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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
HMAEYLRLPHSLAMIRLCNPPVNAVSPTVIREVRNGLQKAGSDHTVKAIVICGANGNFCAGADIHGFSAFTPGLALGSLV
DEIQRYQKPVLAAIQGVALGGGLELALGCHYRIANAKARVGLPEVTLGILPGARGTQLLPRVVGVPVALDLITSGKYLSA
DEALRLGILDAVVKSDPVEEAIKFAQKIIDKPIEPRRIFNKPVPSLPNMDSVFAEAIAKVRKQYPGVLAPETCVRSIQAS
VKHPYEVGIKEEEKLFMYLRASGQAKALQYAFFAEKSANKWSTPSGASWKTASAQPVSSVGVLGLGTMGRGIAISFARVG
ISVVAVESDPKQLDAAKKIITFTLEKEASRAHQNGQASAKPKLRFSSSTKELSTVDLVVEAVFEDMNLKKKVFAELSALC
KPGAFLCTNTSALNVDDIASSTDRPQLVIGTHFFSPAHVMRLLEVIPSRYSSPTTIATVMSLSKKIGKIGVVVGNCYGFV
GNRMLAPYYNQGFFLLEEGSKPEDVDGVLEEFGFKMGPFRVSDLAGLDVGWKIRKGQGLTGPSLPPGTPVRKRGNSRYSP
LGDMLCEAGRFGQKTGKGWYQYDKPLGRIHKPDPWLSTFLSQYREVHHIEQRTISKEEILERCLYSLINEAFRILEEGMA
ARPEHIDVIYLHGYGWPRHKGGPMFYAASVGLPTVLEKLQKYYRQNPDIPQLEPSDYLRRLVAQGSPPLKEWQSLAGP

The query sequence (length=718) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 3zwa:A 727 718 1.0000 0.9876 1.0000 0.0 5mgb:A, 5mgb:B, 5omo:A, 5omo:B, 2x58:A, 2x58:B, 6z5f:AAA, 6z5f:BBB, 6z5o:AAA, 6z5v:AAA, 6z5v:BBB, 6zib:AAA, 6zib:BBB, 6zic:AAA, 6zic:BBB, 3zw9:A, 3zw9:B, 3zwa:B, 3zwb:A, 3zwb:B, 3zwc:A, 3zwc:B
2 6iun:B 692 693 0.4011 0.4162 0.4156 1.75e-169 6iun:A
3 6ysw:A 707 720 0.3357 0.3409 0.3347 2.30e-89
4 6tnm:A 719 700 0.2994 0.2990 0.3071 8.32e-83
5 1wdl:A 715 690 0.2953 0.2965 0.3072 2.45e-78 2d3t:A, 2d3t:B, 1wdk:A, 1wdk:B, 1wdl:B, 1wdm:A, 1wdm:B
6 3k6j:A 430 420 0.1978 0.3302 0.3381 1.73e-75
7 8oqs:B 735 656 0.2604 0.2544 0.2851 3.98e-59 4b3i:A, 4b3i:B, 4b3j:A, 4b3j:B, 7o4s:A, 7o4s:B, 7o4t:A, 7o4t:B, 7o4u:A, 7o4u:B, 7o4v:B, 7o4v:A, 8opu:A, 8opu:B, 8opv:A, 8opv:B, 8oql:A, 8oql:B, 8oqn:A, 8oqn:B, 8oqo:A, 8oqo:B, 8oqp:A, 8oqp:B, 8oqq:A, 8oqq:B, 8oqr:A, 8oqr:B, 8oqs:A, 8oqt:B, 8oqt:A, 8oqu:A, 8oqu:B, 8oqv:A, 8oqv:B, 8pf8:A, 8pf8:B
8 4kug:A 282 292 0.1588 0.4043 0.3904 1.07e-49 4kug:B, 4kug:C, 4kug:D, 4kuh:A, 4kuh:B, 4kuh:C, 4kuh:D, 4kuh:E, 4kuh:F, 4kuh:G, 4kuh:H
9 4kug:A 282 87 0.0390 0.0993 0.3218 0.007 4kug:B, 4kug:C, 4kug:D, 4kuh:A, 4kuh:B, 4kuh:C, 4kuh:D, 4kuh:E, 4kuh:F, 4kuh:G, 4kuh:H
10 6aa8:E 281 293 0.1532 0.3915 0.3754 4.66e-44 6aa8:F
11 6aa8:E 281 87 0.0376 0.0961 0.3103 0.13 6aa8:F
12 4pzd:A 283 294 0.1323 0.3357 0.3231 4.39e-42 4pzd:B, 4pzd:C, 4pzd:D, 4pzd:E, 4pzd:F, 4pzd:G, 4pzd:H, 4pzd:I, 4pze:A, 4pze:B, 4pze:C, 4pze:D, 4pze:G, 4pze:E, 4pze:F, 4pze:H, 4pze:I
13 4pzd:A 283 87 0.0446 0.1131 0.3678 1.67e-06 4pzd:B, 4pzd:C, 4pzd:D, 4pzd:E, 4pzd:F, 4pzd:G, 4pzd:H, 4pzd:I, 4pze:A, 4pze:B, 4pze:C, 4pze:D, 4pze:G, 4pze:E, 4pze:F, 4pze:H, 4pze:I
14 1f12:A 293 296 0.1379 0.3379 0.3345 1.61e-37 1f0y:A, 1f0y:B, 1f17:A, 1f17:B, 3had:A, 3had:B, 2hdh:A, 2hdh:B, 3hdh:A, 3hdh:B, 3hdh:C, 1il0:A, 1il0:B, 1lsj:A, 1lsj:B, 1lso:A, 1lso:B, 1m75:A, 1m75:B, 1m76:A, 1m76:B
15 1f12:A 293 87 0.0390 0.0956 0.3218 0.004 1f0y:A, 1f0y:B, 1f17:A, 1f17:B, 3had:A, 3had:B, 2hdh:A, 2hdh:B, 3hdh:A, 3hdh:B, 3hdh:C, 1il0:A, 1il0:B, 1lsj:A, 1lsj:B, 1lso:A, 1lso:B, 1m75:A, 1m75:B, 1m76:A, 1m76:B
16 5zai:C 259 189 0.1058 0.2934 0.4021 3.43e-33 5zai:A, 5zai:B, 5zai:E
17 1dub:A 260 187 0.1045 0.2885 0.4011 4.89e-29 1dub:B, 1dub:C, 1dub:E, 1dub:F, 1dub:D, 2dub:A, 2dub:B, 2dub:C, 2dub:E, 2dub:F, 2dub:D, 1ey3:A, 1ey3:B, 1ey3:C, 1ey3:D, 1ey3:E, 1ey3:F, 1mj3:A, 1mj3:B, 1mj3:C, 1mj3:E, 1mj3:F
18 4om8:A 309 293 0.1128 0.2621 0.2765 8.15e-28 4om8:B
19 4om8:A 309 52 0.0251 0.0583 0.3462 2.6 4om8:B
20 6eqo:A 1804 194 0.1017 0.0405 0.3763 1.09e-26 6eqo:B
21 2hw5:C 260 193 0.0947 0.2615 0.3523 7.70e-26
22 3h81:A 256 224 0.1031 0.2891 0.3304 8.10e-25 3h81:C, 3q0g:C, 3q0g:D, 3q0g:F, 3q0j:C, 3q0j:F
23 4dyd:A 283 293 0.1156 0.2933 0.2833 7.12e-24 4e13:A
24 5jbx:B 261 155 0.0877 0.2414 0.4065 1.61e-22 5jbx:A
25 3p85:A 224 154 0.0766 0.2455 0.3571 2.80e-18
26 6slb:AAA 257 187 0.0794 0.2218 0.3048 1.30e-17 6sla:AAA, 6sla:BBB, 6sla:CCC, 6sla:DDD, 6sla:EEE, 6sla:FFF
27 1jxz:B 269 240 0.0961 0.2565 0.2875 8.38e-16 1jxz:A, 1jxz:C, 1nzy:A, 1nzy:B, 1nzy:C
28 3f3s:A 312 235 0.0905 0.2083 0.2766 1.38e-15 3f3s:B
29 3pe8:A 219 161 0.0766 0.2511 0.3416 3.76e-15
30 3adp:A 310 236 0.0947 0.2194 0.2881 1.65e-14
31 2uzf:A 260 183 0.0766 0.2115 0.3005 1.88e-14
32 4izc:B 266 185 0.0669 0.1805 0.2595 9.95e-14 4izc:A, 4izd:A, 4izd:B
33 7bor:A 247 143 0.0599 0.1741 0.3007 1.36e-13 7bor:C
34 4i4z:A 275 183 0.0780 0.2036 0.3060 1.91e-13 4eml:A, 4eml:B, 4eml:C, 4eml:D, 4eml:E, 4eml:F, 4i4z:F, 4i4z:B, 4i4z:D, 4i4z:C, 4i4z:E, 4i4z:G, 4i4z:H, 4i4z:I, 4i52:A, 4i52:B, 4i52:C, 4i52:D, 4i52:E, 4i52:F, 4i52:G, 4i52:H, 4i52:I
35 3bpt:A 362 179 0.0766 0.1519 0.3073 3.73e-13
36 7xwt:B 277 180 0.0669 0.1733 0.2667 1.68e-12 7xwv:A, 7xwv:B
37 5duf:A 245 152 0.0682 0.2000 0.3224 1.74e-12 5dtw:A, 5dtw:D, 5du4:A, 5du6:A, 5du6:B, 5du6:C, 5du8:A, 5du8:B, 5du8:C, 5duc:A, 5duc:B, 5duc:C
38 1xx4:A 254 176 0.0696 0.1969 0.2841 3.63e-12
39 6p5u:E 246 180 0.0669 0.1951 0.2667 4.33e-12 6p5u:A, 6p5u:B, 6p5u:C, 6p5u:D, 6p5u:F
40 2vss:B 247 201 0.0752 0.2186 0.2687 4.87e-12 6l3p:A, 6l3p:B, 2vss:D, 2vss:E, 2vss:F, 2vsu:A, 2vsu:B, 2vsu:D, 2vsu:E, 2vsu:F
41 4jvt:A 257 155 0.0696 0.1946 0.3226 6.02e-12 4omr:A
42 4i42:A 285 196 0.0724 0.1825 0.2653 1.10e-11 4els:A, 4els:B, 4els:C, 4els:D, 4els:E, 4els:F, 4elw:A, 4elw:B, 4elw:C, 4elw:D, 4elw:E, 4elw:F, 4elx:A, 4elx:B, 4elx:C, 4elx:D, 4elx:F, 3h02:A, 3h02:B, 3h02:C, 3h02:D, 3h02:E, 3h02:F, 4i42:F, 4i42:B, 4i42:D, 4i42:C, 4i42:E, 4i42:G, 4i42:L, 4i42:H, 4i42:J, 4i42:I, 4i42:K, 3t88:A, 3t88:E, 3t88:B, 3t88:F, 3t88:C, 3t88:D
43 1sg4:B 258 177 0.0738 0.2054 0.2994 2.16e-11
44 1ef9:A 261 178 0.0641 0.1762 0.2584 1.72e-10 6n92:A, 6n92:B, 6n92:C, 6n92:D, 6n92:E, 6n92:F, 6n93:A, 6n93:B, 6n93:C, 6n93:D, 6n93:E, 6n93:F, 6n94:A, 6n94:B, 6n94:C, 6n94:D, 6n94:E, 6n94:F, 6n95:A, 6n95:B, 6n95:C, 6n95:D, 6n95:E, 6n95:F, 6n96:A, 6n96:B, 6n96:C, 6n96:D, 6n96:E, 6n96:F, 6n97:A, 6n97:B, 6n97:C, 6n97:D, 6n97:E, 6n97:F
45 2a81:A 235 197 0.0766 0.2340 0.2792 2.03e-10
46 3ome:C 247 190 0.0738 0.2146 0.2789 2.23e-09 3ome:A, 3ome:B, 3ome:D, 3ome:E, 3ome:F
47 3rrv:B 254 209 0.0850 0.2402 0.2919 1.98e-08 3rrv:A, 3rrv:C, 3rrv:D, 3rrv:E, 3rrv:F
48 3t3w:F 248 196 0.0752 0.2177 0.2755 4.15e-08 3t3w:A, 3t3w:B, 3t3w:C, 3t3w:D, 3t3w:E
49 5kag:D 423 118 0.0543 0.0922 0.3305 3.88e-07 5kag:A, 5kag:B, 5kag:C, 5kag:E, 5kag:F, 5kag:G, 5kag:H, 5kag:I, 5kag:J, 5kag:K, 5kag:L, 5kah:A, 5kah:B, 5kah:C, 5kah:D, 5kah:E, 5kah:F, 5kah:G, 5kah:H, 5kah:I, 5kah:J, 5kah:K, 5kah:L, 5kaj:A, 5kaj:B, 5kaj:C, 5kaj:D, 5kaj:E, 5kaj:F, 5kaj:G, 5kaj:H, 5kaj:I, 5kaj:J, 5kaj:K, 5kaj:L, 2np9:A, 2np9:B, 2np9:C, 2pg8:A, 2pg8:B, 2pg8:C, 4ylh:A, 4ylh:B, 4ylh:C, 4ylh:D, 4ylh:E, 4ylh:F, 4ylh:G, 4ylh:H, 4ylh:I, 4ylh:J, 4ylh:K, 4ylh:L
50 4hdt:A 340 180 0.0641 0.1353 0.2556 1.84e-05
51 6j0p:A 564 160 0.0585 0.0745 0.2625 3.62e-05 6j0p:B, 6j1e:A, 6j1f:A, 6j1f:B, 6j1g:A, 6j1i:A, 6j1j:A
52 8co4:C 379 57 0.0306 0.0580 0.3860 0.001 8co4:A, 8co4:B, 8co4:D, 4gl4:A, 4gl4:B, 4jji:A, 4jji:B, 4l0q:A, 4l0q:B, 3uko:A, 3uko:B
53 1szo:D 251 184 0.0599 0.1713 0.2337 0.001 1szo:A, 1szo:B, 1szo:C, 1szo:E, 1szo:F, 1szo:G, 1szo:H, 1szo:I, 1szo:J, 1szo:K, 1szo:L
54 4dl9:A 379 57 0.0320 0.0607 0.4035 0.002 4dl9:B, 4dla:A, 4dla:B, 4dlb:A, 4dlb:B
55 6z1p:BI 1413 142 0.0446 0.0226 0.2254 0.007
56 7aau:C 378 59 0.0306 0.0582 0.3729 0.095 7aas:A, 7aas:B, 7aas:C, 7aas:D, 7aas:E, 7aas:F, 7aau:A, 7aau:B, 7aau:D, 7aau:E, 7aau:F, 7av7:A, 7av7:B, 7av7:C, 7av7:D, 7av7:E, 7av7:F
57 4fnb:A 232 126 0.0487 0.1509 0.2778 0.29 4fn8:A, 4fnd:A
58 6ynx:t 365 49 0.0223 0.0438 0.3265 0.41
59 1cdo:A 374 57 0.0265 0.0508 0.3333 0.78 1cdo:B
60 7cyi:D 378 57 0.0279 0.0529 0.3509 1.1 7cyi:A, 7cyi:B, 7cyi:C, 6ljh:A
61 2dwc:B 409 37 0.0209 0.0367 0.4054 1.1 2dwc:A
62 7r39:A 412 80 0.0362 0.0631 0.3250 1.2 7r39:B, 7r39:C, 7r39:D, 7r39:E, 7r39:F, 7r39:G, 7r39:H
63 5vj1:D 276 48 0.0306 0.0797 0.4583 1.4 5vj1:L
64 5mh5:A 308 72 0.0279 0.0649 0.2778 1.6 5mh5:B, 5mh6:A, 5mh6:B, 5mh6:C, 5mh6:D, 5mha:A, 5mha:B
65 3meq:A 341 51 0.0237 0.0499 0.3333 1.7 3meq:B, 3meq:C, 3meq:D
66 1llu:A 341 51 0.0237 0.0499 0.3333 1.9 1llu:B, 1llu:C, 1llu:D, 1llu:E, 1llu:F, 1llu:G, 1llu:H
67 2j5s:A 250 175 0.0515 0.1480 0.2114 2.0 2j5s:B
68 6yb5:A 243 80 0.0306 0.0905 0.2750 2.2 6yar:A, 6yar:B, 6yay:A, 6yay:B, 6yb3:A, 6yb3:B, 6yb5:B, 6ybb:A, 6ybb:B, 6ybu:A, 6ybu:B, 6ybu:G, 6ybu:H
69 8qno:A 421 80 0.0362 0.0618 0.3250 2.2 8qno:B, 7r37:A, 7r37:B, 7r38:A, 7r38:B
70 1rjw:A 339 53 0.0237 0.0501 0.3208 2.4 3pii:A, 3pii:C, 3pii:B, 3pii:D, 1rjw:B, 1rjw:C, 1rjw:D
71 1b1x:A 689 58 0.0292 0.0305 0.3621 2.8 1b7z:A, 3cr9:A, 1f9b:A, 1qjm:A
72 8con:A 379 59 0.0279 0.0528 0.3390 3.5 4rqt:A, 4rqu:A, 4rqu:B
73 5jc8:D 262 45 0.0237 0.0649 0.3778 4.0
74 4e5p:A 332 132 0.0460 0.0994 0.2500 6.2 4e5k:A, 4e5k:B, 4e5k:C, 4e5k:D, 4e5m:A, 4e5m:B, 4e5n:A, 4e5n:B, 4e5n:C, 4e5n:D, 4e5n:E, 4e5n:F, 4e5n:G, 4e5n:H, 4e5p:B, 4e5p:C, 4e5p:D, 4e5p:E, 4e5p:F, 4ebf:A, 4ebf:B, 4ebf:C, 4ebf:D, 4nu5:A, 4nu5:B, 4nu6:A, 4nu6:B
75 8c79:A 478 86 0.0320 0.0481 0.2674 6.4 8c79:B
76 6h25:J 868 162 0.0571 0.0472 0.2531 6.5 6d6q:K, 6d6r:K
77 6vpb:B 324 30 0.0181 0.0401 0.4333 7.2
78 7a3w:B 293 120 0.0432 0.1058 0.2583 8.9 7a3w:A
79 3ojl:A 418 37 0.0181 0.0311 0.3514 9.7 3ojl:B, 3ojo:A, 3ojo:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218