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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
HKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNKRRHWRRTKLGL

The query sequence (length=47) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 7a01:D2 50 48 1.0000 0.9400 0.9792 1.12e-26 8a3d:f, 5aj0:Al, 8b5l:l, 8b6c:l, 9bdl:AL39, 9bdn:AL39, 9bdp:AL39, 8bf9:l, 7bhp:Ll, 8bhf:Y1, 8bpo:k2, 8btk:Bl, 7cpu:Ll, 7cpv:Ll, 4d5y:l, 4d67:l, 6d90:l, 6d9j:l, 9f1b:Bl, 9f1c:Bl, 9f1d:Bl, 7f5s:Ll, 8fkz:LZ, 8fl2:LZ, 8fl3:LZ, 8fl4:LZ, 8fl6:LZ, 8fl7:LZ, 8fl9:LZ, 8fla:LZ, 8flb:LZ, 8flc:LZ, 8fld:LZ, 8fle:LZ, 8flf:LZ, 6frk:l, 6ftg:l, 6fti:l, 6ftj:l, 8g5y:Ll, 8g5z:Ll, 8g60:Ll, 8g61:Ll, 8g6j:Ll, 8glp:Ll, 6gz3:Al, 6gz4:Al, 6gz5:Al, 6hcf:l3, 6hcj:l3, 6hcm:l3, 6hcq:l3, 8idt:P, 8idy:P, 8ie3:P, 8ifd:2f, 8ife:2f, 8ine:P, 8inf:P, 8ink:P, 6ip5:2f, 6ip6:2f, 6ip8:2f, 8ipd:P, 8ipx:P, 8ipy:P, 8ir1:P, 8ir3:P, 3j7o:l, 3j7p:l, 3j7q:l, 3j7r:l, 3j92:l, 3jag:l, 3jah:l, 3jai:l, 3jaj:l, 3jan:l, 8jdj:q, 8jdk:q, 8jdl:q, 8jdm:q, 8k2c:Ll, 5lks:Ll, 6lqm:P, 6lsr:P, 6lss:P, 7ls1:f2, 7ls2:f2, 6lu8:P, 5lzs:l, 5lzt:l, 5lzu:l, 5lzv:l, 5lzw:l, 5lzx:l, 5lzy:l, 5lzz:l, 7mdz:l, 6mtb:l, 6mtc:l, 6mtd:l, 6mte:l, 7nfx:l, 7nwg:l3, 7nwh:l, 7nwi:l, 7o7y:Bl, 7o7z:Bl, 7o80:Bl, 7o81:Bl, 7obr:l, 8ohd:Ll, 8oj0:Ll, 8oj5:Ll, 8oj8:Ll, 6ole:m, 6olf:m, 6olg:Al, 6oli:m, 6olz:Al, 6om0:m, 6om7:m, 7ow7:f, 7oya:l1, 7oyb:l1, 7oyc:l1, 7oyd:l, 8p2k:Bl, 6p5i:Al, 6p5j:Al, 6p5k:Al, 6p5n:Al, 8p8n:2, 8pfr:RN, 8q7z:Bl, 8q87:Bl, 8qfd:l, 7qgg:m, 8qoi:Ll, 7qvp:Ml, 7qvp:Ll, 7qwq:l, 7qwr:l, 7qws:l, 6qzp:Ll, 6r5q:l, 6r6g:l, 6r6p:l, 6r7q:l, 8rjb:l, 8rjc:l, 8rjd:l, 8scb:l, 6sgc:l2, 6swa:j, 5t2c:f, 6t59:l3, 7tm3:l, 7toq:AL39, 7tor:AL39, 7tut:l, 7ucj:l, 7uck:l, 4ug0:Ll, 4ujc:Bl, 4ujd:Al, 4uje:Cl, 4v5z:B3, 4v6x:Cl, 6w6l:m, 6xa1:Ll, 7xnx:Ll, 7xny:Ll, 8xsx:Ll, 8xsy:Ll, 8xsz:Ll, 6y0g:Ll, 8y0w:Ll, 8y0x:Ll, 6y2l:Ll, 6y57:Ll, 6y6x:Ll, 8yoo:Ll, 8yop:Ll, 6z6l:Ll, 6z6m:Ll, 6z6n:Ll, 7zjw:Lo, 7zjx:Lo, 6zm7:Ll, 6zme:Ll, 6zmi:Ll, 6zmo:Ll, 6zvk:D2
2 7olc:Ll 50 48 0.8298 0.7800 0.8125 2.23e-21 8i9x:Ll, 8i9y:Ll, 8i9z:Ll, 8ia0:Ll, 7old:Ll, 8oo0:Ll, 8pv1:Ll, 8pv2:Ll, 8pv3:Ll, 8pv4:Ll, 8pv5:Ll, 8pv6:Ll, 8pv7:Ll, 8pv8:Ll, 8pvk:Ll, 8pvl:Ll, 7r81:n1, 7z3n:Ll, 7z3o:Ll
3 4v3p:Lo 51 48 0.8298 0.7647 0.8125 1.96e-20 8azw:X, 8b2l:X3, 8ip8:VA, 8ipa:VA, 8ipb:VA, 8jiv:Cl, 7qiw:n, 7qiz:n, 4v7e:Cl
4 8c3a:AM 50 48 0.7660 0.7200 0.7500 2.99e-19 8c3a:CG, 8cq7:AM, 8cq7:CG, 8cqw:AM, 8cqw:CG, 8cre:AM, 8cre:CG, 8oeq:AM, 8oeq:CG, 7pzy:AM, 7q08:AM, 7q0f:AM, 7q0p:AM, 7q0r:AM, 8q5i:AM
5 9bh5:Cl 50 47 0.7872 0.7400 0.7872 3.74e-18 9cai:Cl
6 5xxb:k 49 47 0.7234 0.6939 0.7234 8.91e-18
7 8eug:8 50 48 0.7021 0.6600 0.6875 9.52e-18 8esq:8, 8etc:8, 8eui:8
8 4v6w:Cl 50 48 0.7660 0.7200 0.7500 3.05e-14 6xu6:Cl, 6xu7:Cl, 6xu8:Cl
9 8a3w:l 50 46 0.5745 0.5400 0.5870 1.92e-12 8a98:l, 6az3:l, 3jcs:l, 8ovj:l, 8rxh:Ll, 8rxx:Ll, 5t2a:o
10 4v6i:Bo 51 48 0.6596 0.6078 0.6458 5.44e-12 8aaf:Y, 8agt:Y, 8agu:Y, 8agv:Y, 8agw:Y, 8agx:Y, 8agz:Y, 5apn:l, 5apo:l, 7azy:M, 7b7d:Lh, 8bip:Ll, 8bjq:Ll, 8bn3:O9, 8bqd:AL, 8bqx:AL, 8ccs:X, 8cdl:X, 8cdr:X, 8ceh:X, 8cf5:X, 8cg8:X, 8cgn:X, 8civ:X, 8cku:X, 8cmj:X, 5dat:O9, 5dat:o9, 5dc3:O9, 5dc3:o9, 5dge:O9, 5dge:o9, 5dgf:O9, 5dgf:o9, 5dgv:O9, 5dgv:o9, 8eub:Al, 8evp:Al, 8evq:Al, 8evr:Al, 8evs:Al, 8evt:Al, 8ewb:Al, 8ewc:Al, 5fci:O9, 5fci:o9, 5fcj:O9, 5fcj:o9, 6ft6:l, 5gak:n, 6gq1:l, 6gqb:l, 6gqv:l, 5h4p:l, 6hd7:n, 8hfr:li, 6hhq:AM, 6hhq:DN, 5i4l:O9, 5i4l:o9, 6i7o:AL, 6i7o:XL, 5it7:ll, 3j6x:79, 3j6y:79, 3j77:89, 3j78:89, 3jct:l, 5jcs:l, 5juo:QA, 5jup:QA, 5jus:QA, 5jut:QA, 5juu:QA, 8k2d:Ll, 8k82:Ll, 5lyb:O9, 5lyb:o9, 5m1j:l5, 6m62:l, 5mc6:AL, 5mei:AM, 5mei:DN, 7mpi:Al, 7mpj:Al, 6n8j:l, 6n8k:l, 6n8l:l, 6n8m:y, 6n8n:y, 6n8o:y, 7n8b:Al, 5ndg:O9, 5ndg:o9, 5ndv:O9, 5ndv:o9, 5ndw:O9, 5ndw:o9, 7nrc:Ln, 7nrd:Ln, 5obm:O9, 5obm:o9, 7of1:l, 7oh3:l, 7ohq:l, 6oig:l, 5on6:AM, 5on6:DN, 7osa:eL39, 7osm:eL39, 8p8u:2, 6q8y:AL, 6qik:k, 6qt0:k, 6qtz:k, 6r84:n, 6r86:n, 6r87:n, 6ri5:k, 7rr5:Ll, 6rzz:k, 6s05:k, 6s47:An, 6snt:ae, 6sv4:AL, 6sv4:XL, 6sv4:zL, 6t4q:Ll, 5t62:y, 5t6r:y, 6t7i:Ll, 6t7t:Ll, 6t83:lb, 6t83:W, 5tbw:AM, 5tbw:DN, 6tb3:AL, 5tga:O9, 5tga:o9, 5tgm:O9, 5tgm:o9, 6tnu:AL, 7too:AL39, 7top:AL39, 4u3m:O9, 4u3m:o9, 4u3n:O9, 4u3n:o9, 4u3u:O9, 4u3u:o9, 4u4n:O9, 4u4n:o9, 4u4o:O9, 4u4o:o9, 4u4q:O9, 4u4q:o9, 4u4r:O9, 4u4r:o9, 4u4u:O9, 4u4u:o9, 4u4y:O9, 4u4y:o9, 4u4z:O9, 4u4z:o9, 4u50:O9, 4u50:o9, 4u51:O9, 4u51:o9, 4u52:O9, 4u52:o9, 4u53:O9, 4u53:o9, 4u55:O9, 4u55:o9, 4u56:O9, 4u56:o9, 4u6f:O9, 4u6f:o9, 7ug6:l, 7uoo:l, 7uqb:l, 7uqz:l, 6uz7:Bl, 7v08:l, 4v7h:B1, 4v7r:Be, 4v7r:De, 4v88:Bl, 4v88:Dl, 4v8t:l, 4v8y:Bl, 4v8z:Bl, 4v91:l, 6woo:l, 2ww9:O, 2wwa:O, 2wwb:O, 6xiq:l, 6xir:l, 8y0u:Ll, 6ylg:l, 6ylh:l, 6ylx:l, 6yly:l, 7z34:l, 6z6j:Ll, 6z6k:Ll, 7zpq:Bk, 7zrs:Bk, 7zs5:Bm, 7zuw:Bk, 7zux:Ek, 7zw0:Lo
11 6zj3:L1 50 47 0.6383 0.6000 0.6383 6.49e-12
12 4v8p:AB 51 48 0.5532 0.5098 0.5417 2.25e-10 4v8p:DB, 4v8p:FB, 4v8p:HB
13 8ova:Bq 50 31 0.4894 0.4600 0.7419 3.16e-10 8ove:Bq, 5t5h:q, 4v8m:Bq
14 3j79:e 43 46 0.5532 0.6047 0.5652 6.24e-10 3jbn:Ae, 3jbo:Ae, 3jbp:Ae, 8tpu:Ae, 5umd:e
15 5xy3:l 50 48 0.5532 0.5200 0.5417 1.73e-09
16 6skf:Bi 50 46 0.5532 0.5200 0.5652 1.99e-07 6skg:Bi, 6th6:Bi
17 8hku:L39E 49 46 0.4681 0.4490 0.4783 1.60e-06 8hkv:L39E, 8hky:L39E, 8hkz:L39E, 8hl1:L39E, 8hl2:L39E, 8hl3:L39E, 8hl4:L39E, 8hl5:L39E
18 6zu5:LLL 51 47 0.5319 0.4902 0.5319 2.37e-06
19 4v4n:Af 51 37 0.4255 0.3922 0.5405 1.90e-05 4v6u:Bf
20 4v9f:2 49 42 0.4043 0.3878 0.4524 4.89e-05 3cc2:2, 3cc4:2, 3cc7:2, 3cce:2, 3ccj:2, 3ccl:2, 3ccm:2, 3ccq:2, 3ccr:2, 3ccs:2, 3ccu:2, 3ccv:2, 3cd6:2, 3cma:2, 3cme:2, 3cpw:1, 3cxc:1, 3g4s:2, 3g6e:2, 3g71:2, 3i55:2, 3i56:2, 1jj2:1, 1k73:3, 1k8a:3, 1k9m:3, 1kc8:3, 1kd1:3, 1kqs:1, 1m1k:3, 1m90:3, 1n8r:3, 1nji:3, 2otj:2, 2otl:2, 3ow2:1, 1q7y:3, 1q81:3, 1q82:3, 1q86:3, 2qa4:2, 2qex:2, 1qvf:1, 1qvg:1, 1s72:2, 1vq4:2, 1vq5:2, 1vq6:2, 1vq7:2, 1vq8:2, 1vq9:2, 1vqk:2, 1vql:2, 1vqm:2, 1vqn:2, 1vqo:2, 1vqp:2, 1w2b:1, 1yhq:2, 1yi2:2, 1yij:2, 1yit:2, 1yj9:2, 1yjn:2, 1yjw:2
21 7qep:O9 50 45 0.4681 0.4400 0.4889 9.74e-05
22 8br8:LG 50 47 0.4894 0.4600 0.4894 2.10e-04 8brm:LG, 8bsi:LG, 8bsj:LG, 8btd:LG, 8btr:LG, 7pwg:l, 7pwo:l2
23 8fru:l 50 47 0.4681 0.4400 0.4681 2.94e-04
24 8p5d:LLL 51 45 0.4681 0.4314 0.4889 6.39e-04 8p60:LLL, 8p60:KLL, 7qca:LLL
25 6rm3:LLL 51 47 0.4468 0.4118 0.4468 0.006
26 4doz:A 557 32 0.2766 0.0233 0.4062 0.21 3ung:C, 3ur3:C
27 3x1l:A 573 32 0.2766 0.0227 0.4062 0.23
28 3w2w:A 618 32 0.2766 0.0210 0.4062 0.24 4h4k:C, 3w2v:A
29 8c20:D 355 27 0.1915 0.0254 0.3333 0.24 8c20:B
30 4w8y:A 835 32 0.2766 0.0156 0.4062 0.30 4w8y:B
31 5nlt:B 227 37 0.2553 0.0529 0.3243 0.65 5nlt:A, 5nlt:C, 5nlt:D, 5nlt:E, 5nlt:F, 6ydc:A, 6ydc:B, 6ydc:C, 6ydc:D, 6ydd:A, 6ydd:B, 6yde:A, 6ydf:A, 6ydf:B
32 8frw:A 395 25 0.1915 0.0228 0.3600 1.6 8aw2:A, 8aw2:E, 8aw2:B, 8aw2:C, 8aw2:D, 8c21:B, 8c21:C, 8cc6:A, 8cc6:B, 8cc6:C, 8cc6:D, 8cc6:E, 8cc7:A, 8cc7:B, 8cc7:C, 8cc7:D, 8cc7:E, 6dg7:A, 6dg7:B, 6dg7:C, 6dg7:D, 6dg7:E, 6dg8:A, 6dg8:E, 6dg8:B, 6dg8:C, 6dg8:D, 8frw:E, 8frw:B, 8frw:C, 8frw:D, 8frx:A, 8frx:E, 8frx:B, 8frx:C, 8frx:D, 8frz:A, 8frz:B, 8frz:C, 8frz:D, 8frz:E, 8fsb:E, 8fsb:A, 8fsb:B, 8fsb:C, 8fsb:D, 8fsp:A, 8fsp:B, 8fsp:C, 8fsp:D, 8fsp:E, 8fsz:A, 8fsz:E, 8fsz:B, 8fsz:C, 8fsz:D, 6hin:A, 6hin:B, 6hin:C, 6hin:D, 6hin:E, 6hio:A, 6hio:B, 6hio:E, 6hio:C, 6hio:D, 6hiq:A, 6hiq:E, 6hiq:B, 6hiq:C, 6hiq:D, 6his:A, 6his:E, 6his:B, 6his:C, 6his:D, 6np0:A, 6np0:E, 6np0:B, 6np0:C, 6np0:D, 6w1j:A, 6w1j:E, 6w1j:B, 6w1j:C, 6w1j:D, 6w1m:A, 6w1m:E, 6w1m:B, 6w1m:C, 6w1m:D, 6w1y:A, 6w1y:E, 6w1y:B, 6w1y:C, 6w1y:D, 6y1z:A, 6y1z:B, 6y1z:D, 6y1z:E, 6y1z:C, 6y5a:A, 6y5a:E, 6y5a:C, 6y5a:B, 6y5a:D
33 4d6g:A 587 36 0.2128 0.0170 0.2778 2.6 4d6d:A, 4d6e:A, 4d6f:A, 4d6h:A, 4d6i:A, 4d6j:A, 4d71:A, 4d72:A, 2wmi:A, 2wmi:B, 2wmj:A, 2wmj:B, 2wmk:A, 2wmk:B
34 7am2:BQ 413 26 0.2128 0.0242 0.3846 5.8
35 3ik5:A 119 27 0.2128 0.0840 0.3704 6.5 3ik5:C, 3ioz:A
36 6xl2:A 257 23 0.1702 0.0311 0.3478 7.2 6xab:A
37 5nui:B 130 27 0.2128 0.0769 0.3704 8.1
38 6qyi:B 520 29 0.1915 0.0173 0.3103 8.1 6b1b:A, 6b1b:B, 6eb0:C, 6qyh:B, 6qyi:A
39 2z93:C 201 22 0.1915 0.0448 0.4091 8.5
40 8a1l:A 354 35 0.2553 0.0339 0.3429 9.6 7a0z:A, 7a0z:B, 7a10:A, 7a10:B, 7a11:A, 7a1e:A, 8a1j:A, 8a1j:B, 8a1k:A, 8a1k:B, 8a1l:B, 8a1m:A, 8a1m:B, 8a1n:A, 8a1o:A, 8bk3:A, 6boi:A, 6boi:B, 5dc2:A, 5dc2:B, 5dcc:A, 5dcc:B, 5duj:A, 5duj:B, 5dvp:A, 5dvp:B, 5dzj:A, 5dzj:B, 5dzp:A, 5e1g:A, 5e1i:A, 7f71:A, 7f71:B, 7f8p:A, 4gsq:A, 4gsr:A, 4gsu:A, 4gsu:B, 6iyv:B, 6iyv:A, 6iyw:A, 6iyw:B, 6iyw:C, 6iyw:D, 6iyw:E, 6iyw:F, 5k69:A, 5k69:B, 7kem:A, 7kem:B, 5lb1:A, 5lb1:B, 5lbg:B, 6lqb:A, 6lqb:B, 8pxy:A, 8pxz:A, 4qr7:A, 4qrb:A, 4qtf:A, 6rrm:A, 6rrm:B, 3tur:A, 3tur:B, 3vyp:A, 3vyp:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218