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●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

BioLiP
Download all results in tab-seperated text for 197122 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
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  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    164601 7ti7:A (1.5) BS02 CA 6.3.2.9 GO:0005524 ... B7H1N2 N/A
    164602 7ti8:A (3.5) BS02 MG ? GO:0000278 ... P38630 35179493
    164603 7tib:A (3.4) BS04 MG ? GO:0000278 ... P38630 35179493
    164604 7tib:C (3.4) BS03 MG ? GO:0000077 ... P38629 35179493
    164605 7tid:C (3.3) BS03 MG ? GO:0000077 ... P38629 35179493
    164606 7tid:D (3.3) BS03 MG ? GO:0000076 ... P40348 35179493
    164607 7tie:A (1.9) BS01 CU 7.1.1.9 GO:0004129 ... P00396 35257742
    164608 7tie:A (1.9) BS02 MG 7.1.1.9 GO:0004129 ... P00396 35257742
    164609 7tie:F (1.9) BS01 ZN ? GO:0005740 ... P00428 35257742
    164610 7tie:N (1.9) BS01 CU 7.1.1.9 GO:0004129 ... P00396 35257742
    164611 7tie:N (1.9) BS02 MG 7.1.1.9 GO:0004129 ... P00396 35257742
    164612 7tie:S (1.9) BS01 ZN ? GO:0005740 ... P00428 35257742
    164613 7tih:A (2.35) BS01 CU 7.1.1.9 GO:0004129 ... P00396 35257742
    164614 7tih:A (2.35) BS02 MG 7.1.1.9 GO:0004129 ... P00396 35257742
    164615 7tih:F (2.35) BS01 ZN ? GO:0005740 ... P00428 35257742
    164616 7tih:N (2.35) BS01 CU 7.1.1.9 GO:0004129 ... P00396 35257742
    164617 7tih:N (2.35) BS02 MG 7.1.1.9 GO:0004129 ... P00396 35257742
    164618 7tih:S (2.35) BS01 ZN ? GO:0005740 ... P00428 35257742
    164619 7tii:A (2.45) BS03 CU 7.1.1.9 GO:0004129 ... P00396 35257742
    164620 7tii:A (2.45) BS04 MG 7.1.1.9 GO:0004129 ... P00396 35257742
    164621 7tii:F (2.45) BS01 ZN ? GO:0005740 ... P00428 35257742
    164622 7tii:N (2.45) BS03 CU 7.1.1.9 GO:0004129 ... P00396 35257742
    164623 7tii:N (2.45) BS04 MG 7.1.1.9 GO:0004129 ... P00396 35257742
    164624 7tii:S (2.45) BS01 ZN ? GO:0005740 ... P00428 35257742
    164625 7tin:A (2.35) BS03 CA 2.2.1.9 GO:0000287 ... Q2FZL7 36633276
    164626 7tin:B (2.35) BS03 CA 2.2.1.9 GO:0000287 ... Q2FZL7 36633276
    164627 7tin:C (2.35) BS03 CA 2.2.1.9 GO:0000287 ... Q2FZL7 36633276
    164628 7tin:D (2.35) BS02 CA 2.2.1.9 GO:0000287 ... Q2FZL7 36633276
    164629 7tiu:A (1.65) BS02 MG 2.1.1.56
    2.1.1.57
    2.7.7.48
    2.7.7.50
    3.1.13.-
    3.4.19.12
    3.4.22.-
    3.4.22.69
    3.6.4.12
    3.6.4.13
    4.6.1.-    		 GO:0008233 ... P0DTD1 35393402
    164630 7tiv:A (2.08) BS02 MG 2.1.1.56
    2.1.1.57
    2.7.7.48
    2.7.7.50
    3.1.13.-
    3.4.19.12
    3.4.22.-
    3.4.22.69
    3.6.4.12
    3.6.4.13
    4.6.1.-    		 GO:0008233 ... P0DTD1 35393402
    164631 7tix:A (2.0) BS02 MG 2.1.1.56
    2.1.1.57
    2.7.7.48
    2.7.7.50
    3.1.13.-
    3.4.19.12
    3.4.22.-
    3.4.22.69
    3.6.4.12
    3.6.4.13
    4.6.1.-    		 GO:0008233 ... P0DTD1 35393402
    164632 7tj4:B (1.8) BS01 ZN 3.5.1.- GO:0008745 ... Q2FXU3 35733252
    164633 7tj4:D (1.8) BS01 ZN 3.5.1.- GO:0008745 ... Q2FXU3 35733252
    164634 7tja:J (1.96) BS05 MG N/A GO:0015979 ... N/A 35350600
    164635 7tjw:B (4.0) BS02 MG ? GO:0005524 ... P07251 35468906
    164636 7tjw:D (4.0) BS02 MG 7.1.2.2 GO:0005515 ... P00830 35468906
    164637 7tjx:D (4.0) BS02 MG 7.1.2.2 GO:0005515 ... P00830 35468906
    164638 7tku:A (4.0) BS02 MG ? GO:0000278 ... P38630 35179493
    164639 7tku:C (4.0) BS02 MG ? GO:0000077 ... P38629 35179493
    164640 7tl7:A (1.9) BS02 ZN 5.4.2.12 GO:0003824 ... G5EFZ1 35904259
    164641 7tl7:A (1.9) BS03 ZN 5.4.2.12 GO:0003824 ... G5EFZ1 35904259
    164642 7tl7:B (1.9) BS02 ZN 5.4.2.12 GO:0003824 ... G5EFZ1 35904259
    164643 7tl7:B (1.9) BS03 ZN 5.4.2.12 GO:0003824 ... G5EFZ1 35904259
    164644 7tl7:C (1.9) BS02 ZN 5.4.2.12 GO:0003824 ... G5EFZ1 35904259
    164645 7tl7:C (1.9) BS03 ZN 5.4.2.12 GO:0003824 ... G5EFZ1 35904259
    164646 7tl7:D (1.9) BS02 ZN 5.4.2.12 GO:0003824 ... G5EFZ1 35904259
    164647 7tl7:D (1.9) BS03 ZN 5.4.2.12 GO:0003824 ... G5EFZ1 35904259
    164648 7tl8:A (1.95) BS02 MN 5.4.2.12 GO:0003824 ... Q5HHP2 35904259
    164649 7tl8:A (1.95) BS03 MN 5.4.2.12 GO:0003824 ... Q5HHP2 35904259
    164650 7tli:A (1.95) BS01 ZN 3.4.24.27 GO:0004222 ... P00800 10651278
    164651 7tli:A (1.95) BS02 CA 3.4.24.27 GO:0004222 ... P00800 10651278
    164652 7tli:A (1.95) BS03 CA 3.4.24.27 GO:0004222 ... P00800 10651278
    164653 7tli:A (1.95) BS04 CA 3.4.24.27 GO:0004222 ... P00800 10651278
    164654 7tli:A (1.95) BS05 CA 3.4.24.27 GO:0004222 ... P00800 10651278
    164655 7tln:A (2.3) BS01 CA 3.4.24.27 GO:0004222 ... P00800 6830761
    164656 7tln:A (2.3) BS02 CA 3.4.24.27 GO:0004222 ... P00800 6830761
    164657 7tln:A (2.3) BS03 CA 3.4.24.27 GO:0004222 ... P00800 6830761
    164658 7tln:A (2.3) BS04 CA 3.4.24.27 GO:0004222 ... P00800 6830761
    164659 7tln:A (2.3) BS05 ZN 3.4.24.27 GO:0004222 ... P00800 6830761
    164660 7tm3:I (3.25) BS03 MG ? GO:0000027 ... B7NZQ2 36261528
    164661 7tm3:g (3.25) BS02 ZN ? GO:0003735 ... G1TXG5 36261528
    164662 7tm3:j (3.25) BS03 ZN ? GO:0003723 ... U3KPD5 36261528
    164663 7tm3:m (3.25) BS02 ZN N/A GO:0003735 ... N/A 36261528
    164664 7tm3:o (3.25) BS02 ZN ? GO:0003735 ... G1T040 36261528
    164665 7tm3:p (3.25) BS02 ZN ? GO:0003735 ... G1SY53 36261528
    164666 7tm9:A (1.95) BS01 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164667 7tm9:A (1.95) BS02 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164668 7tm9:A (1.95) BS03 MG ? GO:0016791 ... A0A0H3GK94 N/A
    164669 7tm9:B (1.95) BS01 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164670 7tm9:B (1.95) BS02 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164671 7tm9:B (1.95) BS03 MG ? GO:0016791 ... A0A0H3GK94 N/A
    164672 7tm9:C (1.95) BS01 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164673 7tm9:C (1.95) BS02 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164674 7tm9:C (1.95) BS03 MG ? GO:0016791 ... A0A0H3GK94 N/A
    164675 7tm9:D (1.95) BS01 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164676 7tm9:D (1.95) BS02 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164677 7tm9:D (1.95) BS03 MG ? GO:0016791 ... A0A0H3GK94 N/A
    164678 7tm9:E (1.95) BS01 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164679 7tm9:E (1.95) BS02 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164680 7tm9:E (1.95) BS03 MG ? GO:0016791 ... A0A0H3GK94 N/A
    164681 7tm9:F (1.95) BS01 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164682 7tm9:F (1.95) BS02 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164683 7tm9:F (1.95) BS03 MG ? GO:0016791 ... A0A0H3GK94 N/A
    164684 7tm9:G (1.95) BS01 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164685 7tm9:G (1.95) BS02 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164686 7tm9:G (1.95) BS03 MG ? GO:0016791 ... A0A0H3GK94 N/A
    164687 7tm9:H (1.95) BS01 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164688 7tm9:H (1.95) BS02 ZN ? GO:0016791 ... A0A0H3GK94 N/A
    164689 7tm9:H (1.95) BS03 MG ? GO:0016791 ... A0A0H3GK94 N/A
    164690 7tmp:A (3.3) BS02 MG 3.1.-.-
    7.1.2.2    		 GO:0005524 ... P17255 35469063
    164691 7tmv:A (2.3) BS01 ZN ? GO:0046872 ... A0A0H3GMY9 N/A
    164692 7tmv:A (2.3) BS02 ZN ? GO:0046872 ... A0A0H3GMY9 N/A
    164693 7tmv:B (2.3) BS01 ZN ? GO:0046872 ... A0A0H3GMY9 N/A
    164694 7tmv:B (2.3) BS02 ZN ? GO:0046872 ... A0A0H3GMY9 N/A
    164695 7tmz:A (2.20002) BS01 CA ? GO:0007155 ... P08514 36113427
    164696 7tmz:A (2.20002) BS02 CA ? GO:0007155 ... P08514 36113427
    164697 7tmz:A (2.20002) BS03 CA ? GO:0007155 ... P08514 36113427
    164698 7tmz:A (2.20002) BS04 CA ? GO:0007155 ... P08514 36113427
    164699 7tmz:B (2.20002) BS01 MG ? N/A P05106 36113427
    164700 7tmz:B (2.20002) BS02 CA ? N/A P05106 36113427
    164701 7tmz:B (2.20002) BS03 CA ? N/A P05106 36113427
    164702 7tmz:C (2.20002) BS01 CA ? GO:0007155 ... P08514 36113427
    164703 7tmz:C (2.20002) BS02 CA ? GO:0007155 ... P08514 36113427
    164704 7tmz:C (2.20002) BS03 CA ? GO:0007155 ... P08514 36113427
    164705 7tmz:C (2.20002) BS04 CA ? GO:0007155 ... P08514 36113427
    164706 7tmz:D (2.20002) BS01 MG ? N/A P05106 36113427
    164707 7tmz:D (2.20002) BS02 CA ? N/A P05106 36113427
    164708 7tmz:D (2.20002) BS03 CA ? N/A P05106 36113427
    164709 7tn0:E (2.85) BS01 ZN 3.4.17.-
    3.4.17.23    		 GO:0006508 ... Q9BYF1 35076256
    164710 7tn0:F (2.85) BS01 ZN 3.4.17.-
    3.4.17.23    		 GO:0006508 ... Q9BYF1 35076256
    164711 7tn4:A (1.85) BS01 MG 3.6.1.10
    3.6.1.52
    3.6.1.59
    3.6.1.61
    3.6.1.62    		 GO:0000287 ... O95989 35635723
    164712 7tn4:A (1.85) BS02 MG 3.6.1.10
    3.6.1.52
    3.6.1.59
    3.6.1.61
    3.6.1.62    		 GO:0000287 ... O95989 35635723
    164713 7tnc:A (1.47) BS01 CU ? GO:0005507 ... P00282 37424080
    164714 7tnx:A (3.54) BS03 ZN 3.6.4.13 GO:0002230 ... O95786 36272408
    164715 7tny:A (3.2) BS03 ZN 3.6.4.13 GO:0002230 ... O95786 36272408
    164716 7tnz:A (3.54) BS03 ZN 3.6.4.13 GO:0002230 ... O95786 36272408
    164717 7to1:A (3.66) BS02 ZN 3.6.4.13 GO:0002230 ... O95786 36272408
    164718 7to2:A (3.2) BS02 ZN 3.6.4.13 GO:0002230 ... O95786 36272408
    164719 7to3:C (2.74) BS01 MG 2.7.7.- GO:0005524 ... P0DSP4 36755092
    164720 7to3:D (2.74) BS01 MG 2.7.7.- GO:0005524 ... P0DSP4 36755092
    164721 7toc:A (2.43) BS02 MG 1.1.1.86 GO:0000166 ... A0A2H0ZMH9 N/A
    164722 7toc:A (2.43) BS04 MG 1.1.1.86 GO:0000166 ... A0A2H0ZMH9 N/A
    164723 7toc:B (2.43) BS03 MG 1.1.1.86 GO:0000166 ... A0A2H0ZMH9 N/A
    164724 7toc:B (2.43) BS04 MG 1.1.1.86 GO:0000166 ... A0A2H0ZMH9 N/A
    164725 7tol:A (2.03) BS01 FE 2.1.1.- GO:0003824 ... Q58036 35882349
    164726 7tom:A (1.85) BS01 FE 2.1.1.- GO:0003824 ... Q58036 35882349
    164727 7too:AL37 (2.7) BS03 ZN ? GO:0000448 ... P49166 35589706
    164728 7too:AL40 (2.7) BS02 ZN ? GO:0000027 ... P0CH08 35589706
    164729 7too:AL42 (2.7) BS03 ZN ? GO:0002181 ... P0CX27 35589706
    164730 7too:AL43 (2.7) BS02 ZN ? GO:0002181 ... P0CX25 35589706
    164731 7top:AL37 (2.4) BS03 ZN ? GO:0000448 ... P49166 35589706
    164732 7top:AL40 (2.4) BS02 ZN ? GO:0000027 ... P0CH08 35589706
    164733 7top:AL42 (2.4) BS03 ZN ? GO:0002181 ... P0CX27 35589706
    164734 7top:AL43 (2.4) BS02 ZN ? GO:0002181 ... P0CX25 35589706
    164735 7toq:AL37 (3.1) BS03 ZN ? GO:0003735 ... U3KPD5 35589706
    164736 7toq:AL40 (3.1) BS02 ZN N/A GO:0003735 ... N/A 35589706
    164737 7toq:AL42 (3.1) BS03 ZN ? GO:0003735 ... A0A5F9D391 35589706
    164738 7toq:AL43 (3.1) BS03 ZN ? GO:0003735 ... G1SY53 35589706
    164739 7tor:AL34 (2.9) BS02 ZN ? GO:0003735 ... G1TXG5 35589706
    164740 7tor:AL37 (2.9) BS03 ZN ? GO:0003735 ... U3KPD5 35589706
    164741 7tor:AL40 (2.9) BS02 ZN N/A GO:0003735 ... N/A 35589706
    164742 7tor:AL42 (2.9) BS04 ZN ? GO:0003735 ... A0A5F9D391 35589706
    164743 7tor:AL43 (2.9) BS02 ZN ? GO:0003735 ... G1SY53 35589706
    164744 7tor:AS26 (2.9) BS02 ZN ? GO:0003735 ... G1TFE8 35589706
    164745 7tow:A (2.15) BS02 CA N/A N/A N/A 35447081
    164746 7tow:B (2.15) BS02 CA N/A N/A N/A 35447081
    164747 7tow:H (2.15) BS02 CA N/A N/A N/A 35447081
    164748 7tow:H (2.15) BS03 CA N/A N/A N/A 35447081
    164749 7tow:L (2.15) BS02 CA N/A N/A N/A 35447081
    164750 7tpd:A (2.6) BS01 CA ? GO:0007155 ... P08514 36113427
    164751 7tpd:A (2.6) BS02 CA ? GO:0007155 ... P08514 36113427
    164752 7tpd:A (2.6) BS03 CA ? GO:0007155 ... P08514 36113427
    164753 7tpd:A (2.6) BS04 CA ? GO:0007155 ... P08514 36113427
    164754 7tpd:B (2.6) BS01 MG ? N/A P05106 36113427
    164755 7tpd:B (2.6) BS02 CA ? N/A P05106 36113427
    164756 7tpd:B (2.6) BS03 CA ? N/A P05106 36113427
    164757 7tpd:C (2.6) BS01 CA ? GO:0007155 ... P08514 36113427
    164758 7tpd:C (2.6) BS02 CA ? GO:0007155 ... P08514 36113427
    164759 7tpd:C (2.6) BS03 CA ? GO:0007155 ... P08514 36113427
    164760 7tpd:C (2.6) BS04 CA ? GO:0007155 ... P08514 36113427
    164761 7tpd:D (2.6) BS01 MG ? N/A P05106 36113427
    164762 7tpd:D (2.6) BS02 CA ? N/A P05106 36113427
    164763 7tpd:D (2.6) BS03 CA ? N/A P05106 36113427
    164764 7tqd:C (2.9) BS01 MG 2.7.7.- GO:0005524 ... P0DSP4 36755092
    164765 7tqd:C (2.9) BS02 MG 2.7.7.- GO:0005524 ... P0DSP4 36755092
    164766 7tql:c (3.2) BS02 ZN ? GO:0003735 ... P62854 35732735
    164767 7tql:f (3.2) BS02 ZN ? GO:0002181 ... P62273 35732735
    164768 7tql:g (3.2) BS02 ZN ? GO:0003735 ... P62979 35732735
    164769 7tqy:K (2.6) BS03 MG ? GO:0003777 ... A0A1D8PKA4 35859148
    164770 7tqz:A (2.7) BS02 MG 3.6.5.- GO:0000226 ... Q2XVP4 35859148
    164771 7tr1:A (3.1) BS02 MG 3.6.5.- GO:0000226 ... Q2XVP4 35859148
    164772 7tr1:K (3.1) BS01 MG ? GO:0003777 ... C4YNU9
    P33176    		 35859148
    164773 7trl:A (1.74) BS02 ZN 2.3.2.27 N/A Q13490 37524969
    164774 7trm:A (2.4) BS01 ZN 2.3.2.27 N/A Q13490 37524969
    164775 7ts1:A (2.06) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164776 7ts1:B (2.06) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164777 7ts1:C (2.06) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164778 7ts1:D (2.06) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164779 7ts2:A (1.9758) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164780 7ts2:B (1.9758) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164781 7ts2:C (1.9758) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164782 7ts2:D (1.9758) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164783 7ts3:A (2.099) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164784 7ts3:B (2.099) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164785 7ts3:C (2.099) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164786 7ts3:D (2.099) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164787 7ts4:A (1.85) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164788 7ts4:B (1.85) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164789 7ts4:C (1.85) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164790 7ts4:D (1.85) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164791 7ts5:A (1.84) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164792 7ts5:B (1.84) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164793 7ts5:C (1.84) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164794 7ts5:D (1.84) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164795 7ts6:A (1.8) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164796 7ts6:B (1.8) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164797 7ts6:C (1.8) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164798 7ts6:D (1.8) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164799 7ts7:A (1.9) BS04 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    164800 7ts7:B (1.9) BS02 ZN 1.14.13.39 GO:0004517 ... P29475 35772285
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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