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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
GRVRTKTVKRASKALIERYYPKLTLDFQTNKRLCDEIATIQSKRLRNKIAGYTTHLMKRIQKGPVRGISFKLQEEERERK
DQYVPEVSSNGVLNVDNQTSDLVKSLGLKLPLSVI

The query sequence (length=115) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4v6i:AQ 136 121 1.0000 0.8456 0.9504 7.03e-79 7a1g:H, 7b7d:G, 8bqd:G, 8bqx:G, 8cah:H, 8cas:I, 8cbj:R, 8ccs:t, 8cdl:t, 8cdr:t, 8ceh:t, 8cf5:t, 8cg8:t, 8cgn:t, 8civ:t, 8cku:t, 8cmj:t, 5dat:C7, 5dat:c7, 5dc3:C7, 5dc3:c7, 5dge:C7, 5dge:c7, 5dgf:C7, 5dgf:c7, 5dgv:C7, 5dgv:c7, 6eml:C, 8eub:BR, 8evp:BR, 8evq:BR, 8evr:BR, 8evs:BR, 8evt:BR, 8ewb:BR, 8ewc:BR, 6fai:R, 5fci:C7, 5fci:c7, 5fcj:C7, 5fcj:c7, 6fyx:R, 6fyy:R, 6gq1:AH, 6gqb:AH, 6gqv:AH, 6gsn:R, 6hhq:S, 6hhq:c7, 5i4l:C7, 5i4l:c7, 6i7o:G, 6i7o:Gb, 8i7j:R, 5it7:R, 5it9:R, 3j6x:17, 3j6y:17, 3j77:17, 3j78:17, 3j80:R, 3j81:R, 3jam:R, 3jap:R, 5juo:OB, 5jup:OB, 5jus:OB, 5jut:OB, 5juu:OB, 8k2d:SR, 8k82:SR, 5lyb:C7, 5lyb:c7, 5m1j:R2, 5mc6:G, 5mei:c7, 5mei:S, 7mpi:BR, 7mpj:BR, 7n8b:BR, 5ndg:C7, 5ndg:c7, 5ndv:C7, 5ndv:c7, 5ndw:C7, 5ndw:c7, 7nrc:SG, 7nrd:SG, 5obm:C7, 5obm:c7, 5on6:c7, 5on6:S, 7osa:eS17, 7osm:eS17, 6q8y:G, 6rbd:R, 6rbe:R, 7rr5:SR, 8rw1:R, 6s47:BS, 8s8d:R, 8s8e:R, 8s8f:R, 8s8g:R, 8s8h:R, 8s8i:R, 8s8j:R, 6snt:R, 6sv4:G, 6sv4:Gb, 6sv4:Gc, 6t4q:SR, 6t7i:SR, 6t7t:SR, 6t83:Rb, 6t83:s, 5tbw:S, 5tbw:c7, 6tb3:G, 5tga:C7, 5tga:c7, 5tgm:C7, 5tgm:c7, 6tnu:G, 4u3m:C7, 4u3m:c7, 4u3n:C7, 4u3n:c7, 4u3u:C7, 4u3u:c7, 4u4n:C7, 4u4n:c7, 4u4o:C7, 4u4o:c7, 4u4q:C7, 4u4q:c7, 4u4r:C7, 4u4r:c7, 4u4u:C7, 4u4u:c7, 4u4y:C7, 4u4y:c7, 4u4z:C7, 4u4z:c7, 4u50:C7, 4u50:c7, 4u51:C7, 4u51:c7, 4u52:C7, 4u52:c7, 4u53:C7, 4u53:c7, 4u55:C7, 4u55:c7, 4u56:C7, 4u56:c7, 4u6f:C7, 4u6f:c7, 4uer:V, 6uz7:R, 4v88:AR, 4v88:CR, 4v8y:AR, 4v8z:AR, 4v92:BR, 6wdr:R, 6woo:RR, 6xiq:AH, 6xir:AH, 6y7c:R, 6z6j:SR, 6z6k:SR, 6zce:S, 7zpq:AR, 7zrs:AR, 6zu9:I, 7zuw:AR, 7zux:DR, 6zvi:z, 7zw0:sG
2 8oeq:DE 125 121 0.8348 0.7680 0.7934 2.92e-66 8c3a:T, 8c3a:DE, 8cq7:T, 8cq7:DE, 8cqw:T, 8cqw:DE, 8cre:T, 8cre:DE, 8oeq:T, 7pzy:S, 7q08:S, 7q0f:S, 7q0p:S, 7q0r:S, 8q5i:S
3 6gsm:R 111 115 0.8435 0.8739 0.8435 1.22e-63
4 7olc:SR 128 123 0.7565 0.6797 0.7073 3.64e-60 7old:SR, 8oo0:SR, 7r81:S2, 7z3n:SR, 7z3o:SR
5 8bn3:C7 92 114 0.8000 1.0000 0.8070 1.69e-58
6 9bh5:AR 121 116 0.6261 0.5950 0.6207 4.49e-49 9cai:AR
7 5xxu:R 117 117 0.6087 0.5983 0.5983 8.74e-49
8 8auv:D 119 118 0.6522 0.6303 0.6356 3.58e-48 8b2l:D1, 7qiy:I, 7qiz:AA
9 8ifd:2y 135 110 0.6261 0.5333 0.6545 9.71e-48 7a01:C3, 7a09:w, 5a2q:R, 5aj0:BR, 9bdl:AS17, 9bdn:AS17, 9bdp:AS17, 8bhf:S3, 9bkd:M, 9bln:M, 8btk:Aq, 7cpu:SR, 7cpv:SR, 6d90:SS, 6d9j:SS, 9f1b:Aq, 9f1c:Aq, 9f1d:Aq, 6fec:e, 5flx:R, 6g18:R, 6g4s:R, 6g4w:R, 6g51:R, 6g53:R, 6g5h:R, 6g5i:R, 8g5y:SR, 8g5z:SR, 8g60:SR, 8g61:SR, 8g6j:SR, 8glp:SR, 6gz3:BR, 6gz4:BR, 6gz5:BR, 6hcf:S1, 6hcj:S2, 6hcm:S1, 6hcq:S2, 8ife:2y, 6ip5:2y, 6ip6:2y, 6ip8:2y, 3j7p:SR, 3j7r:SR, 3jag:RR, 3jah:RR, 3jai:RR, 3jaj:SR, 3jan:SR, 8jdj:AD, 8jdk:AD, 8jdl:AD, 8jdm:AD, 7jqb:S, 7jqc:S, 5k0y:e, 8k2c:SR, 7k5i:R, 4kzx:R, 4kzy:R, 4kzz:R, 5lks:SR, 7ls1:z2, 7ls2:z2, 5lzs:RR, 5lzt:RR, 5lzu:RR, 5lzv:RR, 5lzw:RR, 5lzx:RR, 5lzy:RR, 5lzz:RR, 7mdz:RR, 7mq8:NU, 7mqa:NU, 6mtb:RR, 6mtc:RR, 6mtd:RR, 6mte:RR, 7nwg:S2, 7nwh:RR, 7nwi:RR, 7o7y:Aq, 7o7z:Aq, 7o80:Aq, 7o81:Aq, 5oa3:R, 6ole:SR, 6olf:SR, 6olg:BR, 6oli:SR, 6olz:BR, 6om0:SR, 6om7:SR, 7oya:R2, 7oyb:R2, 7oyc:R2, 7oyd:RR, 8oz0:v, 8p03:T, 8p09:T, 8p2k:Aq, 6p4g:S, 6p4h:S, 6p5i:S, 6p5j:S, 6p5k:S, 6p5n:S, 8pj1:M, 8pj2:M, 8pj3:M, 8pj4:M, 8pj5:M, 8pj6:M, 8ppk:R, 8ppl:AR, 8q7z:Aq, 8q87:Aq, 7qgg:SR, 8qoi:SR, 7qp6:M, 7qp7:M, 7qvp:SR, 7qvp:RR, 6qzp:SR, 7r4x:R, 6r5q:KK, 6r6g:KK, 6r6p:YY, 6r7q:KK, 8scb:RR, 6sgc:S1, 7syg:S, 7syh:S, 7syi:S, 7syj:S, 7syk:S, 7syl:S, 7sym:S, 7syn:S, 7syo:S, 7syp:S, 7syq:S, 7syr:S, 7sys:S, 7syt:S, 7syu:S, 7syv:S, 7syw:S, 7syx:S, 5t2c:Az, 8t4s:R, 7toq:AS17, 7tor:AS17, 7tql:S, 7ucj:RR, 7uck:RR, 4ug0:SR, 4v6x:AR, 5vyc:R1, 5vyc:R2, 5vyc:R3, 5vyc:R4, 5vyc:R5, 5vyc:R6, 6w2s:S, 6w2t:S, 7wtt:R, 7wtu:R, 7wtv:R, 7wtw:R, 7wtx:R, 7wtz:R, 7wu0:R, 6xa1:SR, 7xnx:SR, 7xny:SR, 8xsx:SR, 8xsy:SR, 8xsz:SR, 8xxl:SR, 8xxm:SR, 8xxn:SR, 6y0g:SR, 8y0w:SR, 8y0x:SR, 6y2l:SR, 6y57:SR, 6yal:T, 6yam:T, 6yan:T, 6ybs:X, 6ybw:M, 8yoo:SR, 8yop:SR, 6z6l:SR, 6z6m:SR, 6z6n:SR, 7zjw:Sc, 7zjx:Sc, 6zlw:S, 6zm7:SR, 6zme:SR, 6zmi:SR, 6zmo:SR, 6zmt:S, 6zmw:M, 6zn5:S, 6zoj:R, 6zok:R, 6zol:R, 6zon:w, 6zp4:w, 6zuo:R, 6zv6:R, 6zvh:R, 6zvj:w, 6zvk:C3, 6zxd:R, 6zxe:R, 6zxf:R, 6zxg:R, 6zxh:R
10 4v5o:AV 121 109 0.6174 0.5868 0.6514 3.32e-46 4bts:AV, 4bts:BV, 4bts:CV, 4bts:DV, 4v5o:BV
11 4d5l:R 109 95 0.5739 0.6055 0.6947 9.64e-45 4d61:R, 4ujc:CR, 4ujd:CR, 4uje:BR
12 4v3p:SQ 141 110 0.5652 0.4610 0.5909 2.79e-44 8ip8:qa, 8ip9:qa, 8ipa:qa, 8ipb:qa, 8jiw:BR, 8r57:h, 4v7e:BR
13 4v6w:AR 120 110 0.5826 0.5583 0.6091 2.81e-44 6xu6:AR, 6xu7:AR, 6xu8:AR
14 5xyi:R 118 109 0.5391 0.5254 0.5688 9.21e-44
15 6zj3:SV 125 101 0.5826 0.5360 0.6634 1.47e-41
16 3j7a:W 95 106 0.5478 0.6632 0.5943 1.65e-40 3jbn:W, 3jbo:W, 3jbp:W, 6okk:W, 8tpu:SW
17 4v8m:AL 126 121 0.5565 0.5079 0.5289 2.04e-39 7ase:i, 5opt:k, 8ova:AL, 8ove:AL
18 6az1:V 122 120 0.5304 0.5000 0.5083 1.22e-37 8a3w:SV, 8a98:SV, 8ovj:SV, 8rxh:SV, 8rxx:SV, 5t2a:AL
19 8bsj:SU 121 115 0.5217 0.4959 0.5217 9.32e-26 8br8:SU, 8brm:SU, 8bsi:SU, 8btd:SU, 8btr:SU, 8fvy:R, 8g4s:R
20 6zu5:SR0 113 105 0.4174 0.4248 0.4571 1.99e-22
21 6rm3:SR0 117 105 0.3304 0.3248 0.3619 3.49e-20
22 7qep:C7 117 88 0.3391 0.3333 0.4432 5.00e-20
23 7pwf:R 101 112 0.4522 0.5149 0.4643 5.98e-20 7pwo:R1
24 8p5d:SR0 119 88 0.3391 0.3277 0.4432 5.58e-17 8p60:SR0, 8p60:RR0, 7qca:SR0
25 6skf:At 64 63 0.2087 0.3750 0.3810 1.79e-11 6skg:At, 6skg:Bm, 6th6:At
26 5jb3:S 67 65 0.2000 0.3433 0.3538 2.53e-11 5jbh:S, 6sw9:S, 6swc:S, 6swe:S, 4v4n:BS, 4v6u:AS, 7zag:S, 7zah:S, 7zai:S, 7zhg:S
27 6tmf:T 64 63 0.1913 0.3438 0.3492 4.04e-10
28 8hkx:S17E 62 58 0.1826 0.3387 0.3621 4.51e-09 8hky:S17E, 8hkz:S17E, 8hl1:S17E, 8hl2:S17E, 8hl3:S17E, 8hl4:S17E, 8hl5:S17E, 8wkp:S17E, 8wq2:S17E, 8wq4:S17E
29 2y7h:A 464 39 0.1130 0.0280 0.3333 0.18
30 7pmk:Q 766 70 0.2087 0.0313 0.3429 1.9 7pmn:Q
31 7qhs:G 756 58 0.1826 0.0278 0.3621 4.9 7z13:N, 7z13:Q
32 7asm:H 145 46 0.1478 0.1172 0.3696 5.5 7asn:H, 7aso:M, 7asp:H, 6ddd:V, 6ddg:V, 6fxc:AH, 6fxc:BH, 5hkv:G, 5hl7:G, 6hma:H, 5li0:M, 5nd8:M, 5nd9:M, 5ngm:AH, 7nhl:M, 7nhm:M, 5nrg:G, 8p2f:M, 8p2g:M, 8p2h:M, 7p48:H, 6s0x:H, 6s0z:H, 6s12:H, 6s13:H, 6sj6:M, 5t7v:LM, 5tcu:LM, 7ttu:V, 7ttw:V, 4wce:G, 4wf9:G, 4wfa:G, 4wfb:G, 6wqn:V, 6wqq:V, 6wrs:V, 6wru:V, 8y36:H, 8y37:H, 8y38:H, 8y39:H, 6yef:M
33 8p5e:G 825 58 0.1826 0.0255 0.3621 5.6 8kg6:M, 8kg8:M, 8p62:G, 8p63:G
34 8xgc:8 857 58 0.1826 0.0245 0.3621 5.6
35 8kg9:M 812 58 0.1826 0.0259 0.3621 6.4
36 7orl:A 2183 34 0.0783 0.0041 0.2647 7.3 7oa4:AAA, 7oa4:BBB, 7oa4:DDD, 7oa4:GGG, 7ork:A, 7plr:AAA, 7plr:BBB, 7plr:DDD, 7plr:GGG, 2xi5:A, 2xi5:B, 2xi5:C, 2xi5:D, 2xi7:A, 2xi7:B, 2xi7:C, 2xi7:D
37 2bsl:A 311 32 0.0957 0.0354 0.3438 8.0 2bsl:B, 2bx7:A, 2bx7:B, 1dor:A, 1dor:B, 2dor:A, 2dor:B, 1jqv:A, 1jqv:B, 1jqx:A, 1jqx:B, 1jrb:A, 1jrb:B, 1jrc:A, 1jrc:B, 1jub:A, 1jub:B, 1jue:A, 1jue:B, 1ovd:A, 1ovd:B
38 7kjc:A 376 81 0.1478 0.0452 0.2099 9.2 8bin:A, 8bio:A, 8bk0:A, 8bm8:A, 8boc:A, 8bod:A, 8bof:A, 8bog:A, 8boh:A, 8boi:A, 8bok:A, 8bom:A, 6fnf:A, 6fng:A, 6fnh:A, 6fnh:B, 6fnh:C, 6hes:A, 6het:A, 6heu:A, 6hev:A, 6hew:A, 6hex:A, 6hey:A, 5i9v:A, 5i9w:A, 5i9x:A, 5i9y:A, 5i9z:A, 5ia0:A, 5ia0:B, 5ia0:C, 5ia1:A, 5ia2:A, 5ia3:A, 5ia4:A, 5ia5:A, 7kja:A, 7kja:B, 7kjc:B, 1mqb:A, 1mqb:B, 5njz:A, 5nk0:A, 5nk1:A, 5nk2:A, 5nk3:A, 5nk4:A, 5nk5:A, 5nk6:A, 5nk7:A, 5nk8:A, 5nk9:A, 5nka:A, 5nkb:A, 5nkc:A, 5nkd:A, 5nke:A, 5nkf:A, 5nkg:A, 5nkh:A, 5nki:A, 6q7b:A, 6q7c:A, 6q7d:A, 6q7e:A, 6q7f:A, 6q7g:A, 8qqy:A, 8xpv:A

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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