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BioLiP
Download all results in tab-seperated text for 6 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1q8t:A (2.0) BS02 Y27 2.7.11.11 GO:0001669 ... P00517 14656443 MOAD: Kd=17.5uM
    PDBbind: -logKd/Ki=4.76, Kd=17.5uM
    BindingDB: IC50=42000nM
    2 2etr:A (2.6) BS01 Y27 2.7.11.1 GO:0004672 ... Q13464 16249185 PDBbind: -logKd/Ki=6.82, Ki=0.15uM
    BindingDB: Ki=150nM, IC50=200nM
    3 2etr:B (2.6) BS01 Y27 2.7.11.1 GO:0004672 ... Q13464 16249185 BindingDB: Ki=150nM, IC50=200nM
    4 2gnf:A (2.28) BS02 Y27 2.7.11.11 GO:0001669 ... P00517 16699172 MOAD: ic50=6uM
    PDBbind: -logKd/Ki=5.22, IC50=6uM
    BindingDB: IC50=42000nM
    5 2gnj:A (2.28) BS02 Y27 2.7.11.11 GO:0001669 ... P00517 16699172 MOAD: Ki=6uM
    PDBbind: -logKd/Ki=5.22, IC50=6uM
    BindingDB: IC50=42000nM
    6 2h9v:A (3.1) BS01 Y27 2.7.11.1 GO:0004672 ... Q28021 16891330 BindingDB: IC50=500nM
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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