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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
EKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCP
GHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDF
PGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEV
EIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPF
FKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG

The query sequence (length=391) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 1ob2:A 393 390 0.9974 0.9924 1.0000 0.0 1d8t:A, 1d8t:B, 1dg1:G, 1dg1:H, 1efc:A, 1efc:B, 6eze:A, 6eze:B, 8fr3:A, 8fr3:B, 2fx3:A, 4g5g:A, 8g7p:z, 8g7q:z, 5jbq:A, 5mi3:A, 5mi3:B, 5mi8:A, 5mi8:B, 5mi9:A, 5mi9:B, 4p3y:A, 8qfs:C, 8qhc:C, 3u2q:A, 3u6k:A, 3u6k:B, 5uyk:Z, 5uyl:Z, 5uym:Z, 5uyn:Z, 5uyp:Z, 5uyq:Z, 4v69:AZ, 4v6k:BC, 4v6l:AC, 5wdt:z, 6wd2:8, 6wd3:8, 6wd5:8, 6wd6:8, 6wd8:8, 5we4:z, 5we6:z, 5wf0:z, 5wfk:z, 5wfs:z
2 3avt:A 1203 389 0.9386 0.3051 0.9434 0.0 7abz:6, 5afi:z, 3agp:A, 3agq:A, 3avu:A, 3avv:A, 3avw:A, 3avx:A, 3avy:A, 7bbn:A, 7bbn:B, 2bvn:A, 2bvn:B, 1efm:A, 1etu:A, 4fwt:A, 2hcj:A, 2hcj:B, 2hdn:A, 2hdn:B, 2hdn:C, 2hdn:D, 2hdn:E, 2hdn:F, 2hdn:G, 2hdn:H, 2hdn:I, 2hdn:J, 2hdn:K, 2hdn:L, 5i4r:C, 5i4r:D, 5i4r:G, 5i4r:H, 3mmp:G, 5opd:A, 5opd:B, 4pc2:A, 4pc2:B, 4pc3:A, 4pc3:B, 4pc6:A, 4pc6:B, 4pc7:A, 3u6b:B, 3u6b:A, 3vnu:A, 3vnv:A, 6wd4:8, 6wd7:8, 6wd9:8, 6wda:8
3 4zv4:A 392 389 0.8414 0.8393 0.8458 0.0 4zv4:B
4 6gfu:A 386 385 0.8133 0.8238 0.8260 0.0 5w76:A, 5w7q:A
5 6mij:A 388 386 0.8414 0.8479 0.8523 0.0
6 6htw:B 385 384 0.7980 0.8104 0.8125 0.0 6htw:H, 6i8r:A
7 8rdw:H 386 384 0.8056 0.8161 0.8203 0.0 8rd8:H
8 4iw3:B 380 386 0.7596 0.7816 0.7694 0.0 4iw3:K, 4j0q:A, 4j0q:B, 4j0q:C, 4j0q:D, 4j0q:E
9 8v9l:x 387 387 0.7417 0.7494 0.7494 0.0 7vok:A, 7vok:B, 7vok:C, 7vok:D
10 5w75:C 387 385 0.7136 0.7209 0.7247 0.0 5w75:B, 5w75:D, 5w75:A
11 1b23:P 405 401 0.7315 0.7062 0.7132 0.0 2c77:A, 2c78:A, 1eft:A, 1exm:A, 4h9g:A, 1ha3:A, 4lbv:A, 4lbw:A, 4lby:A, 4lbz:A, 4lc0:A, 1mj1:A, 1ob5:A, 1ob5:C, 1ob5:E, 2p8w:S, 2p8x:S, 2p8z:S, 1ttt:A, 1ttt:B, 1ttt:C, 1tui:A, 1tui:B, 1tui:C, 4v5l:AZ, 4v8q:BZ
12 7paj:9 393 390 0.7033 0.6997 0.7051 0.0 7pak:9, 7pha:9, 7pi9:9, 7pip:9
13 4v5p:AZ 385 400 0.7033 0.7143 0.6875 0.0 1ha3:B, 4v5g:AZ, 4v5g:CZ, 4v5p:CZ, 4v5q:AZ, 4v5q:CZ, 4v5r:AZ, 4v5r:CZ, 4v5s:AZ, 4v5s:CZ, 4v68:AZ
14 7vmx:B 359 385 0.6982 0.7604 0.7091 0.0
15 1d2e:A 397 382 0.5652 0.5567 0.5785 2.08e-164 7a5g:Z, 1d2e:B, 1d2e:C, 1d2e:D, 7o9k:t
16 3wy9:A 416 423 0.3964 0.3726 0.3664 2.93e-65 3wy9:B, 3wya:A
17 6ji2:A 432 435 0.3555 0.3218 0.3195 8.48e-56 4cxg:A, 4cxh:A, 6ji2:E, 3vmf:A, 3wxm:A, 3wxm:C, 3wxm:E, 3wxm:G
18 1skq:A 416 425 0.3350 0.3149 0.3082 7.48e-50 1jny:A, 1jny:B, 1skq:B
19 5lzw:jj 425 430 0.3248 0.2988 0.2953 1.47e-45 5lzx:jj, 5lzy:jj, 5lzz:jj
20 5o8w:A 449 441 0.3325 0.2895 0.2948 1.42e-41 2b7b:A, 9bdp:EF1A, 1g7c:A, 1ije:A, 1ijf:A
21 6ra9:B 458 444 0.3223 0.2751 0.2838 4.65e-41 8b6z:A, 4c0s:A, 4c0s:B, 8g5z:EF, 8g60:EF, 8g6j:EF, 5lzs:jj, 6ra9:A, 6zmo:CD
22 5lzb:z 614 377 0.2967 0.1889 0.3077 1.35e-38 5lzc:z, 5lzd:z, 2pjp:A
23 4ac9:C 471 296 0.2404 0.1996 0.3176 1.23e-37 4ac9:A, 4ac9:B, 4aca:B, 4aca:C, 4acb:A, 4acb:B, 4acb:C
24 5lzt:jj 428 344 0.2660 0.2430 0.3023 6.60e-31 4d61:i, 5hxb:X, 5hxb:A, 7nwh:jj, 6xk9:X, 6xk9:A
25 2dcu:A 407 348 0.2685 0.2580 0.3017 1.33e-29 2d74:A, 1kjz:A, 1kk0:A, 1kk1:A, 1kk2:A, 1kk3:A
26 5izm:B 495 284 0.2072 0.1636 0.2852 4.07e-28 5izk:A, 5izm:A
27 7zjw:E 519 289 0.2225 0.1676 0.3010 6.29e-28 5izl:A, 5izl:B
28 4zu9:A 582 292 0.2302 0.1546 0.3082 5.11e-27
29 3qsy:A 415 301 0.2327 0.2193 0.3023 7.25e-27 2aho:A, 3cw2:B, 6i5m:A, 5jb3:7, 5jbh:7, 4m0l:A, 4m0l:B, 4m0l:C, 4m0l:D, 4m0l:E, 4m0l:F, 4m2l:A, 4m4s:A, 4nbs:A, 3pen:A, 2pmd:A, 2pmd:B, 4qfm:A, 4qhy:A, 2qmu:A, 2qn6:A, 6r8s:A, 6r8t:A, 4rcy:A, 4rcz:A, 4rd0:A, 4rd1:A, 4rd2:A, 4rd3:A, 4rd4:A, 4rd6:A, 4rjl:A, 3sjz:A, 6sw9:7, 6swc:7, 3v11:A
30 1s0u:A 391 321 0.2506 0.2506 0.3053 4.94e-25
31 3p27:B 444 338 0.2276 0.2005 0.2633 4.09e-22 3p27:A
32 5m1j:A6 539 363 0.2404 0.1744 0.2590 4.78e-21
33 7ase:5 421 263 0.1995 0.1853 0.2966 8.04e-21
34 7qp6:t 356 242 0.1867 0.2051 0.3017 2.57e-20 7qp7:t, 6ybv:t, 6zmw:t
35 5aa0:BZ 605 248 0.2123 0.1372 0.3347 4.45e-20 5a9z:CA, 4zck:A, 4zcl:A, 4zcl:B, 4zcm:A, 4zcm:B
36 3j81:k 365 247 0.1944 0.2082 0.3077 7.06e-20
37 8cas:G 396 264 0.2020 0.1995 0.2992 1.11e-19 6fyy:k, 6i3m:O, 6i3m:P, 6i7t:O, 6i7t:P, 3jap:k, 8s8f:k
38 4crn:P 430 345 0.2660 0.2419 0.3014 2.22e-19
39 8pj1:t 472 274 0.1918 0.1589 0.2737 3.71e-18 7d43:P, 6fec:S, 5k0y:S, 6k71:P, 6k72:P, 8oz0:E, 8pj2:t, 8ppl:It, 6yal:B, 6yam:B, 6yan:B
40 8rw1:k 470 267 0.2020 0.1681 0.2959 6.34e-18 6fyx:k, 6gsm:k, 6gsn:k, 6qg0:M, 6qg0:N, 6qg1:M, 6qg1:N, 6qg2:M, 6qg3:M, 6qg5:M, 6qg6:M, 6qg6:N, 8s8d:k, 8s8e:k, 8s8g:k, 8s8h:k, 8s8i:k, 8s8j:k
41 8qzz:A 433 261 0.1918 0.1732 0.2874 1.70e-17 7a09:Y, 6zp4:Y
42 5a9y:A 562 240 0.1893 0.1317 0.3083 2.42e-17 5a9x:A
43 3j9y:w 639 151 0.1304 0.0798 0.3377 1.97e-16 5kcs:1w
44 1r5o:A 409 326 0.2123 0.2029 0.2546 2.76e-15 1r5n:A
45 1zun:B 394 391 0.2481 0.2462 0.2481 5.60e-15
46 7pua:IA 704 303 0.2225 0.1236 0.2871 1.66e-14 7pub:IA
47 5izk:B 451 286 0.1918 0.1663 0.2622 2.41e-14
48 4v6v:A1 639 129 0.1100 0.0673 0.3333 3.18e-13
49 7unv:x 593 125 0.1228 0.0809 0.3840 5.97e-12 7unq:x, 7unr:x, 7unt:x, 7unu:x, 7unw:x
50 3izy:P 537 231 0.1969 0.1434 0.3333 7.90e-12
51 8hl1:AEFG 725 334 0.2251 0.1214 0.2635 1.13e-11 8hl2:AEFG, 8hl3:AEFG, 8hl4:AEFG
52 2lkd:A 178 125 0.1202 0.2640 0.3760 1.26e-11
53 5anb:K 1120 132 0.1100 0.0384 0.3258 1.32e-11 5anc:K
54 6gaw:BC 571 231 0.1790 0.1226 0.3030 5.02e-11 6gaz:BC, 6gb2:BC, 7po2:7, 8qrn:7, 6rw5:7
55 5imr:C 570 239 0.1688 0.1158 0.2762 1.86e-10
56 5j8b:z 671 239 0.1688 0.0984 0.2762 1.88e-10 5imq:B
57 3jce:x 586 328 0.2020 0.1348 0.2409 2.52e-10 3deg:C
58 7yyp:A 597 131 0.1125 0.0737 0.3359 1.67e-09 7yzn:A, 7zag:7, 7zah:7, 7zki:7
59 7pao:9 682 128 0.1049 0.0601 0.3203 6.58e-09 7paq:9, 7par:9, 7pib:9, 7pis:9, 7pit:9
60 3tr5:A 518 129 0.1049 0.0792 0.3178 6.86e-09 3tr5:B, 3tr5:C, 3tr5:D
61 5fg3:A 598 275 0.2097 0.1371 0.2982 7.85e-09 5yt0:A
62 7nsh:BC 700 135 0.1125 0.0629 0.3259 8.51e-09 7l20:w
63 5lmv:a 502 123 0.1074 0.0837 0.3415 1.05e-08
64 8fzi:v 525 147 0.1176 0.0876 0.3129 1.63e-08 8fzd:v, 8fzf:v, 8fzg:v, 8fzj:v, 6gwt:w, 6gxm:w, 6gxn:w, 6gxo:w, 6gxp:w, 2h5e:A, 2h5e:B, 6lkq:v, 7m5d:7, 4v85:AW, 4v89:AW, 4v8o:AY
65 6vlz:v 712 147 0.1100 0.0604 0.2925 1.96e-08 7a5k:r1, 6vmi:v, 6ydp:BC, 6ydw:BC
66 6u45:A 726 151 0.1381 0.0744 0.3576 2.21e-08 6u43:A, 6u44:A, 6u44:B, 6u45:B
67 3vr1:A 516 171 0.1279 0.0969 0.2924 2.76e-08 3vqt:A, 3vqt:B, 3vqt:C, 3vqt:D, 3vr1:B, 3vr1:C, 3vr1:D
68 7n2v:EF 704 148 0.1100 0.0611 0.2905 5.39e-08 3j9z:S1, 3ja1:S3, 7k51:8, 7k52:8, 7k54:8, 7k55:8, 7n2c:EF, 7otc:w, 7pjv:x, 7pjw:x, 7pjy:x, 7pjz:x, 7ss9:8, 7ssd:8, 7ssl:8, 7st7:8, 7ug7:EF, 4v7b:AY, 4v7d:BZ, 4v9o:BV, 4v9o:DV, 4v9o:FV, 4v9o:HV, 4v9p:BV, 4v9p:DV, 4v9p:FV, 4v9p:HV
69 9ax8:z 509 113 0.1125 0.0864 0.3894 8.11e-08 3jcj:f, 3jcn:b, 5me0:W, 5me1:W, 6o7k:f, 6o9k:z
70 5h7l:A 694 159 0.1100 0.0620 0.2704 1.23e-07 5h7k:A, 5h7l:B
71 5h7l:A 694 37 0.0358 0.0202 0.3784 4.1 5h7k:A, 5h7l:B
72 8cf5:Aa 842 158 0.1202 0.0558 0.2975 2.69e-07 8cdr:Aa, 8ceh:Aa, 8cg8:Aa, 8civ:Aa, 8cku:Aa, 8cmj:Aa, 2e1r:A, 8eub:DC, 8evq:DC, 8evr:DC, 8evs:DC, 8ewb:DC, 6gq1:AZ, 6gqb:AZ, 6gqv:AX, 5it7:1, 5juo:DC, 5jup:DC, 5jus:DC, 5jut:DC, 5juu:DC, 8k2d:CD, 1n0u:A, 2npf:A, 2npf:B, 7osa:eEF2, 7osm:eEF2, 2p8w:T, 2p8x:T, 2p8y:T, 2p8z:T, 1u2r:A, 4v4b:AT, 1zm2:E
73 7siq:A 524 137 0.1074 0.0802 0.3066 3.26e-07
74 3wnb:A 361 260 0.1535 0.1662 0.2308 3.62e-07 3wnc:A
75 4v9h:AY 622 142 0.1100 0.0691 0.3028 3.72e-07
76 1g7s:A 576 132 0.0972 0.0660 0.2879 4.48e-07 1g7t:A
77 4v6w:Az 837 170 0.1304 0.0609 0.3000 4.66e-07
78 8q87:A 857 169 0.1253 0.0572 0.2899 6.09e-07 6d9j:9, 6gz3:Ct, 6gz4:Ct, 6gz5:Ct, 3j7p:4, 7ls1:m, 7ls2:m, 6mtd:v, 6mte:v, 7oyc:v2, 4v6x:Az, 8xsx:CB, 6z6m:CB, 6z6n:CB
79 4kjz:C 458 123 0.1049 0.0895 0.3333 7.59e-07 4b43:A, 4b44:A, 4b47:A, 4b48:A, 4kjz:A
80 2ywf:A 532 275 0.1688 0.1241 0.2400 1.81e-06 2ywg:A, 2ywh:A
81 4fn5:A 670 135 0.1023 0.0597 0.2963 2.70e-06
82 8dmf:A 718 181 0.1202 0.0655 0.2597 3.35e-06 7uvp:A
83 5ty0:A 378 130 0.0921 0.0952 0.2769 5.14e-06
84 8ro0:C 898 121 0.0972 0.0423 0.3140 6.21e-06 8ro1:C
85 8y0w:CB 768 147 0.1074 0.0547 0.2857 7.22e-06 8y0x:CB
86 2bv3:A 632 142 0.0972 0.0601 0.2676 9.54e-06 1dar:A
87 4w2e:y 644 232 0.1458 0.0885 0.2457 1.09e-05
88 7old:C 813 144 0.1151 0.0554 0.3125 1.45e-05
89 7pjx:x 522 138 0.0997 0.0747 0.2826 3.12e-05
90 8bsi:a 815 159 0.1228 0.0589 0.3019 4.56e-05
91 8ro2:C 908 135 0.0972 0.0419 0.2815 5.23e-05 7aav:r, 7abf:r, 7abg:r, 7abi:r, 6ah0:C, 6ahd:C, 8c6j:C, 8ch6:b, 7dvq:C, 6ff4:B, 6ff7:B, 9fmd:C, 8h6e:5C, 8h6j:5C, 8h6k:5C, 8h6l:5C, 8i0p:C, 8i0r:C, 8i0s:C, 8i0t:C, 8i0u:C, 8i0v:C, 8i0w:C, 6icz:C, 6id0:C, 6id1:C, 8q7q:C, 8q7v:C, 8q7w:C, 8q7x:C, 8q91:C, 6qdv:C, 8qp8:C, 7qtt:b, 6qw6:5C, 6qx9:5C, 8rc0:C, 7w59:C, 7w5a:C, 7w5b:C, 5xjc:C, 8y6o:D, 5yzg:C, 5z56:C, 5z57:C, 5z58:C, 6zym:B
92 2dy1:A 660 132 0.0895 0.0530 0.2652 1.63e-04 1wdt:A
93 4ncl:B 435 131 0.1049 0.0943 0.3130 1.68e-04 4ncl:A, 4ncn:A, 4ncn:B, 4tmt:A, 4tmt:B, 4tmv:B, 4tmv:A, 4tmw:A, 4tmw:B, 4tmx:A, 4tmx:B, 4tmz:B, 4tmz:A, 4tn1:B, 4tn1:A
94 5hau:1z 730 142 0.0946 0.0507 0.2606 2.01e-04 2bm0:A, 2bm1:A, 1fnm:A, 6gzq:H1, 6gzx:H1, 6gzx:H2, 6gzz:H1, 6gzz:H2, 5hau:2z, 4m1k:A, 4myt:A, 4myu:A, 2om7:L, 5ot7:U, 6q95:G, 6ucq:1v, 6ucq:2v, 4v5f:AY, 4v5f:CY, 4v5m:AY, 4v5n:AY, 4v6t:AY, 4v8u:AY, 4v8u:CY, 4v90:AY, 4v9j:AY, 4v9j:CY, 4v9k:AY, 4v9k:CY, 4v9l:AY, 4v9l:CY, 4v9m:AY, 4v9m:CY, 4w29:AY, 4w29:CY, 4wpo:BZ, 4wpo:DZ, 4wqf:BZ, 4wqf:DZ, 4wqu:BZ, 4wqu:DZ, 4wqy:BZ, 4wqy:DZ
95 7oyd:v 726 132 0.0972 0.0523 0.2879 2.35e-04
96 6uz7:1 600 132 0.1100 0.0717 0.3258 3.82e-04 4v8y:CP
97 8p2f:E 670 134 0.1023 0.0597 0.2985 6.20e-04 8p2g:E, 8p2h:E
98 6woo:1 600 130 0.1049 0.0683 0.3154 8.51e-04 4ncf:A, 4ncf:B, 3wbk:A
99 4v8z:CV 568 130 0.1049 0.0722 0.3154 0.001
100 7syv:x 627 135 0.1074 0.0670 0.3111 0.001 8pj3:0, 8pj4:0, 8pj5:0, 7syw:x, 7syx:x, 7tql:1, 4ujc:AB, 4ujd:BB
101 1efg:A 592 142 0.0972 0.0642 0.2676 0.001 2efg:A
102 3jb9:B 904 127 0.0895 0.0387 0.2756 0.001
103 5lj3:C 882 111 0.0639 0.0283 0.2252 0.002 6exn:C, 5gam:C, 5gan:C, 5lj5:C, 5lqw:B, 5mps:C, 5mq0:C, 5nrl:C
104 6j6g:C 920 111 0.0639 0.0272 0.2252 0.002 7b9v:C, 6bk8:B, 7dco:C, 5gm6:C, 5gmk:C, 6j6h:C, 6j6n:C, 6j6q:C, 3jcm:H, 6teo:A, 6teo:C, 5wsg:C, 5y88:C, 5ylz:C, 5zwm:C, 5zwo:C
105 7cdw:A 683 128 0.0921 0.0527 0.2812 0.061 7cdw:B
106 6fku:A 511 50 0.0537 0.0411 0.4200 1.5 6fku:B
107 1u0l:A 278 135 0.0895 0.1259 0.2593 3.9 1u0l:B, 1u0l:C
108 6ruz:A 443 41 0.0384 0.0339 0.3659 6.6 6ruz:B, 6ruz:C, 6ruz:D, 6rvb:A, 6rvb:B, 6rvb:C, 6rvb:D, 6rvh:A, 6rvh:B, 6rvh:C, 6rvh:D

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218