p6z:J, 8p70:J, 8p71:J, 8p72:J, 8p73:J, 8p74:J, 8p75:J, 8p76:J, 8p77:J, 8p78:J, 8p7l:J, 8plz:J, 8r99:A, 8r9a:A, 8r9b:B, 8r9b:C, 8r9b:D, 8r9o:A, 8r9o:B, 8r9s:A, 8r9s:B, 8r9u:A, 8r9u:B, 1ua2:A, 1ua2:B, 1ua2:C, 1ua2:D, 6xbz:J, 6xd3:J
12 3atg:A 242 27 0.0522 0.0496 0.4444 2.2
13 5yeu:A 381 76 0.0870 0.0525 0.2632 2.3 5yeu:B
14 7c3k:B 389 115 0.1261 0.0746 0.2522 2.5 7c3k:A, 8jqz:A, 8jqz:B
15 1esm:A 311 25 0.0522 0.0386 0.4800 2.5 1esm:B, 1esm:C, 1esm:D, 1esn:A, 1esn:B, 1esn:C, 1esn:D, 4f7w:A, 4f7w:C, 4f7w:B, 4f7w:D, 4f7w:E, 4f7w:F, 4f7w:G, 4f7w:H, 4gi7:A, 4gi7:C, 4gi7:B, 4gi7:D, 4gi7:E, 4gi7:F, 4gi7:G, 4gi7:H, 4ne2:A, 4ne2:B, 1sq5:A, 1sq5:B, 1sq5:C, 1sq5:D
16 7vex:A 412 48 0.0609 0.0340 0.2917 2.6 8h4m:A
17 3tqc:B 305 50 0.0739 0.0557 0.3400 2.8 3tqc:A
18 2ges:A 308 29 0.0478 0.0357 0.3793 4.4 3aez:A, 3af0:A, 3af1:A, 3af2:A, 3af3:A, 3avo:A, 3avq:A, 4bfs:A, 4bft:A, 4bft:B, 4bfu:A, 4bfu:B, 4bfv:A, 4bfv:B, 4bfw:A, 4bfw:B, 4bfx:A, 4bfx:B, 4bfy:A, 4bfy:B, 4bfz:A, 4bfz:B, 2get:A, 2geu:A, 2gev:A, 2zs7:A, 2zs8:A, 2zs9:A, 2zsa:A, 2zsb:A, 2zsd:A, 2zse:A, 2zsf:A
19 5xs2:A 366 20 0.0435 0.0273 0.5000 5.5 5cei:A, 5hbe:A, 5icp:A, 5idp:A, 6r3s:A, 6t41:A, 6y0a:A
20 6nak:D 165 39 0.0522 0.0727 0.3077 5.8 6n9a:E, 6nak:E, 6s84:E, 6s84:B
21 5i5z:A 345 31 0.0565 0.0377 0.4194 6.0 5bnj:A, 4crl:A, 4f6s:A, 4f6u:A, 4f6w:A, 4f70:A, 4f7j:A, 4f7l:A, 4f7n:A, 4f7s:A, 5fgk:A, 5hbh:A, 5hbj:A, 5hnb:A, 5hvy:A, 5idn:A, 6qtg:A, 6qtj:A, 3rgf:A, 6tpa:A, 5xqx:A
22 2cyc:A 371 16 0.0348 0.0216 0.5000 6.0 2cyc:B
23 9ash:A 753 105 0.1348 0.0412 0.2952 9.7 9asi:A, 6xn3:A, 6xn4:A, 6xn5:A, 6xn7:A
24 7ukz:E 299 42 0.0565 0.0435 0.3095 9.7 7ukz:A, 7ukz:B, 7ukz:C, 7ukz:D, 7ukz:F

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218