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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
ESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPI
LYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEG
SVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIAK
TFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIATRKAY
GQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIR
MAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIY
NNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVED
HYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAELLKMFGIDRDAIAQAVRGLIT

The query sequence (length=620) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 6rjb:B 622 620 0.9984 0.9952 0.9984 0.0 6ha3:A, 6had:A, 4kxu:A, 4kxv:A, 4kxw:A, 4kxx:A, 4kxy:A, 4kxy:B, 3mos:A, 3ooy:A, 3ooy:B, 6rjb:A, 8wa8:A, 8wa9:A, 8wa9:B, 8waa:A, 8waa:B
2 6yak:AAA 282 269 0.2016 0.4433 0.4647 5.32e-66 6yak:CCC
3 6yak:DDD 311 309 0.1952 0.3891 0.3916 6.34e-62 6yak:BBB
4 3m34:A 632 591 0.2710 0.2658 0.2843 1.39e-57 3m6l:A, 3m7i:A
5 5nd5:A 669 579 0.2677 0.2481 0.2867 5.47e-49 5nd5:B
6 4xeu:A 632 563 0.2484 0.2437 0.2735 4.53e-47
7 4c7x:A 662 584 0.2774 0.2598 0.2945 6.03e-46
8 8r3q:D 676 583 0.2661 0.2441 0.2830 1.31e-45 8r3q:B, 8r3q:A, 8r3q:C
9 5hht:B 667 687 0.3000 0.2789 0.2707 2.23e-45 5hht:A, 1qgd:A, 1qgd:B, 2r5n:A, 2r5n:B, 2r8o:A, 2r8o:B, 2r8p:A, 2r8p:B, 6rjc:A, 6rjc:B, 6tj8:A, 6tj8:B, 6tj9:A, 6tj9:B, 8wa7:A, 8wa7:B
10 1ay0:A 678 668 0.2871 0.2625 0.2665 1.81e-44 1ay0:B, 1gpu:A, 1gpu:B, 1ngs:A, 1ngs:B, 1tka:A, 1tka:B, 1tkb:A, 1tkb:B, 1tkc:A, 1tkc:B, 1trk:A, 1trk:B
11 5vrb:B 646 656 0.2742 0.2632 0.2591 2.64e-44 5vrb:D
12 8r3o:B 667 671 0.2839 0.2639 0.2623 2.79e-43 8r3o:A, 8r3o:C, 8r3o:D
13 7wrr:A 650 572 0.2597 0.2477 0.2815 5.39e-43 7wrr:B, 7wrr:C, 7wrr:D, 7wrt:A, 7wrt:B, 7wrt:C, 7wrt:D
14 8ci0:AAA 666 679 0.2887 0.2688 0.2636 7.83e-43 8ci0:BBB, 8ci0:CCC, 1itz:A, 1itz:B, 1itz:C
15 8r3s:A 663 590 0.2597 0.2428 0.2729 9.31e-43 8r3s:B, 8r3s:C, 8r3s:D, 8r3s:E, 8r3s:F, 8r3s:G, 8r3s:H, 8r3s:I, 8r3s:J
16 5vrb:A 627 652 0.2710 0.2679 0.2577 1.73e-42 5vrb:C
17 1r9j:B 671 592 0.2694 0.2489 0.2821 1.81e-42 1r9j:A
18 8r3p:A 672 501 0.2355 0.2173 0.2914 4.34e-42 8r3p:B, 8r3p:C, 8r3p:D
19 3m49:A 665 498 0.2194 0.2045 0.2731 4.80e-42 3hyl:A, 3hyl:B, 3m49:B
20 8r3r:A 658 595 0.2484 0.2340 0.2588 4.47e-41 8r3r:B, 8r3r:C, 8r3r:D
21 8qmf:A 678 593 0.2613 0.2389 0.2732 5.28e-41 8qmf:B
22 8cip:A 665 585 0.2548 0.2376 0.2701 3.07e-40 8cip:B, 8cip:C, 8cip:D
23 3upt:A 671 605 0.2710 0.2504 0.2777 5.38e-39 3upt:B
24 3rim:A 694 650 0.2613 0.2334 0.2492 2.78e-35 3rim:C, 3rim:B, 3rim:D
25 5hje:A 676 666 0.2726 0.2500 0.2538 3.62e-35 5hyv:A, 5i51:A, 5i5e:A, 5i5g:A, 5xps:A, 5xqa:A, 5xqk:A, 5xrv:A, 5xry:A, 5xs6:A, 5xsa:A, 5xsb:A, 5xsm:A, 5xt0:A, 5xt4:A, 5xtl:A, 5xtv:A, 5xtx:A, 5xu2:A, 5xu9:A, 5xuf:A, 5xvt:A
26 8a45:F 573 558 0.2161 0.2339 0.2401 1.00e-24 8a29:A, 8a29:B, 8a29:C, 8a29:D, 8a29:E, 8a29:F, 8a45:A, 8a45:B, 8a45:C, 8a45:D, 8a45:E, 8a4d:A, 8a4d:B, 8a4d:C, 8a4d:D, 8a4d:E, 8a4d:F, 8a5k:A, 8a5k:B, 8a5k:C, 8a5k:D, 8a5k:E, 8a5k:F
27 6ouv:A 595 609 0.2323 0.2420 0.2365 1.00e-23 2o1x:A, 2o1x:B, 6ouv:B, 8v9i:A, 8v9i:B
28 8bzx:B 568 437 0.1758 0.1919 0.2494 6.42e-22
29 6xxg:AAA 560 586 0.2226 0.2464 0.2355 1.46e-21 6ouw:A
30 6xxg:BBB 539 262 0.1210 0.1391 0.2863 2.59e-20 2o1x:C, 2o1x:D
31 8bzx:A 546 434 0.1710 0.1941 0.2442 1.36e-19
32 2o1s:A 536 276 0.1129 0.1306 0.2536 1.57e-18 2o1s:C
33 2o1s:A 536 148 0.0661 0.0765 0.2770 0.020 2o1s:C
34 8a9c:B 520 275 0.1177 0.1404 0.2655 4.73e-18
35 8a9c:B 520 36 0.0242 0.0288 0.4167 2.9
36 2o1s:B 493 277 0.1129 0.1420 0.2527 4.84e-18 2o1s:D
37 2o1s:B 493 81 0.0387 0.0487 0.2963 0.31 2o1s:D
38 7a9g:AAA 549 261 0.1194 0.1348 0.2835 2.80e-15 7a9g:BBB, 7a9h:AAA, 7a9h:BBB, 8ogh:A, 8ogh:B
39 8r2h:B 701 267 0.0952 0.0842 0.2210 2.79e-11 8r2h:A
40 2g25:B 831 203 0.0968 0.0722 0.2956 1.54e-09 2g25:A
41 2g28:B 801 203 0.0968 0.0749 0.2956 1.68e-09 2g28:A, 2iea:A, 2iea:B, 1l8a:B, 1l8a:A, 3lpl:A, 3lpl:B, 3lq2:A, 3lq2:B, 3lq4:A, 3lq4:B, 2qta:A, 2qta:B, 2qtc:A, 2qtc:B, 1rp7:A, 1rp7:B
42 3duf:D 324 88 0.0500 0.0957 0.3523 1.34e-06 3duf:B, 3duf:H, 3duf:F, 3dv0:D, 3dv0:B, 3dv0:H, 3dv0:F, 3dva:D, 3dva:B, 3dva:H, 3dva:F, 1w85:D, 1w85:B, 1w85:H, 1w85:F, 1w88:D, 1w88:B, 1w88:H
43 6cer:D 331 321 0.1161 0.2175 0.2243 2.77e-06 6cer:B, 6cer:H, 6cer:F, 6cfo:D, 6cfo:B, 3exe:D, 3exe:B, 3exe:H, 3exe:F, 3exf:D, 3exf:B, 3exf:H, 3exf:F, 3exh:D, 3exh:B, 3exh:H, 3exh:F, 1ni4:D, 1ni4:B, 2ozl:D, 2ozl:B
44 1umb:D 323 224 0.0871 0.1672 0.2411 1.66e-04 1umb:B, 1umc:D, 1umc:B, 1umd:D, 1umd:B
45 3dv0:E 344 204 0.0855 0.1541 0.2598 8.96e-04 1w88:A, 1w88:C, 1w88:E, 1w88:G
46 3duf:A 365 92 0.0468 0.0795 0.3152 0.13 3duf:C, 3duf:E, 3duf:G, 3dv0:A, 3dv0:C, 3dv0:G, 3dva:A, 3dva:C, 3dva:E, 3dva:G, 1w85:A, 1w85:C, 1w85:E, 1w85:G
47 1v1m:A 372 175 0.0629 0.1048 0.2229 0.16 2bfb:A, 2bfc:A, 1olu:A, 1v11:A, 1v16:A, 1x7w:A, 1x7x:A, 1x7y:A, 1x80:A
48 3exe:A 363 64 0.0371 0.0634 0.3594 0.36 6cfo:A, 6cfo:C, 3exe:C, 3exe:E, 3exe:G, 3exf:A, 3exf:C, 3exf:E, 3exf:G, 3exh:A, 3exh:C, 3exh:G, 1ni4:C, 1ni4:A, 2ozl:A, 2ozl:C
49 5wwr:A 461 99 0.0419 0.0564 0.2626 0.43 5wwr:B, 5wws:A, 5wws:B, 5wwt:A, 5wwt:B
50 2bff:A 392 102 0.0452 0.0714 0.2745 0.52 2beu:A, 2bev:A, 2bew:A, 2bfd:A, 2bfe:A, 1dtw:A, 2j9f:A, 2j9f:C, 1ols:A, 1olx:A, 1u5b:A, 1wci:A, 1x7z:A
51 6gua:A 821 109 0.0435 0.0329 0.2477 0.55 6gua:B, 6gua:C, 6gua:D, 6gua:E, 6gua:F, 6gua:G, 6gua:H
52 2j3l:B 570 89 0.0387 0.0421 0.2697 0.68 2j3l:A, 2j3m:A, 2j3m:B
53 4q66:C 134 45 0.0210 0.0970 0.2889 0.70
54 6qe7:A 291 58 0.0355 0.0756 0.3793 0.95 6qe7:B, 6qe7:C
55 6cer:A 342 66 0.0371 0.0673 0.3485 1.1 6cer:C, 6cer:E, 6cer:G, 3exh:E
56 6ke6:RP 2052 76 0.0339 0.0102 0.2763 1.2
57 6lqs:RP 2180 76 0.0339 0.0096 0.2763 1.3 7d63:RP, 6lqp:RP, 6lqq:RP, 6lqr:RP, 6lqt:RP, 6lqu:RP, 6lqv:RP
58 8io8:A 788 140 0.0581 0.0457 0.2571 1.4 8io8:B, 8io9:A, 8io9:B, 8io9:C, 8io9:D, 8io9:E, 8io9:F, 8io9:G, 8io9:H, 8io9:I, 8io9:J, 8io9:K, 8io9:L, 8ioa:A, 8ioa:B, 8ioe:A, 8ioe:B, 8ioe:C, 8ioe:D, 8ioe:E, 8ioe:F, 8ioe:G, 8ioe:H, 8ioe:I, 8ioe:J, 8ioe:K, 8ioe:L
59 8hp4:A 540 48 0.0306 0.0352 0.3958 2.9 8hp4:B
60 7xc2:C 858 63 0.0242 0.0175 0.2381 4.2 7xc2:A, 7xc2:E, 7xc2:G, 7xc2:I, 7xe0:A, 7xe0:C, 7xe0:E, 7xe0:G, 7xe0:I, 7xx2:A, 7xx2:C, 7xx2:E, 7xx2:G, 7xx2:I
61 7aoi:XI 597 104 0.0403 0.0419 0.2404 6.4
62 1o5w:C 512 31 0.0258 0.0312 0.5161 6.4 1o5w:A, 1o5w:B, 1o5w:D
63 7arc:P 347 101 0.0371 0.0663 0.2277 8.0 7ard:P

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218