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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
IHPLPHKIIIKKRKNKFIRFQSERFVRVKPSWRKPRGIDSPMRHQYRGQRPMVSIGYGSDKETRFMLPCGFFKHRISTVH
ELKTLFMNNKTHAAQIAHGVSARSRKQILEEAKKMGVRVLNADAKLR

The query sequence (length=127) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8brm:Lf 130 127 1.0000 0.9769 1.0000 1.25e-92 8br8:Lf, 8bsi:Lf, 8bsj:Lf, 8btd:Lf, 8btr:Lf, 8fru:e, 7pwg:e, 7pwo:e2
2 8fkp:LQ 133 127 0.5039 0.4812 0.5039 1.23e-41 7a01:v2, 8a3d:Y, 5aj0:Ae, 8b5l:e, 8b6c:e, 9bdl:AL32, 9bdn:AL32, 9bdp:AL32, 7bhp:Le, 8bhf:R1, 8bpo:d2, 8btk:Be, 7cpu:Le, 7cpv:Le, 4d5y:e, 4d67:e, 6d90:e, 6d9j:e, 9f1b:Be, 9f1c:Be, 9f1d:Be, 7f5s:Le, 8fkq:LQ, 8fkr:LQ, 8fks:LQ, 8fkt:LQ, 8fku:LQ, 8fkv:LQ, 8fkw:LQ, 8fkx:LQ, 8fky:LQ, 8fkz:LQ, 8fl2:LQ, 8fl3:LQ, 8fl4:LQ, 8fl6:LQ, 8fl7:LQ, 8fl9:LQ, 8fla:LQ, 8flb:LQ, 8flc:LQ, 8fld:LQ, 8fle:LQ, 8flf:LQ, 6frk:e, 6ftg:e, 6fti:e, 6ftj:e, 8g5y:Le, 8g5z:Le, 8g60:Le, 8g61:Le, 8g6j:Le, 8glp:Le, 6gz3:Ae, 6gz4:Ae, 6gz5:Ae, 6hcf:e3, 6hcj:e3, 6hcm:e3, 6hcq:e3, 8idt:k, 8idy:k, 8ie3:k, 8ifd:2Y, 8ife:2Y, 8ine:k, 8inf:k, 8ink:k, 6ip5:2Y, 6ip6:2Y, 6ip8:2Y, 8ipd:k, 8ipx:k, 8ipy:k, 8ir1:k, 8ir3:k, 3j7o:e, 3j7p:e, 3j7q:e, 3j7r:e, 3j92:e, 3jag:e, 3jah:e, 3jai:e, 3jaj:e, 3jan:e, 8jdj:j, 8jdk:j, 8jdl:j, 8jdm:j, 8k2c:Le, 5lks:Le, 6lqm:t, 6lsr:t, 6lss:k, 7ls1:Y2, 7ls2:Y2, 6lu8:k, 5lzs:e, 5lzt:e, 5lzu:e, 5lzv:e, 5lzw:e, 5lzx:e, 5lzy:e, 5lzz:e, 7mdz:e, 6mtb:e, 6mtc:e, 6mtd:e, 6mte:e, 7nfx:e, 7nwg:e3, 7nwh:e, 7nwi:e, 7o7y:Be, 7o7z:Be, 7o80:Be, 7o81:Be, 7obr:e, 8ohd:Le, 8oj0:Le, 8oj5:Le, 8oj8:Le, 6ole:f, 6olf:f, 6olg:Ae, 6oli:f, 6olz:Ae, 6om0:f, 6om7:f, 7ow7:Y, 7oya:e1, 7oyb:e1, 7oyc:e1, 7oyd:e, 8p2k:Be, 6p5i:Ae, 6p5j:Ae, 6p5k:Ae, 6p5n:Ae, 8q7z:Be, 8q87:Be, 8qfd:e, 7qgg:f, 8qoi:Le, 7qvp:Le, 7qvp:Me, 7qwq:e, 7qwr:e, 7qws:e, 6qzp:Le, 6r5q:e, 6r6g:e, 6r6p:e, 6r7q:e, 8rjb:e, 8rjc:e, 8rjd:e, 8scb:e, 6sgc:e2, 6swa:c, 5t2c:Y, 6t59:e3, 7tm3:e, 7toq:AL32, 7tor:AL32, 7tut:e, 7ucj:e, 7uck:e, 4ug0:Le, 4ujc:Be, 4ujd:Ae, 4uje:Ce, 4v5z:By, 4v5z:B9, 4v6x:Ce, 6w6l:f, 6xa1:Le, 7xnx:Le, 7xny:Le, 8xsx:Le, 8xsy:Le, 8xsz:Le, 6y0g:Le, 8y0w:Le, 8y0x:Le, 6y2l:Le, 6y57:Le, 6y6x:Le, 8yoo:Le, 8yop:Le, 6z6l:Le, 6z6m:Le, 6z6n:Le, 7zjw:Lh, 7zjx:Lh, 6zm7:Le, 6zme:Le, 6zmi:Le, 6zmo:Le, 6zvk:v2
3 3j79:8 125 114 0.4882 0.4960 0.5439 1.83e-41 3jbn:A8, 3jbo:A8, 3jbp:A8, 8tpu:A8, 5umd:8
4 5xxb:d 122 118 0.4803 0.5000 0.5169 4.43e-39
5 4v6w:Ce 132 127 0.4724 0.4545 0.4724 3.82e-38 6xu6:Ce, 6xu7:Ce, 6xu8:Ce
6 8eth:e 124 119 0.4882 0.5000 0.5210 1.57e-37 8esq:e, 8esr:e, 8etc:e, 8etg:e, 8eti:e, 8etj:e, 8eug:e, 8eui:e, 8eup:e, 8euy:e, 8ev3:e
7 7r81:g1 121 117 0.4646 0.4876 0.5043 3.22e-37
8 5t2a:g 129 127 0.4488 0.4419 0.4488 1.22e-35
9 8ova:Bi 131 127 0.4331 0.4198 0.4331 4.49e-35 8ove:Bi, 5t5h:i, 4v8m:Bi
10 8i9p:Le 131 121 0.4409 0.4275 0.4628 5.64e-35 8i9r:Le, 8i9t:Le, 8i9v:Le, 8i9w:Le, 8i9x:Le, 8i9y:Le, 8i9z:Le, 8ia0:Le, 7olc:Le, 7old:Le, 8oo0:Le, 8pv1:Le, 8pv2:Le, 8pv3:Le, 8pv4:Le, 8pv5:Le, 8pv6:Le, 8pv7:Le, 8pv8:Le, 8pvk:Le, 8pvl:Le, 7z3n:Le, 7z3o:Le
11 6az3:f 130 127 0.4488 0.4385 0.4488 5.91e-35 8a3w:f, 8a98:f, 3jcs:f, 8ovj:f, 8rxh:Lf, 8rxx:Lf
12 4v3p:Lh 133 125 0.4724 0.4511 0.4800 7.20e-35 8ip8:TA, 8ipa:TA, 8ipb:TA, 8jiv:Ce, 4v7e:Ce
13 4v6i:Bh 130 123 0.4409 0.4308 0.4553 4.21e-33 8aaf:R, 8agt:R, 8agu:R, 8agv:R, 8agw:R, 8agx:R, 8agz:R, 5apn:e, 5apo:e, 7azy:r, 7b7d:La, 8bip:Le, 8bjq:Le, 8bn3:O2, 8bqd:BG, 8bqx:BG, 7bt6:e, 7btb:e, 6c0f:e, 6cb1:e, 8ccs:Q, 8cdl:Q, 8cdr:Q, 8ceh:Q, 8cf5:Q, 8cg8:Q, 8cgn:Q, 8civ:Q, 8cku:Q, 8cmj:Q, 5dat:O2, 5dat:o2, 5dc3:O2, 5dc3:o2, 5dge:O2, 5dge:o2, 5dgf:O2, 5dgf:o2, 5dgv:O2, 5dgv:o2, 8e5t:e, 6elz:e, 6em1:e, 6em3:e, 6em4:e, 6em5:e, 8eub:Ae, 8evp:Ae, 8evq:Ae, 8evr:Ae, 8evs:Ae, 8evt:Ae, 8ewb:Ae, 8ewc:Ae, 5fci:O2, 5fci:o2, 5fcj:O2, 5fcj:o2, 6ft6:e, 5gak:g, 6gq1:e, 6gqb:e, 6gqv:e, 5h4p:e, 6hd7:g, 8hfr:eH, 6hhq:AF, 6hhq:DG, 5i4l:O2, 5i4l:o2, 6i7o:BG, 6i7o:YG, 3j6x:72, 3j6y:72, 3j77:82, 3j78:82, 3jct:e, 5jcs:e, 5juo:JA, 5jup:JA, 5jus:JA, 5jut:JA, 5juu:JA, 8k2d:Le, 8k82:Le, 5lyb:O2, 5lyb:o2, 5m1j:e5, 6m62:e, 5mc6:BG, 5mei:AF, 5mei:DG, 7mpi:Ae, 7mpj:Ae, 6n8j:e, 6n8k:e, 6n8l:e, 6n8m:r, 6n8n:r, 6n8o:r, 7n8b:Ae, 7nac:e, 5ndg:O2, 5ndg:o2, 5ndv:O2, 5ndv:o2, 5ndw:O2, 5ndw:o2, 7nrc:Lg, 7nrd:Lg, 5obm:O2, 5obm:o2, 7of1:e, 7oh3:e, 7ohp:e, 7ohq:e, 7ohr:e, 7ohs:e, 7ohu:e, 7ohv:e, 7ohw:e, 7ohx:e, 7ohy:e, 6oig:e, 5on6:AF, 5on6:DG, 7osa:eL32, 7osm:eL32, 8p8m:RE, 8p8n:RE, 8p8u:RE, 8pfr:RE, 6q8y:BG, 6qik:e, 6qt0:e, 6qtz:e, 7r7a:e, 6r84:g, 6r86:g, 6r87:g, 6ri5:e, 7rr5:Le, 6rzz:e, 6s05:e, 6s47:Ag, 6snt:al, 6sv4:BG, 6sv4:YG, 6sv4:ZG, 6t4q:Le, 5t62:r, 5t6r:r, 6t7i:Le, 6t7t:Le, 6t83:ey, 6t83:P, 5tbw:AF, 5tbw:DG, 6tb3:BG, 5tga:O2, 5tga:o2, 5tgm:O2, 5tgm:o2, 6tnu:BG, 7too:AL32, 7top:AL32, 7u0h:e, 4u3m:O2, 4u3m:o2, 4u3n:O2, 4u3n:o2, 4u3u:O2, 4u3u:o2, 4u4n:O2, 4u4n:o2, 4u4o:O2, 4u4o:o2, 4u4q:O2, 4u4q:o2, 4u4r:O2, 4u4r:o2, 4u4u:O2, 4u4u:o2, 4u4y:O2, 4u4y:o2, 4u4z:O2, 4u4z:o2, 4u50:O2, 4u50:o2, 4u51:O2, 4u51:o2, 4u52:O2, 4u52:o2, 4u53:O2, 4u53:o2, 4u55:O2, 4u55:o2, 4u56:O2, 4u56:o2, 4u6f:O2, 4u6f:o2, 7ug6:e, 7uoo:e, 7uqb:e, 7uqz:e, 7v08:e, 4v4b:B0, 4v7f:d, 4v7h:B0, 4v7r:Bb, 4v7r:Db, 4v88:Be, 4v88:De, 4v8t:e, 4v8y:Be, 4v8z:Be, 8v83:e, 8v84:e, 8v87:e, 4v91:e, 6woo:e, 6xiq:e, 6xir:e, 8y0u:Le, 6ylg:e, 6ylh:e, 6ylx:e, 6yly:e, 5z3g:i, 7z34:e, 6z6j:Le, 6z6k:Le, 7zpq:Bd, 7zrs:Bd, 7zs5:Bf, 7zuw:Bd, 7zux:Ed, 7zw0:Lh
14 8oeq:BZ 125 122 0.4252 0.4320 0.4426 8.00e-33 8c3a:AF, 8c3a:BZ, 8cq7:AF, 8cq7:BZ, 8cqw:AF, 8cqw:BZ, 8cre:AF, 8cre:BZ, 8oeq:AF, 7pzy:AF, 7q08:AF, 7q0f:AF, 7q0p:AF, 7q0r:AF, 8q5i:AF
15 7qiw:g 127 124 0.4803 0.4803 0.4919 2.39e-32 8azw:R, 8b2l:R3, 7qiz:g
16 5it7:ee 122 121 0.4646 0.4836 0.4876 1.46e-31 6uz7:Be
17 5xy3:e 123 116 0.4094 0.4228 0.4483 4.91e-30
18 4v8p:BX 125 125 0.4724 0.4800 0.4800 6.47e-30 4v8p:CX, 4v8p:EX, 4v8p:GX
19 7qep:O2 128 115 0.4331 0.4297 0.4783 7.35e-30
20 6rm3:LEE 123 110 0.4016 0.4146 0.4636 6.72e-29
21 9bh5:Ce 128 109 0.4016 0.3984 0.4679 7.01e-29 9cai:Ce
22 8p5d:LEE 135 115 0.3937 0.3704 0.4348 1.07e-27 8p60:LEE, 8p60:KEE, 7qca:LEE
23 6zj3:Lu 128 110 0.3937 0.3906 0.4545 7.15e-27
24 6zu5:LEE 121 112 0.3543 0.3719 0.4018 1.08e-22
25 8fl0:LQ 90 75 0.2913 0.4111 0.4933 3.84e-21
26 6skf:Bd 124 114 0.3543 0.3629 0.3947 2.18e-19 6skg:Bd, 6th6:Bd
27 4v4n:Ab 127 114 0.3386 0.3386 0.3772 3.32e-19 4v6u:Bb
28 8hku:L32E 123 108 0.2598 0.2683 0.3056 5.97e-17 8hkv:L32E, 8hky:L32E, 8hkz:L32E, 8hl1:L32E, 8hl2:L32E, 8hl3:L32E, 8hl4:L32E, 8hl5:L32E
29 4v9f:Y 144 108 0.3307 0.2917 0.3889 5.25e-15 3cc2:Y, 3cc4:Y, 3cc7:Y, 3cce:Y, 3ccj:Y, 3ccl:Y, 3ccm:Y, 3ccq:Y, 3ccr:Y, 3ccs:Y, 3ccu:Y, 3ccv:Y, 3cd6:Y, 3cma:Y, 3cme:Y, 3cpw:X, 3cxc:X, 1ffk:V, 3g4s:Y, 3g6e:Y, 3g71:Y, 3i55:Y, 3i56:Y, 1jj2:X, 1k73:Z, 1k8a:Z, 1k9m:Z, 1kc8:Z, 1kd1:Z, 1kqs:X, 1m1k:Z, 1m90:Z, 1n8r:Z, 1nji:Z, 2otj:Y, 2otl:Y, 3ow2:X, 1q7y:Z, 1q81:Z, 1q82:Z, 1q86:Z, 2qa4:Y, 2qex:Y, 1qvf:X, 1qvg:X, 1s72:Y, 1vq4:Y, 1vq5:Y, 1vq6:Y, 1vq7:Y, 1vq8:Y, 1vq9:Y, 1vqk:Y, 1vql:Y, 1vqm:Y, 1vqn:Y, 1vqo:Y, 1vqp:Y, 1w2b:X, 1yhq:Y, 1yi2:Y, 1yij:Y, 1yit:Y, 1yj9:Y, 1yjn:Y, 1yjw:Y
30 7oht:e 39 32 0.1024 0.3333 0.4062 0.066
31 3uz5:A 247 90 0.1811 0.0931 0.2556 1.3 3uz5:B, 3uzj:A, 3uzj:B
32 1j5u:A 127 24 0.0787 0.0787 0.4167 2.3
33 3s6t:A 575 31 0.0945 0.0209 0.3871 4.7 3nsn:A, 3ozo:A, 3ozp:A, 3vtr:A, 3wmb:A, 3wmc:A, 5y0v:A, 5y1b:A
34 7t02:A 1752 26 0.0866 0.0063 0.4231 8.5
35 7fgp:A 379 51 0.1260 0.0422 0.3137 9.5 7fgp:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218