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BioLiP
Download all results in tab-seperated text for 39065 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • The sequence is converted from residues with experimentally determined coordinates in the structure; residues not observed in the 3D structure are excluded.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.
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    # PDB
    (resolution)
    Site
    #
    Peptide
    sequence
    EC
    number
    GO
    terms
    UniProt PubMed Binding
    affinity
    18401 5ms4:A
    (2.1)
    BS01 >5ms4:E (identical to 2agi:A, 6bkj:F, 6bkj:G, 6bkj:H, 6bkj:I, 3bpm:D, 3bpm:C, 7ein:C, 7ein:D, 2f9n:E, 2f9n:F, 2f9n:G, 2f9n:H, 2f9p:E, 2f9p:F, 2f9p:G, 2f9p:H, 2fo5:E, 2fo5:F, 2fo5:G, 2fo5:H, 1jrs:B, 1jrt:B, 7mrr:B, 5ms4:F, 5ms4:G, 5ms4:H, 7nev:B, 2nqa:D, 2nqa:E, 2p0r:D, 2p0r:E, 1pop:B, 2psx:B, 2psy:B, 1tl9:B, 6xch:C)
    LLR
    3.4.21.118 GO:0004252 ... O60259 30013126
    18402 5ms4:B
    (2.1)
    BS01 >5ms4:F (identical to 2agi:A, 6bkj:F, 6bkj:G, 6bkj:H, 6bkj:I, 3bpm:D, 3bpm:C, 7ein:C, 7ein:D, 2f9n:E, 2f9n:F, 2f9n:G, 2f9n:H, 2f9p:E, 2f9p:F, 2f9p:G, 2f9p:H, 2fo5:E, 2fo5:F, 2fo5:G, 2fo5:H, 1jrs:B, 1jrt:B, 7mrr:B, 5ms4:E, 5ms4:G, 5ms4:H, 7nev:B, 2nqa:D, 2nqa:E, 2p0r:D, 2p0r:E, 1pop:B, 2psx:B, 2psy:B, 1tl9:B, 6xch:C)
    LLR
    3.4.21.118 GO:0004252 ... O60259 30013126
    18403 5ms4:C
    (2.1)
    BS01 >5ms4:G (identical to 2agi:A, 6bkj:F, 6bkj:G, 6bkj:H, 6bkj:I, 3bpm:D, 3bpm:C, 7ein:C, 7ein:D, 2f9n:E, 2f9n:F, 2f9n:G, 2f9n:H, 2f9p:E, 2f9p:F, 2f9p:G, 2f9p:H, 2fo5:E, 2fo5:F, 2fo5:G, 2fo5:H, 1jrs:B, 1jrt:B, 7mrr:B, 5ms4:E, 5ms4:F, 5ms4:H, 7nev:B, 2nqa:D, 2nqa:E, 2p0r:D, 2p0r:E, 1pop:B, 2psx:B, 2psy:B, 1tl9:B, 6xch:C)
    LLR
    3.4.21.118 GO:0004252 ... O60259 30013126
    18404 5ms4:D
    (2.1)
    BS01 >5ms4:H (identical to 2agi:A, 6bkj:F, 6bkj:G, 6bkj:H, 6bkj:I, 3bpm:D, 3bpm:C, 7ein:C, 7ein:D, 2f9n:E, 2f9n:F, 2f9n:G, 2f9n:H, 2f9p:E, 2f9p:F, 2f9p:G, 2f9p:H, 2fo5:E, 2fo5:F, 2fo5:G, 2fo5:H, 1jrs:B, 1jrt:B, 7mrr:B, 5ms4:E, 5ms4:F, 5ms4:G, 7nev:B, 2nqa:D, 2nqa:E, 2p0r:D, 2p0r:E, 1pop:B, 2psx:B, 2psy:B, 1tl9:B, 6xch:C)
    LLR
    3.4.21.118 GO:0004252 ... O60259 30013126
    18405 5msm:A
    (2.29)
    BS01 >5msm:C
    QTVKIWVKYNEGFSNAVRKNVTWNNLW
    ? GO:0000775 ... P25559 28188145
    18406 5msm:B
    (2.29)
    BS01 >5msm:C
    QTVKIWVKYNEGFSNAVRKNVTWNNLW
    ? GO:0003674 ... P38877 28188145
    18407 5msm:B
    (2.29)
    BS02 >5msm:F (identical to 5okc:G)
    VKIWVKYNEGFSNAVRKNVTWNNLWE
    ? GO:0003674 ... P38877 28188145
    18408 5msm:D
    (2.29)
    BS01 >5msm:C
    QTVKIWVKYNEGFSNAVRKNVTWNNLW
    ? GO:0000775 ... P25559 28188145
    18409 5msm:D
    (2.29)
    BS02 >5msm:F (identical to 5okc:G)
    VKIWVKYNEGFSNAVRKNVTWNNLWE
    ? GO:0000775 ... P25559 28188145
    18410 5msm:E
    (2.29)
    BS01 >5msm:F (identical to 5okc:G)
    VKIWVKYNEGFSNAVRKNVTWNNLWE
    ? GO:0003674 ... P38877 28188145
    18411 5mt6:A
    (2.16)
    BS01 >5mt6:B (identical to 5mt8:B)
    RVRHA
    3.4.21.105 GO:0004252 ... P09391 29107700
    18412 5mt7:A
    (2.05)
    BS01 >5mt7:B
    VRHA
    3.4.21.105 GO:0004252 ... P09391 29107700
    18413 5mt8:A
    (1.95)
    BS01 >5mt8:B (identical to 5mt6:B)
    RVRHA
    3.4.21.105 GO:0004252 ... P09391 29107700
    18414 5mtf:A
    (1.79)
    BS01 >5mtf:C
    RVRHt
    3.4.21.105 GO:0004252 ... P09391 29107700
    18415 5mtw:A
    (1.84)
    BS01 >5mtw:E (identical to 5mtw:F, 5mtw:G)
    EVPTWHRLSSYR
    ? GO:0009274 ... P95257 30770830
    18416 5mtw:A
    (1.84)
    BS02 >5mtw:G (identical to 5mtw:E, 5mtw:F)
    EVPTWHRLSSYR
    ? GO:0009274 ... P95257 30770830
    18417 5mtw:B
    (1.84)
    BS01 >5mtw:F (identical to 5mtw:E, 5mtw:G)
    EVPTWHRLSSYR
    ? GO:0009274 ... P95257 30770830
    18418 5mtw:C
    (1.84)
    BS01 >5mtw:E (identical to 5mtw:F, 5mtw:G)
    EVPTWHRLSSYR
    ? GO:0009274 ... P95257 30770830
    18419 5mtw:C
    (1.84)
    BS02 >5mtw:G (identical to 5mtw:E, 5mtw:F)
    EVPTWHRLSSYR
    ? GO:0009274 ... P95257 30770830
    18420 5mtw:D
    (1.84)
    BS01 >5mtw:F (identical to 5mtw:E, 5mtw:G)
    EVPTWHRLSSYR
    ? GO:0009274 ... P95257 30770830
    18421 5mtw:D
    (1.84)
    BS02 >5mtw:G (identical to 5mtw:E, 5mtw:F)
    EVPTWHRLSSYR
    ? GO:0009274 ... P95257 30770830
    18422 5mu0:A
    (2.7)
    BS01 >5mu0:Q
    PGARGLTGRPG
    N/A N/A N/A 28679953
    18423 5mu0:B
    (2.7)
    BS01 >5mu0:Q
    PGARGLTGRPG
    N/A N/A N/A 28679953
    18424 5mu0:C
    (2.7)
    BS01 >5mu0:R (identical to 5mu0:S, 5mu0:T, 5mu0:U, 5mu0:V, 5mu0:X, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18425 5mu0:D
    (2.7)
    BS01 >5mu0:R (identical to 5mu0:S, 5mu0:T, 5mu0:U, 5mu0:V, 5mu0:X, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18426 5mu0:E
    (2.7)
    BS01 >5mu0:S (identical to 5mu0:R, 5mu0:T, 5mu0:U, 5mu0:V, 5mu0:X, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18427 5mu0:F
    (2.7)
    BS01 >5mu0:S (identical to 5mu0:R, 5mu0:T, 5mu0:U, 5mu0:V, 5mu0:X, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18428 5mu0:G
    (2.7)
    BS01 >5mu0:T (identical to 5mu0:R, 5mu0:S, 5mu0:U, 5mu0:V, 5mu0:X, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18429 5mu0:H
    (2.7)
    BS01 >5mu0:T (identical to 5mu0:R, 5mu0:S, 5mu0:U, 5mu0:V, 5mu0:X, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18430 5mu0:I
    (2.7)
    BS01 >5mu0:U (identical to 5mu0:R, 5mu0:S, 5mu0:T, 5mu0:V, 5mu0:X, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18431 5mu0:J
    (2.7)
    BS01 >5mu0:U (identical to 5mu0:R, 5mu0:S, 5mu0:T, 5mu0:V, 5mu0:X, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18432 5mu0:K
    (2.7)
    BS01 >5mu0:V (identical to 5mu0:R, 5mu0:S, 5mu0:T, 5mu0:U, 5mu0:X, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18433 5mu0:L
    (2.7)
    BS01 >5mu0:V (identical to 5mu0:R, 5mu0:S, 5mu0:T, 5mu0:U, 5mu0:X, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18434 5mu0:M
    (2.7)
    BS01 >5mu0:W (identical to 2w65:E)
    ARGLTGRPG
    N/A N/A N/A 28679953
    18435 5mu0:N
    (2.7)
    BS01 >5mu0:W (identical to 2w65:E)
    ARGLTGRPG
    N/A N/A N/A 28679953
    18436 5mu0:O
    (2.7)
    BS01 >5mu0:X (identical to 5mu0:R, 5mu0:S, 5mu0:T, 5mu0:U, 5mu0:V, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18437 5mu0:P
    (2.7)
    BS01 >5mu0:X (identical to 5mu0:R, 5mu0:S, 5mu0:T, 5mu0:U, 5mu0:V, 5mub:K)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18438 5mu2:A
    (2.7)
    BS01 >5mu2:X (identical to 5mu2:R, 5mu2:S)
    PGPPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18439 5mu2:B
    (2.7)
    BS01 >5mu2:X (identical to 5mu2:R, 5mu2:S)
    PGPPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18440 5mu2:C
    (2.7)
    BS01 >5mu2:Q
    PPGPPGGRGLTGPIG
    N/A N/A N/A 28679953
    18441 5mu2:D
    (2.7)
    BS01 >5mu2:Q
    PPGPPGGRGLTGPIG
    N/A N/A N/A 28679953
    18442 5mu2:E
    (2.7)
    BS01 >5mu2:R (identical to 5mu2:X, 5mu2:S)
    PGPPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18443 5mu2:F
    (2.7)
    BS01 >5mu2:R (identical to 5mu2:X, 5mu2:S)
    PGPPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18444 5mu2:G
    (2.7)
    BS01 >5mu2:S (identical to 5mu2:X, 5mu2:R)
    PGPPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18445 5mu2:H
    (2.7)
    BS01 >5mu2:S (identical to 5mu2:X, 5mu2:R)
    PGPPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18446 5mu2:I
    (2.7)
    BS01 >5mu2:T (identical to 5mv3:K, 5mv3:N)
    PPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18447 5mu2:J
    (2.7)
    BS01 >5mu2:T (identical to 5mv3:K, 5mv3:N)
    PPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18448 5mu2:K
    (2.7)
    BS01 >5mu2:U
    PGGRGLTGPIGPPGP
    N/A N/A N/A 28679953
    18449 5mu2:L
    (2.7)
    BS01 >5mu2:U
    PGGRGLTGPIGPPGP
    N/A N/A N/A 28679953
    18450 5mu2:M
    (2.7)
    BS01 >5mu2:V (identical to 5mv3:H, 5mv3:Q, 5mv3:T, 5mv3:W)
    PGGRGLTGPIGP
    N/A N/A N/A 28679953
    18451 5mu2:N
    (2.7)
    BS01 >5mu2:V (identical to 5mv3:H, 5mv3:Q, 5mv3:T, 5mv3:W)
    PGGRGLTGPIGP
    N/A N/A N/A 28679953
    18452 5mu2:O
    (2.7)
    BS01 >5mu2:W
    GGRGLTGPI
    N/A N/A N/A 28679953
    18453 5mu2:P
    (2.7)
    BS01 >5mu2:W
    GGRGLTGPI
    N/A N/A N/A 28679953
    18454 5mu3:A
    (2.1)
    BS01 >5mu3:C
    NEIYQQDKIDFNLKLKTDFSKPLI
    ? GO:0000776 ... Q6CVQ9 29046335
    18455 5mu3:B
    (2.1)
    BS01 >5mu3:C
    NEIYQQDKIDFNLKLKTDFSKPLI
    ? N/A Q6CRN7 29046335
    18456 5mu3:D
    (2.1)
    BS01 >5mu3:F
    SNEIYQQDKIDFNLKLKTDFSKPLI
    ? GO:0000776 ... Q6CVQ9 29046335
    18457 5mu3:E
    (2.1)
    BS01 >5mu3:F
    SNEIYQQDKIDFNLKLKTDFSKPLI
    ? N/A Q6CRN7 29046335
    18458 5mub:A
    (3.1)
    BS01 >5mub:X
    PPGARGLTGRP
    N/A N/A N/A 28679953
    18459 5mub:B
    (3.1)
    BS01 >5mub:X
    PPGARGLTGRP
    N/A N/A N/A 28679953
    18460 5mub:C
    (3.1)
    BS01 >5mub:E (identical to 5mub:H, 5mub:N, 5mub:W)
    GARGLTGRP
    N/A N/A N/A 28679953
    18461 5mub:D
    (3.1)
    BS01 >5mub:E (identical to 5mub:H, 5mub:N, 5mub:W)
    GARGLTGRP
    N/A N/A N/A 28679953
    18462 5mub:F
    (3.1)
    BS01 >5mub:H (identical to 5mub:E, 5mub:N, 5mub:W)
    GARGLTGRP
    N/A N/A N/A 28679953
    18463 5mub:G
    (3.1)
    BS01 >5mub:H (identical to 5mub:E, 5mub:N, 5mub:W)
    GARGLTGRP
    N/A N/A N/A 28679953
    18464 5mub:I
    (3.1)
    BS01 >5mub:K (identical to 5mu0:R, 5mu0:S, 5mu0:T, 5mu0:U, 5mu0:V, 5mu0:X)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18465 5mub:J
    (3.1)
    BS01 >5mub:K (identical to 5mu0:R, 5mu0:S, 5mu0:T, 5mu0:U, 5mu0:V, 5mu0:X)
    GARGLTGRPG
    N/A N/A N/A 28679953
    18466 5mub:L
    (3.1)
    BS01 >5mub:N (identical to 5mub:E, 5mub:H, 5mub:W)
    GARGLTGRP
    N/A N/A N/A 28679953
    18467 5mub:M
    (3.1)
    BS01 >5mub:N (identical to 5mub:E, 5mub:H, 5mub:W)
    GARGLTGRP
    N/A N/A N/A 28679953
    18468 5mub:O
    (3.1)
    BS01 >5mub:Q
    ARGLTGRP
    N/A N/A N/A 28679953
    18469 5mub:P
    (3.1)
    BS01 >5mub:Q
    ARGLTGRP
    N/A N/A N/A 28679953
    18470 5mub:R
    (3.1)
    BS01 >5mub:T
    GPPGARGLTGRP
    N/A N/A N/A 28679953
    18471 5mub:S
    (3.1)
    BS01 >5mub:T
    GPPGARGLTGRP
    N/A N/A N/A 28679953
    18472 5mub:U
    (3.1)
    BS01 >5mub:W (identical to 5mub:E, 5mub:H, 5mub:N)
    GARGLTGRP
    N/A N/A N/A 28679953
    18473 5mub:V
    (3.1)
    BS01 >5mub:W (identical to 5mub:E, 5mub:H, 5mub:N)
    GARGLTGRP
    N/A N/A N/A 28679953
    18474 5mv3:A
    (2.95)
    BS01 >5mv3:X
    GPPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18475 5mv3:B
    (2.95)
    BS01 >5mv3:X
    GPPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18476 5mv3:C
    (2.95)
    BS01 >5mv3:E
    PGGRGLTGPIGPP
    N/A N/A N/A 28679953
    18477 5mv3:D
    (2.95)
    BS01 >5mv3:E
    PGGRGLTGPIGPP
    N/A N/A N/A 28679953
    18478 5mv3:F
    (2.95)
    BS01 >5mv3:H (identical to 5mu2:V, 5mv3:Q, 5mv3:T, 5mv3:W)
    PGGRGLTGPIGP
    N/A N/A N/A 28679953
    18479 5mv3:G
    (2.95)
    BS01 >5mv3:H (identical to 5mu2:V, 5mv3:Q, 5mv3:T, 5mv3:W)
    PGGRGLTGPIGP
    N/A N/A N/A 28679953
    18480 5mv3:I
    (2.95)
    BS01 >5mv3:K (identical to 5mu2:T, 5mv3:N)
    PPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18481 5mv3:J
    (2.95)
    BS01 >5mv3:K (identical to 5mu2:T, 5mv3:N)
    PPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18482 5mv3:L
    (2.95)
    BS01 >5mv3:N (identical to 5mu2:T, 5mv3:K)
    PPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18483 5mv3:M
    (2.95)
    BS01 >5mv3:N (identical to 5mu2:T, 5mv3:K)
    PPGGRGLTGPIGP
    N/A N/A N/A 28679953
    18484 5mv3:O
    (2.95)
    BS01 >5mv3:Q (identical to 5mu2:V, 5mv3:H, 5mv3:T, 5mv3:W)
    PGGRGLTGPIGP
    N/A N/A N/A 28679953
    18485 5mv3:P
    (2.95)
    BS01 >5mv3:Q (identical to 5mu2:V, 5mv3:H, 5mv3:T, 5mv3:W)
    PGGRGLTGPIGP
    N/A N/A N/A 28679953
    18486 5mv3:R
    (2.95)
    BS01 >5mv3:T (identical to 5mu2:V, 5mv3:H, 5mv3:Q, 5mv3:W)
    PGGRGLTGPIGP
    N/A N/A N/A 28679953
    18487 5mv3:S
    (2.95)
    BS01 >5mv3:T (identical to 5mu2:V, 5mv3:H, 5mv3:Q, 5mv3:W)
    PGGRGLTGPIGP
    N/A N/A N/A 28679953
    18488 5mv3:U
    (2.95)
    BS01 >5mv3:W (identical to 5mu2:V, 5mv3:H, 5mv3:Q, 5mv3:T)
    PGGRGLTGPIGP
    N/A N/A N/A 28679953
    18489 5mv3:V
    (2.95)
    BS01 >5mv3:W (identical to 5mu2:V, 5mv3:H, 5mv3:Q, 5mv3:T)
    PGGRGLTGPIGP
    N/A N/A N/A 28679953
    18490 5mv4:A
    (2.9)
    BS01 >5mv4:X (identical to 5mv4:E, 5mv4:N, 5mv4:Q, 5mv4:T, 5mv4:W)
    PGERGETGPPGP
    N/A N/A N/A 28679953
    18491 5mv4:B
    (2.9)
    BS01 >5mv4:X (identical to 5mv4:E, 5mv4:N, 5mv4:Q, 5mv4:T, 5mv4:W)
    PGERGETGPPGP
    N/A N/A N/A 28679953
    18492 5mv4:C
    (2.9)
    BS01 >5mv4:E (identical to 5mv4:X, 5mv4:N, 5mv4:Q, 5mv4:T, 5mv4:W)
    PGERGETGPPGP
    N/A N/A N/A 28679953
    18493 5mv4:D
    (2.9)
    BS01 >5mv4:E (identical to 5mv4:X, 5mv4:N, 5mv4:Q, 5mv4:T, 5mv4:W)
    PGERGETGPPGP
    N/A N/A N/A 28679953
    18494 5mv4:F
    (2.9)
    BS01 >5mv4:H (identical to 5mv4:K)
    PGERGETGPPGPA
    N/A N/A N/A 28679953
    18495 5mv4:G
    (2.9)
    BS01 >5mv4:H (identical to 5mv4:K)
    PGERGETGPPGPA
    N/A N/A N/A 28679953
    18496 5mv4:I
    (2.9)
    BS01 >5mv4:K (identical to 5mv4:H)
    PGERGETGPPGPA
    N/A N/A N/A 28679953
    18497 5mv4:J
    (2.9)
    BS01 >5mv4:K (identical to 5mv4:H)
    PGERGETGPPGPA
    N/A N/A N/A 28679953
    18498 5mv4:L
    (2.9)
    BS01 >5mv4:N (identical to 5mv4:X, 5mv4:E, 5mv4:Q, 5mv4:T, 5mv4:W)
    PGERGETGPPGP
    N/A N/A N/A 28679953
    18499 5mv4:M
    (2.9)
    BS01 >5mv4:N (identical to 5mv4:X, 5mv4:E, 5mv4:Q, 5mv4:T, 5mv4:W)
    PGERGETGPPGP
    N/A N/A N/A 28679953
    18500 5mv4:O
    (2.9)
    BS01 >5mv4:Q (identical to 5mv4:X, 5mv4:E, 5mv4:N, 5mv4:T, 5mv4:W)
    PGERGETGPPGP
    N/A N/A N/A 28679953

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218