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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
GSNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSP

The query sequence (length=54) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 6miu:A 57 54 1.0000 0.9474 1.0000 1.65e-35 6khz:C, 6khz:D, 6miu:B, 6mj7:A, 7r1o:BBB, 7r1o:DDD, 7r1o:AAA, 7r1o:CCC, 5yp7:A, 5yp7:D, 5yp8:A, 5yp8:B, 5ypa:A, 5ypa:B, 5ypb:C, 5ypb:D, 5ype:C, 5ype:D, 5ypf:C, 5ypf:D, 5ypg:A, 5ypg:B, 5yph:A
2 5ypc:B 50 48 0.8333 0.9000 0.9375 1.18e-28 6khz:A, 6khz:B, 5ypb:A, 5ypb:B, 5ypc:A, 5ypc:C, 5ypc:D, 5ype:A, 5ype:B, 5ypf:A, 5ypf:B, 5yph:B
3 6ww4:B 56 43 0.3333 0.3214 0.4186 1.23e-07 6ww4:A
4 6ww3:A 60 40 0.3333 0.3000 0.4500 1.62e-07 6ww3:B
5 4xi6:A 363 55 0.3704 0.0551 0.3636 2.86e-06 4xi7:A, 4xib:A
6 6cw3:E 120 45 0.3333 0.1500 0.4000 0.003 6cw2:C
7 6ds6:A 53 25 0.2407 0.2453 0.5200 0.003
8 2e5r:A 63 41 0.2963 0.2540 0.3902 0.006
9 5u7g:A 547 33 0.2778 0.0274 0.4545 0.006 4a9k:A, 4a9k:B, 6alc:B, 6axq:A, 6axq:B, 6axq:C, 6axq:D, 6ay3:A, 6ay3:B, 6ay5:A, 5cgp:A, 8cmz:A, 8cn0:A, 8cna:A, 8cnb:A, 8cnd:A, 2d82:A, 5dbm:A, 5dbm:B, 5dbm:C, 6dmk:A, 5eic:B, 5eng:A, 5ep7:A, 7evj:A, 6fqo:A, 6fqo:B, 6fqt:A, 6fqu:A, 6fr0:A, 6fr0:B, 6frf:A, 6frf:B, 6frf:C, 6frf:D, 8fup:A, 8fup:B, 8fv2:A, 8fv2:B, 8fv2:C, 8fv2:D, 8fvs:A, 8fvs:B, 8fxa:A, 8fxa:B, 8fxe:A, 8fxn:A, 8fxo:A, 8g6t:A, 8g6t:B, 8g6t:C, 8g6t:D, 8ga2:A, 8ga2:D, 8ga2:C, 8ga2:B, 5gh9:A, 5h85:A, 5i83:A, 5i86:A, 5i86:B, 5i89:A, 5j0d:A, 1jsp:B, 7juo:A, 7juo:B, 7juo:D, 7juo:C, 7juo:F, 7juo:E, 7juo:G, 7juo:H, 7kpy:A, 7kpy:B, 5ktu:A, 5ktu:B, 5ktw:A, 5ktw:B, 5ktw:C, 5ktx:A, 2l84:A, 2l85:A, 5lpj:A, 5lpl:A, 6lqx:B, 5mme:A, 5mme:B, 5mmg:A, 5mpk:A, 5mpk:B, 5mpn:A, 5mpz:A, 5mqe:A, 5mqe:B, 5mqg:A, 5mqg:B, 5mqk:A, 5mqk:B, 2n1a:B, 4n3w:A, 5nlk:A, 4nr4:A, 4nr4:B, 4nr5:A, 4nr6:A, 4nr7:A, 5nrw:A, 5nu3:A, 4nyv:A, 4nyv:B, 4nyv:C, 4nyv:D, 4nyw:A, 4nyx:A, 8og2:A, 5owk:A, 3p1c:A, 3p1d:A, 3p1f:A, 3p1f:B, 6qst:A, 6qst:B, 6qst:C, 6qst:D, 2rny:A, 6sqe:A, 6sqf:A, 6sqm:A, 6sqm:B, 6sqm:C, 3svh:A, 3svh:B, 6sxx:A, 6sxx:B, 5tb6:A, 1tot:A, 4tqn:A, 4ts8:A, 5u7g:B, 7uge:A, 7uge:B, 7ugl:A, 7ugl:B, 5w0e:A, 5w0f:A, 5w0i:A, 5w0l:A, 5w0l:B, 5w0q:A, 4whu:A, 7wx2:A, 7xh6:A, 7xh6:B, 7xhe:A, 7xhe:B, 7xi0:A, 7xi0:B, 7xm7:A, 7xm7:D, 7xm7:C, 7xne:A, 7xne:B, 7xng:A, 7xng:B, 5xxh:A, 6yij:A, 6yij:B, 6yij:C, 6yij:D, 6yij:E, 6yij:F, 6yij:G, 6yik:A, 6yik:C, 6yik:B, 6yil:A, 6yim:A, 4yk0:A, 4yk0:B, 4yk0:C, 4yk0:D
10 2dip:A 98 43 0.2963 0.1633 0.3721 0.017
11 6cw3:G 92 36 0.2593 0.1522 0.3889 0.027
12 7dd9:A 1129 38 0.2037 0.0097 0.2895 0.097 7dd9:C, 7dd9:E, 7dd9:G, 6lz1:A, 6lz1:B, 6lz1:C, 6lz1:D
13 6k15:H 393 52 0.2963 0.0407 0.3077 0.18 6kw4:H, 6kw5:H, 6v8o:I, 6v92:I
14 7dde:A 525 33 0.1852 0.0190 0.3030 0.28 7dde:C, 7dde:E, 7dde:G, 7dde:I, 7dde:K, 7dde:M, 7dde:O, 7dde:Q, 7dde:S, 7dde:V, 7dde:X
15 8que:A 486 13 0.1852 0.0206 0.7692 1.5
16 8sy7:J 1052 28 0.2037 0.0105 0.3929 1.6 8sy5:J
17 4jk1:D 1160 28 0.2037 0.0095 0.3929 1.6 4jk1:I, 4jk2:D, 4jk2:I, 4kmu:D, 4kmu:I, 4kn4:D, 4kn4:I, 4kn7:D, 4kn7:I, 4mex:D, 4mex:J, 4mey:D, 4mey:J, 4s20:D, 4zh3:D, 4zh4:D
18 8txo:J 1162 28 0.2037 0.0095 0.3929 1.6
19 5ipl:D 1173 28 0.2037 0.0094 0.3929 1.6 6byu:D, 6byu:J, 6cux:D, 6cux:J, 8hkc:F, 8igr:J, 8igs:J, 4ljz:D, 4lk1:D, 6pst:J, 4s20:I, 5uac:D, 5uac:J, 5uag:D, 5uag:J, 5uah:D, 5uah:J, 5uaj:D, 5uaj:J, 5ual:D, 5ual:J, 5uaq:D, 5uaq:J, 6vjs:D, 6vjs:I, 5vsw:D, 5vsw:J, 5w1s:D, 5w1s:J, 5w1t:D, 5w1t:J, 4xsx:D, 4xsy:D, 4xsz:D, 4yfk:D, 4yfk:J, 4yfn:D, 4yfn:J, 4yfx:D, 4yfx:J, 4yg2:D, 4yg2:J, 4zh2:D
20 6n61:D 1239 28 0.2037 0.0089 0.3929 1.6 6n60:D, 6n62:D, 4xsx:J, 4xsy:J, 4xsz:J
21 6kj6:D 1265 28 0.2037 0.0087 0.3929 1.6
22 8sy6:J 1269 28 0.2037 0.0087 0.3929 1.6
23 7yp9:D 1285 28 0.2037 0.0086 0.3929 1.6
24 6awc:04 1345 28 0.2037 0.0082 0.3929 1.6 6b6h:D, 7c17:D, 8egb:J, 6flp:D, 6flq:D, 8fvr:G, 8fvw:G, 6gfw:D, 6gh5:D, 4jkr:D, 4jkr:J, 6ldi:D, 4ljz:J, 4lk0:D, 4lk0:J, 4lk1:J, 4llg:D, 4llg:J, 7m8e:D, 7mkd:J, 7mke:J, 7mki:J, 7mkj:J, 7mkq:D, 7n4e:D, 6omf:D, 6p18:D, 6p19:D, 6p1k:J, 6pb4:D, 6pb5:D, 6pb6:D, 8pbl:G, 6pmi:D, 6pmj:D, 7py3:D, 7pyj:D, 7pyk:D, 8re4:D, 8rea:D, 8reb:D, 8rec:D, 8red:D, 8ree:D, 8to6:J, 8to8:J, 8toe:J, 7ubm:D, 7ubn:D, 5ui8:J, 7uwe:J, 7uwh:J, 5vt0:J, 7vwy:D, 7vwz:D, 7w5w:D, 7w5x:D, 7w5y:D, 6xas:J, 6xav:J, 6xh7:D, 6xh8:D, 6xl5:D, 6xlj:D, 6xll:D, 6xlm:D, 6xln:D, 7xui:J, 8y6u:D, 7ypb:D, 4zh2:J, 4zh3:J, 4zh4:J, 6ztj:CD, 6ztl:CD, 6ztm:CD, 6ztn:CD, 6zto:CD, 6ztp:CD, 6zu1:CD
25 5my1:Y 1372 28 0.2037 0.0080 0.3929 1.6 8aby:D, 8abz:D, 8ac0:D, 8ac1:D, 8ac2:D, 8acp:D, 7adb:Y, 7adc:Y, 7add:Y, 7ade:Y, 8ad1:D, 6alf:J, 6alg:J, 6alh:J, 6asx:J, 7bef:D, 7beg:D, 6bjs:J, 6c6s:J, 6c6t:J, 6c6u:J, 6c9y:D, 7c97:D, 6ca0:D, 7chw:D, 7d7c:D, 7d7d:D, 7dy6:D, 8e3f:B, 8e5k:B, 8e5o:B, 8e6x:B, 8e6z:B, 8eg7:J, 8eg8:J, 8eh8:J, 8eh9:J, 8eha:J, 8ehf:J, 8ehi:J, 8f1i:J, 8f1j:J, 8f1k:J, 8f3c:J, 8fix:D, 8fiy:D, 8ftd:J, 8g00:J, 8g1s:J, 8g2w:J, 8g4w:J, 8g7e:J, 8g8z:J, 6gov:Y, 5ipm:D, 5ipn:D, 3iyd:D, 6jbq:D, 6jnx:D, 8jo2:D, 6k4y:D, 8k58:D, 8k5a:D, 7khb:D, 7khc:D, 7khe:D, 7khi:D, 3lu0:D, 7mkn:D, 7mko:D, 7mkp:D, 5ms0:D, 6n4c:D, 6n57:J, 6n58:J, 5nwt:D, 6oul:J, 8pdy:J, 8pen:J, 8pfg:J, 8pfj:J, 8ph9:J, 8phk:J, 8pib:J, 8pid:J, 8pil:J, 8pim:J, 6psq:J, 6psr:J, 6pss:J, 6psu:J, 6psv:J, 6psw:J, 7py0:D, 7py1:D, 7py5:D, 7py6:D, 7py7:D, 7py8:D, 7q0j:D, 7q0k:D, 6rh3:D, 6ri7:D, 6ri9:D, 6rin:D, 6rip:D, 7szj:D, 7szk:D, 8to1:J, 8tom:J, 6tqn:Y, 6tqo:Y, 8u3b:D, 8upo:AE, 8upr:AE, 8uql:AE, 8uqm:AE, 8uqp:AE, 8ur0:AE, 8urh:AE, 8uri:AE, 8urx:AE, 8ury:AE, 6utv:DDD, 6utw:DDD, 6utx:DDD, 6uty:DDD, 6utz:DDD, 6uu0:DDD, 6uu1:DDD, 6uu2:DDD, 6uu3:DDD, 6uu4:DDD, 6uu5:DDD, 6uu6:DDD, 6uu7:DDD, 6uu8:DDD, 6uu9:DDD, 6uua:DDD, 6uub:DDD, 6uuc:DDD, 6vu3:AE, 6vyq:AE, 6vyr:AE, 6vys:AE, 6vyt:AE, 6vyu:AE, 6vyw:AE, 6vyx:AE, 6vyy:AE, 6vyz:AE, 6vz2:AE, 6vz3:AE, 6vz5:AE, 6vz7:AE, 6vzj:AE, 6wmu:D, 6x26:J, 6x2f:J, 6x2n:J, 6x43:J, 6x4w:J, 6x4y:J, 6x50:J, 6x6t:AE, 6x7f:AE, 6x7k:AE, 6x9q:AE, 6xdq:AE, 6xdr:AE, 6xgf:AE, 6xii:AE, 6xij:AE, 6xl9:D, 7xue:J, 7xug:J, 4yln:D, 4yln:J, 4yln:P, 4ylo:D, 4ylo:J, 4ylo:P, 4ylp:D, 4ylp:J, 4ylp:P, 7ypa:D, 6z9p:Y, 6z9q:Y, 6z9r:Y, 6z9s:Y, 6z9t:Y
26 6tda:L 596 44 0.2593 0.0235 0.3182 2.9
27 2ybf:A 150 37 0.2407 0.0867 0.3514 3.6
28 7xt2:B 388 17 0.1667 0.0232 0.5294 3.8 7xt2:A
29 2fc7:A 82 38 0.2407 0.1585 0.3421 4.8 6e83:B, 6e86:B
30 6npa:A 188 25 0.1852 0.0532 0.4000 4.8 6npa:B, 6npa:C, 6npa:D
31 7xyz:B 456 17 0.1667 0.0197 0.5294 4.9 7xv2:A, 7xyy:A, 7xyy:B, 7xyz:A, 7xyz:C, 7xyz:D, 7xz0:A, 7xz0:B, 7xz1:A, 7xz1:B, 7xz2:A, 7xz2:B, 7xz2:C, 7xz2:D
32 7f0r:D 1339 16 0.1296 0.0052 0.4375 6.4 7vf9:D, 7xl3:D, 7xl4:D, 7xya:D, 7xyb:D
33 6j9f:D 1215 28 0.1852 0.0082 0.3571 6.7 6j9e:D
34 8kcx:A 571 35 0.2593 0.0245 0.4000 6.9 8kcx:C
35 8woq:A 647 35 0.2593 0.0216 0.4000 6.9 8j6m:B, 8j6m:A, 8jul:A, 8jul:B, 8kcw:A, 8kcw:C, 8woq:B, 8wor:A, 8wor:B, 8wos:A, 8wos:B, 8wot:A, 8wot:B
36 8jun:A 678 35 0.2593 0.0206 0.4000 7.0 8jun:B
37 7pfo:B 759 30 0.2222 0.0158 0.4000 9.0 7plo:B, 5vbn:B, 5vbn:F

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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