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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
AVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTG
YQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKE
EKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKI
YERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKLVELLEIFRDGILIFAQTEEE
GKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRF
VLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQASGRSSRILNGVLV
KGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLG
RASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSK
NIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKA
QIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVV
ELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLRKIGKEDIFM
GRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQI
VEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYK
RVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEE

The query sequence (length=1102) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4ddt:A 1102 1102 1.0000 1.0000 1.0000 0.0 4ddu:A, 4ddv:A, 4ddv:B, 4ddw:A, 4ddx:A, 4ddx:B, 7fsf:A
2 7fse:A 1040 647 0.5871 0.6221 1.0000 0.0 8ofb:A, 3oiy:A, 3p4x:A
3 7fse:A 1040 393 0.3566 0.3779 1.0000 0.0 8ofb:A, 3oiy:A, 3p4x:A
4 1gl9:B 1020 1105 0.3993 0.4314 0.3982 0.0 1gl9:C
5 6ozw:A 538 593 0.1633 0.3346 0.3035 1.85e-53
6 8czq:A 655 595 0.1670 0.2809 0.3092 1.39e-49
7 4rul:A 823 607 0.1552 0.2078 0.2817 1.23e-47 1cy1:A, 1cy2:A, 1cy4:A, 1cy6:A, 1cy7:A, 1cy8:A, 1mw8:X, 3px7:A
8 6pcm:A 793 619 0.1534 0.2131 0.2730 9.76e-47 6pcm:B
9 6cq2:A 688 628 0.1652 0.2645 0.2898 2.58e-45 6cqi:A
10 9c9y:A 612 617 0.1352 0.2435 0.2415 1.97e-20 9ca0:A, 9ca1:A
11 6k8n:A 668 488 0.0998 0.1647 0.2254 7.67e-14 6k8n:B, 6k8n:C, 6k8n:D, 6k8o:A
12 2o5c:A 634 546 0.1116 0.1940 0.2253 1.31e-13 1i7d:A, 2o19:A, 2o19:B, 2o54:A, 2o54:B, 2o59:A, 2o59:B, 2o5c:B, 2o5e:A, 2o5e:B
13 2db3:A 420 96 0.0254 0.0667 0.2917 0.006 2db3:B, 2db3:C, 2db3:D
14 5lst:A 617 130 0.0263 0.0470 0.2231 0.016
15 9bct:I 65 27 0.0127 0.2154 0.5185 0.058
16 1ryq:A 64 28 0.0118 0.2031 0.4643 0.092 8oki:I, 8p2i:I, 3p8b:A, 3p8b:C, 3qqc:E
17 2p6r:A 683 88 0.0254 0.0410 0.3182 0.13
18 6gej:M 688 164 0.0327 0.0523 0.2195 0.23 6gen:M
19 7zsa:7 616 113 0.0272 0.0487 0.2655 1.1 8cen:7, 8ceo:7, 7o4i:7, 7o4j:7, 7o4k:7, 7o4l:7, 7o72:7, 7o73:7, 7o75:7, 7zs9:7, 7zsb:7
20 7ml3:7 548 113 0.0272 0.0547 0.2655 1.1
21 7k04:7 638 113 0.0272 0.0470 0.2655 1.2 5fmf:1, 7m2u:7, 7ml0:7, 7ml1:7, 7ml2:7, 5sva:Z
22 2vso:A 366 129 0.0290 0.0874 0.2481 1.5 1fuk:A, 2vso:B, 2vsx:A, 2vsx:B
23 6p4f:C 436 77 0.0245 0.0619 0.3506 1.6 6p4f:A, 6p4w:A
24 6yxy:EB 663 245 0.0399 0.0664 0.1796 1.9 7aoi:XB, 6yxx:EB
25 8h1j:A 362 57 0.0145 0.0442 0.2807 2.8 8ex9:A, 8exa:A
26 1gm5:A 729 63 0.0172 0.0261 0.3016 3.1
27 9bha:A 793 71 0.0200 0.0277 0.3099 3.2 5a9f:A, 5aga:A, 9bh8:A, 9bh8:B, 9bh9:A, 9bh9:B, 9bha:B, 9c5q:C, 9c5q:A
28 5jb2:A 670 65 0.0181 0.0299 0.3077 3.3 5jaj:A, 5jbg:A
29 9asj:A 741 71 0.0200 0.0297 0.3099 4.0 9asj:B, 9bp9:A, 9bp9:C, 9bpa:A, 9bpa:C, 9bpa:E, 9bpa:G
30 5jbj:A 627 65 0.0181 0.0319 0.3077 4.0
31 4nmn:A 425 155 0.0381 0.0988 0.2710 4.7 4nmn:B
32 8w0a:C 636 71 0.0200 0.0346 0.3099 4.7 8w0a:A
33 8fkv:NI 647 88 0.0227 0.0386 0.2841 4.7 8fkt:NI, 8fku:NI, 8fkw:NI, 8fkx:NI, 8fky:NI
34 6a6u:A 432 69 0.0172 0.0440 0.2754 5.0 6a6r:A, 6a6s:A, 6a6t:A, 6a6v:A, 6a6v:H
35 6htj:A 119 25 0.0091 0.0840 0.4000 5.0 6htj:B
36 1im2:A 346 128 0.0327 0.1040 0.2812 5.3 1g3i:T, 1g41:A
37 1g3i:A 326 132 0.0327 0.1104 0.2727 5.7 1g3i:B, 1g3i:C, 1g3i:D, 1g3i:E, 1g3i:F, 1g3i:S, 1g3i:U, 1g3i:V, 1g3i:W, 1g3i:X, 1kyi:A, 1kyi:B, 1kyi:C, 1kyi:D, 1kyi:E, 1kyi:F, 1kyi:S, 1kyi:T, 1kyi:U, 1kyi:V, 1kyi:W, 1kyi:X
38 6n2i:A 338 36 0.0127 0.0414 0.3889 6.1
39 3nvo:A 250 55 0.0127 0.0560 0.2545 6.5 3nvo:B, 3nwi:A, 3nwi:B, 3nwi:C, 3nwi:D, 3nwi:E
40 5tky:A 597 113 0.0236 0.0436 0.2301 6.5 5tky:B
41 6znq:B 711 110 0.0236 0.0366 0.2364 6.5 6znp:B
42 6znp:A 748 110 0.0236 0.0348 0.2364 6.6 6znq:A
43 5crg:A 354 134 0.0336 0.1045 0.2761 6.6 5crd:A, 5cre:A, 5crg:B, 5crg:C, 5crg:D, 5crh:A, 5crh:B, 5kn0:A, 5kn0:B, 5kn0:C, 5kn0:D, 5kn1:A, 5kn1:B, 5kn1:C, 5kn2:A, 5kn2:B, 5kn2:C, 5kn3:A, 3trp:A, 3trq:A, 3uom:A, 3uom:B, 3uom:C, 3uom:D, 3uom:E, 3uom:F, 3us3:A, 3v1w:A
44 6fwr:A 699 45 0.0145 0.0229 0.3556 6.7 6fws:A, 6fws:B
45 6zns:A 635 110 0.0236 0.0409 0.2364 6.7
46 6li9:A 623 123 0.0299 0.0530 0.2683 7.3 6li9:C, 6lid:A, 6lid:C, 6yup:A, 6yup:C, 6yuz:A, 6yuz:C
47 5ean:A 1051 144 0.0327 0.0343 0.2500 7.5 5eaw:A, 5eaw:B, 5eax:A, 5eax:B
48 5f9h:G 653 97 0.0209 0.0352 0.2371 7.5 5e3h:A, 5f98:A, 5f98:C, 5f98:E, 5f98:G, 5f98:I, 5f98:K, 5f9h:A, 5f9h:C, 5f9h:E, 5f9h:I, 5f9h:K, 6gpg:A, 7jl3:A, 7jl3:C, 7jl3:E
49 6v11:C 503 98 0.0218 0.0477 0.2449 7.9 6v11:A, 6v11:B, 6v11:F
50 8dvs:A 682 97 0.0209 0.0337 0.2371 8.2 7bah:A, 7bah:B, 7bai:A, 7bai:B, 7bai:E, 8dvu:A, 5f9f:A, 5f9f:C, 5f9f:E, 5f9f:G, 5f9f:I, 5f9f:K, 7jl1:A, 6kyv:B, 6kyv:D, 6kyv:F, 6kyv:H, 6kyv:J, 6kyv:L, 3lrn:A, 3lrn:B, 3lrr:A, 3lrr:B, 7mk1:A, 7mk1:B, 3ncu:A, 3ncu:B, 3og8:A, 3og8:B, 2qfb:A, 2qfb:B, 2qfb:C, 2qfb:D, 2qfb:E, 2qfb:F, 2qfb:G, 2qfb:H, 2qfb:I, 2qfb:J, 7tny:A, 7tnz:A, 7to0:A, 7to2:A
51 4o6o:D 199 47 0.0145 0.0804 0.3404 8.2 4o6o:A, 4o6o:B, 4o6o:C, 4o6p:B, 4o6p:C, 3vdp:A, 3vdp:B, 3vdp:C, 3vdp:D, 3vdu:A, 3ve5:D, 3ve5:A
52 1oyw:A 516 53 0.0145 0.0310 0.3019 8.3 1oyy:A
53 8g7t:A 647 97 0.0209 0.0355 0.2371 8.4 4ay2:A, 4bpb:A, 8dvr:A, 8g7u:A, 8g7u:C, 8g7v:A, 8g7v:C, 8scz:A, 8sd0:A, 7tnx:A, 7to1:A, 2ykg:A, 3zd6:A
54 3zd7:A 623 51 0.0154 0.0273 0.3333 8.8 8g7t:C
55 4s1h:A 287 112 0.0245 0.0941 0.2411 9.0 4s1h:B, 4s1i:A, 4s1i:B
56 1htn:A 156 34 0.0136 0.0962 0.4412 9.0 1tn3:A
57 3dkp:A 240 61 0.0172 0.0792 0.3115 9.3
58 7sxo:F 549 30 0.0136 0.0273 0.5000 9.3 7sxo:A, 7sxo:E, 7sxo:B, 7sxo:C, 7sxo:D

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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