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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
HMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNP

The query sequence (length=58) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8fl0:LQ 90 58 1.0000 0.6444 1.0000 5.21e-38
2 8fkp:LQ 133 58 1.0000 0.4361 1.0000 1.05e-37 7a01:v2, 8a3d:Y, 5aj0:Ae, 8b5l:e, 8b6c:e, 9bdl:AL32, 9bdn:AL32, 9bdp:AL32, 7bhp:Le, 8bhf:R1, 8bpo:d2, 8btk:Be, 7cpu:Le, 7cpv:Le, 4d5y:e, 4d67:e, 6d90:e, 6d9j:e, 9f1b:Be, 9f1c:Be, 9f1d:Be, 7f5s:Le, 8fkq:LQ, 8fkr:LQ, 8fks:LQ, 8fkt:LQ, 8fku:LQ, 8fkv:LQ, 8fkw:LQ, 8fkx:LQ, 8fky:LQ, 8fkz:LQ, 8fl2:LQ, 8fl3:LQ, 8fl4:LQ, 8fl6:LQ, 8fl7:LQ, 8fl9:LQ, 8fla:LQ, 8flb:LQ, 8flc:LQ, 8fld:LQ, 8fle:LQ, 8flf:LQ, 6frk:e, 6ftg:e, 6fti:e, 6ftj:e, 8g5y:Le, 8g5z:Le, 8g60:Le, 8g61:Le, 8g6j:Le, 8glp:Le, 6gz3:Ae, 6gz4:Ae, 6gz5:Ae, 6hcf:e3, 6hcj:e3, 6hcm:e3, 6hcq:e3, 8idt:k, 8idy:k, 8ie3:k, 8ifd:2Y, 8ife:2Y, 8ine:k, 8inf:k, 8ink:k, 6ip5:2Y, 6ip6:2Y, 6ip8:2Y, 8ipd:k, 8ipx:k, 8ipy:k, 8ir1:k, 8ir3:k, 3j7o:e, 3j7p:e, 3j7q:e, 3j7r:e, 3j92:e, 3jag:e, 3jah:e, 3jai:e, 3jaj:e, 3jan:e, 8jdj:j, 8jdk:j, 8jdl:j, 8jdm:j, 8k2c:Le, 5lks:Le, 6lqm:t, 6lsr:t, 6lss:k, 7ls1:Y2, 7ls2:Y2, 6lu8:k, 5lzs:e, 5lzt:e, 5lzu:e, 5lzv:e, 5lzw:e, 5lzx:e, 5lzy:e, 5lzz:e, 7mdz:e, 6mtb:e, 6mtc:e, 6mtd:e, 6mte:e, 7nfx:e, 7nwg:e3, 7nwh:e, 7nwi:e, 7o7y:Be, 7o7z:Be, 7o80:Be, 7o81:Be, 7obr:e, 8ohd:Le, 8oj0:Le, 8oj5:Le, 8oj8:Le, 6ole:f, 6olf:f, 6olg:Ae, 6oli:f, 6olz:Ae, 6om0:f, 6om7:f, 7ow7:Y, 7oya:e1, 7oyb:e1, 7oyc:e1, 7oyd:e, 8p2k:Be, 6p5i:Ae, 6p5j:Ae, 6p5k:Ae, 6p5n:Ae, 8q7z:Be, 8q87:Be, 8qfd:e, 7qgg:f, 8qoi:Le, 7qvp:Le, 7qvp:Me, 7qwq:e, 7qwr:e, 7qws:e, 6qzp:Le, 6r5q:e, 6r6g:e, 6r6p:e, 6r7q:e, 8rjb:e, 8rjc:e, 8rjd:e, 8scb:e, 6sgc:e2, 6swa:c, 5t2c:Y, 6t59:e3, 7tm3:e, 7toq:AL32, 7tor:AL32, 7tut:e, 7ucj:e, 7uck:e, 4ug0:Le, 4ujc:Be, 4ujd:Ae, 4uje:Ce, 4v5z:By, 4v5z:B9, 4v6x:Ce, 6w6l:f, 6xa1:Le, 7xnx:Le, 7xny:Le, 8xsx:Le, 8xsy:Le, 8xsz:Le, 6y0g:Le, 8y0w:Le, 8y0x:Le, 6y2l:Le, 6y57:Le, 6y6x:Le, 8yoo:Le, 8yop:Le, 6z6l:Le, 6z6m:Le, 6z6n:Le, 7zjw:Lh, 7zjx:Lh, 6zm7:Le, 6zme:Le, 6zmi:Le, 6zmo:Le, 6zvk:v2
3 4v6w:Ce 132 58 0.7586 0.3333 0.7586 6.77e-29 6xu6:Ce, 6xu7:Ce, 6xu8:Ce
4 7qiw:g 127 57 0.6552 0.2992 0.6667 2.52e-24 8azw:R, 8b2l:R3, 7qiz:g
5 4v3p:Lh 133 57 0.6897 0.3008 0.7018 5.04e-24 8ip8:TA, 8ipa:TA, 8ipb:TA, 8jiv:Ce, 4v7e:Ce
6 8i9p:Le 131 57 0.6207 0.2748 0.6316 4.22e-22 8i9r:Le, 8i9t:Le, 8i9v:Le, 8i9w:Le, 8i9x:Le, 8i9y:Le, 8i9z:Le, 8ia0:Le, 7olc:Le, 7old:Le, 8oo0:Le, 8pv1:Le, 8pv2:Le, 8pv3:Le, 8pv4:Le, 8pv5:Le, 8pv6:Le, 8pv7:Le, 8pv8:Le, 8pvk:Le, 8pvl:Le, 7z3n:Le, 7z3o:Le
7 4v8p:BX 125 57 0.5517 0.2560 0.5614 1.84e-21 4v8p:CX, 4v8p:EX, 4v8p:GX
8 7r81:g1 121 57 0.6207 0.2975 0.6316 2.49e-21
9 6zj3:Lu 128 57 0.5862 0.2656 0.5965 3.62e-19
10 9bh5:Ce 128 56 0.5690 0.2578 0.5893 4.04e-19 9cai:Ce
11 6rm3:LEE 123 57 0.5517 0.2602 0.5614 9.01e-19
12 4v6i:Bh 130 57 0.5862 0.2615 0.5965 1.67e-18 8aaf:R, 8agt:R, 8agu:R, 8agv:R, 8agw:R, 8agx:R, 8agz:R, 5apn:e, 5apo:e, 7azy:r, 7b7d:La, 8bip:Le, 8bjq:Le, 8bn3:O2, 8bqd:BG, 8bqx:BG, 7bt6:e, 7btb:e, 6c0f:e, 6cb1:e, 8ccs:Q, 8cdl:Q, 8cdr:Q, 8ceh:Q, 8cf5:Q, 8cg8:Q, 8cgn:Q, 8civ:Q, 8cku:Q, 8cmj:Q, 5dat:O2, 5dat:o2, 5dc3:O2, 5dc3:o2, 5dge:O2, 5dge:o2, 5dgf:O2, 5dgf:o2, 5dgv:O2, 5dgv:o2, 8e5t:e, 6elz:e, 6em1:e, 6em3:e, 6em4:e, 6em5:e, 8eub:Ae, 8evp:Ae, 8evq:Ae, 8evr:Ae, 8evs:Ae, 8evt:Ae, 8ewb:Ae, 8ewc:Ae, 5fci:O2, 5fci:o2, 5fcj:O2, 5fcj:o2, 6ft6:e, 5gak:g, 6gq1:e, 6gqb:e, 6gqv:e, 5h4p:e, 6hd7:g, 8hfr:eH, 6hhq:AF, 6hhq:DG, 5i4l:O2, 5i4l:o2, 6i7o:BG, 6i7o:YG, 3j6x:72, 3j6y:72, 3j77:82, 3j78:82, 3jct:e, 5jcs:e, 5juo:JA, 5jup:JA, 5jus:JA, 5jut:JA, 5juu:JA, 8k2d:Le, 8k82:Le, 5lyb:O2, 5lyb:o2, 5m1j:e5, 6m62:e, 5mc6:BG, 5mei:AF, 5mei:DG, 7mpi:Ae, 7mpj:Ae, 6n8j:e, 6n8k:e, 6n8l:e, 6n8m:r, 6n8n:r, 6n8o:r, 7n8b:Ae, 7nac:e, 5ndg:O2, 5ndg:o2, 5ndv:O2, 5ndv:o2, 5ndw:O2, 5ndw:o2, 7nrc:Lg, 7nrd:Lg, 5obm:O2, 5obm:o2, 7of1:e, 7oh3:e, 7ohp:e, 7ohq:e, 7ohr:e, 7ohs:e, 7ohu:e, 7ohv:e, 7ohw:e, 7ohx:e, 7ohy:e, 6oig:e, 5on6:AF, 5on6:DG, 7osa:eL32, 7osm:eL32, 8p8m:RE, 8p8n:RE, 8p8u:RE, 8pfr:RE, 6q8y:BG, 6qik:e, 6qt0:e, 6qtz:e, 7r7a:e, 6r84:g, 6r86:g, 6r87:g, 6ri5:e, 7rr5:Le, 6rzz:e, 6s05:e, 6s47:Ag, 6snt:al, 6sv4:BG, 6sv4:YG, 6sv4:ZG, 6t4q:Le, 5t62:r, 5t6r:r, 6t7i:Le, 6t7t:Le, 6t83:ey, 6t83:P, 5tbw:AF, 5tbw:DG, 6tb3:BG, 5tga:O2, 5tga:o2, 5tgm:O2, 5tgm:o2, 6tnu:BG, 7too:AL32, 7top:AL32, 7u0h:e, 4u3m:O2, 4u3m:o2, 4u3n:O2, 4u3n:o2, 4u3u:O2, 4u3u:o2, 4u4n:O2, 4u4n:o2, 4u4o:O2, 4u4o:o2, 4u4q:O2, 4u4q:o2, 4u4r:O2, 4u4r:o2, 4u4u:O2, 4u4u:o2, 4u4y:O2, 4u4y:o2, 4u4z:O2, 4u4z:o2, 4u50:O2, 4u50:o2, 4u51:O2, 4u51:o2, 4u52:O2, 4u52:o2, 4u53:O2, 4u53:o2, 4u55:O2, 4u55:o2, 4u56:O2, 4u56:o2, 4u6f:O2, 4u6f:o2, 7ug6:e, 7uoo:e, 7uqb:e, 7uqz:e, 7v08:e, 4v4b:B0, 4v7f:d, 4v7h:B0, 4v7r:Bb, 4v7r:Db, 4v88:Be, 4v88:De, 4v8t:e, 4v8y:Be, 4v8z:Be, 8v83:e, 8v84:e, 8v87:e, 4v91:e, 6woo:e, 6xiq:e, 6xir:e, 8y0u:Le, 6ylg:e, 6ylh:e, 6ylx:e, 6yly:e, 5z3g:i, 7z34:e, 6z6j:Le, 6z6k:Le, 7zpq:Bd, 7zrs:Bd, 7zs5:Bf, 7zuw:Bd, 7zux:Ed, 7zw0:Lh
13 5xxb:d 122 57 0.5690 0.2705 0.5789 6.31e-18
14 8oeq:BZ 125 55 0.5172 0.2400 0.5455 6.51e-16 8c3a:AF, 8c3a:BZ, 8cq7:AF, 8cq7:BZ, 8cqw:AF, 8cqw:BZ, 8cre:AF, 8cre:BZ, 8oeq:AF, 7pzy:AF, 7q08:AF, 7q0f:AF, 7q0p:AF, 7q0r:AF, 8q5i:AF
15 8eth:e 124 57 0.5172 0.2419 0.5263 1.36e-15 8esq:e, 8esr:e, 8etc:e, 8etg:e, 8eti:e, 8etj:e, 8eug:e, 8eui:e, 8eup:e, 8euy:e, 8ev3:e
16 3j79:8 125 56 0.5172 0.2400 0.5357 2.12e-15 3jbn:A8, 3jbo:A8, 3jbp:A8, 8tpu:A8, 5umd:8
17 8p5d:LEE 135 56 0.5172 0.2222 0.5357 7.49e-14 8p60:LEE, 8p60:KEE, 7qca:LEE
18 8ova:Bi 131 57 0.4655 0.2061 0.4737 8.46e-14 8ove:Bi, 5t5h:i, 4v8m:Bi
19 5t2a:g 129 57 0.4138 0.1860 0.4211 1.75e-13
20 6az3:f 130 57 0.4138 0.1846 0.4211 2.14e-13 8a3w:f, 8a98:f, 3jcs:f, 8ovj:f, 8rxh:Lf, 8rxx:Lf
21 5it7:ee 122 56 0.5517 0.2623 0.5714 2.17e-13 6uz7:Be
22 8brm:Lf 130 56 0.4655 0.2077 0.4821 3.64e-13 8br8:Lf, 8bsi:Lf, 8bsj:Lf, 8btd:Lf, 8btr:Lf, 8fru:e, 7pwg:e, 7pwo:e2
23 4v4n:Ab 127 55 0.5000 0.2283 0.5273 5.09e-12 4v6u:Bb
24 7qep:O2 128 53 0.4310 0.1953 0.4717 1.08e-11
25 6zu5:LEE 121 57 0.4138 0.1983 0.4211 7.18e-10
26 6skf:Bd 124 54 0.3966 0.1855 0.4259 3.39e-08 6skg:Bd, 6th6:Bd
27 5xy3:e 123 56 0.3448 0.1626 0.3571 5.13e-07
28 4v9f:Y 144 55 0.3793 0.1528 0.4000 2.00e-06 3cc2:Y, 3cc4:Y, 3cc7:Y, 3cce:Y, 3ccj:Y, 3ccl:Y, 3ccm:Y, 3ccq:Y, 3ccr:Y, 3ccs:Y, 3ccu:Y, 3ccv:Y, 3cd6:Y, 3cma:Y, 3cme:Y, 3cpw:X, 3cxc:X, 1ffk:V, 3g4s:Y, 3g6e:Y, 3g71:Y, 3i55:Y, 3i56:Y, 1jj2:X, 1k73:Z, 1k8a:Z, 1k9m:Z, 1kc8:Z, 1kd1:Z, 1kqs:X, 1m1k:Z, 1m90:Z, 1n8r:Z, 1nji:Z, 2otj:Y, 2otl:Y, 3ow2:X, 1q7y:Z, 1q81:Z, 1q82:Z, 1q86:Z, 2qa4:Y, 2qex:Y, 1qvf:X, 1qvg:X, 1s72:Y, 1vq4:Y, 1vq5:Y, 1vq6:Y, 1vq7:Y, 1vq8:Y, 1vq9:Y, 1vqk:Y, 1vql:Y, 1vqm:Y, 1vqn:Y, 1vqo:Y, 1vqp:Y, 1w2b:X, 1yhq:Y, 1yi2:Y, 1yij:Y, 1yit:Y, 1yj9:Y, 1yjn:Y, 1yjw:Y
29 7oht:e 39 28 0.2931 0.4359 0.6071 7.34e-06
30 8hku:L32E 123 54 0.2586 0.1220 0.2778 3.49e-04 8hkv:L32E, 8hky:L32E, 8hkz:L32E, 8hl1:L32E, 8hl2:L32E, 8hl3:L32E, 8hl4:L32E, 8hl5:L32E
31 4cej:A 1177 41 0.2414 0.0119 0.3415 3.8 4ceh:A, 4cei:A
32 3u44:A 1122 41 0.2414 0.0125 0.3415 4.0 3u4q:A
33 4d90:A 127 50 0.2414 0.1102 0.2800 5.8 4d90:B
34 8jal:B 573 44 0.2414 0.0244 0.3182 6.6 8jal:A, 8jaq:A, 8jaq:B, 8jaq:J, 8jaq:K, 8jar:A, 8jar:B, 8jas:A, 8jas:B, 8jas:K, 8jas:J, 8jau:A, 8jau:B, 8jav:A, 8jav:B, 8jav:J, 8jav:K
35 6hvg:A 1278 23 0.1552 0.0070 0.3913 6.7 6hvg:B, 6syq:A, 6syq:B, 6szi:A, 6szi:B, 6t16:B, 6t16:A, 6t18:A, 6t18:B, 6t1p:A, 6t1p:B
36 8eew:A 766 42 0.2414 0.0183 0.3333 7.6 8eew:B, 8eff:A, 8eff:B, 8eff:C, 8eff:D, 8efr:A, 8efr:B, 8efr:C, 8efr:K, 8efr:D, 8efr:L, 8efr:E, 8efr:M, 8efr:F, 8efr:N, 8efr:G, 8efr:O, 8efr:H, 8efr:P, 8efr:I, 8efr:Q, 8efr:J, 8efr:R, 6jtg:A
37 2ygk:A 319 16 0.1379 0.0251 0.5000 9.4 2ygk:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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