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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
AKQSLDVSSDRRKARKAYFTAPSSQRRVLLSAPLSKELRAQYGIKALPIRRDDEVLVVRGSKKGQEGKISSVYRLKFAVQ
VDKVTKEKVNGASVPINLHPSKLVITKLHLDKDRKALIQRKGGK

The query sequence (length=124) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 2ww9:L 127 124 1.0000 0.9764 1.0000 2.55e-85 8aaf:L, 8agt:L, 8agu:L, 8agv:L, 8agw:L, 8agx:L, 8agz:L, 5apn:Y, 5apo:Y, 7azy:q, 7b7d:LU, 8bip:LY, 8bjq:LY, 8bn3:N6, 8bqd:AK, 8bqx:AK, 7bt6:Y, 7btb:Y, 6c0f:Y, 6cb1:Y, 8ccs:K, 8cdl:K, 8cdr:K, 8ceh:K, 8cf5:K, 8cg8:K, 8cgn:K, 8civ:K, 8cku:K, 8cmj:K, 5dat:N6, 5dat:n6, 5dc3:N6, 5dc3:n6, 5dge:N6, 5dge:n6, 5dgf:N6, 5dgf:n6, 5dgv:N6, 5dgv:n6, 6elz:Y, 6em1:Y, 6em3:Y, 6em4:Y, 6em5:Y, 8eub:AY, 8evp:AY, 8evq:AY, 8evr:AY, 8evs:AY, 8evt:AY, 8ewb:AY, 8ewc:AY, 5fci:N6, 5fci:n6, 5fcj:N6, 5fcj:n6, 6ft6:Y, 5gak:a, 6gq1:Y, 6gqb:Y, 6gqv:Y, 5h4p:Y, 6hd7:a, 8hfr:YU, 6hhq:9, 6hhq:DA, 5i4l:N6, 5i4l:n6, 6i7o:AK, 6i7o:XK, 5it7:YY, 3j6x:66, 3j6y:66, 3j77:76, 3j78:76, 3jct:Y, 5jcs:Y, 5juo:DA, 5jup:DA, 5jus:DA, 5jut:DA, 5juu:DA, 8k2d:LY, 8k82:LY, 5lyb:N6, 5lyb:n6, 5m1j:Y5, 6m62:Y, 5mc6:AK, 5mei:9, 5mei:DA, 7mpi:AY, 7mpj:AY, 6n8j:Y, 6n8k:Y, 6n8l:Y, 6n8m:l, 6n8n:l, 6n8o:l, 7n8b:AY, 7nac:Y, 5ndg:N6, 5ndg:n6, 5ndv:N6, 5ndv:n6, 5ndw:N6, 5ndw:n6, 7nrc:La, 7nrd:La, 5obm:N6, 5obm:n6, 7of1:Y, 7oh3:Y, 7ohp:Y, 7ohq:Y, 7ohr:Y, 7ohs:Y, 7ohu:Y, 7ohv:Y, 7ohw:Y, 7ohx:Y, 7ohy:Y, 6oig:Y, 5on6:9, 5on6:DA, 7osa:uL24, 7osm:uL24, 8p8m:QY, 8p8n:QY, 8p8u:QY, 8pfr:QY, 6q8y:AK, 6qik:X, 6qt0:X, 6qtz:X, 7r7a:Y, 6r84:a, 6r86:a, 6r87:a, 6ri5:X, 7rr5:LY, 6rzz:X, 6s05:X, 6s47:Aa, 6snt:ar, 6sv4:AK, 6sv4:XK, 6sv4:zK, 6t4q:LY, 5t62:l, 5t6r:l, 6t7i:LY, 6t7t:LY, 6t83:Yy, 6t83:J, 5tbw:9, 5tbw:DA, 6tb3:AK, 5tga:N6, 5tga:n6, 5tgm:N6, 5tgm:n6, 6tnu:AK, 7too:AL26, 7top:AL26, 7u0h:Y, 4u3m:N6, 4u3m:n6, 4u3n:N6, 4u3n:n6, 4u3u:N6, 4u3u:n6, 4u4n:N6, 4u4n:n6, 4u4o:N6, 4u4o:n6, 4u4q:N6, 4u4q:n6, 4u4r:N6, 4u4r:n6, 4u4u:N6, 4u4u:n6, 4u4y:N6, 4u4y:n6, 4u4z:N6, 4u4z:n6, 4u50:N6, 4u50:n6, 4u51:N6, 4u51:n6, 4u52:N6, 4u52:n6, 4u53:N6, 4u53:n6, 4u55:N6, 4u55:n6, 4u56:N6, 4u56:n6, 4u6f:N6, 4u6f:n6, 7ug6:Y, 7uoo:Y, 7uqb:Y, 7uqz:Y, 6uz7:AY, 7v08:Y, 4v4b:BU, 4v6i:BY, 4v7h:BU, 4v7r:BX, 4v7r:DX, 4v88:BY, 4v88:DY, 4v8t:Y, 4v8y:BY, 4v8z:BY, 8v83:Y, 8v84:Y, 8v87:Y, 4v91:Y, 6woo:Y, 2wwa:L, 2wwb:L, 6xiq:Y, 6xir:Y, 8y0u:LY, 6ylg:Y, 6ylh:Y, 6ylx:Y, 6yly:Y, 5z3g:c, 7z34:Y, 6z6j:LY, 6z6k:LY, 7zpq:BX, 7zrs:BX, 7zs5:BZ, 7zuw:BX, 7zux:EX, 7zw0:Lb
2 8c3a:9 126 124 0.8226 0.8095 0.8226 7.58e-70 8c3a:BT, 8cq7:9, 8cq7:BT, 8cqw:9, 8cqw:BT, 8cre:9, 8cre:BT, 8oeq:9, 8oeq:BT, 7pzy:9, 7q08:9, 7q0f:9, 7q0p:9, 7q0r:9, 8q5i:9
3 8esq:Y 125 123 0.6774 0.6720 0.6829 5.53e-56 8esr:Y, 8etc:Y, 8etg:Y, 8eth:Y, 8eti:Y, 8etj:Y, 8eug:Y, 8eui:Y, 8eup:Y, 8euy:Y, 8ev3:Y
4 7r81:a1 121 114 0.5806 0.5950 0.6316 2.68e-52
5 8i9p:LY 134 114 0.5726 0.5299 0.6228 6.95e-51 8i9r:LY, 8i9t:LY, 8i9v:LY, 8i9w:LY, 8i9x:LY, 8i9y:LY, 8i9z:LY, 8ia0:LY, 7olc:LY, 7old:LY, 8onz:LY, 8oo0:LY, 8pv1:LY, 8pv2:LY, 8pv3:LY, 8pv4:LY, 8pv5:LY, 8pv6:LY, 8pv7:LY, 8pv8:LY, 8pvk:LY, 8pvl:LY, 7z3n:LY, 7z3o:LY
6 8ip8:PA 130 121 0.5726 0.5462 0.5868 8.13e-50 8ipa:PA, 8ipb:PA, 8jiv:CY, 4v3p:LY, 4v7e:CY
7 5xxb:X 124 121 0.5645 0.5645 0.5785 2.08e-48
8 9bh5:CY 132 115 0.5484 0.5152 0.5913 3.95e-48 9cai:CY
9 5t5h:Z 113 111 0.5161 0.5664 0.5766 1.01e-47
10 6az3:W 121 114 0.5161 0.5289 0.5614 5.27e-46 8a3w:W, 8a98:W, 3jcs:W, 8ovj:W, 8rxh:LW, 8rxx:LW, 5t2a:X
11 4v8m:BZ 124 112 0.5000 0.5000 0.5536 8.63e-45 8ova:BZ, 8ove:BZ
12 7qiw:a 132 106 0.4919 0.4621 0.5755 1.93e-44 8azw:m, 8b2l:m3, 7qiz:a
13 4v6w:CY 131 122 0.5645 0.5344 0.5738 1.04e-43 6xu6:CY, 6xu7:CY, 6xu8:CY
14 7a01:o2 134 117 0.5161 0.4776 0.5470 1.20e-42 8a3d:S, 5aj0:AY, 8b5l:Y, 8b6c:Y, 9bdl:AL26, 9bdn:AL26, 9bdp:AL26, 8bf9:Y, 7bhp:LY, 8bhf:L1, 8bpo:X2, 8btk:BY, 7cpu:LY, 7cpv:LY, 4d5y:Y, 4d67:Y, 6d90:Y, 6d9j:Y, 9f1b:BY, 9f1c:BY, 9f1d:BY, 7f5s:LY, 8fkp:LI, 8fkq:LI, 8fkr:LI, 8fks:LI, 8fkt:LI, 8fku:LI, 8fkv:LI, 8fkw:LI, 8fkx:LI, 8fky:LI, 8fkz:LI, 8fl2:LI, 8fl3:LI, 8fl4:LI, 8fl6:LI, 8fl7:LI, 8fl9:LI, 8fla:LI, 8flb:LI, 8flc:LI, 8fld:LI, 8fle:LI, 8flf:LI, 9fpz:LY, 9fq0:LY, 6frk:Y, 6ftg:Y, 6fti:Y, 6ftj:Y, 8g5y:LY, 8g5z:LY, 8g60:LY, 8g61:LY, 8g6j:LY, 8glp:LY, 6gz3:AY, 6gz4:AY, 6gz5:AY, 6hcf:Y3, 6hcj:Y3, 6hcm:Y3, 6hcq:Y3, 8idt:h, 8idy:h, 8ie3:h, 8ifd:2S, 8ife:2S, 8ine:h, 8inf:h, 8ink:h, 6ip5:2S, 6ip6:2S, 6ip8:2S, 8ipd:h, 8ipx:h, 8ipy:h, 8ir1:h, 8ir3:h, 3j7o:Y, 3j7p:Y, 3j7q:Y, 3j7r:Y, 3j92:Y, 3jag:Y, 3jah:Y, 3jai:Y, 3jaj:Y, 3jan:Y, 8jdj:d, 8jdk:d, 8jdl:d, 8jdm:d, 8k2c:LY, 5lks:LY, 6lqm:h, 6lsr:h, 6lss:h, 7ls1:S2, 7ls2:S2, 6lu8:h, 5lzs:Y, 5lzt:Y, 5lzu:Y, 5lzv:Y, 5lzw:Y, 5lzx:Y, 5lzy:Y, 5lzz:Y, 7mdz:Y, 6mtb:Y, 6mtc:Y, 6mtd:Y, 6mte:Y, 7nfx:Y, 7nwg:Y3, 7nwh:Y, 7nwi:Y, 7o7y:BY, 7o7z:BY, 7o80:BY, 7o81:BY, 7obr:Y, 8ohd:LY, 8oj0:LY, 8oj5:LY, 8oj8:LY, 6ole:Z, 6olf:Z, 6olg:AY, 6oli:Z, 6olz:AY, 6om0:Z, 6om7:Z, 8ony:LY, 7ow7:S, 7oya:Y1, 7oyb:Y1, 7oyc:Y1, 7oyd:Y, 8p2k:BY, 6p5i:AY, 6p5j:AY, 6p5k:AY, 6p5n:AY, 8q7z:BY, 8q87:BY, 8qfd:Y, 7qgg:Z, 8qoi:LY, 7qvp:MY, 7qvp:LY, 7qwq:Y, 7qwr:Y, 7qws:Y, 6qzp:LY, 6r5q:Y, 6r6g:Y, 6r6p:Y, 6r7q:Y, 8rjb:Y, 8rjc:Y, 8rjd:Y, 8scb:Y, 6sgc:Y2, 6swa:W, 6sxo:LY, 5t2c:S, 6t59:Y3, 7tm3:Y, 7toq:AL26, 7tor:AL26, 7tut:Y, 7ucj:Y, 7uck:Y, 4ug0:LY, 4ujc:BY, 4ujd:AY, 4uje:CY, 4v6x:CY, 6w6l:Z, 6xa1:LY, 7xnx:LY, 7xny:LY, 8xsx:LY, 8xsy:LY, 8xsz:LY, 6y0g:LY, 8y0w:LY, 8y0x:LY, 6y2l:LY, 6y57:LY, 6y6x:LY, 8yoo:LY, 8yop:LY, 6z6l:LY, 6z6m:LY, 6z6n:LY, 7zjw:Lb, 7zjx:Lb, 6zm7:LY, 6zme:LY, 6zmi:LY, 6zmo:LY, 6zvk:o2
15 4v8p:BS 126 122 0.5161 0.5079 0.5246 2.51e-42 4v8p:CS, 4v8p:ES, 4v8p:GS
16 6zj3:Ll 124 99 0.4919 0.4919 0.6162 1.02e-40
17 3j79:Z 121 115 0.4839 0.4959 0.5217 3.27e-40 3jbn:AZ, 3jbo:AZ, 3jbp:AZ, 8tpu:AZ, 5umd:Z
18 5xy3:Y 134 113 0.4597 0.4254 0.5044 3.48e-33
19 6zu5:LY0 138 114 0.3952 0.3551 0.4298 2.52e-28
20 6skf:BX 120 112 0.4032 0.4167 0.4464 1.91e-25 6skg:BX, 6th6:BX
21 4v4n:AU 121 117 0.3952 0.4050 0.4188 3.78e-25 4v6u:BU
22 8p5d:LY0 131 116 0.3790 0.3588 0.4052 7.00e-24 8p60:LY0, 8p60:KY0, 7qca:LY0
23 8fru:Y 135 117 0.3790 0.3481 0.4017 8.64e-23 8br8:LZ, 8brm:LZ, 8bsi:LZ, 8bsj:LZ, 8btd:LZ, 8btr:LZ, 7pwg:Y, 7pwo:Y2
24 7qep:N6 142 114 0.3548 0.3099 0.3860 2.89e-22
25 8hku:L24P 122 116 0.4032 0.4098 0.4310 5.50e-22 8hkv:L24P, 8hky:L24P, 8hkz:L24P, 8hl1:L24P, 8hl2:L24P, 8hl3:L24P, 8hl4:L24P, 8hl5:L24P
26 6rm3:LY0 134 114 0.3387 0.3134 0.3684 1.24e-19
27 3cc2:T 119 108 0.3145 0.3277 0.3611 3.98e-13 3cc4:T, 3cc7:T, 3cce:T, 3ccj:T, 3ccl:T, 3ccm:T, 3ccq:T, 3ccr:T, 3ccs:T, 3ccu:T, 3ccv:T, 3cd6:T, 3cma:T, 3cme:T, 3cpw:S, 3cxc:S, 3g4s:T, 3g6e:T, 3g71:T, 3i55:T, 3i56:T, 1jj2:S, 1k73:U, 1k8a:U, 1k9m:U, 1kc8:U, 1kd1:U, 1kqs:S, 1m1k:U, 1m90:U, 1n8r:U, 1nji:U, 2otj:T, 2otl:T, 3ow2:S, 1q7y:U, 1q81:U, 1q82:U, 1q86:U, 2qa4:T, 2qex:T, 1qvf:S, 1qvg:S, 1s72:T, 4v4p:AU, 4v4r:BY, 4v4s:BY, 4v4t:BY, 4v9f:T, 1vq4:T, 1vq5:T, 1vq6:T, 1vq7:T, 1vq8:T, 1vq9:T, 1vqk:T, 1vql:T, 1vqm:T, 1vqn:T, 1vqo:T, 1vqp:T, 1w2b:S, 1yhq:T, 1yi2:T, 1yij:T, 1yit:T, 1yj9:T, 1yjn:T, 1yjw:T
28 7zq5:u 91 27 0.1210 0.1648 0.5556 0.009 7zq6:u
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31 6gsj:C5 52 38 0.1210 0.2885 0.3947 0.22 6gsk:C5
32 4v7m:BY 87 57 0.1694 0.2414 0.3684 0.23
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34 2vg8:A 465 48 0.1452 0.0387 0.3750 0.51 2vce:A, 2vch:A
35 7jil:U 94 39 0.1371 0.1809 0.4359 0.69
36 6xyw:Au 142 39 0.1210 0.1056 0.3846 0.76
37 7m4v:T 103 24 0.0806 0.0971 0.4167 3.7 7m4w:T, 7m4x:T, 7m4y:T, 7m4z:T, 7ryf:T, 7ryg:T, 7ryh:T, 7uvv:T, 7uvw:T, 7uvx:T, 7uvy:T, 7uvz:T, 7uw1:T, 6v39:T, 6v3a:T, 6v3b:T, 6v3d:T, 6yhs:Q, 6ysi:Q
38 7oik:A 4426 39 0.1048 0.0029 0.3333 5.1 7oim:A, 6tax:A, 6tay:A
39 6pvk:U 90 42 0.1129 0.1556 0.3333 5.2
40 6i8v:A 216 24 0.0887 0.0509 0.4583 5.5
41 3j3v:U 103 44 0.1129 0.1359 0.3182 5.7 7aqc:U, 7aqd:U, 7as8:Y, 7as9:Y, 8buu:U, 6ha1:U, 6ha8:U, 6htq:U, 3j3w:U, 3j9w:BX, 5njt:n, 7o5b:t, 7ope:Y, 6ppf:U, 6ppk:U, 8qcq:U, 7qgu:U, 7qh4:U, 8qpp:t, 7qv1:U, 7qv2:U, 7qv3:U, 8r55:t, 8s1p:U, 8s1u:U, 7s9u:U, 7sae:U, 6tnn:n, 6tpq:n
42 4bql:A 436 41 0.1371 0.0390 0.4146 5.7 4bql:B, 4bql:D, 4cj7:A, 4cj7:B, 5ly3:A, 5mw1:B, 5mw1:A, 5mw1:C, 5mw1:D, 5mw1:E, 5mw1:F
43 2bi7:A 383 39 0.1290 0.0418 0.4103 6.1 2bi8:A, 3gf4:A, 3gf4:B, 3inr:A, 3inr:B, 3int:A, 3int:B, 3kyb:A, 3kyb:B, 1wam:A
44 4xtt:A 85 21 0.0726 0.1059 0.4286 6.6 4xtt:B
45 5xym:U 83 42 0.1129 0.1687 0.3333 7.7
46 6tmf:F 241 48 0.1452 0.0747 0.3750 9.2
47 6dzi:V 97 42 0.1129 0.1443 0.3333 9.5 6dzp:V, 7f0d:U, 8fr8:1, 8kab:V, 7kgb:U, 7msc:U, 7msh:U, 7msm:U, 7msz:U, 7mt2:U, 7mt3:U, 7mt7:U, 5o60:V, 5o61:V, 7s0s:W, 7sfr:U, 5v7q:U, 5v93:U, 8v9j:W, 8v9k:W, 8v9l:W, 8whx:X, 8why:X, 8wi7:X, 8wi8:X, 8wib:X, 8wic:X, 7xam:V, 8xz3:V, 7y41:V, 5zeb:V, 5zep:V, 5zet:V

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218