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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
GISRDSRHKRSHTGAKRAFYRKKRAFELGRQPANTRIGPKRIHIVRTRGGNHKYRALRLDSGNFAWGSEGCTRKTRIIGV
VYHPSNNELVRTNTLTKSAVVQIDAAPFRQWYEAHYGQPLGRRRQQKQGQVVEEVKKSKSVEKKQAARFAAHGKVDPALE
KQFEAGRLYAIISSRPGQSGRADGYILEGEELAFYQRKLHK

The query sequence (length=201) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 7olc:SI 201 201 1.0000 1.0000 1.0000 3.01e-149 7old:SI, 8oo0:SI, 5oql:q, 7r81:J2, 7z3n:SI, 7z3o:SI
2 6rxu:Cf 174 201 0.8657 1.0000 0.8657 9.96e-124 6rxv:Cf, 6rxx:Cf, 6rxz:Cf
3 8bn3:S8 188 199 0.7214 0.7713 0.7286 7.44e-102 7a1g:V, 7ajt:DI, 7aju:DI, 7b7d:V, 8bqd:V, 8bqx:V, 8c00:V, 8c01:V, 8c83:V, 8cah:V, 8cas:V, 8cbj:I, 8ccs:l, 8cdl:l, 8cdr:l, 8ceh:l, 8cf5:l, 8cg8:l, 8cgn:l, 8civ:l, 8cku:l, 8cmj:l, 5dat:S8, 5dat:s8, 5dc3:S8, 5dc3:s8, 5dge:S8, 5dge:s8, 5dgf:S8, 5dgf:s8, 5dgv:S8, 5dgv:s8, 6eml:V, 8eub:BI, 8evp:BI, 8evq:BI, 8evr:BI, 8evs:BI, 8evt:BI, 8ewb:BI, 8ewc:BI, 6fai:I, 5fci:S8, 5fci:s8, 5fcj:S8, 5fcj:s8, 6gq1:y, 6gqb:y, 6gqv:y, 6hhq:J, 6hhq:s8, 5i4l:S8, 5i4l:s8, 6i7o:V, 6i7o:Vb, 3j6x:S8, 3j6y:S8, 3j77:S8, 3j78:S8, 5juo:FB, 5jup:FB, 5jus:FB, 5jut:FB, 5juu:FB, 8k2d:SI, 8k82:SI, 5ll6:V, 5lyb:S8, 5lyb:s8, 5m1j:I2, 5mc6:V, 5mei:J, 5mei:s8, 7mpi:BI, 7mpj:BI, 7n8b:BI, 5ndg:S8, 5ndg:s8, 5ndv:S8, 5ndv:s8, 5ndw:S8, 5ndw:s8, 7nrc:SV, 7nrd:SV, 5obm:S8, 5obm:s8, 5on6:J, 5on6:s8, 7osa:eS8, 7osm:eS8, 6q8y:V, 6rbd:I, 6rbe:I, 7rr5:SI, 6s47:BJ, 6snt:I, 7suk:L8, 6sv4:V, 6sv4:Vb, 6sv4:Vc, 6t4q:SI, 6t7i:SI, 6t7t:SI, 6t83:Ib, 6t83:j, 5tbw:J, 5tbw:s8, 6tb3:V, 5tga:S8, 5tga:s8, 5tgm:S8, 5tgm:s8, 6tnu:V, 5tzs:8, 4u3m:S8, 4u3m:s8, 4u3n:S8, 4u3n:s8, 4u3u:S8, 4u3u:s8, 4u4n:S8, 4u4n:s8, 4u4o:S8, 4u4o:s8, 4u4q:S8, 4u4q:s8, 4u4r:S8, 4u4r:s8, 4u4u:S8, 4u4u:s8, 4u4y:S8, 4u4y:s8, 4u4z:S8, 4u4z:s8, 4u50:S8, 4u50:s8, 4u51:S8, 4u51:s8, 4u52:S8, 4u52:s8, 4u53:S8, 4u53:s8, 4u55:S8, 4u55:s8, 4u56:S8, 4u56:s8, 4u6f:S8, 4u6f:s8, 4uer:2, 4v88:AI, 4v88:CI, 4v8y:AI, 4v8z:AI, 4v92:BI, 6wdr:I, 5wlc:L8, 6woo:II, 7wtl:SI, 7wtm:SI, 7wtn:SI, 7wto:SI, 7wtp:SI, 7wtq:SI, 7wtr:SI, 6xiq:y, 6xir:y, 8y0u:SI, 6y7c:I, 6z6j:SI, 6z6k:SI, 6zce:J, 7zpq:AI, 6zqb:DI, 6zqc:DI, 6zqd:DI, 6zqe:DI, 6zqf:DI, 6zqg:DI, 7zrs:AI, 6zu9:V, 7zuw:AI, 7zux:DI, 6zvi:q, 7zw0:sV
4 8c3a:K 203 202 0.7264 0.7192 0.7228 8.20e-101 8c3a:CV, 8cq7:K, 8cq7:CV, 8cqw:K, 8cqw:CV, 8cre:K, 8cre:CV, 8oeq:K, 8oeq:CV, 7pzy:J, 7q08:J, 7q0f:J, 7q0p:J, 7q0r:J, 8q5i:J
5 6fyx:I 188 199 0.7065 0.7553 0.7136 3.21e-98 6fyy:I, 6gsm:I, 6gsn:I, 8i7j:I, 5it7:I, 5it9:I, 3j80:I, 3j81:I, 3jam:I, 3jap:I, 8rw1:I, 8s8d:I, 8s8e:I, 8s8f:I, 8s8g:I, 8s8h:I, 8s8i:I, 8s8j:I, 6uz7:I
6 5wyj:SJ 170 199 0.6617 0.7824 0.6683 1.12e-92 7d4i:SJ, 7d5t:SJ, 7d63:SJ, 6ke6:SJ, 6lqp:SJ, 6lqq:SJ, 6lqr:SJ, 6lqs:SJ, 6lqt:SJ, 6lqu:SJ, 6lqv:SJ, 5wyk:SJ
7 5aj0:BI 207 201 0.6070 0.5894 0.6070 5.81e-82 7a01:c3, 7a09:t, 5a2q:I, 9bdl:AS08, 9bdn:AS08, 9bdp:AS08, 8bhf:J3, 9bkd:R, 9bln:R, 8btk:Ah, 7cpu:SI, 7cpv:SI, 4d5l:I, 4d61:I, 6d90:JJ, 6d9j:JJ, 9f1b:Ah, 9f1c:Ah, 9f1d:Ah, 6fec:o, 5flx:I, 6g18:I, 6g4s:I, 6g4w:I, 6g51:I, 6g53:I, 6g5h:I, 6g5i:I, 8g5y:SI, 8g5z:SI, 8g60:SI, 8g61:SI, 8g6j:SI, 8glp:SI, 6gz3:BI, 6gz4:BI, 6gz5:BI, 6hcf:J1, 6hcj:J2, 6hcm:J1, 6hcq:J2, 8ifd:2t, 8ife:2t, 6ip5:2t, 6ip6:2t, 6ip8:2t, 3j7p:SI, 3j7r:SI, 3jag:II, 3jah:II, 3jai:II, 3jaj:SI, 3jan:SI, 8jdj:5, 8jdk:5, 8jdl:5, 8jdm:5, 7jqb:J, 7jqc:J, 5k0y:o, 8k2c:SI, 7k5i:I, 4kzx:I, 4kzy:I, 4kzz:I, 5lks:SI, 7ls1:u, 7ls2:u, 5lzs:II, 5lzt:II, 5lzu:II, 5lzv:II, 5lzw:II, 5lzx:II, 5lzy:II, 5lzz:II, 7mdz:II, 6mtb:II, 6mtc:II, 6mtd:II, 6mte:II, 7nwg:J2, 7nwh:II, 7nwi:II, 7o7y:Ah, 7o7z:Ah, 7o80:Ah, 7o81:Ah, 5oa3:I, 6ole:SI, 6olf:SI, 6olg:BI, 6oli:SI, 6olz:BI, 6om0:SI, 6om7:SI, 7oya:I2, 7oyb:I2, 7oyc:I2, 7oyd:II, 8oz0:d, 8p03:K, 8p09:K, 8p2k:Ah, 6p4g:J, 6p4h:J, 6p5i:J, 6p5j:J, 6p5k:J, 6p5n:J, 8pj1:R, 8pj2:R, 8pj3:R, 8pj4:R, 8pj5:R, 8pj6:R, 8ppk:I, 8ppl:AI, 8q7z:Ah, 8q87:Ah, 7qgg:SI, 8qoi:SI, 7qp6:R, 7qp7:R, 7qvp:SI, 7qvp:RI, 6qzp:SI, 7r4x:I, 6r5q:CC, 6r6g:CC, 6r6p:CC, 6r7q:CC, 8scb:II, 6sgc:J1, 7syg:J, 7syh:J, 7syi:J, 7syj:J, 7syk:J, 7syl:J, 7sym:J, 7syn:J, 7syo:J, 7syp:J, 7syq:J, 7syr:J, 7sys:J, 7syt:J, 7syu:J, 7syv:J, 7syw:J, 7syx:J, 5t2c:Au, 8t4s:I, 7toq:AS08, 7tor:AS08, 7tql:I, 7ucj:II, 7uck:II, 4ug0:SI, 4ujc:CI, 4ujd:CI, 4uje:BI, 4v6x:AI, 5vyc:I1, 5vyc:I3, 5vyc:I2, 5vyc:I4, 5vyc:I6, 5vyc:I5, 6w2s:J, 6w2t:J, 7wts:I, 7wtt:I, 7wtu:I, 7wtv:I, 7wtw:I, 7wtx:I, 7wtz:I, 7wu0:I, 6xa1:SI, 7xnx:SI, 7xny:SI, 8xsx:SI, 8xsy:SI, 8xsz:SI, 8xxl:SI, 8xxm:SI, 8xxn:SI, 6y0g:SI, 8y0w:SI, 8y0x:SI, 6y2l:SI, 6y57:SI, 6yal:K, 6yam:K, 6yan:K, 6ybw:R, 8yoo:SI, 8yop:SI, 6z6l:SI, 6z6m:SI, 6z6n:SI, 7zjw:ST, 7zjx:ST, 6zlw:I, 6zm7:SI, 6zme:SI, 6zmi:SI, 6zmo:SI, 6zmt:I, 6zmw:R, 6zn5:I, 6zoj:I, 6zok:I, 6zon:t, 6zp4:t, 6zuo:I, 6zv6:I, 6zvh:I, 6zvj:t, 6zvk:c3, 6zxd:I, 6zxe:I, 6zxf:I, 6zxg:I, 6zxh:I
8 7mq8:L8 180 199 0.5821 0.6500 0.5879 6.82e-82 7mq9:L8, 7mqa:L8
9 4v6w:AI 207 204 0.6368 0.6184 0.6275 5.89e-79 6xu6:AI, 6xu7:AI, 6xu8:AI
10 8jiw:BI 186 202 0.5821 0.6290 0.5792 9.11e-78 8ip8:ca, 8ip9:ca, 8ipa:ca, 8ipb:ca, 8r6f:I
11 9bh5:AI 207 202 0.5821 0.5652 0.5792 2.51e-76 9cai:AI
12 5xxu:I 185 206 0.5572 0.6054 0.5437 9.87e-75
13 8auv:P 186 202 0.5970 0.6452 0.5941 3.85e-73 8b2l:P1, 7qix:I, 7qiz:y
14 5xyi:I 166 199 0.5174 0.6265 0.5226 3.90e-67
15 4bts:A2 207 208 0.5373 0.5217 0.5192 1.05e-65 4bts:B2, 4bts:C2, 4bts:D2, 5jpq:t, 4v5o:A2, 4v5o:B2
16 4v8m:A5 194 201 0.5025 0.5206 0.5025 2.17e-63 7ase:Z, 5opt:Z, 8ova:A5, 8ove:A5
17 8rxx:SK 198 201 0.4826 0.4899 0.4826 1.35e-61 8a3w:SK, 8a98:SK, 6az1:K, 8ovj:SK, 8rxh:SK, 5t2a:5
18 3j7a:L 172 198 0.4776 0.5581 0.4848 8.45e-60 3jbn:L, 3jbo:L, 3jbp:L, 6okk:L, 8tpu:SL
19 6zu5:SI0 169 199 0.4378 0.5207 0.4422 2.68e-55
20 8p5d:SI0 167 201 0.4677 0.5629 0.4677 5.83e-55 8p60:SI0, 8p60:RI0, 7qca:SI0
21 7qep:S8 164 200 0.4478 0.5488 0.4500 9.34e-51
22 6zj3:SK 199 200 0.4826 0.4874 0.4850 2.32e-48
23 8br8:SI 173 208 0.4428 0.5145 0.4279 2.22e-47 8brm:SI, 8bsi:SI, 8bsj:SI, 8btd:SI, 8btr:SI, 8fvy:I, 8g4s:I, 7pwf:I, 7pwo:I1
24 6rm3:SI0 158 195 0.3532 0.4494 0.3641 3.33e-36
25 4v7e:BI 66 63 0.1741 0.5303 0.5556 1.35e-16
26 6tmf:K 126 101 0.1891 0.3016 0.3762 6.05e-14
27 6skf:Ak 125 100 0.1891 0.3040 0.3800 7.60e-14 6skg:Ak, 6th6:Ak
28 5jb3:J 127 101 0.1891 0.2992 0.3762 2.91e-13 5jbh:J, 6sw9:J, 6swc:J, 6swd:J, 4v4n:BJ, 4v6u:AJ, 7zag:J, 7zah:J, 7zai:J, 7zhg:J
29 8hkx:AS8E 126 96 0.1542 0.2460 0.3229 2.94e-07 8hky:AS8E, 8hkz:AS8E, 8hl1:AS8E, 8hl2:AS8E, 8hl3:AS8E, 8hl4:AS8E, 8hl5:AS8E, 8wkp:AS8E, 8wq2:AS8E, 8wq4:AS8E
30 8c4t:A 1268 72 0.1095 0.0174 0.3056 0.031
31 8qh3:A 1310 72 0.1095 0.0168 0.3056 0.031 8c4u:A, 8c4v:A, 8p1m:A, 8p1n:A, 8qgt:A
32 4ccw:A 285 106 0.1343 0.0947 0.2547 0.42
33 8esq:r 166 56 0.0746 0.0904 0.2679 0.49 8esr:r, 8etc:r, 8etg:r, 8eti:r, 8etj:r, 8eup:r, 8euy:r, 8ev3:r
34 5ddg:A 226 49 0.0697 0.0619 0.2857 2.8 5ddg:B, 5deq:A, 5deq:B
35 2wbt:A 125 28 0.0597 0.0960 0.4286 2.9 2wbt:B
36 3sks:A 544 94 0.1294 0.0478 0.2766 2.9
37 7jil:L 150 57 0.1095 0.1467 0.3860 5.5
38 7m4u:n 100 72 0.1144 0.2300 0.3194 5.8 7m4w:n, 7m4x:n, 7m4y:n, 7m4z:n, 7ryf:n, 7ryg:n, 7ryh:n, 7uvv:n, 7uvw:n, 7uvx:n, 7uvy:n, 7uvz:n, 7uw1:n, 6v39:n, 6v3a:n, 6v3b:n, 6v3e:n, 6ys5:o, 6ytf:o
39 6xyw:Am 142 135 0.1642 0.2324 0.2444 7.1
40 7os3:AAA 369 17 0.0398 0.0217 0.4706 8.4 7os3:BBB, 7os5:AAA, 7os5:BBB, 7os6:AAA, 7os6:DDD, 7os6:BBB, 7os6:CCC, 7ou1:AAA, 7ou1:BBB, 7ou1:CCC, 7ou1:DDD, 7oz6:AAA, 7oz6:BBB, 8rue:A, 8rue:B, 8rue:C, 8rue:D, 8ruf:A, 8ruf:B, 8ruf:C, 8ruf:D

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218