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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
AQRVTFRRRNPYNTRSNKIKVVKTPGGILRAQHVKKLATRPKCGDCGSALQGISTLRPRQYATVSKTHKTVSRAYGGSRC
ANCVKERIIRAFLIEEQKIVKKVVKEQTE

The query sequence (length=109) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 6woo:g 121 109 1.0000 0.9008 1.0000 3.67e-77 8aaf:T, 8agt:T, 8agu:T, 8agv:T, 8agw:T, 8agx:T, 8agz:T, 5apn:g, 5apo:g, 7azy:B, 7b7d:Lc, 8bip:Lg, 8bjq:Lg, 8bn3:O4, 8bqd:BN, 8bqx:BN, 7bt6:g, 7btb:g, 6cb1:g, 8ccs:S, 8cdl:S, 8cdr:S, 8ceh:S, 8cf5:S, 8cg8:S, 8cgn:S, 8civ:S, 8cku:S, 8cmj:S, 5dat:O4, 5dat:o4, 5dc3:O4, 5dc3:o4, 5dge:O4, 5dge:o4, 5dgf:O4, 5dgf:o4, 5dgv:O4, 5dgv:o4, 6elz:g, 6em5:g, 8eub:Ag, 8evp:Ag, 8evq:Ag, 8evr:Ag, 8evs:Ag, 8evt:Ag, 8ewb:Ag, 8ewc:Ag, 5fci:O4, 5fci:o4, 5fcj:O4, 5fcj:o4, 6ft6:g, 5gak:i, 6gq1:g, 6gqb:g, 6gqv:g, 5h4p:g, 6hd7:i, 8hfr:g2, 6hhq:AH, 6hhq:DI, 5i4l:O4, 5i4l:o4, 6i7o:BN, 6i7o:YN, 3j6x:74, 3j6y:74, 3j77:84, 3j78:84, 3jct:g, 5jcs:g, 5juo:LA, 5jup:LA, 5jus:LA, 5jut:LA, 5juu:LA, 8k2d:Lg, 8k82:Lg, 5lyb:O4, 5lyb:o4, 5m1j:g5, 6m62:g, 5mc6:BN, 5mei:AH, 5mei:DI, 7mpi:Ag, 7mpj:Ag, 6n8j:g, 6n8k:g, 6n8l:g, 6n8m:t, 6n8n:t, 6n8o:t, 7n8b:Ag, 7nac:g, 7nad:g, 5ndg:O4, 5ndg:o4, 5ndv:O4, 5ndv:o4, 5ndw:O4, 5ndw:o4, 7nrc:Li, 7nrd:Li, 5obm:O4, 5obm:o4, 7of1:g, 7oh3:g, 7ohq:g, 7ohr:g, 6oig:g, 5on6:AH, 5on6:DI, 7osa:eL34, 7osm:eL34, 8p8m:RG, 8p8n:RG, 8p8u:RG, 8pfr:RG, 6q8y:BN, 6qik:g, 6qt0:g, 6qtz:g, 7r72:g, 7r7a:g, 6r84:i, 6r86:i, 6r87:i, 6ri5:g, 7rr5:Lg, 6rzz:g, 6s05:g, 6s47:Ai, 6snt:aj, 6sv4:BN, 6sv4:YN, 6sv4:ZN, 6t4q:Lg, 5t62:t, 5t6r:t, 6t7i:Lg, 6t7t:Lg, 6t83:gy, 6t83:R, 5tbw:AH, 5tbw:DI, 6tb3:BN, 5tga:O4, 5tga:o4, 5tgm:O4, 5tgm:o4, 6tnu:BN, 7too:AL34, 7top:AL34, 7u0h:g, 4u3m:O4, 4u3m:o4, 4u3n:O4, 4u3n:o4, 4u3u:O4, 4u3u:o4, 4u4n:O4, 4u4n:o4, 4u4o:O4, 4u4o:o4, 4u4q:O4, 4u4q:o4, 4u4r:O4, 4u4r:o4, 4u4u:O4, 4u4u:o4, 4u4y:O4, 4u4y:o4, 4u4z:O4, 4u4z:o4, 4u50:O4, 4u50:o4, 4u51:O4, 4u51:o4, 4u52:O4, 4u52:o4, 4u53:O4, 4u53:o4, 4u55:O4, 4u55:o4, 4u56:O4, 4u56:o4, 4u6f:O4, 4u6f:o4, 7ug6:g, 7uoo:g, 7uqb:g, 7uqz:g, 7v08:g, 4v6i:Bi, 4v7f:f, 4v88:Bg, 4v88:Dg, 4v8t:g, 4v8y:Bg, 4v8z:Bg, 8v87:g, 4v91:g, 6xiq:g, 6xir:g, 8y0u:Lg, 6ylg:g, 6ylh:g, 6ylx:g, 6yly:g, 7z34:g, 6z6j:Lg, 6z6k:Lg, 7zpq:Bf, 7zrs:Bf, 7zs5:Bh, 7zuw:Bf, 7zux:Ef, 7zw0:Lj
2 8c3a:AH 112 109 0.8716 0.8482 0.8716 2.97e-66 8c3a:CB, 8cq7:AH, 8cq7:CB, 8cqw:AH, 8cqw:CB, 8cre:AH, 8cre:CB, 8oeq:AH, 8oeq:CB, 7pzy:AH, 7q08:AH, 7q0f:AH, 7q0p:AH, 7q0r:AH, 8q5i:AH
3 5it7:gg 121 108 0.8532 0.7686 0.8611 1.20e-65 6uz7:Bg
4 8pv1:Lg 118 107 0.7156 0.6610 0.7290 1.02e-54 8i9x:Lg, 8i9y:Lg, 8i9z:Lg, 8ia0:Lg, 7olc:Lg, 7old:Lg, 8oo0:Lg, 8pv2:Lg, 8pv3:Lg, 8pv4:Lg, 8pv5:Lg, 8pv6:Lg, 8pv7:Lg, 8pv8:Lg, 8pvk:Lg, 8pvl:Lg, 7r81:i1, 7z3n:Lg, 7z3o:Lg
5 8esq:g 106 105 0.5963 0.6132 0.6190 8.08e-43 8esr:g, 8etc:g, 8etg:g, 8eug:g, 8eui:g
6 3j79:a 106 106 0.5505 0.5660 0.5660 1.23e-38 3jbn:Aa, 3jbo:Aa, 3jbp:Aa, 8tpu:Aa, 5umd:a
7 4v8p:AL 108 104 0.5688 0.5741 0.5962 3.69e-38 4v8p:DL, 4v8p:FL, 4v8p:HL
8 4v6w:Cg 113 109 0.5780 0.5575 0.5780 3.89e-36 6xu6:Cg, 6xu7:Cg, 6xu8:Cg
9 4v3p:Li 119 109 0.5413 0.4958 0.5413 4.03e-33 8azw:T, 8b2l:T3, 8ip8:PB, 8ipa:PB, 8ipb:PB, 8jiv:Cg, 7qiw:i, 7qiz:i, 4v7e:Cg
10 7qgg:h 116 110 0.5413 0.5086 0.5364 4.70e-33 7a01:y2, 8a3d:a, 5aj0:Ag, 8b5l:g, 8b6c:g, 9bdl:AL34, 9bdn:AL34, 9bdp:AL34, 7bhp:Lg, 8bhf:T1, 8bpo:f2, 8btk:Bg, 7cpu:Lg, 7cpv:Lg, 4d5y:g, 4d67:g, 6d90:g, 6d9j:g, 9f1b:Bg, 9f1c:Bg, 9f1d:Bg, 7f5s:Lg, 8fky:LR, 8fkz:LR, 8fl2:LR, 8fl3:LR, 8fl4:LR, 8fl6:LR, 8fl7:LR, 8fl9:LR, 8fla:LR, 8flb:LR, 8flc:LR, 8fld:LR, 8fle:LR, 8flf:LR, 6frk:g, 6ftg:g, 6fti:g, 6ftj:g, 8g5y:Lg, 8g5z:Lg, 8g60:Lg, 8g61:Lg, 8g6j:Lg, 8glp:Lg, 6gz3:Ag, 6gz4:Ag, 6gz5:Ag, 6hcf:g3, 6hcj:g3, 6hcm:g3, 6hcq:g3, 8idt:F, 8idy:F, 8ie3:F, 8ifd:2a, 8ife:2a, 8ine:F, 8inf:F, 8ink:F, 6ip5:2a, 6ip6:2a, 6ip8:2a, 8ipd:F, 8ipx:F, 8ipy:F, 8ir1:F, 8ir3:F, 3j7o:g, 3j7p:g, 3j7q:g, 3j7r:g, 3j92:g, 3jag:g, 3jah:g, 3jai:g, 3jaj:g, 3jan:g, 8jdj:l, 8jdk:l, 8jdl:l, 8jdm:l, 8k2c:Lg, 5lks:Lg, 6lqm:F, 6lsr:F, 6lss:F, 7ls1:a2, 7ls2:a2, 6lu8:F, 5lzs:g, 5lzt:g, 5lzu:g, 5lzv:g, 5lzw:g, 5lzx:g, 5lzy:g, 5lzz:g, 7mdz:g, 6mtb:g, 6mtc:g, 6mtd:g, 6mte:g, 7nfx:g, 7nwg:g3, 7nwh:g, 7nwi:g, 7o7y:Bg, 7o7z:Bg, 7o80:Bg, 7o81:Bg, 7obr:g, 8ohd:Lg, 8oj0:Lg, 8oj5:Lg, 8oj8:Lg, 6ole:h, 6olf:h, 6olg:Ag, 6oli:h, 6olz:Ag, 6om0:h, 6om7:h, 7ow7:a, 7oya:g1, 7oyb:g1, 7oyc:g1, 7oyd:g, 8p2k:Bg, 6p5i:Ag, 6p5j:Ag, 6p5k:Ag, 6p5n:Ag, 8q7z:Bg, 8q87:Bg, 8qfd:g, 8qoi:Lg, 7qvp:Lg, 7qvp:Mg, 7qwq:g, 7qwr:g, 7qws:g, 6qzp:Lg, 6r5q:g, 6r6g:g, 6r6p:g, 6r7q:g, 8rjb:g, 8rjc:g, 8rjd:g, 8scb:g, 6sgc:g2, 6swa:e, 5t2c:a, 6t59:g3, 7tm3:g, 7toq:AL34, 7tor:AL34, 7tut:g, 7ucj:g, 7uck:g, 4ug0:Lg, 4ujc:Bg, 4ujd:Ag, 4uje:Cg, 4v6x:Cg, 6w6l:h, 6xa1:Lg, 7xnx:Lg, 7xny:Lg, 8xsx:Lg, 8xsy:Lg, 8xsz:Lg, 6y0g:Lg, 8y0w:Lg, 8y0x:Lg, 6y2l:Lg, 6y57:Lg, 6y6x:Lg, 8yoo:Lg, 8yop:Lg, 6z6l:Lg, 6z6m:Lg, 6z6n:Lg, 7zjw:Lj, 7zjx:Lj, 6zm7:Lg, 6zme:Lg, 6zmi:Lg, 6zmo:Lg, 6zvk:y2
11 9bh5:Cg 104 102 0.5229 0.5481 0.5588 2.62e-32 9cai:Cg
12 5xxb:f 107 105 0.4862 0.4953 0.5048 3.84e-32
13 6zj3:Lw 114 109 0.5046 0.4825 0.5046 3.42e-25
14 8ovj:h 127 111 0.4220 0.3622 0.4144 1.56e-19 8a3w:h, 8a98:h, 6az3:h, 3jcs:h, 8rxh:Lh, 8rxx:Lh, 5t2a:h
15 6zu5:LGG 100 99 0.3670 0.4000 0.4040 4.03e-19
16 6rm3:LGG 100 90 0.3578 0.3900 0.4333 6.44e-19
17 8p5d:LGG 104 102 0.4128 0.4327 0.4412 6.28e-18 8p60:LGG, 8p60:KGG, 7qca:LGG
18 7qep:O4 100 89 0.3211 0.3500 0.3933 8.38e-18
19 5xy3:g 115 108 0.3578 0.3391 0.3611 9.92e-17
20 4v8m:Bj 161 109 0.3945 0.2671 0.3945 2.56e-16 8ova:Bj, 8ove:Bj, 5t5h:j
21 8btd:Lh 116 104 0.3119 0.2931 0.3269 6.06e-15 8br8:Lh, 8brm:Lh, 8bsi:Lh, 8bsj:Lh, 8btr:Lh, 8fru:g, 7pwg:g, 7pwo:g2
22 7r6q:g 35 49 0.2844 0.8857 0.6327 1.62e-09
23 6skf:Be 89 75 0.2110 0.2584 0.3067 6.12e-05 6skg:Be, 6th6:Be
24 4v4n:Ad 89 84 0.2661 0.3258 0.3452 9.44e-05 4v6u:Bd
25 8hku:L34E 77 68 0.1927 0.2727 0.3088 0.005 8hkv:L34E, 8hky:L34E, 8hkz:L34E, 8hl1:L34E, 8hl2:L34E, 8hl3:L34E, 8hl4:L34E, 8hl5:L34E
26 3r11:B 364 20 0.1284 0.0385 0.7000 2.2 3r0u:A, 3r10:A, 3r11:A, 3r1z:A, 3r1z:B
27 3nfu:A 441 26 0.1101 0.0272 0.4615 2.5 3nfu:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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