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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
DLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGIVIRSILTDKREKYYDSKGIGCYMFRIDDSEV
VDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFKLPCNCGAKKCRKFL

The query sequence (length=149) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 2w5z:A 180 156 0.9866 0.8167 0.9423 2.15e-106 5f5e:A, 5f6l:A, 6pwv:C, 6pww:C, 7u5v:A, 6u9k:A, 6u9k:B, 6u9m:A, 6u9m:B, 6u9n:A, 6u9n:B, 6u9r:A, 6u9r:B, 2w5y:A, 7w67:C, 7w6a:C, 7w6i:C, 7w6j:C
2 6kiu:K 179 149 0.9732 0.8101 0.9732 1.16e-105 6kiv:K, 6kix:K, 6kiz:K, 7ud5:K
3 7bre:B 163 154 0.8725 0.7975 0.8442 9.43e-97 7bre:E
4 7w6l:C 158 150 0.4564 0.4304 0.4533 3.08e-44 5f59:A, 5f6k:C, 5f6k:E, 6kiw:K, 7w6l:E
5 6ugm:M 188 149 0.4899 0.3883 0.4899 1.57e-43
6 6uh5:M 222 136 0.4832 0.3243 0.5294 4.08e-43 6chg:C
7 6ven:N 218 135 0.4631 0.3165 0.5111 1.19e-41
8 4z4p:A 161 150 0.4430 0.4099 0.4400 9.69e-40
9 7at8:A 311 124 0.3289 0.1576 0.3952 5.72e-24
10 5ij7:B 469 124 0.3289 0.1045 0.3952 1.11e-23 6b3w:A, 6b3w:B, 6c23:K, 6c24:K, 5ij7:A, 5ij8:A, 5ij8:B, 4w2r:A, 4w2r:B
11 5wg6:A 517 124 0.3289 0.0948 0.3952 1.33e-23 5wg6:C
12 6wkr:C 606 124 0.3289 0.0809 0.3952 1.36e-23 4mi0:A, 4mi5:A, 8t9g:I
13 5hyn:A 581 124 0.3289 0.0843 0.3952 1.51e-23 5hyn:F, 5hyn:K, 5hyn:Q, 5ls6:A, 5ls6:G, 5ls6:J, 5ls6:D
14 7td5:F 447 111 0.3154 0.1051 0.4234 2.12e-23
15 8tas:E 570 124 0.3289 0.0860 0.3952 3.44e-23 8tb9:E
16 8t9g:C 536 124 0.3289 0.0914 0.3952 3.52e-23 8fyh:A, 8fyh:G
17 7td5:A 497 111 0.3154 0.0946 0.4234 4.07e-23
18 7kso:A 395 122 0.3221 0.1215 0.3934 4.40e-23 7ksr:A, 7ktp:A
19 9c8u:A 475 124 0.3289 0.1032 0.3952 4.86e-23
20 5jlb:A 248 148 0.3289 0.1976 0.3311 6.41e-23 7ea8:L, 4fmu:A, 4h12:A, 6j9j:A, 5jjy:A, 5jle:A, 5lss:A, 5lsx:A, 5lsy:A, 5lsz:A, 5lt6:A, 5lt6:B, 5lt7:A, 5lt8:A, 7lzb:A, 7lzd:A, 7lzf:A, 8q5p:A, 7ty2:A, 7ty3:A, 5v21:A, 5v22:A, 6vdb:A
21 8fbh:A 232 138 0.3356 0.2155 0.3623 1.35e-22 8fbg:A, 8fbg:B, 6kqp:A, 6kqq:A, 6kqq:B, 3ooi:A
22 2r3a:A 270 156 0.3893 0.2148 0.3718 2.09e-22 6p0r:A, 6p0r:B
23 6ine:A 247 130 0.3221 0.1943 0.3692 2.55e-21 6ago:A, 6ago:B, 3ope:A, 3ope:B, 6wzw:A, 6x0p:A, 6x0p:B, 6x0p:C, 6x0p:D, 4ynm:A, 4ynm:B, 4ynp:A, 4ynp:B, 4ypa:A, 4ypa:B, 4ypa:C, 4ypa:D, 4ype:A, 4ype:B, 4ypu:A, 4ypu:B
24 5lsu:A 231 129 0.3356 0.2165 0.3876 3.76e-21 7cro:I, 7e8d:K, 5lsu:B
25 6cen:A 226 134 0.3020 0.1991 0.3358 1.14e-19 7crp:I, 7crq:L, 7crq:I, 7crr:I, 5upd:A
26 7ea5:K 228 148 0.3087 0.2018 0.3108 8.53e-19
27 6nzo:S 233 148 0.3289 0.2103 0.3311 1.27e-18 6px3:S
28 7xpx:K 167 110 0.2886 0.2575 0.3909 1.11e-16 6boz:A, 6boz:B, 2bqz:A, 2bqz:E, 3f9w:B, 3f9w:A, 3f9w:C, 3f9w:D, 3f9x:B, 3f9x:A, 3f9x:C, 3f9x:D, 3f9y:A, 3f9y:B, 3f9z:B, 3f9z:A, 3f9z:C, 3f9z:D, 4ij8:A, 4ij8:B, 5t5g:A, 5teg:A, 5teg:B, 5th7:A, 5th7:B, 5w1y:A, 5w1y:B, 1zkk:A, 1zkk:B, 1zkk:C, 1zkk:D
29 4qen:A 472 147 0.3557 0.1123 0.3605 6.69e-16 4qeo:A, 4qep:A
30 3hna:A 280 156 0.3758 0.2000 0.3590 2.08e-15 3fpd:A, 3fpd:B, 3hna:B, 4i51:A, 4i51:B, 2igq:A, 2igq:B, 6mbo:A, 6mbo:B, 6mbp:A, 6mbp:B, 3mo0:A, 3mo0:B, 3mo2:A, 3mo2:B, 3mo2:C, 3mo2:D, 3mo5:A, 3mo5:B, 3mo5:C, 3mo5:D, 2rfi:A, 2rfi:B, 3sw9:A, 3sw9:B, 3swc:A, 3swc:B, 7t7m:A, 7t7m:B, 7t7m:C, 7t7m:D, 5ttg:A, 5ttg:B, 5tuz:A, 5tuz:B, 5v9j:A, 5v9j:B, 5vsd:A, 5vsd:B, 5vsf:A, 5vsf:B, 8xpt:A, 8xpt:B, 8xpt:C, 8xpt:D
31 3bo5:A 269 166 0.3624 0.2007 0.3253 2.72e-15
32 1peg:A 266 160 0.3423 0.1917 0.3187 6.95e-15 1ml9:A, 1peg:B
33 6a5m:A 488 175 0.3154 0.0963 0.2686 4.62e-14 6a5k:A
34 6z2a:A 283 147 0.3356 0.1767 0.3401 7.77e-14 6box:A, 6box:B, 6bp4:B, 6bp4:A, 1mvh:A, 1mvx:A, 6z2a:B
35 7x73:A 274 154 0.3423 0.1861 0.3312 8.92e-14 7btv:A, 7btv:B, 7buc:A, 7buc:B, 7dcf:A, 7dcf:B, 5jhn:A, 5jhn:B, 5jin:A, 5jin:B, 5jiy:A, 5jiy:B, 5jj0:A, 5jj0:B, 3k5k:A, 3k5k:B, 4nvq:A, 4nvq:B, 2o8j:A, 2o8j:B, 2o8j:C, 2o8j:D, 3rjw:A, 3rjw:B, 5t0k:A, 5t0k:B, 5t0m:A, 5t0m:B, 7t7l:A, 7t7l:B, 7t7l:C, 7t7l:D, 5ttf:A, 5ttf:B, 5ttf:C, 5ttf:D, 5tuy:A, 5tuy:B, 5v9i:A, 5v9i:B, 5v9i:C, 5v9i:D, 5vsc:A, 5vsc:B, 5vse:A, 5vse:B, 7x73:B, 7xua:A, 7xua:B, 7xub:A, 7xub:B, 7xuc:A, 7xuc:B, 7xud:A, 7xud:B
36 5tqr:B 809 132 0.2819 0.0519 0.3182 2.08e-13 5bjs:B, 5vk3:B
37 5wf7:B 765 131 0.2752 0.0536 0.3130 2.43e-13 5kji:B
38 5kkl:B 839 141 0.2953 0.0524 0.3121 1.17e-12
39 5kjh:B 807 132 0.2819 0.0520 0.3182 1.29e-12 5m5g:B
40 5wfd:B 774 131 0.2752 0.0530 0.3130 3.22e-12 5wfc:B
41 6a5n:A 502 162 0.2953 0.0876 0.2716 5.10e-11
42 2g46:A 119 116 0.2416 0.3025 0.3103 8.47e-05 2g46:B, 3kmt:A, 3kmt:B, 3kmt:C
43 5ex0:A 429 41 0.1342 0.0466 0.4878 0.006 7bj1:A, 5ccl:A, 5ccm:A, 5ex3:A, 5hi7:A, 5hq8:A, 5hq8:B, 6ijl:A, 3mek:A, 7o2a:A, 7o2b:A, 7o2c:A, 6o9o:A, 8owo:A, 3oxf:A, 3oxf:B, 3oxg:A, 3oxl:A, 6p6g:A, 6p6k:A, 6p7z:A, 6paf:A, 3pdn:A, 7qlb:A, 7qnr:A, 7qnu:A, 3qwp:A, 3ru0:A, 3ru0:B, 5v37:A, 5xxd:A, 5xxg:A, 5xxj:A, 5yjo:A, 6yuh:A, 6zrb:A
44 8sr6:A 451 109 0.1812 0.0599 0.2477 0.025 5czy:A, 8swi:A
45 4o30:A 217 54 0.1342 0.0922 0.3704 0.025 4o30:B, 5va6:A, 5va6:B, 5vac:A, 5vah:A, 5vah:B, 5vbc:A, 5vbc:B
46 8qma:J 426 53 0.1275 0.0446 0.3585 0.029 8r5o:L, 8r6s:L, 8ras:L, 8rdj:L
47 4k50:A 460 78 0.1409 0.0457 0.2692 0.046 4k50:I, 4k50:E, 4k50:M, 1tp7:A
48 4au7:A 243 50 0.1275 0.0782 0.3800 0.12 4au7:B, 3rq4:A
49 7yrg:L 240 47 0.1141 0.0708 0.3617 0.14
50 8t9f:K 264 47 0.1141 0.0644 0.3617 0.15 4bup:A, 4bup:B, 5cpr:B, 8jhf:K, 8jhg:K, 3s8p:A, 3s8p:B, 5wbv:A, 5wbv:B, 7yrd:K, 7yrg:K
51 3n71:A 468 78 0.1745 0.0556 0.3333 0.61
52 4hei:A 92 50 0.0872 0.1413 0.2600 0.68 4hei:B
53 9fmd:M 224 34 0.0872 0.0580 0.3824 1.5 8c6j:y, 8i0u:M, 8i0v:M, 8i0w:M, 6icz:M, 6id0:M, 6id1:M, 5mqf:N, 6qdv:y, 8ro2:M, 7w59:M, 7w5a:M, 7w5b:M, 5xjc:M, 5yzg:M
54 4nj5:A 482 158 0.2483 0.0768 0.2342 1.6
55 3b1j:A 338 43 0.0940 0.0414 0.3256 2.5 3b1j:B, 3b1k:A, 3b1k:H, 3b1k:B, 3b1k:G, 3b20:A, 3b20:B, 3b20:O, 3b20:P, 3b20:Q, 3b20:R, 2d2i:A, 2d2i:B, 2d2i:O, 2d2i:P, 2d2i:Q, 2d2i:R, 2duu:A, 2duu:B, 2duu:O, 2duu:P, 2duu:Q, 2duu:R
56 1eje:A 192 68 0.1141 0.0885 0.2500 5.5
57 4mz0:B 823 53 0.0872 0.0158 0.2453 5.9
58 4mz0:A 896 53 0.0872 0.0145 0.2453 5.9
59 6jcy:C 1139 61 0.1208 0.0158 0.2951 6.4 6bzo:C, 6c04:C, 6c06:C, 6dv9:C, 6dvb:C, 6dvc:C, 6dvd:C, 6dve:C, 8e74:C, 8e79:C, 8e82:C, 8e8m:C, 8e95:C, 6edt:C, 6ee8:C, 6eec:C, 8ehq:C, 8ej3:C, 8eoe:C, 8eof:C, 8eos:C, 8eot:C, 8exy:C, 6fbv:C, 8hih:C, 6jcx:C, 7kif:C, 7kin:C, 6koo:C, 6kop:C, 6koq:C, 6m7j:C, 7p5x:AC, 7rwi:C, 6tye:C, 6tyf:C, 6tyg:C, 7u22:C, 5uh5:C, 5uh6:C, 5uh8:C, 5uh9:C, 5uha:C, 5uhb:C, 5uhc:C, 5uhd:C, 5uhe:C, 5uhf:C, 5uhg:C, 5vi5:C, 6vvx:C, 6vvy:C, 6vvz:C, 6vw0:C, 5zx2:C

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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