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BioLiP
Download all results in tab-seperated text for 197122 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
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  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    113801 5wwp:B (3.0) BS01 ZN 2.1.1.57
    3.4.19.12
    3.6.4.12
    3.6.4.13
    GO:0005524 ... K0BWD0 28651017
    113802 5wwp:B (3.0) BS02 ZN 2.1.1.57
    3.4.19.12
    3.6.4.12
    3.6.4.13
    GO:0005524 ... K0BWD0 28651017
    113803 5wwp:B (3.0) BS03 ZN 2.1.1.57
    3.4.19.12
    3.6.4.12
    3.6.4.13
    GO:0005524 ... K0BWD0 28651017
    113804 5wxg:A (1.703) BS02 ZN ? N/A Q5VWG9 28808021
    113805 5wxg:A (1.703) BS03 ZN ? N/A Q5VWG9 28808021
    113806 5wxh:A (1.297) BS02 ZN ? N/A Q5VWG9 28808021
    113807 5wxh:A (1.297) BS03 ZN ? N/A Q5VWG9 28808021
    113808 5wxh:C (1.297) BS02 ZN ? N/A Q5VWG9 28808021
    113809 5wxh:C (1.297) BS03 ZN ? N/A Q5VWG9 28808021
    113810 5wy1:A (3.27) BS01 ZN 2.1.1.37 GO:0003677 ... P13864 28369487
    113811 5wy1:A (3.27) BS02 ZN 2.1.1.37 GO:0003677 ... P13864 28369487
    113812 5wy1:A (3.27) BS03 ZN 2.1.1.37 GO:0003677 ... P13864 28369487
    113813 5wy1:A (3.27) BS04 ZN 2.1.1.37 GO:0003677 ... P13864 28369487
    113814 5wy5:A (2.92) BS01 ZN 2.3.2.27 GO:0006281 ... Q8WV22 20864041
    113815 5wy5:A (2.92) BS02 ZN 2.3.2.27 GO:0006281 ... Q8WV22 20864041
    113816 5wy8:B (3.07) BS01 ZN 3.2.2.6 N/A Q9NZN1 29081732
    113817 5wz3:A (1.804) BS01 ZN 3.4.21.91
    3.6.1.15
    3.6.4.13
    GO:0003968 ... A0A109PRQ3 28254839
    113818 5wz3:A (1.804) BS02 ZN 3.4.21.91
    3.6.1.15
    3.6.4.13
    GO:0003968 ... A0A109PRQ3 28254839
    113819 5wze:A (1.783) BS02 MN ? GO:0004177 ... Q9HTW6 29259588
    113820 5wze:A (1.783) BS03 MN ? GO:0004177 ... Q9HTW6 29259588
    113821 5wze:B (1.783) BS02 MN ? GO:0004177 ... Q9HTW6 29259588
    113822 5wze:B (1.783) BS03 MN ? GO:0004177 ... Q9HTW6 29259588
    113823 5wze:C (1.783) BS02 CA ? GO:0004177 ... Q9HTW6 29259588
    113824 5wze:C (1.783) BS03 MN ? GO:0004177 ... Q9HTW6 29259588
    113825 5wze:C (1.783) BS04 MN ? GO:0004177 ... Q9HTW6 29259588
    113826 5wze:D (1.783) BS01 MN ? GO:0004177 ... Q9HTW6 29259588
    113827 5wze:D (1.783) BS02 MN ? GO:0004177 ... Q9HTW6 29259588
    113828 5wzm:A (2.0) BS01 CA 3.1.1.4 GO:0004623 ... Q9NZK7 28883454
    113829 5wzm:A (2.0) BS02 CA 3.1.1.4 GO:0004623 ... Q9NZK7 28883454
    113830 5wzn:A (2.1) BS01 ZN 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113831 5wzn:A (2.1) BS02 CA 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113832 5wzn:B (2.1) BS01 ZN 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113833 5wzn:B (2.1) BS02 CA 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113834 5wzo:A (1.9) BS01 CA 3.1.1.4 GO:0004623 ... Q9NZK7 28883454
    113835 5wzo:A (1.9) BS02 CA 3.1.1.4 GO:0004623 ... Q9NZK7 28883454
    113836 5wzp:A (2.64) BS01 ZN 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113837 5wzp:A (2.64) BS02 CA 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113838 5wzp:B (2.64) BS01 ZN 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113839 5wzp:B (2.64) BS02 CA 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113840 5wzq:A (1.9) BS01 ZN 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113841 5wzq:B (1.9) BS01 ZN 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113842 5wzr:A (2.79) BS01 ZN 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113843 5wzr:A (2.79) BS03 CA 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113844 5wzr:B (2.79) BS01 ZN 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113845 5wzr:B (2.79) BS03 CA 3.2.1.- GO:0016798 ... G5ELM1 28546425
    113846 5wzs:A (2.3) BS02 CA 3.1.1.4 GO:0004623 ... Q9NZK7 28883454
    113847 5wzt:A (2.4) BS01 CA 3.1.1.4 GO:0004623 ... Q9NZK7 28883454
    113848 5wzu:A (2.2) BS01 CA 3.1.1.4 GO:0004623 ... Q9NZK7 28883454
    113849 5wzv:A (2.2) BS01 CA 3.1.1.4 GO:0004623 ... Q9NZK7 28883454
    113850 5wzw:A (1.95) BS01 CA 3.1.1.4 GO:0004623 ... Q9NZK7 28883454
    113851 5wzz:A (2.103) BS02 ZN 2.3.2.27 GO:0005737 ... Q8IUQ4 28546513
    113852 5wzz:A (2.103) BS03 ZN 2.3.2.27 GO:0005737 ... Q8IUQ4 28546513
    113853 5wzz:B (2.103) BS02 ZN 2.3.2.27 GO:0005737 ... Q8IUQ4 28546513
    113854 5wzz:B (2.103) BS03 ZN 2.3.2.27 GO:0005737 ... Q8IUQ4 28546513
    113855 5wzz:C (2.103) BS02 ZN 2.3.2.27 GO:0005737 ... Q8IUQ4 28546513
    113856 5wzz:C (2.103) BS03 ZN 2.3.2.27 GO:0005737 ... Q8IUQ4 28546513
    113857 5wzz:D (2.103) BS02 ZN 2.3.2.27 GO:0005737 ... Q8IUQ4 28546513
    113858 5wzz:D (2.103) BS03 ZN 2.3.2.27 GO:0005737 ... Q8IUQ4 28546513
    113859 5x0i:A (2.64) BS04 MG 2.7.10.2
    2.7.11.1
    2.7.1.40
    GO:0000287 ... P14618 30911680
    113860 5x0i:B (2.64) BS04 MG 2.7.10.2
    2.7.11.1
    2.7.1.40
    GO:0000287 ... P14618 30911680
    113861 5x0i:C (2.64) BS04 MG 2.7.10.2
    2.7.11.1
    2.7.1.40
    GO:0000287 ... P14618 30911680
    113862 5x0i:D (2.64) BS04 MG 2.7.10.2
    2.7.11.1
    2.7.1.40
    GO:0000287 ... P14618 30911680
    113863 5x16:A (1.97) BS02 ZN 2.3.1.-
    2.3.1.286
    2.4.2.-
    GO:0070403 ... Q8N6T7 N/A
    113864 5x19:A (2.2) BS03 CU 7.1.1.9 GO:0004129 ... P00396 28740863
    113865 5x19:A (2.2) BS04 MG 7.1.1.9 GO:0004129 ... P00396 28740863
    113866 5x19:F (2.2) BS01 ZN ? GO:0005740 ... P00428 28740863
    113867 5x19:N (2.2) BS03 CU 7.1.1.9 GO:0004129 ... P00396 28740863
    113868 5x19:N (2.2) BS04 MG 7.1.1.9 GO:0004129 ... P00396 28740863
    113869 5x19:S (2.2) BS01 ZN ? GO:0005740 ... P00428 28740863
    113870 5x1b:A (2.4) BS03 CU 7.1.1.9 GO:0004129 ... P00396 28740863
    113871 5x1b:A (2.4) BS04 MG 7.1.1.9 GO:0004129 ... P00396 28740863
    113872 5x1b:F (2.4) BS01 ZN ? GO:0005740 ... P00428 28740863
    113873 5x1b:N (2.4) BS03 CU 7.1.1.9 GO:0004129 ... P00396 28740863
    113874 5x1b:N (2.4) BS04 MG 7.1.1.9 GO:0004129 ... P00396 28740863
    113875 5x1b:S (2.4) BS01 ZN ? GO:0005740 ... P00428 28740863
    113876 5x1f:A (2.2) BS03 CU 7.1.1.9 GO:0004129 ... P00396 28740863
    113877 5x1f:A (2.2) BS04 MG 7.1.1.9 GO:0004129 ... P00396 28740863
    113878 5x1f:F (2.2) BS01 ZN ? GO:0005740 ... P00428 28740863
    113879 5x1f:N (2.2) BS03 CU 7.1.1.9 GO:0004129 ... P00396 28740863
    113880 5x1f:N (2.2) BS04 MG 7.1.1.9 GO:0004129 ... P00396 28740863
    113881 5x1f:S (2.2) BS01 ZN ? GO:0005740 ... P00428 28740863
    113882 5x1h:A (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113883 5x1h:C (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113884 5x1h:E (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113885 5x1h:G (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113886 5x1h:I (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113887 5x1h:K (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113888 5x1h:M (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113889 5x1h:O (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113890 5x1h:Q (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113891 5x1h:S (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113892 5x1h:U (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113893 5x1h:W (3.005) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113894 5x21:A (3.323) BS01 MG 2.7.7.6 GO:0000428 ... Q5SHR6 28622509
    113895 5x21:D (3.323) BS03 ZN 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113896 5x21:D (3.323) BS04 ZN 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113897 5x21:D (3.323) BS05 MG 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113898 5x21:F (3.323) BS03 MG ? GO:0003677 ... Q5SKW1 28622509
    113899 5x22:B (3.35) BS01 MG 2.7.7.6 GO:0000428 ... Q5SHR6 28622509
    113900 5x22:D (3.35) BS02 ZN 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113901 5x22:D (3.35) BS03 ZN 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113902 5x22:D (3.35) BS04 MG 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113903 5x22:D (3.35) BS05 MG 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113904 5x22:F (3.35) BS02 MG ? GO:0003677 ... Q5SKW1 28622509
    113905 5x22:L (3.35) BS01 MG 2.7.7.6 GO:0000428 ... Q5SHR6 28622509
    113906 5x22:N (3.35) BS04 ZN 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113907 5x22:N (3.35) BS05 ZN 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113908 5x22:N (3.35) BS06 MG 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113909 5x22:N (3.35) BS07 MG 2.7.7.6 GO:0000287 ... Q8RQE8 28622509
    113910 5x22:P (3.35) BS02 MG ? GO:0003677 ... Q5SKW1 28622509
    113911 5x2a:D (1.85) BS02 MG 2.7.10.1 GO:0004672 ... P00533 29568384
    113912 5x2b:A (2.08) BS01 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113913 5x2b:A (2.08) BS03 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113914 5x2b:A (2.08) BS04 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113915 5x2b:B (2.08) BS02 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113916 5x2b:B (2.08) BS03 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113917 5x2b:B (2.08) BS04 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113918 5x2b:D (2.08) BS02 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113919 5x2b:D (2.08) BS03 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113920 5x2b:F (2.08) BS02 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113921 5x2b:G (2.08) BS02 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113922 5x2b:G (2.08) BS03 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113923 5x2b:I (2.08) BS02 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113924 5x2b:J (2.08) BS02 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113925 5x2b:J (2.08) BS03 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113926 5x2b:K (2.08) BS02 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113927 5x2b:K (2.08) BS03 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113928 5x2b:L (2.08) BS02 CA 2.8.2.- GO:0008146 ... B7ZWN4 N/A
    113929 5x2e:A (1.299) BS01 CA ? GO:0005509 ... Q2PMV7 28496122
    113930 5x2i:A (2.05) BS01 CA 4.2.2.2 GO:0005576 ... P39116 N/A
    113931 5x2j:A (1.4) BS01 MN 1.15.1.1 GO:0004784 ... A0A1E5TT85 29497016
    113932 5x2l:A (1.806) BS02 MG 4.3.1.17
    4.3.1.18
    5.1.1.18
    GO:0000287 ... Q9GZT4 29277459
    113933 5x2l:B (1.806) BS02 MG 4.3.1.17
    4.3.1.18
    5.1.1.18
    GO:0000287 ... Q9GZT4 29277459
    113934 5x2m:L (2.206) BS01 CA N/A N/A N/A 28534491
    113935 5x31:A (2.6) BS01 CU ? GO:0005507 ... P04377 28291752
    113936 5x31:B (2.6) BS01 CU ? GO:0005507 ... P04377 28291752
    113937 5x40:A (1.45) BS01 MG 7.2.2.- GO:0005524 ... O68106 28322252
    113938 5x40:B (1.45) BS02 MG 7.2.2.- GO:0005524 ... O68106 28322252
    113939 5x42:A (1.8) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113940 5x42:C (1.8) BS01 ZN ? GO:0005737 ... Q5ZYB7 28714967
    113941 5x45:A (2.602) BS01 ZN 2.7.7.48
    3.4.22.28
    3.4.22.29
    3.6.1.15
    GO:0006508 ... E5D8F2 29633974
    113942 5x45:B (2.602) BS01 ZN 2.7.7.48
    3.4.22.28
    3.4.22.29
    3.6.1.15
    GO:0006508 ... E5D8F2 29633974
    113943 5x45:C (2.602) BS01 ZN 2.7.7.48
    3.4.22.28
    3.4.22.29
    3.6.1.15
    GO:0006508 ... E5D8F2 29633974
    113944 5x45:D (2.602) BS01 ZN 2.7.7.48
    3.4.22.28
    3.4.22.29
    3.6.1.15
    GO:0006508 ... E5D8F2 29633974
    113945 5x49:A (1.65) BS01 MN 3.4.11.9 GO:0003094 ... Q9NQH7 28476889
    113946 5x49:A (1.65) BS02 MN 3.4.11.9 GO:0003094 ... Q9NQH7 28476889
    113947 5x49:B (1.65) BS01 MN 3.4.11.9 GO:0003094 ... Q9NQH7 28476889
    113948 5x49:B (1.65) BS02 MN 3.4.11.9 GO:0003094 ... Q9NQH7 28476889
    113949 5x4h:A (2.801) BS01 MG ? GO:0003676 ... Q8TZE0 30053256
    113950 5x4i:A (2.092) BS01 MN ? GO:0003676 ... Q8TZE0 30053256
    113951 5x4j:A (2.04) BS01 ZN ? GO:0003676 ... Q8TZE0 30053256
    113952 5x4k:A (1.749) BS01 ZN ? GO:0003676 ... Q8TZE0 30053256
    113953 5x4k:A (1.749) BS02 ZN ? GO:0003676 ... Q8TZE0 30053256
    113954 5x4z:A (7.8) BS01 ZN 2.7.7.6 GO:0000428 ... C4R4Y0 28412353
    113955 5x4z:B (7.8) BS01 ZN 2.7.7.6 GO:0000428 ... C4QZQ7 28412353
    113956 5x4z:C (7.8) BS01 ZN ? GO:0000428 ... C4R7L2 28412353
    113957 5x4z:I (7.8) BS01 ZN ? GO:0000428 ... F2QPE6 28412353
    113958 5x4z:J (7.8) BS01 ZN ? GO:0000428 ... C4R009 28412353
    113959 5x4z:M (7.8) BS01 ZN 2.7.7.6 GO:0000428 ... C4R4Y0 28412353
    113960 5x4z:N (7.8) BS01 ZN 2.7.7.6 GO:0000428 ... C4QZQ7 28412353
    113961 5x4z:O (7.8) BS01 ZN ? GO:0000428 ... C4R7L2 28412353
    113962 5x4z:U (7.8) BS01 ZN ? GO:0000428 ... F2QPE6 28412353
    113963 5x4z:V (7.8) BS01 ZN ? GO:0000428 ... C4R009 28412353
    113964 5x50:A (4.293) BS01 ZN 2.7.7.6 GO:0000428 ... C4R4Y0 28412353
    113965 5x50:C (4.293) BS01 ZN ? GO:0000428 ... C4R7L2 28412353
    113966 5x50:I (4.293) BS01 ZN ? GO:0000428 ... F2QPE6 28412353
    113967 5x50:J (4.293) BS01 ZN ? GO:0000428 ... C4R009 28412353
    113968 5x50:L (4.293) BS01 ZN ? GO:0001054 ... C4QWA8 28412353
    113969 5x51:A (6.996) BS01 ZN 2.7.7.6 GO:0000428 ... C4R4Y0 28412353
    113970 5x51:B (6.996) BS01 ZN 2.7.7.6 GO:0000428 ... C4QZQ7 28412353
    113971 5x51:C (6.996) BS01 ZN ? GO:0000428 ... C4R7L2 28412353
    113972 5x51:I (6.996) BS01 ZN ? GO:0000428 ... F2QPE6 28412353
    113973 5x51:J (6.996) BS01 ZN ? GO:0000428 ... C4R009 28412353
    113974 5x51:M (6.996) BS01 ZN 2.7.7.6 GO:0000428 ... C4R4Y0 28412353
    113975 5x51:M (6.996) BS02 ZN 2.7.7.6 GO:0000428 ... C4R4Y0 28412353
    113976 5x51:N (6.996) BS01 ZN 2.7.7.6 GO:0000428 ... C4QZQ7 28412353
    113977 5x51:O (6.996) BS01 ZN ? GO:0000428 ... C4R7L2 28412353
    113978 5x51:U (6.996) BS01 ZN ? GO:0000428 ... F2QPE6 28412353
    113979 5x51:V (6.996) BS01 ZN ? GO:0000428 ... C4R009 28412353
    113980 5x5h:A (1.51) BS02 MG 2.5.1.48 GO:0003962 ... Q79VD9 28675039
    113981 5x5h:A (1.51) BS03 MG 2.5.1.48 GO:0003962 ... Q79VD9 28675039
    113982 5x5p:A (2.7) BS01 FE ? GO:0005515 ... P02787 35690040
    113983 5x6a:A (1.7) BS01 MG 3.2.1.4 GO:0003674 ... Q4WP32 N/A
    113984 5x6a:B (1.7) BS01 MG 3.2.1.4 GO:0003674 ... Q4WP32 N/A
    113985 5x6g:A (3.05) BS02 ZN ? GO:0005667 ... P97454 26304548
    113986 5x6g:B (3.05) BS02 ZN ? GO:0005667 ... P97454 26304548
    113987 5x6h:B (3.1) BS02 ZN ? GO:0005667 ... P97454 26304548
    113988 5x6i:A (2.0) BS01 ZN 2.7.4.3 GO:0004017 ... P16304 31111079
    113989 5x6i:A (2.0) BS03 CA 2.7.4.3 GO:0004017 ... P16304 31111079
    113990 5x6j:A (2.1) BS01 ZN 2.7.4.3 GO:0004017 ... P84139 31111079
    113991 5x6m:A (3.2) BS03 ZN ? GO:0005667 ... P97454 26304548
    113992 5x6m:B (3.2) BS03 ZN ? GO:0005667 ... P97454 26304548
    113993 5x6m:E (3.2) BS03 ZN ? GO:0005667 ... P97454 26304548
    113994 5x6m:F (3.2) BS03 ZN ? GO:0005667 ... P97454 26304548
    113995 5x6t:A (-1.00) BS01 ZN ? N/A Q96C24 28906046
    113996 5x6t:A (-1.00) BS02 ZN ? N/A Q96C24 28906046
    113997 5x7g:A (2.2) BS01 CA 2.4.1.248 GO:0030246 ... G9MBW2 28385816
    113998 5x7g:A (2.2) BS02 CA 2.4.1.248 GO:0030246 ... G9MBW2 28385816
    113999 5x7h:A (2.6) BS08 CA 2.4.1.248 GO:0030246 ... G9MBW2 28385816
    114000 5x7h:A (2.6) BS09 CA 2.4.1.248 GO:0030246 ... G9MBW2 28385816

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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