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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
GSHMVIRESVSRIYVGNLPSHVSSRDVENEFRKYGNILKCDVKKTVSGAAFAFIEFEDARDAADAIKEKDGCDFEGNKLR
VEVPFNARE

The query sequence (length=89) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 2n7c:A 89 89 1.0000 1.0000 1.0000 1.09e-61
2 6hpj:B 84 73 0.4382 0.4643 0.5342 7.52e-24
3 2i2y:A 150 72 0.3483 0.2067 0.4306 2.39e-12 9asq:H, 5bmg:A, 5bmg:B, 5bmg:H, 5bmg:D, 5bmg:E, 5bmg:F, 5bmg:G, 5bmh:A, 3v3x:C, 3v3x:D
4 2mxy:A 105 78 0.3146 0.2667 0.3590 1.57e-08 2mz1:A
5 2l41:A 77 75 0.3258 0.3766 0.3867 1.80e-08 2xnr:A
6 2leb:A 101 79 0.2921 0.2574 0.3291 3.20e-08 2lec:A
7 2mb0:B 95 82 0.2809 0.2632 0.3049 7.63e-08
8 7dvq:Y 140 79 0.2697 0.1714 0.3038 2.51e-06 8i0p:Y, 8i0r:Y
9 2n82:B 104 84 0.2921 0.2500 0.3095 2.65e-06 2err:A, 7vrl:B
10 7zew:A 117 92 0.3258 0.2479 0.3152 1.34e-05 7zex:A
11 2fy1:A 108 81 0.2697 0.2222 0.2963 1.62e-05
12 2rra:A 99 77 0.2472 0.2222 0.2857 1.89e-05 2kxn:B
13 5x8p:v 190 77 0.2472 0.1158 0.2857 1.99e-05 5mmj:v, 5mmm:v, 5x8r:v
14 5x8p:v 190 79 0.2135 0.1000 0.2405 0.015 5mmj:v, 5mmm:v, 5x8r:v
15 3lqv:B 115 79 0.2809 0.2174 0.3165 2.01e-05 2f9j:B, 3lqv:A, 7q4o:F, 8qo9:B6, 8qxd:B6, 8qzs:B6, 8r08:B6, 8r09:B6, 8r0a:B6, 8r0b:B6, 8rm5:B6
16 5kw6:A 201 73 0.2472 0.1095 0.3014 3.60e-05 5kvy:A, 5kvy:B, 5kw1:A, 5kw1:B, 5kw6:B, 7q8a:B, 7q8a:A, 2qfj:A, 2qfj:B, 7z3x:A, 7z3x:B
17 5kw6:A 201 80 0.2360 0.1045 0.2625 3.78e-04 5kvy:A, 5kvy:B, 5kw1:A, 5kw1:B, 5kw6:B, 7q8a:B, 7q8a:A, 2qfj:A, 2qfj:B, 7z3x:A, 7z3x:B
18 5ifm:C 256 71 0.2697 0.0938 0.3380 3.85e-05 5ifm:A
19 4ed5:B 169 78 0.2584 0.1361 0.2949 4.83e-05 4ed5:A
20 5m8i:A 114 88 0.2472 0.1930 0.2500 5.44e-05
21 7qde:B 169 73 0.2809 0.1479 0.3425 1.01e-04 7qdd:B
22 2mkc:A 118 76 0.2247 0.1695 0.2632 1.16e-04 2my3:A
23 7dco:X 128 76 0.2247 0.1562 0.2632 1.19e-04 5gm6:V, 5zwm:X
24 4a8x:A 88 73 0.2022 0.2045 0.2466 1.33e-04
25 6r5k:H 394 73 0.2697 0.0609 0.3288 1.57e-04 6r5k:D, 6r5k:F
26 6r5k:H 394 73 0.2247 0.0508 0.2740 2.40e-04 6r5k:D, 6r5k:F
27 6r5k:H 394 79 0.2135 0.0482 0.2405 0.024 6r5k:D, 6r5k:F
28 5mqf:o 223 74 0.2697 0.1076 0.3243 1.63e-04 6id1:y, 7w59:y, 7w5a:y, 7w5b:y
29 7uj1:B 270 76 0.2809 0.0926 0.3289 1.85e-04 7pu5:B, 7pu5:D, 7pu5:H, 7pu5:J, 7pu5:L, 7sp0:B, 7uj1:A
30 8esq:o 137 59 0.2247 0.1460 0.3390 2.89e-04 8esr:o, 8etg:o, 8eth:o, 8eti:o, 8eup:o, 8euy:o, 8ev3:o
31 4f02:A 175 76 0.2360 0.1200 0.2763 4.76e-04 1cvj:A, 1cvj:B, 1cvj:C, 1cvj:D, 1cvj:E, 1cvj:F, 1cvj:G, 1cvj:H, 4f02:D
32 4f02:A 175 75 0.2022 0.1029 0.2400 1.3 1cvj:A, 1cvj:B, 1cvj:C, 1cvj:D, 1cvj:E, 1cvj:F, 1cvj:G, 1cvj:H, 4f02:D
33 6qx9:1K 201 74 0.2360 0.1045 0.2838 5.45e-04 7b0y:b, 4pjo:K, 4pjo:k, 4pjo:N, 4pjo:n, 8r08:1K, 7vpx:O
34 4pkd:B 240 74 0.2360 0.0875 0.2838 6.70e-04 1aud:A, 7b0y:c, 3bo2:A, 3bo3:A, 3bo4:A, 4c4w:A, 4c4w:E, 3cul:A, 3cul:B, 3cun:A, 3cun:B, 7d7v:C, 5ddo:G, 5ddo:C, 5ddp:D, 5ddp:C, 5ddq:D, 5ddq:C, 5ddr:D, 5ddr:C, 7dlz:A, 7dlz:B, 1drz:A, 7dwh:A, 7dwh:B, 1dz5:A, 1dz5:B, 3egz:A, 5fj4:A, 5fj4:E, 3g8s:A, 3g8s:B, 3g8s:C, 3g8s:D, 3g8t:A, 3g8t:B, 3g8t:C, 3g8t:D, 3g96:A, 3g96:B, 3g96:C, 3g96:D, 3g9c:A, 3g9c:B, 3g9c:C, 3g9c:D, 8gxb:C, 8gxb:D, 8gxb:F, 8gxc:C, 8gxc:D, 8gxc:F, 3hhn:B, 3hhn:D, 3iin:A, 3irw:P, 3iwn:C, 3iwn:D, 8jy0:A, 8jy0:C, 8jy0:E, 3k0j:A, 3k0j:B, 3l3c:A, 3l3c:B, 3l3c:C, 3l3c:D, 6las:E, 6las:D, 6las:C, 6lau:E, 6lau:D, 6lau:C, 6lax:D, 6lax:E, 6lax:C, 6laz:D, 6laz:E, 6laz:C, 1m5k:C, 1m5k:F, 1m5o:C, 1m5o:F, 1m5p:C, 1m5p:F, 1m5v:C, 1m5v:F, 3mum:P, 3mur:P, 3mut:P, 3muv:P, 3mxh:P, 2nz4:A, 2nz4:B, 2nz4:C, 2nz4:D, 2oih:A, 2oj3:A, 3p49:B, 4pr6:A, 4prf:A, 7qr3:A, 7qr3:B, 7qr4:A, 6qx9:1A, 3r1h:A, 3r1h:D, 3r1l:A, 3r1l:D, 1sj3:P, 1sj4:P, 1sjf:A, 6sqn:A, 6sqn:B, 6sqn:C, 6sqq:AAA, 6sqq:BBB, 6sqq:CCC, 1u6b:A, 3ucu:P, 3ucz:P, 3ud3:P, 3ud4:P, 1urn:A, 1urn:B, 1urn:C, 1vbx:A, 1vby:A, 1vbz:A, 1vc0:A, 1vc5:A, 1vc6:A, 7vpx:M, 4w90:B, 4w92:B, 1zzn:A
35 2rqc:A 115 76 0.1910 0.1478 0.2237 6.84e-04
36 7slp:B 321 63 0.2584 0.0717 0.3651 7.64e-04 6d12:A, 6d12:B, 7slq:B, 4wkr:A, 4wkr:B
37 4qqb:A 169 76 0.2472 0.1302 0.2895 8.97e-04 1b7f:A, 1b7f:B, 4qqb:B
38 4qqb:A 169 69 0.2135 0.1124 0.2754 0.006 1b7f:A, 1b7f:B, 4qqb:B
39 6xh2:A 93 74 0.2022 0.1935 0.2432 0.001 6cmn:A, 3k0j:D, 3k0j:C, 6xh0:A, 6xh1:A, 6xh3:A
40 8xxm:3G 84 73 0.2809 0.2976 0.3425 0.001 5k0y:O, 8pj1:o, 8pj2:o, 8pj3:o, 8pj4:o, 8pj5:o, 8pj6:o
41 1fnx:H 174 78 0.2472 0.1264 0.2821 0.002 1fxl:A, 1g2e:A
42 4bs2:A 174 99 0.2809 0.1437 0.2525 0.003 4iuf:A, 4y00:A, 4y00:B, 4y00:C, 4y00:D, 4y0f:A, 4y0f:B
43 4bs2:A 174 57 0.1573 0.0805 0.2456 2.0 4iuf:A, 4y00:A, 4y00:B, 4y00:C, 4y00:D, 4y0f:A, 4y0f:B
44 2mgz:B 105 78 0.2247 0.1905 0.2564 0.003 4ch1:A, 4cio:A, 2ru3:A
45 7q33:A 93 73 0.2022 0.1935 0.2466 0.003 6pai:D, 6q0r:D, 6q0v:D, 6q0w:D, 6sj7:C, 6ud7:C, 6ue5:C
46 2mgz:A 94 73 0.2135 0.2021 0.2603 0.003
47 7vsj:A 160 80 0.2584 0.1437 0.2875 0.005 6fqr:A, 6gx6:A, 7yew:A, 7yew:C, 7yex:A
48 7vsj:A 160 75 0.1798 0.1000 0.2133 0.008 6fqr:A, 6gx6:A, 7yew:A, 7yew:C, 7yex:A
49 2mki:A 203 68 0.2022 0.0887 0.2647 0.005
50 7abg:B 169 74 0.1685 0.0888 0.2027 0.005 7a5p:X, 1a9n:B, 1a9n:D, 7abi:B, 6ah0:p, 6ahd:p, 8c6j:Y, 8ch6:s, 7evo:G, 9fmd:p, 8h6e:2C, 8h6j:2C, 8h6k:2C, 8h6l:2C, 8hk1:G, 8i0p:p, 8i0r:p, 8i0s:p, 8i0t:p, 8i0u:p, 8i0v:p, 8i0w:p, 6icz:p, 6id0:p, 6id1:p, 5mqf:X, 6qdv:Y, 8qo9:2B, 6qx9:2B, 8qxd:2B, 8qzs:2B, 8r08:2B, 8r09:2B, 8r0a:2B, 8r0b:2B, 8rm5:2B, 7vpx:G, 7w59:p, 7w5a:p, 7w5b:p, 5xjc:p, 6y53:b, 6y5q:b, 5yzg:p, 5z56:p, 5z57:p, 5z58:p
51 7ohx:o 112 74 0.2247 0.1786 0.2703 0.006
52 6xlv:A 203 81 0.2247 0.0985 0.2469 0.006 5ev1:A, 5ev2:A, 5ev3:A, 5ev4:A, 2g4b:A, 2hzc:A, 7s3a:A, 7s3b:A, 7s3c:A, 4tu7:A, 4tu7:B, 4tu8:A, 4tu8:B, 4tu9:A, 4tu9:B, 3vaf:A, 3vaf:B, 3vag:A, 3vag:B, 3vah:B, 3vah:A, 3vai:A, 3vai:B, 3vaj:A, 3vaj:B, 3vak:A, 3vak:B, 3val:I, 3val:A, 3val:D, 3val:B, 3vam:A, 3vam:B, 5w0g:A, 6xlw:A, 6xlx:A, 2yh1:A
53 6c0f:o 133 74 0.2247 0.1504 0.2703 0.008 7btb:o, 6cb1:o, 8e5t:o, 6elz:o, 6em1:o, 6em3:o, 6em4:o, 6em5:o, 3jct:o, 6m62:o, 7nac:o, 7ohp:o, 7ohq:o, 7ohr:o, 7ohs:o, 7ohv:o, 7ohw:o, 7r6q:o, 7r7a:o, 7u0h:o, 7uoo:o, 7uqb:o, 7uqz:o, 7v08:o, 8v83:o, 8v84:o, 8v87:o, 6ylx:o, 6yly:o, 5z3g:E
54 8by6:B 152 90 0.2697 0.1579 0.2667 0.008 7abg:A1, 6d0y:A, 1h2t:Z, 1h2u:X, 1h2u:Y, 1n52:B, 5oo6:B, 5oo6:E, 5oo6:H, 5oo6:K, 5oo6:N, 5oo6:Q, 5oo6:T, 5oo6:W, 5oob:D, 5oob:J, 5oob:B, 5oob:G, 8pmp:B, 8pnt:B, 8srr:B, 8suy:B
55 7abi:P 237 65 0.2247 0.0844 0.3077 0.008 7aav:P, 7abg:P
56 8h6e:4R 106 63 0.2022 0.1698 0.2857 0.009 8h6j:4R, 8qp8:R, 8qp9:R, 8qpk:R, 6qw6:R, 6qx9:R, 8qxd:R, 8r08:R, 8r0a:R
57 8ova:Az 100 33 0.1461 0.1300 0.3939 0.009
58 6g90:B 193 70 0.2247 0.1036 0.2857 0.012
59 8ch6:U 295 62 0.2247 0.0678 0.3226 0.012 7a5p:P, 8c6j:M, 6ff4:P, 6ff7:P, 9fmd:O, 8i0p:O, 8i0r:O, 8i0s:O, 8i0t:O, 8i0u:O, 8i0v:O, 8i0w:O, 6icz:O, 6id0:O, 6id1:O, 5mqf:P, 6qdv:M, 7qtt:U, 8ro2:O, 7w59:O, 7w5a:O, 7w5b:O, 5xjc:O, 5yzg:O, 5z56:O, 5z57:O, 6zym:P
60 7csz:A 175 77 0.2584 0.1314 0.2987 0.013
61 8ch6:V 285 80 0.2472 0.0772 0.2750 0.014 7qtt:V
62 8i0s:Y 320 80 0.2472 0.0688 0.2750 0.014 8i0t:Y, 8i0u:Y, 8i0v:Y
63 6n7p:A 186 70 0.2247 0.1075 0.2857 0.015 6n7r:A, 6n7x:A, 7oqc:B, 7oqe:B, 8w2o:A, 5zwn:Q
64 8pv1:CI 152 74 0.2472 0.1447 0.2973 0.016 8i9p:CI, 8i9r:CI, 8i9t:CI, 8i9v:CI, 8i9w:CI, 8i9x:CI, 8i9y:CI, 8i9z:CI, 8ia0:CI, 8pv3:CI, 8pv4:CI, 8pv7:CI, 8pvk:CI
65 5tkz:A 89 82 0.2584 0.2584 0.2805 0.017 5tkz:B
66 6dg0:B 84 80 0.2135 0.2262 0.2375 0.031 6dg0:A
67 7ase:J 173 33 0.1348 0.0694 0.3636 0.032 5opt:h
68 8fkp:SH 150 70 0.2022 0.1200 0.2571 0.049 8fkq:SH, 8fkr:SH, 8fks:SH, 8fkt:SH, 8fku:SH, 8fkv:SH, 8fkw:SH, 8fkx:SH, 8fky:SH, 8fkz:SH, 8fl2:SH, 8fl6:SH, 8fla:SH, 8fld:SH, 8ine:t, 8inf:t, 8ipx:t, 8ipy:t, 8ir3:t
69 8y6o:W 167 71 0.2135 0.1138 0.2676 0.052
70 6jvx:A 87 80 0.2135 0.2184 0.2375 0.070 6jvy:A
71 7dco:4 174 76 0.2022 0.1034 0.2368 0.072 6g90:R, 5gm6:e, 5nrl:R, 7oqb:R, 7oqe:R, 5zwm:4
72 7dco:4 174 58 0.1910 0.0977 0.2931 0.41 6g90:R, 5gm6:e, 5nrl:R, 7oqb:R, 7oqe:R, 5zwm:4
73 8i0v:4 161 74 0.2360 0.1304 0.2838 0.077
74 3d2w:A 72 58 0.1685 0.2083 0.2586 0.093
75 6m75:A 167 59 0.1573 0.0838 0.2373 0.10
76 6m75:A 167 49 0.1461 0.0778 0.2653 0.11
77 8fnk:13 127 67 0.2247 0.1575 0.2985 0.11 6e4p:C, 6e4p:I, 6e4p:B
78 2x1f:A 94 62 0.1573 0.1489 0.2258 0.17 2km8:B, 2x1a:A
79 8wq5:A 99 78 0.2247 0.2020 0.2564 0.17 8wq5:B, 8wq5:C, 8wq5:D
80 7q4l:A 227 77 0.2135 0.0837 0.2468 0.18
81 5x3z:A 96 61 0.2247 0.2083 0.3279 0.21
82 6f4h:C 96 51 0.1461 0.1354 0.2549 0.29 6f4g:B, 6f4g:E, 6f4h:A, 6f4h:E
83 3smz:A 280 32 0.1461 0.0464 0.4062 0.32
84 9gpj:A 184 69 0.2022 0.0978 0.2609 0.40 6dcl:A, 6dcl:B, 9f4d:A, 9f4e:A, 9f4f:A, 9f4g:A, 9f4h:A, 9f4j:A, 9f4k:A, 9f4l:A, 9f4m:A, 9f4n:A, 9f4o:A, 9f4p:A, 9f4q:A, 9f4r:A, 9f4s:A, 9f4t:A, 9f4u:A, 9f4v:A, 9f4w:A, 9f4x:A, 9f4y:A, 9f4z:A, 9f50:A, 9f51:A, 9f52:A, 9f53:A, 9f54:A, 9f55:A, 9f5c:A, 9f5d:A, 9f5e:A, 9f5f:A, 9f5g:A, 9f5k:A, 9f7f:A, 9f7h:A, 5mpg:A, 5mpl:A, 1pgz:A, 1po6:A, 8rzv:A, 1u1k:A, 1u1l:A, 1u1m:A, 1u1n:A, 1u1o:A, 1u1p:A, 1u1q:A, 1u1r:A, 2up1:A, 4yoe:A
85 2xs2:A 87 71 0.1573 0.1609 0.1972 0.93 2xs5:A, 2xs5:B, 2xs7:A
86 7pcv:A 116 64 0.2022 0.1552 0.2812 1.0 2lk0:A, 2lk1:A, 7pcv:B, 7pdv:E, 7pdv:A, 7pdv:C, 7pdv:G
87 7ba4:A 377 40 0.1236 0.0292 0.2750 1.1 7ba4:B, 7ba4:C, 7ba4:D
88 2adb:A 127 71 0.2360 0.1654 0.2958 1.3 3zzy:A, 3zzy:B, 3zzz:A, 3zzz:B
89 5en1:A 184 69 0.1798 0.0870 0.2319 2.1 8hni:A, 8hni:B, 8hni:G, 8hni:I, 8hni:H, 8hni:E, 8hni:K, 8hni:C, 8hni:D, 8hni:J, 8hni:F, 8hni:L, 5ho4:A, 7wm3:A, 7wm3:B, 7wm3:C, 7wm3:D, 5wwe:A, 5wwf:A, 5wwf:C, 5wwg:A
90 4c25:A 212 74 0.2135 0.0896 0.2568 2.3 4c24:A
91 6snj:A 131 81 0.2584 0.1756 0.2840 2.4 6gbm:B
92 1js8:A 382 87 0.2472 0.0576 0.2529 2.4 1js8:B
93 4ka7:A 695 47 0.1685 0.0216 0.3191 3.9 4ka8:A, 4put:A
94 8bwv:B 80 25 0.1124 0.1250 0.4000 4.0 8bwv:A, 8bwv:C, 8bwv:D, 8bwv:E, 8bwv:F
95 5osg:h 173 33 0.1236 0.0636 0.3333 4.5 8a3w:Sh, 8a98:Sh, 8ovj:Sh, 8rxh:Sh, 8rxx:Sh
96 4lmz:A 176 31 0.0899 0.0455 0.2581 5.3 3nmr:A, 3nna:A, 3nnc:A, 3nnh:A, 3nnh:C, 3nnh:B, 3nnh:D
97 4l0o:H 373 46 0.1461 0.0349 0.2826 6.0 4l0o:A, 4l0o:C, 4l0o:E, 4l0o:G, 4l0o:M, 4l0o:O

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218