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BioLiP
Download all results in tab-seperated text for 197122 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    182001 8gxn:B (1.34) BS02 MG N/A GO:0008171 ... N/A 37604798
    182002 8gxo:A (1.74) BS02 MG 2.1.1.104 GO:0008168 ... A0A7J7GXF2 37604798
    182003 8gxq:BA (5.04) BS03 ZN 2.3.1.48 GO:0000776 ... Q00403 36201575
    182004 8gxq:EA (5.04) BS01 ZN ? GO:0001113 ... P29083 36201575
    182005 8gxq:HD (5.04) BS01 ZN ? GO:0000082 ... P51948 36201575
    182006 8gxq:HE (5.04) BS01 ZN ? GO:0000438 ... Q13889 36201575
    182007 8gxq:HE (5.04) BS02 ZN ? GO:0000438 ... Q13889 36201575
    182008 8gxq:HG (5.04) BS01 ZN ? GO:0000438 ... Q13888 36201575
    182009 8gxq:HG (5.04) BS02 ZN ? GO:0000438 ... Q13888 36201575
    182010 8gxq:HG (5.04) BS03 ZN ? GO:0000438 ... Q13888 36201575
    182011 8gxq:PA (5.04) BS01 ZN 2.7.7.6 GO:0000428 ... A0A8D1DPV6 36201575
    182012 8gxq:PA (5.04) BS02 ZN 2.7.7.6 GO:0000428 ... A0A8D1DPV6 36201575
    182013 8gxq:PA (5.04) BS03 MG 2.7.7.6 GO:0000428 ... A0A8D1DPV6 36201575
    182014 8gxq:PB (5.04) BS01 ZN 2.7.7.6 GO:0000428 ... A0A4X1TVZ5 36201575
    182015 8gxq:PC (5.04) BS01 ZN ? GO:0000428 ... I3LCH3 36201575
    182016 8gxq:PI (5.04) BS01 ZN ? GO:0000428 ... P60899 36201575
    182017 8gxq:PI (5.04) BS02 ZN ? GO:0000428 ... P60899 36201575
    182018 8gxq:PJ (5.04) BS01 ZN ? GO:0000428 ... A0A493TD97 36201575
    182019 8gxq:PL (5.04) BS01 ZN ? GO:0003677 ... A0A4X1TRS6 36201575
    182020 8gxq:c (5.04) BS01 ZN ? GO:0000151 ... Q6P2C8 36201575
    182021 8gxq:p (5.04) BS01 ZN ? GO:0003713 ... Q9Y2X0 36201575
    182022 8gxs:BA (4.16) BS03 ZN 2.3.1.48 GO:0000776 ... Q00403 36201575
    182023 8gxs:EA (4.16) BS01 ZN ? GO:0001113 ... P29083 36201575
    182024 8gxs:HD (4.16) BS01 ZN ? GO:0000082 ... P51948 36201575
    182025 8gxs:HE (4.16) BS01 ZN ? GO:0000438 ... Q13889 36201575
    182026 8gxs:HE (4.16) BS02 ZN ? GO:0000438 ... Q13889 36201575
    182027 8gxs:HG (4.16) BS01 ZN ? GO:0000438 ... Q13888 36201575
    182028 8gxs:HG (4.16) BS02 ZN ? GO:0000438 ... Q13888 36201575
    182029 8gxs:HG (4.16) BS03 ZN ? GO:0000438 ... Q13888 36201575
    182030 8gxs:PA (4.16) BS01 ZN 2.7.7.6 GO:0000428 ... A0A8D1DPV6 36201575
    182031 8gxs:PA (4.16) BS02 ZN 2.7.7.6 GO:0000428 ... A0A8D1DPV6 36201575
    182032 8gxs:PA (4.16) BS03 MG 2.7.7.6 GO:0000428 ... A0A8D1DPV6 36201575
    182033 8gxs:PB (4.16) BS01 ZN 2.7.7.6 GO:0000428 ... A0A4X1TVZ5 36201575
    182034 8gxs:PC (4.16) BS01 ZN ? GO:0000428 ... I3LCH3 36201575
    182035 8gxs:PI (4.16) BS01 ZN ? GO:0000428 ... P60899 36201575
    182036 8gxs:PI (4.16) BS02 ZN ? GO:0000428 ... P60899 36201575
    182037 8gxs:PJ (4.16) BS01 ZN ? GO:0000428 ... A0A493TD97 36201575
    182038 8gxs:PL (4.16) BS01 ZN ? GO:0003677 ... A0A4X1TRS6 36201575
    182039 8gxs:c (4.16) BS01 ZN ? GO:0000151 ... Q6P2C8 36201575
    182040 8gxs:p (4.16) BS01 ZN ? GO:0003713 ... Q9Y2X0 36201575
    182041 8gxv:A (2.2) BS01 ZN ? GO:0004867 ... B3ECZ8 N/A
    182042 8gxv:A (2.2) BS02 ZN ? GO:0004867 ... B3ECZ8 N/A
    182043 8gxv:A (2.2) BS03 ZN ? GO:0004867 ... B3ECZ8 N/A
    182044 8gy1:A (1.9) BS01 AG 1.16.3.1 GO:0005737 ... A0A8F4Y4C2 36904538
    182045 8gy1:A (1.9) BS02 AG 1.16.3.1 GO:0005737 ... A0A8F4Y4C2 36904538
    182046 8gy2:A (2.5) BS03 CA 1.1.5.5 GO:0005509 ... O05542 N/A
    182047 8gy7:R (3.3) BS02 CA ? GO:0004930 ... P0ABE7
    Q01718
    36588120
    182048 8gyc:B (1.8) BS01 CA ? GO:0001786 ... P08758 N/A
    182049 8gyc:B (1.8) BS02 CA ? GO:0001786 ... P08758 N/A
    182050 8gyg:A (2.0) BS01 CA ? GO:0016787 ... A0A9J9EP68 N/A
    182051 8gyg:A (2.0) BS02 CA ? GO:0016787 ... A0A9J9EP68 N/A
    182052 8gyg:A (2.0) BS03 MN ? GO:0016787 ... A0A9J9EP68 N/A
    182053 8gyg:B (2.0) BS01 CA ? GO:0016787 ... A0A9J9EP68 N/A
    182054 8gyg:B (2.0) BS02 CA ? GO:0016787 ... A0A9J9EP68 N/A
    182055 8gyk:A (3.14) BS02 MG ? GO:0000150 ... Q06609 37591853
    182056 8gyk:B (3.14) BS02 MG ? GO:0000150 ... Q06609 37591853
    182057 8gyk:C (3.14) BS02 MG ? GO:0000150 ... Q06609 37591853
    182058 8gyk:D (3.14) BS02 MG ? GO:0000150 ... Q06609 37591853
    182059 8gyk:E (3.14) BS02 MG ? GO:0000150 ... Q06609 37591853
    182060 8gyk:F (3.14) BS02 MG ? GO:0000150 ... Q06609 37591853
    182061 8gyk:G (3.14) BS02 MG ? GO:0000150 ... Q06609 37591853
    182062 8gyk:H (3.14) BS02 MG ? GO:0000150 ... Q06609 37591853
    182063 8gym:C1 (2.96) BS03 CU 7.1.1.9 GO:0004129 ... Q950Y4 37248254
    182064 8gym:C1 (2.96) BS04 MG 7.1.1.9 GO:0004129 ... Q950Y4 37248254
    182065 8gym:C2 (2.96) BS02 CU 7.1.1.9 GO:0004129 ... Q950Y9 37248254
    182066 8gym:C2 (2.96) BS03 CU 7.1.1.9 GO:0004129 ... Q950Y9 37248254
    182067 8gym:S6 (2.96) BS01 ZN ? GO:0005739 ... I7MK02 37248254
    182068 8gym:VB (2.96) BS01 ZN ? GO:0005740 ... Q23FF5 37248254
    182069 8gym:VB (2.96) BS02 ZN ? GO:0005740 ... Q23FF5 37248254
    182070 8gym:c1 (2.96) BS02 CU 7.1.1.9 GO:0004129 ... Q950Y4 37248254
    182071 8gym:c1 (2.96) BS04 MG 7.1.1.9 GO:0004129 ... Q950Y4 37248254
    182072 8gym:c2 (2.96) BS02 CU 7.1.1.9 GO:0004129 ... Q950Y9 37248254
    182073 8gym:c2 (2.96) BS03 CU 7.1.1.9 GO:0004129 ... Q950Y9 37248254
    182074 8gym:s6 (2.96) BS01 ZN ? GO:0005739 ... I7MK02 37248254
    182075 8gym:vb (2.96) BS01 ZN ? GO:0005740 ... Q23FF5 37248254
    182076 8gym:vb (2.96) BS02 ZN ? GO:0005740 ... Q23FF5 37248254
    182077 8gyr:A (1.87) BS01 CA ? N/A C0J1Q2 37336372
    182078 8gyr:B (1.87) BS01 CA ? N/A C0J1Q2 37336372
    182079 8gyw:A (3.9) BS01 MG 2.7.8.1
    2.7.8.2
    2.7.8.22
    GO:0004142 ... Q9Y6K0 37137909
    182080 8gyw:A (3.9) BS02 MG 2.7.8.1
    2.7.8.2
    2.7.8.22
    GO:0004142 ... Q9Y6K0 37137909
    182081 8gyw:B (3.9) BS01 MG 2.7.8.1
    2.7.8.2
    2.7.8.22
    GO:0004142 ... Q9Y6K0 37137909
    182082 8gyw:B (3.9) BS02 MG 2.7.8.1
    2.7.8.2
    2.7.8.22
    GO:0004142 ... Q9Y6K0 37137909
    182083 8gyx:A (3.7) BS01 MG 2.7.8.1
    2.7.8.2
    2.7.8.22
    GO:0004142 ... Q9Y6K0 37137909
    182084 8gyx:A (3.7) BS02 MG 2.7.8.1
    2.7.8.2
    2.7.8.22
    GO:0004142 ... Q9Y6K0 37137909
    182085 8gyx:B (3.7) BS01 MG 2.7.8.1
    2.7.8.2
    2.7.8.22
    GO:0004142 ... Q9Y6K0 37137909
    182086 8gyx:B (3.7) BS02 MG 2.7.8.1
    2.7.8.2
    2.7.8.22
    GO:0004142 ... Q9Y6K0 37137909
    182087 8gz0:A (2.22) BS01 CA ? GO:0046872 ... Q5SH57 N/A
    182088 8gz0:A (2.22) BS02 CA ? GO:0046872 ... Q5SH57 N/A
    182089 8gz0:A (2.22) BS03 CA ? GO:0046872 ... Q5SH57 N/A
    182090 8gz0:B (2.22) BS01 CA ? GO:0046872 ... Q5SH57 N/A
    182091 8gz0:B (2.22) BS02 CA ? GO:0046872 ... Q5SH57 N/A
    182092 8gz0:B (2.22) BS03 CA ? GO:0046872 ... Q5SH57 N/A
    182093 8gz1:B (3.4) BS01 NA ? GO:0001508 ... Q9UQD0 36823201
    182094 8gzc:A (2.0) BS01 ZN 2.3.1.-
    2.3.1.48
    GO:0004402 ... Q09472 36572866
    182095 8gzc:A (2.0) BS02 ZN 2.3.1.-
    2.3.1.48
    GO:0004402 ... Q09472 36572866
    182096 8gzc:A (2.0) BS03 ZN 2.3.1.-
    2.3.1.48
    GO:0004402 ... Q09472 36572866
    182097 8gzc:B (2.0) BS01 ZN 2.3.1.-
    2.3.1.48
    GO:0004402 ... Q09472 36572866
    182098 8gzc:B (2.0) BS02 ZN 2.3.1.-
    2.3.1.48
    GO:0004402 ... Q09472 36572866
    182099 8gzc:B (2.0) BS03 ZN 2.3.1.-
    2.3.1.48
    GO:0004402 ... Q09472 36572866
    182100 8gzg:D (3.13) BS04 MG 2.7.7.6 GO:0000287 ... P74177 N/A
    182101 8gzg:Z (3.13) BS02 ZN 2.7.7.6 GO:0000428 ... P73334 N/A
    182102 8gzh:D (2.96) BS02 MG 2.7.7.6 GO:0000287 ... P74177 N/A
    182103 8gzh:D (2.96) BS03 ZN 2.7.7.6 GO:0000287 ... P74177 N/A
    182104 8gzh:D (2.96) BS04 MG 2.7.7.6 GO:0000287 ... P74177 N/A
    182105 8gzh:Z (2.96) BS03 ZN 2.7.7.6 GO:0000428 ... P73334 N/A
    182106 8gzp:A (3.6) BS02 ZN 3.4.21.91
    3.6.1.15
    3.6.4.13
    GO:0003968 ... Q5I3C1 37478848
    182107 8gzp:A (3.6) BS03 ZN 3.4.21.91
    3.6.1.15
    3.6.4.13
    GO:0003968 ... Q5I3C1 37478848
    182108 8gzq:A (3.9) BS02 ZN 3.4.21.91
    3.6.1.15
    3.6.4.13
    GO:0003968 ... Q5I3C1 37478848
    182109 8gzq:A (3.9) BS03 ZN 3.4.21.91
    3.6.1.15
    3.6.4.13
    GO:0003968 ... Q5I3C1 37478848
    182110 8gzr:A (2.8) BS02 MN 3.4.21.91
    3.6.1.15
    3.6.4.13
    GO:0003968 ... Q5I3C1 37478848
    182111 8gzr:A (2.8) BS03 MN 3.4.21.91
    3.6.1.15
    3.6.4.13
    GO:0003968 ... Q5I3C1 37478848
    182112 8gzr:A (2.8) BS04 ZN 3.4.21.91
    3.6.1.15
    3.6.4.13
    GO:0003968 ... Q5I3C1 37478848
    182113 8gzr:A (2.8) BS05 ZN 3.4.21.91
    3.6.1.15
    3.6.4.13
    GO:0003968 ... Q5I3C1 37478848
    182114 8gzu:27 (4.18) BS01 CU 7.1.1.9 GO:0004129 ... Q950Y9 37248254
    182115 8gzu:29 (4.18) BS01 ZN ? GO:0005740 ... Q23FF5 37248254
    182116 8gzu:82 (4.18) BS01 CU 7.1.1.9 GO:0004129 ... Q950Y9 37248254
    182117 8gzu:84 (4.18) BS01 ZN ? GO:0005740 ... Q23FF5 37248254
    182118 8gzu:84 (4.18) BS02 ZN ? GO:0005740 ... Q23FF5 37248254
    182119 8gzu:C2 (4.18) BS01 CU 7.1.1.9 GO:0004129 ... Q950Y9 37248254
    182120 8gzu:VB (4.18) BS01 ZN ? GO:0005740 ... Q23FF5 37248254
    182121 8gzu:c2 (4.18) BS01 CU 7.1.1.9 GO:0004129 ... Q950Y9 37248254
    182122 8gzu:vb (4.18) BS01 ZN ? GO:0005740 ... Q23FF5 37248254
    182123 8gzu:vb (4.18) BS02 ZN ? GO:0005740 ... Q23FF5 37248254
    182124 8h06:A (2.66) BS01 ZN 3.4.17.-
    3.4.17.23
    GO:0006508 ... Q9BYF1 37479708
    182125 8h09:B (1.81) BS03 MG ? GO:0006629 ... A0A7Y4B3E8 37558668
    182126 8h0a:B (1.94) BS01 MG ? GO:0006629 ... A0A7Y4B3E8 37558668
    182127 8h0b:B (1.931) BS01 MG ? GO:0006629 ... A0A7Y4B3E8 37558668
    182128 8h0c:B (1.98) BS02 MG ? GO:0006629 ... A0A7Y4B3E8 37558668
    182129 8h0d:B (2.01) BS03 MG ? GO:0006629 ... A0A7Y4B3E8 37558668
    182130 8h0i:A (2.8) BS02 ZN 3.5.4.38 GO:0003824 ... Q9HC16 37419875
    182131 8h0i:A (2.8) BS03 ZN 3.5.4.38 GO:0003824 ... Q9HC16 37419875
    182132 8h0i:B (2.8) BS02 ZN 3.5.4.38 GO:0003824 ... Q9HC16 37419875
    182133 8h0i:B (2.8) BS03 ZN 3.5.4.38 GO:0003824 ... Q9HC16 37419875
    182134 8h0j:A (2.23) BS01 CA ? GO:0001786 ... P08758 N/A
    182135 8h0j:A (2.23) BS02 CA ? GO:0001786 ... P08758 N/A
    182136 8h0j:A (2.23) BS03 CA ? GO:0001786 ... P08758 N/A
    182137 8h0j:A (2.23) BS04 CA ? GO:0001786 ... P08758 N/A
    182138 8h0l:B (1.8) BS03 MG N/A N/A N/A 37702119
    182139 8h0v:A (3.8) BS04 ZN 2.7.7.6 GO:0000428 ... C4R4Y0 36435862
    182140 8h0v:A (3.8) BS05 ZN 2.7.7.6 GO:0000428 ... C4R4Y0 36435862
    182141 8h0v:A (3.8) BS06 MG 2.7.7.6 GO:0000428 ... C4R4Y0 36435862
    182142 8h0v:B (3.8) BS03 ZN 2.7.7.6 GO:0000428 ... C4QZQ7 36435862
    182143 8h0v:C (3.8) BS01 ZN ? GO:0000428 ... C4R7L2 36435862
    182144 8h0v:I (3.8) BS01 ZN ? GO:0000428 ... F2QPE6 36435862
    182145 8h0v:I (3.8) BS02 ZN ? GO:0000428 ... F2QPE6 36435862
    182146 8h0v:J (3.8) BS01 ZN ? GO:0000428 ... C4R009 36435862
    182147 8h0v:L (3.8) BS01 ZN ? GO:0001054 ... F2QMI1 36435862
    182148 8h0w:A (4.6) BS03 ZN 2.7.7.6 GO:0000428 ... C4R4Y0 36435862
    182149 8h0w:A (4.6) BS04 ZN 2.7.7.6 GO:0000428 ... C4R4Y0 36435862
    182150 8h0w:A (4.6) BS05 MG 2.7.7.6 GO:0000428 ... C4R4Y0 36435862
    182151 8h0w:B (4.6) BS03 ZN 2.7.7.6 GO:0000428 ... C4QZQ7 36435862
    182152 8h0w:C (4.6) BS01 ZN ? GO:0000428 ... C4R7L2 36435862
    182153 8h0w:I (4.6) BS01 ZN ? GO:0000428 ... F2QPE6 36435862
    182154 8h0w:I (4.6) BS02 ZN ? GO:0000428 ... F2QPE6 36435862
    182155 8h0w:J (4.6) BS01 ZN ? GO:0000428 ... C4R009 36435862
    182156 8h0w:L (4.6) BS01 ZN ? GO:0001054 ... F2QMI1 36435862
    182157 8h18:A (1.499) BS01 MG N/A GO:0003676 ... N/A 37663930
    182158 8h1e:A (1.22) BS01 MN ? GO:0005524 ... O67518 37487639
    182159 8h1e:A (1.22) BS02 MN ? GO:0005524 ... O67518 37487639
    182160 8h1e:A (1.22) BS03 MN ? GO:0005524 ... O67518 37487639
    182161 8h1f:A (1.22) BS01 ZN ? GO:0005524 ... O67518 37487639
    182162 8h1f:A (1.22) BS02 ZN ? GO:0005524 ... O67518 37487639
    182163 8h1g:A (1.43) BS01 CD ? GO:0005524 ... O67518 37487639
    182164 8h1g:A (1.43) BS02 CD ? GO:0005524 ... O67518 37487639
    182165 8h1i:A (2.1) BS01 CA ? GO:0046872 ... W6EBY7 N/A
    182166 8h1j:A (3.1) BS04 ZN 3.1.21.- GO:0003677 ... Q7DF80 37020030
    182167 8h2a:A (2.5) BS02 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182168 8h2a:A (2.5) BS03 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182169 8h2a:B (2.5) BS02 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182170 8h2a:B (2.5) BS03 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182171 8h2a:C (2.5) BS02 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182172 8h2a:C (2.5) BS03 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182173 8h2a:D (2.5) BS02 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182174 8h2a:D (2.5) BS03 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182175 8h2a:E (2.5) BS02 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182176 8h2a:E (2.5) BS03 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182177 8h2a:F (2.5) BS02 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182178 8h2a:F (2.5) BS03 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182179 8h2a:G (2.5) BS02 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182180 8h2a:G (2.5) BS03 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182181 8h2a:H (2.5) BS02 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182182 8h2a:H (2.5) BS03 ZN 1.1.1.1 GO:0000166 ... T2KM87 N/A
    182183 8h2b:A (2.1) BS02 ZN 1.1.1.1 GO:0000166 ... G0L712 N/A
    182184 8h2b:A (2.1) BS03 ZN 1.1.1.1 GO:0000166 ... G0L712 N/A
    182185 8h2b:B (2.1) BS02 ZN 1.1.1.1 GO:0000166 ... G0L712 N/A
    182186 8h2b:B (2.1) BS03 ZN 1.1.1.1 GO:0000166 ... G0L712 N/A
    182187 8h2b:C (2.1) BS02 ZN 1.1.1.1 GO:0000166 ... G0L712 N/A
    182188 8h2b:C (2.1) BS03 ZN 1.1.1.1 GO:0000166 ... G0L712 N/A
    182189 8h2b:D (2.1) BS02 ZN 1.1.1.1 GO:0000166 ... G0L712 N/A
    182190 8h2b:D (2.1) BS03 ZN 1.1.1.1 GO:0000166 ... G0L712 N/A
    182191 8h2c:A (2.9) BS01 MN 2.5.1.97 GO:0016051 ... Q0P8U0 36283338
    182192 8h2c:B (2.9) BS01 MN 2.5.1.97 GO:0016051 ... Q0P8U0 36283338
    182193 8h2c:C (2.9) BS01 MN 2.5.1.97 GO:0016051 ... Q0P8U0 36283338
    182194 8h2c:D (2.9) BS01 MN 2.5.1.97 GO:0016051 ... Q0P8U0 36283338
    182195 8h2f:A (1.448) BS02 MG N/A GO:0003676 ... N/A 37663930
    182196 8h2n:A (4.41) BS01 MG ? N/A A7XXD0 38182597
    182197 8h2n:B (4.41) BS01 MG ? N/A A7XXD0 38182597
    182198 8h2n:C (4.41) BS01 MG ? N/A A7XXD0 38182597
    182199 8h2n:D (4.41) BS01 MG ? N/A A7XXD0 38182597
    182200 8h2t:B (2.59) BS03 FE ? GO:0005506 ... C5CSP6 37459330

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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