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BioLiP
Download all results in tab-seperated text for 197122 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
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  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    168201 7w49:A (3.1) BS01 MG 7.2.2.19 GO:0000166 ... P19156 35604136
    168202 7w4a:A (2.76) BS02 MG 7.2.2.19 GO:0000166 ... P19156 35604136
    168203 7w4c:M (2.7) BS04 MG ? GO:0005743 ... A0A4X1V1H9 35145322
    168204 7w4c:T (2.7) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168205 7w4d:M (3.0) BS04 MG ? GO:0005743 ... A0A4X1V1H9 35145322
    168206 7w4d:T (3.0) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168207 7w4e:M (3.0) BS04 MG ? GO:0005743 ... A0A4X1V1H9 35145322
    168208 7w4e:T (3.0) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168209 7w4f:M (2.7) BS04 MG ? GO:0005743 ... A0A4X1V1H9 35145322
    168210 7w4f:T (2.7) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168211 7w4g:T (3.1) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168212 7w4j:M (3.2) BS04 MG ? GO:0005743 ... A0A4X1V1H9 35145322
    168213 7w4j:T (3.2) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168214 7w4k:M (3.2) BS04 MG ? GO:0005743 ... A0A4X1V1H9 35145322
    168215 7w4k:T (3.2) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168216 7w4l:M (3.1) BS04 MG ? GO:0005743 ... A0A4X1V1H9 35145322
    168217 7w4l:T (3.1) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168218 7w4m:M (3.3) BS04 MG ? GO:0005743 ... A0A4X1V1H9 35145322
    168219 7w4m:T (3.3) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168220 7w4n:M (3.0) BS04 MG ? GO:0005743 ... A0A4X1V1H9 35145322
    168221 7w4n:T (3.0) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168222 7w4o:B (2.96) BS02 MG ? GO:0001508 ... A0A1U7R319 35589716
    168223 7w4o:D (2.96) BS02 MG ? GO:0001508 ... A0A1U7R319 35589716
    168224 7w4o:F (2.96) BS02 MG ? GO:0001508 ... A0A1U7R319 35589716
    168225 7w4o:H (2.96) BS02 MG ? GO:0001508 ... A0A1U7R319 35589716
    168226 7w4p:B (3.19) BS02 MG ? GO:0001508 ... A0A1U7R319 35589716
    168227 7w4p:D (3.19) BS02 MG ? GO:0001508 ... A0A1U7R319 35589716
    168228 7w4p:F (3.19) BS02 MG ? GO:0001508 ... A0A1U7R319 35589716
    168229 7w4p:H (3.19) BS02 MG ? GO:0001508 ... A0A1U7R319 35589716
    168230 7w4q:T (3.3) BS01 ZN ? GO:0006120 ... F1S031 35145322
    168231 7w4x:A (2.20007) BS01 ZN 3.1.4.53 GO:0004114 ... Q08499 35188767
    168232 7w4x:B (2.20007) BS01 ZN 3.1.4.53 GO:0004114 ... Q08499 35188767
    168233 7w4y:A (2.10003) BS01 ZN 3.1.4.53 GO:0004114 ... Q08499 35188767
    168234 7w4y:B (2.10003) BS01 ZN 3.1.4.53 GO:0004114 ... Q08499 35188767
    168235 7w4z:B (1.15) BS01 CA ? GO:0051015 ... Q94707 36252034
    168236 7w4z:B (1.15) BS02 CA ? GO:0051015 ... Q94707 36252034
    168237 7w50:B (1.15) BS01 CA ? GO:0051015 ... Q94707 36252034
    168238 7w50:B (1.15) BS02 CA ? GO:0051015 ... Q94707 36252034
    168239 7w51:B (1.2) BS01 CA ? GO:0051015 ... Q94707 36252034
    168240 7w51:B (1.2) BS02 CA ? GO:0051015 ... Q94707 36252034
    168241 7w52:B (2.001) BS01 CA ? GO:0051015 ... Q94707 36252034
    168242 7w52:B (2.001) BS02 CA ? GO:0051015 ... Q94707 36252034
    168243 7w52:D (2.001) BS01 CA ? GO:0051015 ... Q94707 36252034
    168244 7w52:D (2.001) BS02 CA ? GO:0051015 ... Q94707 36252034
    168245 7w52:F (2.001) BS01 CA ? GO:0051015 ... Q94707 36252034
    168246 7w52:F (2.001) BS02 CA ? GO:0051015 ... Q94707 36252034
    168247 7w52:H (2.001) BS01 CA ? GO:0051015 ... Q94707 36252034
    168248 7w52:H (2.001) BS02 CA ? GO:0051015 ... Q94707 36252034
    168249 7w59:N (3.6) BS02 ZN ? GO:0000398 ... P41223 35705093
    168250 7w59:N (3.6) BS03 ZN ? GO:0000398 ... P41223 35705093
    168251 7w59:N (3.6) BS04 ZN ? GO:0000398 ... P41223 35705093
    168252 7w59:O (3.6) BS03 ZN ? GO:0000398 ... Q9NW64 35705093
    168253 7w59:O (3.6) BS04 ZN ? GO:0000398 ... Q9NW64 35705093
    168254 7w59:O (3.6) BS05 ZN ? GO:0000398 ... Q9NW64 35705093
    168255 7w5a:1 (3.6) BS02 ZN ? GO:0000375 ... O95391 35705093
    168256 7w5a:N (3.6) BS02 ZN ? GO:0000398 ... P41223 35705093
    168257 7w5a:N (3.6) BS03 ZN ? GO:0000398 ... P41223 35705093
    168258 7w5a:N (3.6) BS04 ZN ? GO:0000398 ... P41223 35705093
    168259 7w5a:O (3.6) BS03 ZN ? GO:0000398 ... Q9NW64 35705093
    168260 7w5a:O (3.6) BS04 ZN ? GO:0000398 ... Q9NW64 35705093
    168261 7w5a:O (3.6) BS05 ZN ? GO:0000398 ... Q9NW64 35705093
    168262 7w5b:1 (4.3) BS02 ZN ? GO:0000375 ... O95391 35705093
    168263 7w5b:N (4.3) BS02 ZN ? GO:0000398 ... P41223 35705093
    168264 7w5b:N (4.3) BS03 ZN ? GO:0000398 ... P41223 35705093
    168265 7w5b:N (4.3) BS04 ZN ? GO:0000398 ... P41223 35705093
    168266 7w5b:O (4.3) BS03 ZN ? GO:0000398 ... Q9NW64 35705093
    168267 7w5b:O (4.3) BS04 ZN ? GO:0000398 ... Q9NW64 35705093
    168268 7w5b:O (4.3) BS05 ZN ? GO:0000398 ... Q9NW64 35705093
    168269 7w5c:A (2.201) BS03 MG 2.7.11.24 GO:0000165 ... Q39024 37243525
    168270 7w5e:A (1.65) BS01 FE ? GO:0004462 ... Q4R0L3 35415958
    168271 7w5e:A (1.65) BS02 FE ? GO:0004462 ... Q4R0L3 35415958
    168272 7w5e:A (1.65) BS03 FE ? GO:0004462 ... Q4R0L3 35415958
    168273 7w5e:B (1.65) BS01 FE ? GO:0004462 ... Q4R0L3 35415958
    168274 7w5e:B (1.65) BS02 FE ? GO:0004462 ... Q4R0L3 35415958
    168275 7w5e:B (1.65) BS03 FE ? GO:0004462 ... Q4R0L3 35415958
    168276 7w5e:C (1.65) BS01 FE ? GO:0004462 ... Q4R0L3 35415958
    168277 7w5e:C (1.65) BS02 FE ? GO:0004462 ... Q4R0L3 35415958
    168278 7w5e:C (1.65) BS03 FE ? GO:0004462 ... Q4R0L3 35415958
    168279 7w5e:C (1.65) BS04 FE ? GO:0004462 ... Q4R0L3 35415958
    168280 7w5e:D (1.65) BS01 FE ? GO:0004462 ... Q4R0L3 35415958
    168281 7w5e:D (1.65) BS02 FE ? GO:0004462 ... Q4R0L3 35415958
    168282 7w5e:D (1.65) BS03 FE ? GO:0004462 ... Q4R0L3 35415958
    168283 7w5e:D (1.65) BS04 FE ? GO:0004462 ... Q4R0L3 35415958
    168284 7w5f:A (2.53) BS01 MG 4.2.3.-
    4.2.3.104
    4.2.3.137
    4.2.3.157
    4.2.3.182
    4.2.3.57    		 GO:0016829 ... A0A5S9I252 35504416
    168285 7w5f:B (2.53) BS01 MG 4.2.3.-
    4.2.3.104
    4.2.3.137
    4.2.3.157
    4.2.3.182
    4.2.3.57    		 GO:0016829 ... A0A5S9I252 35504416
    168286 7w5h:A (2.05) BS02 MG 4.2.3.-
    4.2.3.104
    4.2.3.137
    4.2.3.157
    4.2.3.182
    4.2.3.57    		 GO:0016829 ... A0A5S9I252 35504416
    168287 7w5h:B (2.05) BS02 MG 4.2.3.-
    4.2.3.104
    4.2.3.137
    4.2.3.157
    4.2.3.182
    4.2.3.57    		 GO:0016829 ... A0A5S9I252 35504416
    168288 7w5i:A (2.13) BS02 MG 4.2.3.-
    4.2.3.104
    4.2.3.137
    4.2.3.157
    4.2.3.182
    4.2.3.57    		 GO:0016829 ... A0A5S9I252 35504416
    168289 7w5i:B (2.13) BS02 MG 4.2.3.-
    4.2.3.104
    4.2.3.137
    4.2.3.157
    4.2.3.182
    4.2.3.57    		 GO:0016829 ... A0A5S9I252 35504416
    168290 7w5j:A (2.05) BS03 MG 4.2.3.-
    4.2.3.104
    4.2.3.137
    4.2.3.157
    4.2.3.182
    4.2.3.57    		 GO:0016829 ... A0A5S9I252 35504416
    168291 7w5j:B (2.05) BS02 MG 4.2.3.-
    4.2.3.104
    4.2.3.137
    4.2.3.157
    4.2.3.182
    4.2.3.57    		 GO:0016829 ... A0A5S9I252 35504416
    168292 7w5p:A (2.3) BS03 MN ? GO:0046872 ... A8P1J0 35654845
    168293 7w5p:D (2.3) BS03 MN ? GO:0046872 ... A8P1J0 35654845
    168294 7w5p:G (2.3) BS03 MN ? GO:0046872 ... A8P1J0 35654845
    168295 7w5p:H (2.3) BS03 MN ? GO:0046872 ... A8P1J0 35654845
    168296 7w5r:E (3.87) BS01 MG 3.6.5.2 GO:0003924 ... P01116 36516586
    168297 7w5r:I (3.87) BS01 MG 3.6.5.2 GO:0003924 ... P01116 36516586
    168298 7w5r:M (3.87) BS01 MG 3.6.5.2 GO:0003924 ... P01116 36516586
    168299 7w5r:Q (3.87) BS01 MG 3.6.5.2 GO:0003924 ... P01116 36516586
    168300 7w5s:A (1.76) BS01 FE2 ? GO:0046872 ... A0A1U8X168 35435717
    168301 7w5t:A (1.74) BS03 FE2 ? GO:0046872 ... A0A1U8X168 35435717
    168302 7w5v:A (1.81) BS02 FE ? GO:0046872 ... A0A1U8X168 35435717
    168303 7w5w:D (4.55) BS03 ZN 2.7.7.6 GO:0000287 ... P0A8T7 36243985
    168304 7w5w:D (4.55) BS04 ZN 2.7.7.6 GO:0000287 ... P0A8T7 36243985
    168305 7w5w:D (4.55) BS05 MG 2.7.7.6 GO:0000287 ... P0A8T7 36243985
    168306 7w5z:5B (3.02) BS01 ZN ? GO:0005740 ... Q23FF5 35357889
    168307 7w5z:5b (3.02) BS01 ZN ? GO:0005740 ... Q23FF5 35357889
    168308 7w5z:C1 (3.02) BS03 CU 7.1.1.9 GO:0004129 ... Q950Y4 35357889
    168309 7w5z:C1 (3.02) BS04 MG 7.1.1.9 GO:0004129 ... Q950Y4 35357889
    168310 7w5z:C2 (3.02) BS02 CU 7.1.1.9 GO:0004129 ... Q950Y9 35357889
    168311 7w5z:C2 (3.02) BS03 CU 7.1.1.9 GO:0004129 ... Q950Y9 35357889
    168312 7w5z:M (3.02) BS01 ZN ? GO:0016020 ... W7WZP1 35357889
    168313 7w5z:c1 (3.02) BS03 CU 7.1.1.9 GO:0004129 ... Q950Y4 35357889
    168314 7w5z:c1 (3.02) BS04 MG 7.1.1.9 GO:0004129 ... Q950Y4 35357889
    168315 7w5z:c2 (3.02) BS02 CU 7.1.1.9 GO:0004129 ... Q950Y9 35357889
    168316 7w5z:c2 (3.02) BS03 CU 7.1.1.9 GO:0004129 ... Q950Y9 35357889
    168317 7w5z:m (3.02) BS01 ZN ? GO:0016020 ... W7WZP1 35357889
    168318 7w64:A (2.3) BS03 CA ? GO:0003674 ... P23476 36240278
    168319 7w64:D (2.3) BS03 CA ? GO:0003674 ... P23476 36240278
    168320 7w64:E (2.3) BS03 CA ? GO:0003674 ... P23476 36240278
    168321 7w67:C (2.194) BS04 ZN 2.1.1.-
    2.1.1.364    		 N/A Q03164 36108631
    168322 7w6a:C (2.21) BS03 ZN 2.1.1.-
    2.1.1.364    		 N/A Q03164 36108631
    168323 7w6b:A (2.984) BS01 MG N/A N/A N/A 35561142
    168324 7w6b:A (2.984) BS02 CA N/A N/A N/A 35561142
    168325 7w6i:C (2.56) BS04 ZN 2.1.1.-
    2.1.1.364    		 N/A Q03164 36108631
    168326 7w6j:C (2.68) BS04 ZN 2.1.1.-
    2.1.1.364    		 N/A Q03164 36108631
    168327 7w6l:C (2.26) BS03 ZN 2.1.1.364 N/A Q8NEZ4 36108631
    168328 7w6l:E (2.26) BS02 ZN 2.1.1.364 N/A Q8NEZ4 36108631
    168329 7w6r:A (2.6) BS01 ZN 3.4.-.-
    3.4.17.23    		 GO:0006508 ... F6V9L3 N/A
    168330 7w6u:A (2.56) BS01 ZN 3.4.-.-
    3.4.17.23    		 GO:0006508 ... F6V9L3 N/A
    168331 7w6v:A (2.47) BS01 CO ? GO:0005507 ... Q9XAL8 36322668
    168332 7w6w:A (1.94) BS01 MN 1.15.1.1 GO:0004784 ... A0A1E5TT85 36701098
    168333 7w6w:B (1.94) BS02 MN 1.15.1.1 GO:0004784 ... A0A1E5TT85 36701098
    168334 7w6w:C (1.94) BS01 MN 1.15.1.1 GO:0004784 ... A0A1E5TT85 36701098
    168335 7w6w:D (1.94) BS02 MN 1.15.1.1 GO:0004784 ... A0A1E5TT85 36701098
    168336 7w6x:A (3.2) BS01 ZN 3.4.24.- GO:0004175 ... P0AEH1 36001659
    168337 7w6x:A (3.2) BS03 ZN 3.4.24.- GO:0004175 ... P0AEH1 36001659
    168338 7w6y:A (3.1) BS01 ZN 3.4.24.- GO:0004222 ... C7R5Z1 36001659
    168339 7w6z:A (3.15) BS01 ZN 3.4.24.- GO:0004222 ... C7R5Z1 36001659
    168340 7w72:K (3.1) BS01 CA 3.-.-.- GO:0003923 ... Q92643 35165458
    168341 7w78:A (2.884) BS01 MG ? GO:0005524 ... Q6NEF2 35767641
    168342 7w79:A (3.1) BS02 MN ? GO:0005524 ... Q6NEF2 35767641
    168343 7w79:A (3.1) BS03 MN ? GO:0005524 ... Q6NEF2 35767641
    168344 7w79:A (3.1) BS04 MN ? GO:0005524 ... Q6NEF2 35767641
    168345 7w7g:A (3.2) BS01 ZN ? N/A E5CYJ9 35550517
    168346 7w7g:B (3.2) BS01 ZN ? GO:0005515 ... Q8BLN6 35550517
    168347 7w7h:A (2.6) BS01 ZN N/A GO:0004371 ... N/A 36054360
    168348 7w7h:B (2.6) BS01 ZN N/A GO:0004371 ... N/A 36054360
    168349 7w7o:A (1.59) BS02 CA 3.4.22.52 GO:0004198 ... P07384 N/A
    168350 7w7o:A (1.59) BS03 CA 3.4.22.52 GO:0004198 ... P07384 N/A
    168351 7w7t:A (3.4) BS01 CA 7.2.2.10 GO:0000045 ... P16615 36476867
    168352 7w7t:A (3.4) BS02 CA 7.2.2.10 GO:0000045 ... P16615 36476867
    168353 7w7t:A (3.4) BS04 MG 7.2.2.10 GO:0000045 ... P16615 36476867
    168354 7w7u:A (3.0) BS02 MG 7.2.2.10 GO:0000045 ... P16615 36476867
    168355 7w7v:A (3.0) BS02 MG 7.2.2.10 GO:0000045 ... P16615 36476867
    168356 7w7w:A (3.2) BS02 MG 7.2.2.10 GO:0000045 ... P16615 36476867
    168357 7w86:A (1.8) BS01 ZN ? GO:0008270 ... P0C7R1 36342219
    168358 7w86:A (1.8) BS02 ZN ? GO:0008270 ... P0C7R1 36342219
    168359 7w8d:A (2.75016) BS01 MG 3.1.21.10 GO:0000287 ... Q9RX75 36000732
    168360 7w8f:A (1.9) BS02 FE ? GO:0006826 ... Q845T3 N/A
    168361 7w8f:A (1.9) BS03 MG ? GO:0006826 ... Q845T3 N/A
    168362 7w8f:A (1.9) BS04 MG ? GO:0006826 ... Q845T3 N/A
    168363 7w8g:2 (2.52) BS02 ZN 3.6.4.12 GO:0000727 ... P29469 35296675
    168364 7w8g:4 (2.52) BS02 ZN 3.6.4.12 GO:0000727 ... P30665 35296675
    168365 7w8g:5 (2.52) BS03 ZN 3.6.4.12 GO:0000727 ... P29496 35296675
    168366 7w8g:6 (2.52) BS03 MG 3.6.4.12 GO:0000727 ... P53091 35296675
    168367 7w8g:6 (2.52) BS04 ZN 3.6.4.12 GO:0000727 ... P53091 35296675
    168368 7w8g:7 (2.52) BS03 ZN 3.6.4.12 GO:0000727 ... P38132 35296675
    168369 7w8g:B (2.52) BS02 ZN 3.6.4.12 GO:0000727 ... P29469 35296675
    168370 7w8g:D (2.52) BS02 ZN 3.6.4.12 GO:0000727 ... P30665 35296675
    168371 7w8g:E (2.52) BS03 ZN 3.6.4.12 GO:0000727 ... P29496 35296675
    168372 7w8g:F (2.52) BS03 ZN 3.6.4.12 GO:0000727 ... P53091 35296675
    168373 7w8g:G (2.52) BS03 ZN 3.6.4.12 GO:0000727 ... P38132 35296675
    168374 7w8j:A (2.5) BS01 FE 3.5.1.56 GO:0016787 ... I6NT79 N/A
    168375 7w8j:C (2.5) BS01 FE 3.5.1.56 GO:0016787 ... I6NT79 N/A
    168376 7w8j:E (2.5) BS01 FE 3.5.1.56 GO:0016787 ... I6NT79 N/A
    168377 7w8j:G (2.5) BS01 FE 3.5.1.56 GO:0016787 ... I6NT79 N/A
    168378 7w8l:A (2.301) BS01 CO 4.2.1.84 GO:0003824 ... Q7SID2 35919716
    168379 7w8m:A (2.6) BS01 CO 4.2.1.84 GO:0003824 ... Q7SID2 35919716
    168380 7w8s:A (2.85) BS01 ZN 3.4.-.-
    3.4.17.23    		 GO:0006508 ... A0A8C7BTF2 36000849
    168381 7w9h:A (2.28) BS01 CA ? GO:0000160 ... Q9I4N3 38058307
    168382 7w9h:B (2.28) BS01 CA ? GO:0000160 ... Q9I4N3 38058307
    168383 7w9h:B (2.28) BS02 CA ? GO:0000160 ... Q9I4N3 38058307
    168384 7w9q:A (1.599) BS02 CA ? N/A P02766 36472374
    168385 7w9s:A (2.53) BS04 ZN 2.7.7.48
    3.4.22.28
    3.4.22.29
    3.6.1.15    		 GO:0003723 ... E5RPG3 36477355
    168386 7w9s:A (2.53) BS05 MG 2.7.7.48
    3.4.22.28
    3.4.22.29
    3.6.1.15    		 GO:0003723 ... E5RPG3 36477355
    168387 7w9s:A (2.53) BS06 MG 2.7.7.48
    3.4.22.28
    3.4.22.29
    3.6.1.15    		 GO:0003723 ... E5RPG3 36477355
    168388 7w9u:A (2.163) BS01 ZN 2.7.10.2 GO:0004713 ... Q05397 N/A
    168389 7w9u:C (2.163) BS01 ZN 2.7.10.2 GO:0004713 ... Q05397 N/A
    168390 7w9u:D (2.163) BS01 ZN 2.7.10.2 GO:0004713 ... Q05397 N/A
    168391 7wa0:A (1.77) BS01 CA 3.4.21.4 GO:0004175 ... P00760 35647681
    168392 7wa1:A (2.9) BS01 ZN 3.4.-.-
    3.4.17.23    		 GO:0006508 ... A0A8C7BTF2 36000849
    168393 7wa2:A (1.52) BS02 CA 3.4.21.4 GO:0004175 ... P00760 35647681
    168394 7wa3:A (2.28) BS01 ZN 3.4.-.-
    3.4.17.23    		 GO:0006508 ... A0A8C7BTF2 N/A
    168395 7wa3:B (2.28) BS01 ZN 3.4.-.-
    3.4.17.23    		 GO:0006508 ... A0A8C7BTF2 N/A
    168396 7wad:A (2.96) BS01 MG 6.3.2.29
    6.3.2.30    		 GO:0004326 ... Q113V7 36042318
    168397 7wad:B (2.96) BS01 MG 6.3.2.29
    6.3.2.30    		 GO:0004326 ... Q113V7 36042318
    168398 7wad:C (2.96) BS01 MG 6.3.2.29
    6.3.2.30    		 GO:0004326 ... Q113V7 36042318
    168399 7wad:D (2.96) BS01 MG 6.3.2.29
    6.3.2.30    		 GO:0004326 ... Q113V7 36042318
    168400 7wae:A (2.64) BS02 MG 6.3.2.29
    6.3.2.30    		 GO:0004326 ... Q113V7 36042318
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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