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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
DVVTREYTINLHKRLHGVSFKKRAPRAVKEIKKFAKLHMGTDDVRLAPELNQAIWKRGVKGVEYRLRLRISRKRNEEEDA
KNPLFSYVEPVLVASAKGLQTVVVE

The query sequence (length=105) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8hfr:dG 110 105 1.0000 0.9545 1.0000 1.14e-73 8aaf:Q, 8agt:Q, 8agu:Q, 8agv:Q, 8agw:Q, 8agx:Q, 8agz:Q, 5apn:d, 5apo:d, 7azy:n, 7b7d:LZ, 8bip:Ld, 8bjq:Ld, 8bn3:O1, 8bqd:BC, 8bqx:BC, 7bt6:d, 7btb:d, 8ccs:P, 8cdl:P, 8cdr:P, 8ceh:P, 8cf5:P, 8cg8:P, 8cgn:P, 8civ:P, 8cku:P, 8cmj:P, 5dat:O1, 5dat:o1, 5dc3:O1, 5dc3:o1, 5dge:O1, 5dge:o1, 5dgf:O1, 5dgf:o1, 5dgv:O1, 5dgv:o1, 6elz:d, 6em5:d, 8eub:Ad, 8evp:Ad, 8evq:Ad, 8evr:Ad, 8evs:Ad, 8evt:Ad, 8ewb:Ad, 8ewc:Ad, 5fci:O1, 5fci:o1, 5fcj:O1, 5fcj:o1, 6ft6:d, 5gak:f, 6gq1:d, 6gqb:d, 6gqv:d, 5h4p:d, 6hd7:f, 6hhq:AE, 6hhq:DF, 5i4l:O1, 5i4l:o1, 6i7o:BC, 6i7o:YC, 3j6x:71, 3j6y:71, 3j77:81, 3j78:81, 3jct:d, 5jcs:d, 5juo:IA, 5jup:IA, 5jus:IA, 5jut:IA, 5juu:IA, 8k2d:Ld, 8k82:Ld, 5lyb:O1, 5lyb:o1, 5m1j:d5, 6m62:d, 5mc6:BC, 5mei:AE, 5mei:DF, 7mpi:Ad, 7mpj:Ad, 6n8j:d, 6n8k:d, 6n8l:d, 6n8m:q, 6n8n:q, 6n8o:q, 7n8b:Ad, 7nac:d, 5ndg:O1, 5ndg:o1, 5ndv:O1, 5ndv:o1, 5ndw:O1, 5ndw:o1, 7nrc:Lf, 7nrd:Lf, 5obm:O1, 5obm:o1, 7of1:d, 7oh3:d, 7ohq:d, 7ohr:d, 7ohv:d, 6oig:d, 5on6:AE, 5on6:DF, 7osa:eL31, 7osm:eL31, 8p8m:RD, 8p8n:RD, 8p8u:RD, 8pfr:RD, 6q8y:BC, 6qik:d, 6qt0:d, 6qtz:d, 7r7a:d, 6r84:f, 6r86:f, 6r87:f, 6ri5:d, 7rr5:Ld, 6rzz:d, 6s05:d, 6s47:Af, 6snt:am, 6sv4:BC, 6sv4:YC, 6sv4:ZC, 6t4q:Ld, 5t62:q, 5t6r:q, 6t7i:Ld, 6t7t:Ld, 6t83:dy, 6t83:O, 5tbw:AE, 5tbw:DF, 6tb3:BC, 5tga:O1, 5tga:o1, 5tgm:O1, 5tgm:o1, 6tnu:BC, 7too:AL31, 7top:AL31, 7u0h:d, 4u3m:O1, 4u3m:o1, 4u3n:O1, 4u3n:o1, 4u3u:O1, 4u3u:o1, 4u4n:O1, 4u4n:o1, 4u4o:O1, 4u4o:o1, 4u4q:O1, 4u4q:o1, 4u4r:O1, 4u4r:o1, 4u4u:O1, 4u4u:o1, 4u4y:O1, 4u4y:o1, 4u4z:O1, 4u4z:o1, 4u50:O1, 4u50:o1, 4u51:O1, 4u51:o1, 4u52:O1, 4u52:o1, 4u53:O1, 4u53:o1, 4u55:O1, 4u55:o1, 4u56:O1, 4u56:o1, 4u6f:O1, 4u6f:o1, 7ug6:d, 7uoo:d, 7uqb:d, 7uqz:d, 7v08:d, 4v4b:BW, 4v6i:Bg, 4v7h:BW, 4v7r:Ba, 4v7r:Da, 4v88:Bd, 4v88:Dd, 4v8t:d, 4v8y:Bd, 4v8z:Bd, 8v87:d, 4v91:d, 6woo:d, 6xiq:d, 6xir:d, 8y0u:Ld, 6ylg:d, 6ylh:d, 6ylx:d, 6yly:d, 7z34:d, 6z6j:Ld, 6z6k:Ld, 7zpq:Bc, 7zrs:Bc, 7zs5:Be, 7zuw:Bc, 7zux:Ec, 7zw0:Lg
2 8c3a:AE 110 105 0.8381 0.8000 0.8381 1.28e-60 8c3a:BY, 8cq7:AE, 8cq7:BY, 8cqw:AE, 8cqw:BY, 8cre:AE, 8cre:BY, 8oeq:AE, 8oeq:BY, 7pzy:AE, 7q08:AE, 7q0f:AE, 7q0p:AE, 7q0r:AE, 8q5i:AE
3 5it7:dd 106 105 0.8857 0.8774 0.8857 2.26e-58 6uz7:Bd
4 4v6x:Cd 113 105 0.6095 0.5664 0.6095 6.27e-43 7a01:u2, 8a3d:X, 5aj0:Ad, 8b5l:d, 8b6c:d, 9bdl:AL31, 9bdn:AL31, 9bdp:AL31, 8bf9:d, 7bhp:Ld, 8bhf:Q1, 8bpo:c2, 8btk:Bd, 7cpu:Ld, 7cpv:Ld, 4d5y:d, 4d67:d, 6d90:d, 6d9j:d, 9f1b:Bd, 9f1c:Bd, 9f1d:Bd, 7f5s:Ld, 8fkv:LP, 8fkw:LP, 8fkx:LP, 8fky:LP, 8fkz:LP, 8fl2:LP, 8fl3:LP, 8fl4:LP, 8fl6:LP, 8fl7:LP, 8fl9:LP, 8fla:LP, 8flb:LP, 8flc:LP, 8fld:LP, 8fle:LP, 8flf:LP, 6frk:d, 6ftg:d, 6fti:d, 6ftj:d, 8g5y:Ld, 8g5z:Ld, 8g60:Ld, 8g61:Ld, 8g6j:Ld, 8glp:Ld, 6gz3:Ad, 6gz4:Ad, 6gz5:Ad, 6hcf:d3, 6hcj:d3, 6hcm:d3, 6hcq:d3, 8idt:j, 8idy:j, 8ie3:j, 8ifd:2X, 8ife:2X, 8ine:j, 8inf:j, 8ink:j, 6ip5:2X, 6ip6:2X, 6ip8:2X, 8ipd:j, 8ipx:j, 8ipy:j, 8ir1:j, 8ir3:j, 3j7o:d, 3j7p:d, 3j7q:d, 3j7r:d, 3j92:d, 3jag:d, 3jah:d, 3jai:d, 3jaj:d, 3jan:d, 8jdj:i, 8jdk:i, 8jdl:i, 8jdm:i, 8k2c:Ld, 5lks:Ld, 6lqm:T, 6lsr:T, 6lss:j, 7ls1:X2, 7ls2:X2, 6lu8:j, 5lzs:d, 5lzt:d, 5lzu:d, 5lzv:d, 5lzw:d, 5lzx:d, 5lzy:d, 5lzz:d, 7mdz:d, 6mtb:d, 6mtc:d, 6mtd:d, 6mte:d, 7nfx:d, 7nwg:d3, 7nwh:d, 7nwi:d, 7o7y:Bd, 7o7z:Bd, 7o80:Bd, 7o81:Bd, 7obr:d, 8ohd:Ld, 8oj0:Ld, 8oj5:Ld, 8oj8:Ld, 6ole:e, 6olf:e, 6olg:Ad, 6oli:e, 6olz:Ad, 6om0:e, 6om7:e, 7ow7:X, 7oya:d1, 7oyb:d1, 7oyc:d1, 7oyd:d, 8p2k:Bd, 6p5i:Ad, 6p5j:Ad, 6p5k:Ad, 6p5n:Ad, 8q7z:Bd, 8q87:Bd, 8qfd:d, 7qgg:e, 8qoi:Ld, 7qvp:Ld, 7qvp:Md, 7qwq:d, 7qwr:d, 7qws:d, 6qzp:Ld, 6r5q:d, 6r6g:d, 6r6p:d, 6r7q:d, 8rjb:d, 8rjc:d, 8rjd:d, 8scb:d, 6sgc:d2, 6swa:b, 5t2c:X, 6t59:d3, 7tm3:d, 7toq:AL31, 7tor:AL31, 7tut:d, 7ucj:d, 7uck:d, 4ug0:Ld, 4ujc:Bd, 4ujd:Ad, 4uje:Cd, 4v5z:Bx, 6w6l:e, 6xa1:Ld, 7xnx:Ld, 7xny:Ld, 8xsx:Ld, 8xsy:Ld, 8xsz:Ld, 6y0g:Ld, 8y0w:Ld, 8y0x:Ld, 6y2l:Ld, 6y57:Ld, 6y6x:Ld, 8yoo:Ld, 8yop:Ld, 6z6l:Ld, 6z6m:Ld, 6z6n:Ld, 7zjw:Lg, 7zjx:Lg, 6zm7:Ld, 6zme:Ld, 6zmi:Ld, 6zmo:Ld, 6zvk:u2
5 7nad:d 72 91 0.6857 1.0000 0.7912 1.55e-41 7r72:d
6 7z3n:Ld 119 105 0.6762 0.5966 0.6762 2.82e-41 8i9v:Ld, 8i9w:Ld, 8i9x:Ld, 8i9y:Ld, 8i9z:Ld, 8ia0:Ld, 7olc:Ld, 7old:Ld, 8oo0:Ld, 8pv1:Ld, 8pv2:Ld, 8pv3:Ld, 8pv4:Ld, 8pv5:Ld, 8pv6:Ld, 8pv7:Ld, 8pv8:Ld, 8pvk:Ld, 8pvl:Ld, 7z3o:Ld
7 7r81:f1 104 104 0.6667 0.6731 0.6731 2.11e-40
8 4v6w:Cd 111 105 0.5333 0.5045 0.5333 7.17e-31 6xu6:Cd, 6xu7:Cd, 6xu8:Cd
9 4v3p:Lg 120 107 0.6095 0.5333 0.5981 1.23e-30 8ip8:SA, 8ipa:SA, 8ipb:SA, 8jiv:Cd, 4v7e:Cd
10 8etc:d 102 104 0.5905 0.6078 0.5962 1.69e-30 8esq:d, 8esr:d, 8etg:d, 8eti:d, 8etj:d, 8eug:d, 8eui:d
11 7qiw:f 110 107 0.5714 0.5455 0.5607 7.15e-30 8azw:Q, 8b2l:Q3, 2go5:6, 2j37:6, 7qiz:f
12 4v8p:BW 110 96 0.4286 0.4091 0.4688 2.99e-29 4v8p:CW, 4v8p:EW, 4v8p:GW
13 9bh5:Cd 105 104 0.5143 0.5143 0.5192 1.88e-28 9cai:Cd
14 6zj3:Lt 111 100 0.4476 0.4234 0.4700 7.83e-26
15 5xxb:c 107 102 0.4857 0.4766 0.5000 8.99e-23
16 7naf:d 44 60 0.4190 1.0000 0.7333 5.66e-22
17 3j79:7 96 97 0.4286 0.4688 0.4639 8.67e-22 3jbn:A7, 3jbo:A7, 3jbp:A7, 8tpu:A7, 5umd:7
18 8rxh:Le 186 106 0.4571 0.2581 0.4528 9.07e-19 8a3w:e, 8a98:e, 6az3:e, 3jcs:e, 8ovj:e, 8rxx:Le, 5t2a:f
19 4v8m:Bh 188 106 0.4000 0.2234 0.3962 1.14e-15 8ova:Bh, 8ove:Bh
20 5t5h:h 150 104 0.4000 0.2800 0.4038 2.91e-15
21 6zu5:LDD 103 99 0.3143 0.3204 0.3333 2.42e-12
22 8br8:Le 100 99 0.3143 0.3300 0.3333 2.38e-09 8brm:Le, 8bsi:Le, 8bsj:Le, 8btd:Le, 8btr:Le, 8fru:d, 7pwg:d, 7pwo:d2
23 5xy3:d 99 99 0.3810 0.4040 0.4040 1.69e-08
24 6rm3:LDD 102 100 0.2762 0.2843 0.2900 7.07e-08
25 4v6u:Ba 90 64 0.2095 0.2444 0.3438 8.66e-08 4v4n:Aa
26 8p5d:LDD 109 100 0.2952 0.2844 0.3100 7.15e-07 8p60:LDD, 8p60:KDD, 7qca:LDD
27 7qep:O1 108 102 0.2571 0.2500 0.2647 2.69e-05
28 6skf:Bc 89 64 0.1714 0.2022 0.2812 5.90e-05 6skg:Bc, 6th6:Bc
29 4v9f:X 90 59 0.2000 0.2333 0.3559 4.33e-04 3cc2:X, 3cc4:X, 3cc7:X, 3cce:X, 3ccj:X, 3ccl:X, 3ccm:X, 3ccq:X, 3ccr:X, 3ccs:X, 3ccu:X, 3ccv:X, 3cd6:X, 3cma:X, 3cme:X, 3cpw:W, 3cxc:W, 3g4s:X, 3g6e:X, 3g71:X, 3i55:X, 3i56:X, 1jj2:W, 1k73:Y, 1k8a:Y, 1k9m:Y, 1kc8:Y, 1kd1:Y, 1kqs:W, 1m1k:Y, 1m90:Y, 1n8r:Y, 1nji:Y, 2otj:X, 2otl:X, 3ow2:W, 1q7y:Y, 1q81:Y, 1q82:Y, 1q86:Y, 2qa4:X, 2qex:X, 1qvf:W, 1qvg:W, 1s72:X, 1vq4:X, 1vq5:X, 1vq6:X, 1vq7:X, 1vq8:X, 1vq9:X, 1vqk:X, 1vql:X, 1vqm:X, 1vqn:X, 1vqo:X, 1vqp:X, 1w2b:W, 1yhq:X, 1yi2:X, 1yij:X, 1yit:X, 1yj9:X, 1yjn:X, 1yjw:X
30 8hku:L31E 75 67 0.1905 0.2667 0.2985 0.055 8hkv:L31E, 8hky:L31E, 8hkz:L31E, 8hl1:L31E, 8hl2:L31E, 8hl3:L31E, 8hl4:L31E, 8hl5:L31E
31 8wcs:A 1044 31 0.1143 0.0115 0.3871 2.4
32 1u8v:A 490 17 0.0952 0.0204 0.5882 3.4 1u8v:B, 1u8v:C, 1u8v:D
33 7d72:K 360 38 0.1333 0.0389 0.3684 8.7 7d72:I, 7d72:E, 7d72:F, 7d72:G, 7d72:H, 7d72:J, 7d72:L, 7d73:E, 7d73:F, 7d73:G, 7d73:I, 7d73:J, 7d73:K, 7d73:L, 7d73:H, 7d74:E, 7d74:F, 7d74:G, 7d74:H, 7d74:I, 7d74:J, 7d74:K, 7d74:L
34 4rzy:A 439 43 0.1524 0.0364 0.3721 9.2 4rzy:B, 4rzy:C, 4rzy:D, 4rzz:A, 4rzz:B, 4rzz:C, 4rzz:D, 4s00:A, 4s00:B, 4s00:C, 4s00:D, 4s01:A, 4s01:B, 4s01:C, 4s01:D

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218