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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
AGDTLGLTRPNESDAPKISIGAKDTAVVQWQGDLLAIGATENDMARDENSKFKNPLLQQLDSELNGLLSAASSEEDFSGK
SGQSVNLRFPGGRITLVGLGSSASSPTSYHSLGQAAAAAAKSSQARNIAVALASTDGLSAESKINSASAIATGVVLGSFE
DNRFRSESKKSTLESLDILGLGTGPEIERKIKYAEHVCAGVILGRELVNAPANIVTPAVLAEEAKKIASTYSDVISVNIL
DAEQCKELKMGAYLAVAAAATENPPYFIHLCFKTPTKERKTKLALVGKGLTFDSGLMKNDMGGAAAVLGAAKALGEIRPS
RVEVHFIVAACENMISAEGMRPGDIVTASNGKTIEVNNTDAEGRLTLADALIYACNQGVEKIIDLATLTGAIMVALGPSV
AGAFTPNDDLAREVVEAAEASGEKLWRMPMEESYWESMKSGVADMINTGPGNGGAITGALFLKQFVDEKVQWLHLDVAGP
VWSDEKKNATGYGVSTLVEWVLRN

The query sequence (length=504) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4ksi:A 517 517 1.0000 0.9749 0.9749 0.0 5d8n:A, 5d8n:B, 5d8n:C
2 7k5k:A 545 474 0.3472 0.3211 0.3692 2.88e-86 7k5k:B, 7k5k:C, 7k5k:D, 7k5k:E, 7k5k:F, 6wvv:A, 6wvv:B, 6wvv:C, 6wvv:D, 6wvv:E
3 8ez4:C 525 360 0.2956 0.2838 0.4139 1.02e-85 5cbm:A, 5cbm:B, 5cbm:C, 5cbm:D, 5cbm:E, 5cbm:F, 5cbm:G, 5cbm:H, 5cbm:I, 5cbm:J, 5cbm:K, 5cbm:L, 6ee2:A, 6ee2:B, 6ee2:C, 6ee2:D, 6ee2:E, 6ee2:F, 6ee2:G, 6ee2:H, 6ee2:I, 6ee2:J, 6ee2:K, 6ee2:L, 6eee:A, 6eee:B, 6eee:C, 6eee:D, 6eee:E, 6eee:F, 6eee:G, 6eee:H, 6eee:I, 6eee:J, 6eee:K, 6eee:L, 8ez4:A, 8ez4:B, 8ez4:D, 8ez4:E, 8ez4:F, 8ez4:G, 8ez4:H, 8ez4:I, 8ez4:J, 8ez4:K, 8ez4:L, 4k3n:A, 4k3n:B, 4k3n:C, 4k3n:D, 4k3n:E, 4k3n:F, 4k3n:G, 4k3n:H, 4k3n:I, 4k3n:J, 4k3n:K, 4k3n:L, 3kqx:A, 3kqx:B, 3kqx:C, 3kqx:D, 3kqx:E, 3kqx:F, 3kqx:G, 3kqx:H, 3kqx:I, 3kqx:J, 3kqx:K, 3kqx:L, 3kqz:A, 3kqz:B, 3kqz:C, 3kqz:D, 3kqz:E, 3kqz:F, 3kqz:G, 3kqz:H, 3kqz:I, 3kqz:J, 3kqz:K, 3kqz:L, 3kr4:A, 3kr4:B, 3kr4:C, 3kr4:D, 3kr4:E, 3kr4:F, 3kr4:G, 3kr4:H, 3kr4:I, 3kr4:J, 3kr4:K, 3kr4:L, 3kr5:A, 3kr5:B, 3kr5:C, 3kr5:D, 3kr5:E, 3kr5:F, 3kr5:G, 3kr5:H, 3kr5:I, 3kr5:J, 3kr5:K, 3kr5:L, 4r6t:A, 4r6t:B, 4r6t:C, 4r6t:D, 4r6t:E, 4r6t:F, 4r6t:G, 4r6t:H, 4r6t:I, 4r6t:J, 4r6t:K, 4r6t:L, 4r76:A, 4r76:B, 4r76:C, 4r76:D, 4r76:E, 4r76:F, 4r76:G, 4r76:H, 4r76:I, 4r76:J, 4r76:K, 4r76:L, 4r7m:A, 4r7m:B, 4r7m:C, 4r7m:D, 4r7m:E, 4r7m:F, 4r7m:G, 4r7m:H, 4r7m:I, 4r7m:J, 4r7m:K, 4r7m:L, 7rie:A, 7rie:B, 7rie:C, 7rie:D, 7rie:E, 7rie:F, 7rie:G, 7rie:H, 7rie:I, 7rie:J, 7rie:K, 7rie:L, 7srv:A, 7srv:B, 7srv:C, 7srv:D, 7srv:E, 7srv:F, 8svm:A, 8svm:B, 8svm:C, 8svm:D, 8svm:E, 8svm:F, 8svm:G, 8svm:H, 8svm:I, 8svm:J, 8svm:K, 8svm:L, 8sw9:A, 8sw9:B, 8sw9:C, 8sw9:D, 8sw9:E, 8sw9:F, 8sw9:G, 8sw9:H, 8sw9:I, 8sw9:J, 8sw9:K, 8sw9:L, 7t3v:A, 7t3v:B, 7t3v:C, 7t3v:D, 7t3v:E, 7t3v:F, 3t8w:A, 3t8w:B, 3t8w:E, 3t8w:C, 3t8w:D, 3t8w:F, 3t8w:G, 3t8w:H, 3t8w:K, 3t8w:I, 3t8w:J, 3t8w:L, 4x2t:A, 4x2t:B, 4x2t:C, 4x2t:D, 4x2t:E, 4x2t:F, 4x2t:G, 4x2t:H, 4x2t:I, 4x2t:J, 4x2t:K, 4x2t:L, 4zx8:A, 4zx8:B, 4zx8:C, 4zx8:D, 4zx8:E, 4zx8:F, 4zx8:G, 4zx8:H, 4zx8:I, 4zx8:J, 4zx8:K, 4zx8:L, 4zx9:A, 4zx9:B, 4zx9:C, 4zx9:D, 4zx9:E, 4zx9:F, 4zx9:G, 4zx9:H, 4zx9:I, 4zx9:J, 4zx9:K, 4zx9:L, 4zy0:A, 4zy0:B, 4zy0:C, 4zy0:D, 4zy0:E, 4zy0:F, 4zy0:G, 4zy0:H, 4zy0:I, 4zy0:J, 4zy0:K, 4zy0:L, 4zy1:A, 4zy1:B, 4zy1:C, 4zy1:D, 4zy1:E, 4zy1:F, 4zy1:G, 4zy1:H, 4zy1:I, 4zy1:J, 4zy1:K, 4zy1:L, 4zy2:A, 4zy2:B, 4zy2:C, 4zy2:D, 4zy2:E, 4zy2:F, 4zy2:G, 4zy2:H, 4zy2:I, 4zy2:J, 4zy2:K, 4zy2:L, 4zyq:A, 4zyq:B, 4zyq:C, 4zyq:D, 4zyq:E, 4zyq:F, 4zyq:G, 4zyq:H, 4zyq:I, 4zyq:J, 4zyq:K, 4zyq:L
4 6wvv:K 440 397 0.3155 0.3614 0.4005 1.44e-83
5 6wvv:F 497 356 0.2996 0.3038 0.4242 1.54e-82 6wvv:G, 6wvv:H, 6wvv:I, 6wvv:J, 6wvv:L
6 6ome:A 499 457 0.3492 0.3527 0.3851 5.84e-73
7 3h8f:A 497 475 0.3214 0.3260 0.3411 6.65e-73 3h8f:B, 3h8f:C, 3h8f:D, 3h8f:E, 3h8f:F, 3h8g:F, 3h8g:A, 3h8g:B, 3h8g:C, 3h8g:D, 3h8g:E
8 1gyt:A 503 471 0.3234 0.3241 0.3461 5.95e-71 1gyt:B, 1gyt:C, 1gyt:D, 1gyt:E, 1gyt:F, 1gyt:G, 1gyt:H, 1gyt:I, 1gyt:J, 1gyt:K, 1gyt:L
9 8pz0:A 500 465 0.3155 0.3180 0.3419 2.31e-67 8pzm:A, 8pzy:A, 8pzy:B, 8pzy:C, 8pzy:D, 8pzy:E, 8pzy:F
10 3jru:B 490 469 0.3333 0.3429 0.3582 2.19e-64 3jru:A
11 4zla:A 485 371 0.2798 0.2907 0.3801 9.21e-63 4zi6:A, 4zi6:B, 4zi6:C, 4zi6:D, 4zi6:E, 4zi6:F, 4zla:B, 4zla:C, 4zla:D, 4zla:E, 4zla:F
12 7y1s:A 494 444 0.2917 0.2976 0.3311 7.57e-62
13 2ewb:A 486 441 0.3056 0.3169 0.3492 1.05e-59 1bll:E, 1bpm:A, 1bpn:A, 2j9a:A, 1lam:A, 1lan:A, 1lap:A, 1lcp:A, 1lcp:B
14 8d1x:D 469 359 0.2659 0.2857 0.3733 1.51e-56 8d1x:A, 8d1x:B, 8d1x:C, 8d1x:E, 8d1x:F
15 5lhk:A 455 455 0.3155 0.3495 0.3495 1.02e-54
16 6ov8:A 429 317 0.2480 0.2914 0.3943 1.49e-47 6oad:A, 6oad:B, 6oad:C, 6oad:D, 6oad:E, 6oad:F, 6oad:G, 6oad:H, 6oad:I, 6oad:J, 6oad:K, 6oad:L, 6ov8:B, 6ov8:C, 6ov8:D, 6ov8:E, 6ov8:F
17 5ntg:A 512 325 0.2321 0.2285 0.3600 5.43e-40 5ntg:B
18 2hc9:A 489 306 0.2123 0.2188 0.3497 2.49e-36
19 5ntd:G 520 329 0.2143 0.2077 0.3283 3.33e-33 4efd:F, 5nsm:A, 5nsm:B, 5nsm:C, 5nsm:D, 5nsm:E, 5nsm:F, 5nsm:G, 5nsm:H, 5nsm:I, 5nsm:J, 5nsm:K, 5nsm:L, 5nsq:A, 5nsq:B, 5nsq:C, 5nsq:D, 5nsq:E, 5nsq:F, 5ntd:A, 5ntd:B, 5ntd:D, 5ntd:C, 5ntd:E, 5ntd:F, 5ntd:H, 5ntd:I, 5ntd:J, 5ntd:K, 5ntd:L
20 5nth:A 537 339 0.2063 0.1937 0.3068 9.88e-30
21 7uws:E 422 102 0.0536 0.0640 0.2647 1.9 6bjy:A, 6bjy:B, 6bjy:C, 6bjy:D, 6bjy:E, 2gic:A, 2gic:B, 2gic:C, 2gic:D, 2gic:E, 3hhz:K, 3hhz:L, 3hhz:M, 3hhz:N, 3hhz:O, 3pmk:A, 3pmk:D, 3pmk:B, 3pmk:C, 3ptx:A, 3ptx:B, 3ptx:C, 3ptx:D, 3ptx:E, 3pu0:A, 3pu0:B, 3pu0:C, 3pu0:D, 3pu0:E, 3pu1:A, 3pu1:B, 3pu1:C, 3pu1:D, 3pu1:E, 3pu4:A, 3pu4:B, 3pu4:C, 3pu4:D, 3pu4:E, 5uk4:P, 5uk4:Q, 5uk4:N, 5uk4:M, 5uk4:O, 5uk4:R, 5uk4:S, 5uk4:T, 5uk4:K, 5uk4:L, 5uk4:B, 5uk4:C, 5uk4:D, 5uk4:E, 5uk4:F, 5uk4:G, 5uk4:H, 5uk4:I, 5uk4:J, 5uk4:A, 5ukb:D, 5ukb:C, 5ukb:B, 5ukb:A, 5ukb:E, 7umk:A, 7uws:A, 7uws:B, 7uws:C, 7uws:D, 7uws:F, 2wyy:A, 2wyy:C, 2wyy:D, 2wyy:F, 2wyy:H, 2wyy:I, 2wyy:J, 2wyy:K, 2wyy:L, 2wyy:M
22 2ya1:A 981 120 0.0615 0.0316 0.2583 2.4 2j44:A, 2ya0:A, 2ya2:A
23 2vyn:D 334 86 0.0536 0.0808 0.3140 2.7 2vyv:D
24 4rep:A 489 19 0.0258 0.0266 0.6842 2.7
25 3k57:A 782 36 0.0298 0.0192 0.4167 8.6 3k58:A, 3k59:A, 3k5l:A, 3k5m:A, 3maq:A
26 3k5n:A 759 36 0.0298 0.0198 0.4167 8.7
27 6agm:A 334 58 0.0337 0.0509 0.2931 9.1 6agm:B, 6agm:C, 6agm:D

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218