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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
DKIRILWVDDEIDLLKPHILFLEKKNYEVTTSNNGLDAIALFEEENFDIVFLDENMPGMSGLETLSEMKEKKSAIPMIMI
TKSEEEYIMEEAIGSKIADYLIKPVNPNQILLSLKKNLDDSRLITEKTTLDYQKEFRKISMELAMVNSYEDWVELYKKLL
FWELKLEDINDQAMIEILESQKVEANSQFGKYIERNYEDWFAPKADKPIQSHNLFKELVVPEIKKKDKPILFVVIDNLRY
DQWKSFETVISNYYKLEKEVPYFSILPTATQYARNAIFSGLMPLDMEKQFPQYWKNDVEDGGKNLYEAEFLSAQIKRLGL
NIKEDYFKITNYAGGKKLAENFKALKGNDLVTVVYNFVDMLSHAKTEMEVVKELASDDKAYRSLTLSWFKNSPLLEIIQQ
AQLLGFKLILTTDHGTINVKNPSKVVNLRYKTGRSLTYEQKDVYVVKEPKTIGLPAINMSSSFIFAKNDFFLAYVNNYNH
YVSYYKNTYQHGGISLEEMIIPFLVFNPK

The query sequence (length=509) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8tef:A 516 516 1.0000 0.9864 0.9864 0.0 8p6f:A, 8p6f:B, 8ted:A, 8ted:B, 8tef:B, 8tef:C, 8tef:D, 8tff:A, 8tff:B, 8tfm:A, 8tfm:B, 8thp:A, 8thp:B
2 7pv7:C 514 512 0.5128 0.5078 0.5098 1.42e-175 7pv7:D, 7pv7:B, 7pv7:A, 7pva:A, 7pva:B, 7pva:C, 7pva:D, 7pvk:A, 7pvk:D, 7pvk:B, 7pvk:C
3 2oqr:A 226 126 0.0766 0.1726 0.3095 2.24e-13
4 1mvo:A 121 109 0.0648 0.2727 0.3028 2.01e-12
5 2jk1:A 138 143 0.0884 0.3261 0.3147 4.72e-12 2vui:B
6 4h60:A 120 117 0.0688 0.2917 0.2991 9.82e-12
7 3a10:A 116 78 0.0629 0.2759 0.4103 4.25e-11 3a0u:A
8 2a9r:A 118 123 0.0806 0.3475 0.3333 3.29e-10 2a9o:A, 2a9p:A, 6eb7:A, 6ebr:A, 1nxp:A, 1nxt:A
9 6swl:A 133 117 0.0668 0.2556 0.2906 9.17e-10 6swl:B
10 7cci:B 134 120 0.0688 0.2612 0.2917 1.99e-09 7cci:A, 5xjp:A
11 1l5y:B 151 140 0.0707 0.2384 0.2571 3.95e-09 1l5y:A
12 6is1:B 121 112 0.0629 0.2645 0.2857 4.75e-09 6is1:A, 6is1:C, 6is1:D, 6is1:E, 6is1:F, 6is1:G, 6is1:H, 6is2:A, 6is2:B, 6is2:C, 6is2:D, 6is3:C
13 7qz2:B 132 113 0.0688 0.2652 0.3097 6.02e-09 7qz2:A
14 4b09:A 218 143 0.0806 0.1881 0.2867 7.11e-09 4b09:B, 4b09:C, 4b09:D, 4b09:E, 4b09:F, 4b09:G, 4b09:I, 4b09:K
15 2gwr:A 225 106 0.0570 0.1289 0.2736 7.63e-09 3nhz:B, 3nhz:C, 3nhz:D
16 2v0n:A 459 109 0.0688 0.0763 0.3211 1.76e-08 2v0n:B, 1w25:A, 1w25:B, 2wb4:A, 2wb4:B
17 6ifh:A 119 105 0.0629 0.2689 0.3048 2.83e-08
18 5ed4:E 224 114 0.0668 0.1518 0.2982 2.86e-08 5ed4:A, 5ed4:B, 5ed4:F, 2pmu:E
19 4qpj:D 121 109 0.0550 0.2314 0.2569 3.93e-08
20 7od9:B 129 112 0.0668 0.2636 0.3036 5.25e-08 6ekg:Y, 6ekh:Y, 7od9:A
21 6c40:D 118 114 0.0609 0.2627 0.2719 7.82e-08 6c40:B, 4iga:A, 3tmy:A, 3tmy:B, 4tmy:A, 4tmy:B
22 4hnq:A 124 90 0.0550 0.2258 0.3111 7.95e-08 4hns:A, 4jp1:A, 4lx8:A, 3to5:A
23 2iyn:B 124 114 0.0589 0.2419 0.2632 8.84e-08 2iyn:A, 2iyn:C, 1zes:A, 1zes:B, 1zes:C
24 1srr:C 121 118 0.0747 0.3140 0.3220 1.16e-07 1f51:E, 2ftk:E, 2ftk:F, 2ftk:G, 2ftk:H, 1pey:A, 1pey:B, 1pey:C, 3q15:C, 1srr:A
25 6rgz:D 122 121 0.0747 0.3115 0.3140 1.44e-07 6azr:B, 6azr:D, 3gl9:A, 3gl9:B, 3gl9:C, 3gl9:D, 4ja2:A, 4jas:B, 4jav:C, 4jav:D, 6rfv:C, 6rfv:D, 6rgy:C, 6rgy:D, 6rgz:C, 6rh0:C, 6rh0:D, 5uht:B, 5uht:D
26 3nnn:A 119 113 0.0609 0.2605 0.2743 1.75e-07 3nnn:B
27 8phn:A 124 118 0.0570 0.2339 0.2458 1.79e-07
28 1s8n:A 190 141 0.0766 0.2053 0.2766 3.02e-07
29 6br7:B 125 114 0.0668 0.2720 0.2982 4.20e-07 6br7:A, 6vbf:A, 6vbf:B
30 5m7o:A 448 143 0.0786 0.0893 0.2797 6.42e-07 4d6y:A, 4d6y:B, 5m7n:A, 5m7o:B, 5m7p:A, 5m7p:B
31 8pdc:A 122 112 0.0648 0.2705 0.2946 8.47e-07
32 6ob8:A 307 128 0.0668 0.1107 0.2656 8.73e-07 6oap:A, 6oap:B, 6oaq:A, 6oaq:B, 6ob8:B
33 1j56:A 124 105 0.0550 0.2258 0.2667 1.26e-06 1krx:A
34 3q15:D 100 81 0.0589 0.3000 0.3704 1.36e-06
35 1xhf:B 122 112 0.0589 0.2459 0.2679 1.47e-06 1xhf:A
36 7w9h:B 122 108 0.0570 0.2377 0.2685 2.34e-06 7w9h:A
37 1mav:A 117 101 0.0589 0.2564 0.2970 2.46e-06 1mb0:A, 1mb3:A
38 6qrj:A 463 114 0.0589 0.0648 0.2632 3.03e-06 6qrl:A, 6qrl:B
39 4zmr:A 207 128 0.0668 0.1643 0.2656 4.38e-06 4e7o:A, 4e7o:B, 4e7p:A, 4e7p:B, 4zmr:B, 4zms:A, 4zms:B
40 5lwk:A 122 107 0.0570 0.2377 0.2710 4.65e-06 5lwk:B
41 5wq0:D 129 108 0.0668 0.2636 0.3148 1.04e-05 5wq0:B, 5wq0:A, 5wq0:C, 5wq0:E, 5wq0:F, 5wq0:G
42 5m7n:B 428 141 0.0747 0.0888 0.2695 2.93e-05
43 7lza:A 219 102 0.0570 0.1324 0.2843 3.02e-05 7lz9:A
44 3hzh:A 134 110 0.0550 0.2090 0.2545 3.84e-05
45 8phx:C 130 88 0.0491 0.1923 0.2841 7.00e-05 8phx:A, 8phx:B, 8phx:D
46 3hdg:A 124 113 0.0570 0.2339 0.2566 1.00e-04 3hdg:B, 3hdg:D, 3hdg:E
47 7cfw:A 123 85 0.0413 0.1707 0.2471 1.02e-04 7c1j:A
48 8t85:A 335 74 0.0413 0.0627 0.2838 1.03e-04 7lcm:A
49 5ic5:A 166 123 0.0648 0.1988 0.2683 1.07e-04
50 6ont:A 121 92 0.0413 0.1736 0.2283 1.14e-04
51 7p8d:A 139 126 0.0707 0.2590 0.2857 1.25e-04 7p8d:B
52 5xt2:B 204 106 0.0589 0.1471 0.2830 1.36e-04 5xt2:A, 5xt2:C, 5xt2:D, 5xt2:E
53 1yio:A 198 118 0.0589 0.1515 0.2542 1.60e-04 1zn2:A
54 3nns:A 117 79 0.0472 0.2051 0.3038 1.97e-04 3nns:B
55 1qmp:A 126 79 0.0452 0.1825 0.2911 2.04e-04 1qmp:B, 1qmp:C, 1qmp:D
56 1dck:B 125 109 0.0550 0.2240 0.2569 2.55e-04 1dck:A, 1dcm:B
57 3m6m:D 118 117 0.0609 0.2627 0.2650 3.02e-04 3m6m:E, 3m6m:F
58 3rvr:B 131 78 0.0432 0.1679 0.2821 4.68e-04 1a0o:A, 1a0o:C, 1a0o:E, 1a0o:G, 2b1j:A, 2b1j:B, 1bdj:A, 1chn:A, 2che:A, 3chy:A, 5chy:A, 5d2c:A, 5d2c:B, 5dgc:A, 5dgc:B, 5dkf:A, 5dkf:B, 1f4v:A, 1f4v:B, 1f4v:C, 3f7n:A, 3f7n:B, 1ffg:A, 1ffg:C, 1ffs:A, 1ffs:C, 1ffw:A, 1ffw:C, 3fft:A, 3fft:B, 3ffw:A, 3ffw:B, 3ffx:A, 3ffx:B, 3fgz:A, 3fgz:B, 2fka:A, 2flk:A, 2flw:A, 2fmf:A, 2fmh:A, 2fmi:A, 2fmk:A, 1fqw:A, 1fqw:B, 1kmi:Y, 1mih:A, 1mih:B, 3myy:A, 3myy:B, 3olv:A, 3olv:B, 3olw:A, 3olw:B, 3olx:A, 3olx:B, 3oly:A, 3oly:B, 3oo0:A, 3oo0:B, 3oo1:A, 3oo1:B, 2pl9:A, 2pl9:B, 2pl9:C, 2pmc:A, 2pmc:B, 3rvj:A, 3rvj:B, 3rvk:A, 3rvl:A, 3rvl:B, 3rvm:A, 3rvn:A, 3rvn:B, 3rvo:A, 3rvp:A, 3rvp:B, 3rvq:A, 3rvr:A, 3rvs:A, 3rvs:B, 6tg7:A, 1u8t:A, 1u8t:B, 1ymv:A, 1zdm:A, 1zdm:B
59 6xvu:D 141 111 0.0589 0.2128 0.2703 4.70e-04 6xvu:A, 6xvu:C, 6xvu:B
60 3rqi:A 170 96 0.0472 0.1412 0.2500 5.84e-04
61 4ldz:A 196 123 0.0589 0.1531 0.2439 0.001 5iuk:C, 5iul:C, 5iul:F, 4ldz:B, 4le0:A, 4le0:B, 7ssj:B, 7ssj:E, 7ssj:F
62 5brj:A 140 69 0.0413 0.1500 0.3043 0.001
63 8svz:A 120 120 0.0648 0.2750 0.2750 0.001 8svz:B
64 4kny:B 226 133 0.0648 0.1460 0.2481 0.002 4kfc:A, 4kfc:B, 4kny:A, 1zh2:A, 1zh2:B, 1zh4:A, 1zh4:B
65 1k68:A 140 93 0.0491 0.1786 0.2688 0.002 1k68:B
66 1ny5:B 385 117 0.0668 0.0883 0.2906 0.003 4bs1:A, 4bs1:B, 4bt0:A, 4bt0:B, 4bt1:A, 4bt1:B, 4ly6:A, 4ly6:B, 4ly6:C, 4ly6:D, 4ly6:E, 4ly6:G, 4ly6:H, 4ly6:I, 4ly6:J, 4ly6:K, 4ly6:L, 4ly6:M, 4ly6:N, 4ly6:O, 4ly6:P, 4ly6:Q, 4ly6:R, 4ly6:S, 4ly6:T, 4ly6:U, 4ly6:V, 4ly6:W, 4ly6:X, 4lzz:A, 4lzz:B, 4lzz:C, 4lzz:D, 4lzz:E, 4lzz:F, 4lzz:G, 4lzz:H, 4lzz:I, 4lzz:J, 4lzz:K, 4lzz:L, 4lzz:M, 4lzz:N, 4lzz:O, 4lzz:P, 4lzz:Q, 4lzz:R, 4lzz:S, 4lzz:T, 4lzz:U, 4lzz:V, 4lzz:W, 4lzz:X, 3m0e:A, 3m0e:B, 3m0e:C, 3m0e:D, 3m0e:E, 3m0e:F, 3m0e:G, 1ny5:A, 1ny6:A, 1ny6:B, 1ny6:C, 1ny6:D, 1ny6:E, 1ny6:F, 1ny6:G, 1ny6:H, 1ny6:I, 1ny6:J, 1ny6:K, 1ny6:L, 1ny6:M, 1ny6:N, 1zy2:A
67 2pl1:A 121 114 0.0472 0.1983 0.2105 0.003
68 8uvx:A 222 116 0.0550 0.1261 0.2414 0.003 8uvk:A, 8uvk:B, 8uvx:B
69 3cg4:A 126 109 0.0452 0.1825 0.2110 0.004
70 7p8e:A 126 118 0.0530 0.2143 0.2288 0.006
71 3gwg:A 123 113 0.0609 0.2520 0.2743 0.006 3h1e:A, 3h1g:A
72 4nic:A 117 106 0.0491 0.2137 0.2358 0.009 4nic:B, 4nic:C, 4nic:D
73 3luf:B 246 121 0.0530 0.1098 0.2231 0.011 3luf:A, 3mf4:A, 3mf4:B
74 3dzd:A 368 117 0.0609 0.0842 0.2650 0.026 3dzd:B
75 4if4:A 208 118 0.0570 0.1394 0.2458 0.035 4if4:B, 4if4:C, 4if4:D, 7ve5:B, 7ve5:A, 7ve6:A, 7ve6:B
76 6zxb:A 293 69 0.0393 0.0683 0.2899 0.036 6zxb:B, 6zxc:A, 6zxc:B, 6zxc:C, 6zxc:D, 6zxm:A, 6zxm:B, 6zxm:C, 6zxm:D, 6zxm:E, 6zxm:F
77 6ww6:B 192 141 0.0648 0.1719 0.2340 0.037 6wsh:A, 6wsh:B, 6ww6:A
78 1jlk:A 141 70 0.0373 0.1348 0.2714 0.061
79 4euk:A 136 64 0.0354 0.1324 0.2812 0.068
80 3bre:B 328 68 0.0373 0.0579 0.2794 0.074 3bre:A
81 1ys6:B 227 95 0.0452 0.1013 0.2421 0.20 1ys6:A, 1ys7:A, 1ys7:B
82 3i5a:A 319 57 0.0334 0.0533 0.2982 0.27
83 2r25:B 133 62 0.0295 0.1128 0.2419 0.88
84 1mqs:A 588 47 0.0275 0.0238 0.2979 1.7
85 4af1:A 410 72 0.0452 0.0561 0.3194 2.3
86 4yn8:A 201 59 0.0314 0.0796 0.2712 3.3
87 5n2n:A 149 105 0.0629 0.2148 0.3048 3.5 3mmn:A
88 5osy:A 300 36 0.0275 0.0467 0.3889 3.8 3bl7:A, 3bl9:A, 3bla:A, 3bla:B, 5osy:B, 4qde:A, 4qde:D, 4qdv:A, 4qdv:C, 4qdv:D, 4qeb:A, 1st0:B, 1st0:A, 1st4:B, 1st4:A, 1xmm:B, 1xmm:A, 1xmm:C, 1xmm:D
89 1z63:A 468 103 0.0530 0.0577 0.2621 5.7 1z63:B
90 8hr5:A 466 90 0.0570 0.0622 0.3222 6.9
91 1syo:A 422 55 0.0255 0.0308 0.2364 8.1 1syo:B, 1sz0:A, 1sz0:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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