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BioLiP
Download all results in tab-seperated text for 42 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1zw5:A (2.3) BS04 ZOL 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 16684881 BindingDB: IC50=100nM, Ki=85.9nM
    2 2e91:A (2.14) BS03 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... Q12051 17535895 PDBbind: -logKd/Ki=6.59, Ki=0.26uM
    BindingDB: IC50=6.6e+2nM, Ki=260nM
    3 2e91:B (2.14) BS03 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... Q12051 17535895 BindingDB: IC50=6.6e+2nM, Ki=260nM
    4 2f8c:F (2.2) BS04 ZOL 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 16892359 BindingDB: IC50=100nM, Ki=85.9nM
    5 2f8z:F (2.6) BS04 ZOL 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 16892359 BindingDB: IC50=100nM, Ki=85.9nM
    6 2f9k:F (2.06) BS04 ZOL 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 16892359 PDBbind: -logKd/Ki=7.07, Ki=85.9nM
    BindingDB: IC50=100nM, Ki=85.9nM
    7 2q58:A (2.37) BS03 ZOL ? GO:0004161 ... Q5CR09 19101474 BindingDB: IC50=30.1nM, Ki=0.050nM
    8 2q58:B (2.37) BS03 ZOL ? GO:0004161 ... Q5CR09 19101474 BindingDB: IC50=30.1nM, Ki=0.050nM
    9 3ez3:A (2.304) BS01 ZOL ? GO:0004161 ... A5K4U6 N/A
    10 3ez3:B (2.304) BS01 ZOL ? GO:0004161 ... A5K4U6 N/A
    11 3ez3:C (2.304) BS01 ZOL ? GO:0004161 ... A5K4U6 N/A
    12 3ez3:D (2.304) BS01 ZOL ? GO:0004161 ... A5K4U6 N/A
    13 3iba:A (2.4) BS03 ZOL 2.5.1.10 GO:0004161 ... Q95WL3 19876942
    14 3ldw:A (2.47) BS01 ZOL ? GO:0004161 ... A5K4U6 21084289 MOAD: Ki=10.7nM
    PDBbind: -logKd/Ki=7.97, Ki=10.7nM
    15 3ldw:B (2.47) BS01 ZOL ? GO:0004161 ... A5K4U6 21084289 MOAD: Ki=10.7nM
    16 3ldw:C (2.47) BS01 ZOL ? GO:0004161 ... A5K4U6 21084289 MOAD: Ki=10.7nM
    17 3ldw:D (2.47) BS01 ZOL ? GO:0004161 ... A5K4U6 21084289 MOAD: Ki=10.7nM
    18 3n45:F (1.88) BS02 ZOL 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 20711197 BindingDB: IC50=100nM, Ki=85.9nM
    19 3n46:F (2.35) BS02 ZOL 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 20711197 BindingDB: IC50=100nM, Ki=85.9nM
    20 4kfa:A (1.98) BS03 ZOL 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A BindingDB: IC50=100nM, Ki=85.9nM
    21 4kq5:A (2.4) BS03 ZOL 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A BindingDB: IC50=100nM, Ki=85.9nM
    22 4p0v:A (2.4) BS01 ZOL 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 24927548 BindingDB: IC50=100nM, Ki=85.9nM
    23 4p0w:A (2.406) BS02 ZOL 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 24927548 BindingDB: IC50=100nM, Ki=85.9nM
    24 6g31:A (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    25 6g31:B (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    26 6g31:C (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    27 6g31:D (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    28 6g31:E (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    29 6g31:F (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    30 6g31:G (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    31 6g31:H (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    32 6g31:I (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    33 6g31:J (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    34 6g31:K (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    35 6g31:L (3.0) BS01 ZOL 2.5.1.-
    2.5.1.1
    2.5.1.10
    2.5.1.29    		 GO:0004161 ... O95749 30275041 BindingDB: IC50=100000nM, Ki=2700nM
    36 8a7c:A (1.2) BS04 ZOL 2.5.1.1 GO:0004659 ... M1JS91 37308711
    37 8a7c:B (1.2) BS04 ZOL 2.5.1.1 GO:0004659 ... M1JS91 37308711
    38 8a7j:A (1.2) BS04 ZOL 2.5.1.1 GO:0004659 ... M1JS91 37308711
    39 8a7j:B (1.2) BS04 ZOL 2.5.1.1 GO:0004659 ... M1JS91 37308711
    40 8a7k:A (1.3) BS06 ZOL 2.5.1.1 GO:0004659 ... M1JS91 37308711
    41 8a7k:B (1.3) BS06 ZOL 2.5.1.1 GO:0004659 ... M1JS91 37308711
    42 8a7l:A (1.85) BS03 ZOL 2.5.1.1 GO:0004659 ... M1JS91 37308711
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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