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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
GRMHSRGKGISSSALPYKRTPPSWVKTAVADVDELITKAAKKGQMPSQIGVLLRDQHGIPLVKSVTGSKILRILKAHGLA
PEIPEDLYFLIKKAVAIRKHLERNRKDKDSKFRLILVESRIHRLARYYKRTKKLPPTWKYESATASTLVA

The query sequence (length=150) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8ip8:pa 150 150 1.0000 1.0000 1.0000 3.13e-107 8ip9:pa, 8ipa:pa, 8ipb:pa, 8jiw:BN, 8r6f:N, 4v3p:SO, 4v7e:BN, 1ysh:E
2 7qix:R 150 150 0.8600 0.8600 0.8600 2.37e-90 8auv:W, 8b2l:W1, 7qiz:HA
3 7olc:SN 150 150 0.7667 0.7667 0.7667 4.96e-82 7old:SN, 8oo0:SN, 7r81:O2, 6rxx:Ch, 7z3n:SN, 7z3o:SN
4 5xxu:N 150 150 0.7600 0.7600 0.7600 3.00e-81
5 6fyx:N 151 149 0.7200 0.7152 0.7248 2.87e-77 7a1g:Y, 7ajt:DN, 7aju:DN, 7b7d:Y, 8bn3:C3, 8bqd:Y, 8bqx:Y, 8c00:Y, 8c01:Y, 8c3a:P, 8c3a:DA, 8c83:Y, 8cah:Y, 8cas:Y, 8cbj:N, 8ccs:p, 8cdl:p, 8cdr:p, 8ceh:p, 8cf5:p, 8cg8:p, 8cgn:p, 8civ:p, 8cku:p, 8cmj:p, 8cq7:P, 8cq7:DA, 8cqw:P, 8cqw:DA, 8cre:P, 8cre:DA, 7d4i:SO, 7d5s:SO, 7d5t:SO, 7d63:SO, 5dat:C3, 5dat:c3, 5dc3:C3, 5dc3:c3, 5dge:C3, 5dge:c3, 5dgf:C3, 5dgf:c3, 5dgv:C3, 5dgv:c3, 6eml:Y, 8eub:BN, 8evp:BN, 8evq:BN, 8evr:BN, 8evs:BN, 8evt:BN, 8ewb:BN, 8ewc:BN, 6fai:N, 5fci:C3, 5fci:c3, 5fcj:C3, 5fcj:c3, 6fyy:N, 6gq1:AD, 6gqb:AD, 6gqv:AD, 6gsm:N, 6gsn:N, 6hhq:O, 6hhq:c3, 5i4l:C3, 5i4l:c3, 6i7o:Y, 6i7o:Yb, 8i7j:N, 5it7:N, 5it9:N, 3j6x:13, 3j6y:13, 3j77:13, 3j78:13, 3j80:N, 3j81:N, 3jam:N, 3jap:N, 5juo:KB, 5jup:KB, 5jus:KB, 5jut:KB, 5juu:KB, 8k2d:SN, 8k82:SN, 6ke6:SO, 5ll6:Y, 6lqp:SO, 6lqq:SO, 6lqr:SO, 6lqs:SO, 6lqt:SO, 6lqu:SO, 5lyb:C3, 5lyb:c3, 5m1j:N2, 5mc6:Y, 5mei:O, 5mei:c3, 7mpi:BN, 7mpj:BN, 7n8b:BN, 5ndg:C3, 5ndg:c3, 5ndv:C3, 5ndv:c3, 5ndw:C3, 5ndw:c3, 7nrc:SY, 7nrd:SY, 5obm:C3, 5obm:c3, 8oeq:P, 8oeq:DA, 5on6:O, 5on6:c3, 7osa:uS15, 7osm:uS15, 7pzy:O, 7q08:O, 7q0f:O, 7q0p:O, 7q0r:O, 8q5i:O, 6q8y:Y, 6rbd:N, 6rbe:N, 7rr5:SN, 8rw1:N, 6s47:BO, 8s8d:N, 8s8e:N, 8s8f:N, 8s8g:N, 8s8h:N, 8s8i:N, 8s8j:N, 6snt:N, 7suk:NF, 6sv4:Y, 6sv4:Yb, 6sv4:Yc, 6t4q:SN, 6t7i:SN, 6t7t:SN, 6t83:Nb, 6t83:o, 5tbw:O, 5tbw:c3, 6tb3:Y, 5tga:C3, 5tga:c3, 5tgm:C3, 5tgm:c3, 6tnu:Y, 4u3m:C3, 4u3m:c3, 4u3n:C3, 4u3n:c3, 4u3u:C3, 4u3u:c3, 4u4n:C3, 4u4n:c3, 4u4o:C3, 4u4o:c3, 4u4q:C3, 4u4q:c3, 4u4r:C3, 4u4r:c3, 4u4u:C3, 4u4u:c3, 4u4y:C3, 4u4y:c3, 4u4z:C3, 4u4z:c3, 4u50:C3, 4u50:c3, 4u51:C3, 4u51:c3, 4u52:C3, 4u52:c3, 4u53:C3, 4u53:c3, 4u55:C3, 4u55:c3, 4u56:C3, 4u56:c3, 4u6f:C3, 4u6f:c3, 4uer:O, 6uz7:N, 4v4b:AO, 4v6i:AO, 4v7h:AO, 4v7r:AG, 4v7r:CG, 4v88:AN, 4v88:CN, 4v8y:AN, 4v8z:AN, 4v92:BN, 6wdr:N, 5wlc:NF, 6woo:NN, 7wtl:SN, 7wtm:SN, 7wtn:SN, 7wto:SN, 7wtp:SN, 7wtq:SN, 7wtr:SN, 5wyj:SO, 5wyk:SO, 6xiq:AD, 6xir:AD, 8y0u:SN, 6y7c:N, 6z6j:SN, 6z6k:SN, 6zce:O, 7zpq:AN, 6zqa:DN, 6zqb:DN, 6zqc:DN, 6zqd:DN, 6zqe:DN, 6zqf:DN, 6zqg:DN, 7zrs:AN, 6zu9:Y, 7zuw:AN, 7zux:DN, 6zvi:v, 7zw0:sY
6 7a01:F3 150 150 0.7200 0.7200 0.7200 6.73e-76 7a09:m, 5a2q:N, 5aj0:BN, 9bdl:AS13, 9bdn:AS13, 9bdp:AS13, 8bhf:O3, 9bkd:I, 9bln:I, 8btk:Am, 7cpu:SN, 7cpv:SN, 4d5l:N, 4d61:N, 6d90:OO, 6d9j:OO, 9f1b:Am, 9f1c:Am, 9f1d:Am, 6fec:Z, 5flx:N, 6g18:N, 6g4s:N, 6g4w:N, 6g51:N, 6g53:N, 6g5h:N, 6g5i:N, 8g5y:SN, 8g5z:SN, 8g60:SN, 8g61:SN, 8g6j:SN, 8glp:SN, 6gz3:BN, 6gz4:BN, 6gz5:BN, 6hcf:O1, 6hcj:O2, 6hcm:O1, 6hcq:O2, 8ifd:3K, 8ife:3K, 6ip5:3K, 6ip6:3K, 6ip8:3K, 3j7p:SN, 3j7r:SN, 3jag:NN, 3jah:NN, 3jai:NN, 3jaj:SN, 3jan:SN, 8jdj:9, 8jdk:9, 8jdl:9, 8jdm:9, 7jqb:P, 7jqc:P, 5k0y:Z, 8k2c:SN, 7k5i:N, 4kzx:N, 4kzy:N, 4kzz:N, 5lks:SN, 7ls1:N3, 7ls2:N3, 5lzs:NN, 5lzt:NN, 5lzu:NN, 5lzv:NN, 5lzw:NN, 5lzx:NN, 5lzy:NN, 5lzz:NN, 7mdz:NN, 7mq8:NF, 7mq9:NF, 7mqa:NF, 6mtb:NN, 6mtc:NN, 6mtd:NN, 6mte:NN, 7nwg:O2, 7nwh:NN, 7nwi:NN, 7o7y:Am, 7o7z:Am, 7o80:Am, 7o81:Am, 5oa3:N, 6ole:SN, 6olf:SN, 6olg:BN, 6oli:SN, 6olz:BN, 6om0:SN, 6om7:SN, 5oql:s, 7oya:N2, 7oyb:N2, 7oyc:N2, 7oyd:NN, 8oz0:V, 8p03:P, 8p09:P, 8p2k:Am, 6p4g:O, 6p4h:O, 6p5i:O, 6p5j:O, 6p5k:O, 6p5n:O, 8pj1:I, 8pj2:I, 8pj3:I, 8pj4:I, 8pj5:I, 8pj6:I, 8ppk:N, 8ppl:AN, 8q7z:Am, 8q87:Am, 7qgg:SN, 8qoi:SN, 7qp6:I, 7qp7:I, 7qvp:RN, 7qvp:SN, 6qzp:SN, 7r4x:N, 6r5q:QQ, 6r6g:QQ, 6r6p:QQ, 6r7q:QQ, 8rg0:I, 6rxt:Ch, 6rxu:Ch, 6rxv:Ch, 6rxy:Ch, 6rxz:Ch, 8scb:NN, 6sgc:O1, 7syg:O, 7syh:O, 7syi:O, 7syj:O, 7syk:O, 7syl:O, 7sym:O, 7syn:O, 7syo:O, 7syp:O, 7syq:O, 7syr:O, 7sys:O, 7syt:O, 7syu:O, 7syv:O, 7syw:O, 7syx:O, 5t2c:AN, 8t4s:N, 7toq:AS13, 7tor:AS13, 7tql:N, 7ucj:NN, 7uck:NN, 4ug0:SN, 4ujc:CN, 4ujd:CN, 4uje:BN, 4v6x:AN, 5vyc:N1, 5vyc:N2, 5vyc:N3, 5vyc:N4, 5vyc:N5, 5vyc:N6, 6w2s:O, 6w2t:O, 7wts:N, 7wtt:N, 7wtu:N, 7wtv:N, 7wtw:N, 7wtx:N, 7wtz:N, 7wu0:N, 6xa1:SN, 7xnx:SN, 7xny:SN, 8xsx:SN, 8xsy:SN, 8xsz:SN, 8xxl:SN, 8xxm:SN, 8xxn:SN, 6y0g:SN, 8y0w:SN, 8y0x:SN, 6y2l:SN, 6y57:SN, 6yal:P, 6yam:P, 6yan:P, 6ybw:I, 8yoo:SN, 8yop:SN, 6z6l:SN, 6z6m:SN, 6z6n:SN, 7zjw:SY, 7zjx:SY, 6zlw:N, 6zm7:SN, 6zme:SN, 6zmi:SN, 6zmo:SN, 6zmt:N, 6zmw:I, 6zn5:N, 6zoj:N, 6zok:N, 6zon:m, 6zp4:m, 6zuo:N, 6zv6:N, 6zvh:N, 6zvj:m, 6zvk:F3, 6zxd:N, 6zxe:N, 6zxf:N, 6zxg:N, 6zxh:N
7 6zj3:ST 148 149 0.7133 0.7230 0.7181 1.80e-74
8 4v6w:AN 150 150 0.7133 0.7133 0.7133 4.94e-74 6xu6:AN, 6xu7:AN, 6xu8:AN
9 3j7a:U 149 149 0.6800 0.6846 0.6846 8.27e-74 3jbn:U, 3jbo:U, 3jbp:U, 6okk:U, 8tpu:SU
10 8ova:AG 150 149 0.6867 0.6867 0.6913 1.04e-72 7ase:R, 5opt:R, 8ove:AG, 4v8m:AG
11 8fvy:N 153 150 0.7000 0.6863 0.7000 8.26e-72 8br8:SP, 8brm:SP, 8bsi:SP, 8bsj:SP, 8btd:SP, 8btr:SP, 8g4s:N, 7pwf:N, 7pwo:N1
12 9bh5:AN 151 150 0.6667 0.6623 0.6667 9.42e-72 9cai:AN
13 4bts:AO 152 148 0.6733 0.6645 0.6824 1.07e-70 4bts:BO, 4bts:CO, 4bts:DO, 4v5o:AO, 4v5o:BO
14 8ovj:ST 143 141 0.6467 0.6783 0.6879 1.10e-70 8a3w:ST, 8a98:ST, 6az1:T, 8rxh:ST, 8rxx:ST, 5t2a:AG
15 5xyi:N 150 150 0.5933 0.5933 0.5933 6.24e-64
16 6zu5:SN0 142 139 0.4867 0.5141 0.5252 1.68e-47
17 6tmf:R 151 149 0.5000 0.4967 0.5034 1.37e-46 6skf:Aq, 6skg:Aq, 6th6:Aq
18 5jb3:Q 158 156 0.5067 0.4810 0.4872 2.43e-44 5jbh:Q, 6sw9:Q, 6swc:Q, 6swd:Q, 4v4n:BQ, 4v6u:AQ, 7zag:Q, 7zah:Q, 7zai:Q, 7zhg:Q
19 8hkx:S15P 149 145 0.4733 0.4765 0.4897 1.74e-39 8hky:S15P, 8hkz:S15P, 8hl1:S15P, 8hl2:S15P, 8hl3:S15P, 8hl4:S15P, 8hl5:S15P, 8wkp:S15P, 8wq2:S15P, 8wq4:S15P
20 8p5d:SN0 142 139 0.4267 0.4507 0.4604 3.90e-39 8p60:SN0, 8p60:RN0, 7qca:SN0
21 7qep:C3 146 138 0.3933 0.4041 0.4275 1.21e-35
22 6rm3:SN0 147 140 0.3600 0.3673 0.3857 2.69e-31
23 3e2y:A 410 59 0.0867 0.0317 0.2203 0.87 3e2y:B, 3e2z:A, 3e2z:B, 5vep:A, 5veq:A, 5veq:B, 5ver:A, 5ver:B
24 3mk0:A 481 72 0.1667 0.0520 0.3472 2.2 1ew2:A, 2glq:A, 3mk1:A, 3mk2:A, 1zeb:A, 1zed:A, 1zef:A
25 6tux:A 330 25 0.0800 0.0364 0.4800 2.7 6tuw:A, 6tux:B
26 2wjy:A 773 27 0.0733 0.0142 0.4074 2.7 2gjk:A, 2gk6:A, 2gk6:B, 2gk7:A, 8rxb:E, 8rxb:A, 8rxb:D, 8rxb:I, 8rxb:L, 8rxb:P, 2wjv:A, 2wjv:B, 2xzo:A
27 6l8u:C 229 44 0.0867 0.0568 0.2955 4.4 6l8u:A, 6l8u:B, 6l8u:D
28 8x5v:A 892 23 0.0600 0.0101 0.3913 5.6
29 8zjf:B 510 36 0.0867 0.0255 0.3611 6.2 3v4p:B, 3v4p:D, 3v4v:B, 3v4v:D
30 3mmt:A 341 39 0.1000 0.0440 0.3846 9.0 3mmt:B, 3mmt:C, 3mmt:D
31 6vd1:A 395 35 0.1000 0.0380 0.4286 9.3 6vcy:A, 6vd0:A, 6vd0:B, 6vd0:C, 6vd0:D, 6vd1:B, 6vd2:A, 6vd2:B
32 4b4a:A 225 39 0.1000 0.0667 0.3846 9.6

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218