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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
GMRRTHYAGSLRETHVGEEVVLEGWVNRRRDLGGLIFLDLRDREGLVQLVAHPASPAYATAERVRPEWVVRAKGLVRLRP
EPNPRLATGRVEVELSALEVLAEAKTPPFPVDAGWRGEEEKEASEELRLKYRYLDLRRRRMQENLRLRHRVIKAIWDFLD
REGFVQVETPFLTKSPEGARDFLVPYRHEPGLFYALPQSPQLFKQMLMVAGLDRYFQIARCFRDEDLRADRQPDFTQLDL
EMSFVEVEDVLELNERLMAHVFREALGVELPLPFPRLSYEEAMERYGSDKPDLRFGLELKEVGPLFRQSGFRVFQEAESV
KALALPKALSRKEVAELEEVAKRHKAQGLAWARVEEGGFSGGVAKFLEPVREALLQATEARPGDTLLFVAGPRKVAATAL
GAVRLRAADLLGLKREGFRFLWVVDFPLLEWDEEEEAWTYMHHPFTSPHPEDLPLLEKDPGRVRALAYDLVLNGVEVGGG
SIRIHDPRLQARVFRLLGIGEEEQREKFGFFLEALEYGAPPHGGIAWGLDRLLALMTGSPSIREVIAFPKNKEGKDPLTG
APSPVPEEQLRELGLMVVRP

The query sequence (length=580) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 6sjc:B 581 581 1.0000 0.9983 0.9983 0.0 7ap4:A, 7ap4:B, 1efw:A, 1efw:B, 1g51:A, 1g51:B, 6hhv:A, 6hhv:B, 6hhw:A, 6hhw:B, 6hhx:A, 6hhx:B, 6sjc:A
2 4o2d:A 580 590 0.5241 0.5241 0.5153 0.0 4rmf:A
3 4wj3:M 589 589 0.5103 0.5025 0.5025 0.0 4wj3:N, 4wj3:O, 4wj3:P, 4wj4:A
4 5w25:A 583 589 0.5172 0.5146 0.5093 0.0 5w25:B
5 1c0a:A 585 594 0.4948 0.4906 0.4832 2.06e-179 1il2:A, 1il2:B
6 4o2d:B 515 586 0.4793 0.5398 0.4744 8.24e-166
7 1b8a:A 438 322 0.1862 0.2466 0.3354 1.87e-38 1b8a:B, 3nel:A, 3nem:A, 3nem:B
8 1b8a:A 438 86 0.0586 0.0776 0.3953 6.53e-11 1b8a:B, 3nel:A, 3nem:A, 3nem:B
9 4up7:A 529 308 0.1414 0.1550 0.2662 1.35e-22 4up9:A, 4upa:A
10 4up7:A 529 86 0.0448 0.0491 0.3023 5.38e-05 4up9:A, 4upa:A
11 1e1t:A 485 321 0.1517 0.1814 0.2741 2.57e-22 1e1o:A, 1e22:A, 1e24:A, 1lyl:A, 1lyl:B, 1lyl:C, 5yzx:A, 5yzx:B, 5yzx:C
12 1e1t:A 485 86 0.0517 0.0619 0.3488 3.38e-08 1e1o:A, 1e22:A, 1e24:A, 1lyl:A, 1lyl:B, 1lyl:C, 5yzx:A, 5yzx:B, 5yzx:C
13 1bbu:A 486 295 0.1466 0.1749 0.2881 3.45e-22
14 1bbu:A 486 86 0.0500 0.0597 0.3372 3.40e-07
15 4ex5:A 486 352 0.1603 0.1914 0.2642 1.50e-20 4ex5:B
16 4ex5:A 486 123 0.0724 0.0864 0.3415 2.72e-11 4ex5:B
17 3kfu:C 377 284 0.1466 0.2255 0.2993 3.13e-20 3kfu:A, 3kfu:D, 3kfu:B
18 3kfu:C 377 84 0.0552 0.0849 0.3810 3.10e-08 3kfu:A, 3kfu:D, 3kfu:B
19 1x54:A 434 315 0.1466 0.1959 0.2698 9.41e-20 1x55:A
20 1x54:A 434 77 0.0397 0.0530 0.2987 0.38 1x55:A
21 1asy:A 490 282 0.1397 0.1653 0.2872 1.66e-19 1asy:B, 1asz:A, 1asz:B
22 1asy:A 490 85 0.0448 0.0531 0.3059 1.10e-05 1asy:B, 1asz:A, 1asz:B
23 6chd:A 506 325 0.1328 0.1522 0.2369 3.32e-19 3bju:A, 3bju:B, 3bju:C, 3bju:D, 6chd:B, 4dpg:A, 4dpg:B, 4dpg:C, 4dpg:D, 4dpg:E, 4dpg:F, 4dpg:G, 4dpg:H, 7ea9:A, 7ea9:B, 7ea9:C, 7ea9:D, 6ild:A, 6ild:B, 6ilh:A, 6ilh:B, 4ycu:A, 4ycu:B, 4ycw:A, 4ycw:B, 4ycw:E, 4ycw:F
24 6chd:A 506 120 0.0603 0.0692 0.2917 2.23e-06 3bju:A, 3bju:B, 3bju:C, 3bju:D, 6chd:B, 4dpg:A, 4dpg:B, 4dpg:C, 4dpg:D, 4dpg:E, 4dpg:F, 4dpg:G, 4dpg:H, 7ea9:A, 7ea9:B, 7ea9:C, 7ea9:D, 6ild:A, 6ild:B, 6ilh:A, 6ilh:B, 4ycu:A, 4ycu:B, 4ycw:A, 4ycw:B, 4ycw:E, 4ycw:F
25 6bni:A 502 274 0.1328 0.1534 0.2810 2.55e-18 6bni:B, 6c86:A, 6c86:B, 5eln:A, 5eln:B, 5eln:C, 5eln:D, 5elo:A, 5elo:B, 5elo:C, 5elo:D, 6hcw:A, 6hcw:B, 7zog:A, 7zog:B, 7zog:C, 7zog:D
26 6bni:A 502 86 0.0466 0.0538 0.3140 2.81e-04 6bni:B, 6c86:A, 6c86:B, 5eln:A, 5eln:B, 5eln:C, 5eln:D, 5elo:A, 5elo:B, 5elo:C, 5elo:D, 6hcw:A, 6hcw:B, 7zog:A, 7zog:B, 7zog:C, 7zog:D
27 6aqg:C 490 291 0.1466 0.1735 0.2921 1.93e-16 6aqg:A, 6aqg:B, 6aqg:D, 5vl1:A, 5vl1:B, 5vl1:C, 5vl1:D
28 6aqg:C 490 86 0.0569 0.0673 0.3837 1.04e-06 6aqg:A, 6aqg:B, 6aqg:D, 5vl1:A, 5vl1:B, 5vl1:C, 5vl1:D
29 3a74:A 484 253 0.1121 0.1343 0.2569 2.99e-16 3a74:B, 3a74:C, 3a74:D, 3e9h:A, 3e9h:B, 3e9h:C, 3e9h:D, 3e9i:A, 3e9i:B, 3e9i:C, 3e9i:D
30 3a74:A 484 112 0.0759 0.0909 0.3929 8.37e-12 3a74:B, 3a74:C, 3a74:D, 3e9h:A, 3e9h:B, 3e9h:C, 3e9h:D, 3e9i:A, 3e9i:B, 3e9i:C, 3e9i:D
31 5hgq:B 482 139 0.0724 0.0871 0.3022 1.34e-15 5hgq:A, 5hgq:D, 5hgq:C
32 5hgq:B 482 113 0.0586 0.0705 0.3009 4.27e-06 5hgq:A, 5hgq:D, 5hgq:C
33 6aqh:B 490 157 0.0931 0.1102 0.3439 5.33e-15 6aqh:A, 6aqh:C, 6aqh:D
34 6aqh:B 490 89 0.0534 0.0633 0.3483 1.55e-05 6aqh:A, 6aqh:C, 6aqh:D
35 7f6w:A 506 146 0.0741 0.0850 0.2945 5.55e-15
36 7f6w:A 506 122 0.0672 0.0771 0.3197 6.24e-07
37 7qh8:A 471 157 0.0948 0.1168 0.3503 1.74e-14 7qhn:A, 7qi8:A
38 7qh8:A 471 88 0.0586 0.0722 0.3864 1.30e-06 7qhn:A, 7qi8:A
39 6wbd:B 485 282 0.1207 0.1443 0.2482 6.66e-14 6wbd:A
40 6wbd:B 485 131 0.0828 0.0990 0.3664 1.03e-12 6wbd:A
41 5zh2:A 464 176 0.0793 0.0991 0.2614 5.09e-13
42 5zh2:A 464 109 0.0603 0.0754 0.3211 4.39e-08
43 6nrz:A 517 201 0.0879 0.0986 0.2537 1.58e-12 6nrz:B, 6ns0:A, 6ns0:B, 6o3f:A, 6o3f:B
44 6nrz:A 517 39 0.0362 0.0406 0.5385 9.36e-06 6nrz:B, 6ns0:A, 6ns0:B, 6o3f:A, 6o3f:B
45 6agt:B 506 180 0.0793 0.0909 0.2556 1.87e-12 6agt:A, 6agt:C, 6agt:D, 7bt5:A, 7bt5:B, 6hcu:A, 6hcu:B, 6hcv:A, 6hcv:B, 8k9s:A, 8k9s:B, 8k9u:A, 8k9u:B, 8k9v:A, 8k9v:B, 8k9w:A, 8k9w:B, 8k9x:A, 8k9x:B, 6ka6:A, 6ka6:B, 6ka6:C, 6ka6:D, 6kab:A, 6kab:B, 6kab:C, 6kab:D, 6kbf:A, 6kbf:B, 6kcn:A, 6kcn:B, 6kcn:C, 6kcn:D, 6kct:A, 6kct:B, 6kct:C, 6kct:D, 6l3y:B, 6l3y:A, 6l4q:B, 6l4q:A, 6m0t:A, 6m0t:B, 6m0t:C, 6m0t:D, 4pg3:A, 4pg3:B, 4pg3:C, 4pg3:D, 4ycv:A, 4ycv:B, 4ycv:C, 4ycv:D, 5zh2:B, 5zh3:A, 5zh3:B, 5zh4:A, 5zh4:B, 5zh5:A, 5zh5:B
46 6agt:B 506 113 0.0638 0.0731 0.3274 1.44e-08 6agt:A, 6agt:C, 6agt:D, 7bt5:A, 7bt5:B, 6hcu:A, 6hcu:B, 6hcv:A, 6hcv:B, 8k9s:A, 8k9s:B, 8k9u:A, 8k9u:B, 8k9v:A, 8k9v:B, 8k9w:A, 8k9w:B, 8k9x:A, 8k9x:B, 6ka6:A, 6ka6:B, 6ka6:C, 6ka6:D, 6kab:A, 6kab:B, 6kab:C, 6kab:D, 6kbf:A, 6kbf:B, 6kcn:A, 6kcn:B, 6kcn:C, 6kcn:D, 6kct:A, 6kct:B, 6kct:C, 6kct:D, 6l3y:B, 6l3y:A, 6l4q:B, 6l4q:A, 6m0t:A, 6m0t:B, 6m0t:C, 6m0t:D, 4pg3:A, 4pg3:B, 4pg3:C, 4pg3:D, 4ycv:A, 4ycv:B, 4ycv:C, 4ycv:D, 5zh2:B, 5zh3:A, 5zh3:B, 5zh4:A, 5zh4:B, 5zh5:A, 5zh5:B
47 8tc8:A 435 290 0.1379 0.1839 0.2759 2.63e-12 8h53:A, 8h53:B, 8h53:C, 8h53:D, 8tc8:B, 8tc8:C, 8tc8:D, 8tc9:A, 8tc9:B, 8tc9:C, 8tc9:D
48 8tc8:A 435 81 0.0431 0.0575 0.3086 0.001 8h53:A, 8h53:B, 8h53:C, 8h53:D, 8tc8:B, 8tc8:C, 8tc8:D, 8tc9:A, 8tc9:B, 8tc9:C, 8tc9:D
49 3m4p:A 435 294 0.1259 0.1678 0.2483 2.88e-11 3m4p:B, 3m4p:C, 3m4p:D
50 3m4p:A 435 90 0.0466 0.0621 0.3000 2.70e-05 3m4p:B, 3m4p:C, 3m4p:D
51 2xgt:B 433 301 0.1362 0.1824 0.2625 3.22e-09 2xgt:A, 2xti:A, 2xti:B
52 2xgt:B 433 85 0.0466 0.0624 0.3176 7.56e-06 2xgt:A, 2xti:A, 2xti:B
53 3a5z:C 324 165 0.0793 0.1420 0.2788 1.29e-06 3a5y:B, 3a5y:C, 3a5y:D, 3a5z:A, 3a5z:E, 3a5z:G, 3g1z:A, 3g1z:B
54 3a5z:C 324 95 0.0466 0.0833 0.2842 2.09e-04 3a5y:B, 3a5y:C, 3a5y:D, 3a5z:A, 3a5z:E, 3a5z:G, 3g1z:A, 3g1z:B
55 3p8v:A 294 108 0.0621 0.1224 0.3333 1.55e-06 3p8v:B, 3p8y:A, 3p8y:B, 3reu:A, 3reu:B, 3rex:A, 3rex:B, 3rl6:A, 3rl6:B
56 3a5y:A 297 124 0.0655 0.1279 0.3065 1.94e-06
57 3a5y:A 297 95 0.0466 0.0909 0.2842 2.85e-04
58 8ppt:A 447 68 0.0431 0.0559 0.3676 0.035 6hmf:A, 6hmf:B, 5ihe:A, 5ihe:B, 8ppu:A, 8ppv:A, 6t8h:A
59 7z8n:A 292 248 0.1086 0.2158 0.2540 0.18 7z8n:B
60 7aoi:BI 323 63 0.0345 0.0619 0.3175 0.29 6hiv:BI, 6hix:BI, 6yxx:BI, 6yxy:BI
61 8cip:A 665 89 0.0483 0.0421 0.3146 0.46 8cip:B, 8cip:C, 8cip:D
62 3i54:D 228 129 0.0569 0.1447 0.2558 0.58 4a2u:A, 4a2u:B, 4a2u:C, 4a2u:D, 4a2u:E, 4a2u:F, 4a2u:G, 4a2u:H, 3h3u:B, 3i54:A, 3i54:B, 3i54:C, 3i59:A, 3i59:B, 3mzh:A, 3mzh:B
63 1iyz:A 299 42 0.0328 0.0635 0.4524 1.6
64 8po7:A 594 49 0.0276 0.0269 0.3265 1.6
65 6dj8:A 384 27 0.0224 0.0339 0.4815 3.7 6dj8:B
66 6llz:A 436 66 0.0310 0.0413 0.2727 4.0 7cyw:A, 6llw:A, 6llw:B, 6llz:B
67 5gug:A 1721 78 0.0448 0.0151 0.3333 4.2 5gug:B, 1n4k:A, 3t8s:B, 3uj0:A, 3uj0:B, 5xa1:A, 5xa1:B
68 7agb:A 339 28 0.0190 0.0324 0.3929 4.2 7agb:B, 7agb:C, 7agb:D, 7agc:D, 7agc:A, 7agc:B, 7agc:F, 7agd:A, 7agd:B, 7agd:C, 7agd:D, 7age:A, 7age:B, 7age:D, 7age:F, 3fv3:A, 3fv3:B, 3fv3:C, 3fv3:D, 3fv3:E, 3fv3:F, 3fv3:G, 3fv3:H, 3tne:A, 3tne:B
69 6l5s:A 454 66 0.0397 0.0507 0.3485 4.5 6l5p:A, 6l5q:A, 6l5r:A, 6l7h:A
70 7wq5:A 172 48 0.0328 0.1105 0.3958 5.4 7wq5:B
71 2zni:A 279 192 0.0879 0.1828 0.2656 6.2 2zni:B
72 6lg1:A 429 49 0.0345 0.0466 0.4082 6.8 6lg1:B
73 7ye1:D 1144 62 0.0293 0.0149 0.2742 6.8 7ye2:D
74 8ita:A 429 47 0.0328 0.0443 0.4043 9.4 8inp:A

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218