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●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

BioLiP
Download all results in tab-seperated text for 136 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1aq1:A (2.0) BS01 STU 2.7.11.22 GO:0000082 ... P24941 9334743 PDBbind: -logKd/Ki=8.15, IC50=7nM
    2 1byg:A (2.4) BS01 STU 2.7.10.2 GO:0004672 ... P41240 9878439
    3 1e8z:A (2.4) BS01 STU 2.7.11.1
    2.7.1.137
    2.7.1.153
    2.7.1.154    		 GO:0016301 ... P48736 11090628
    4 1nvr:A (1.8) BS02 STU 2.7.11.1 GO:0000077 ... O14757 12244092 MOAD: Ki=7.8nM
    PDBbind: -logKd/Ki=8.11, Ki=7.8nM
    5 1nxk:A (2.7) BS01 STU 2.7.11.1 GO:0000165 ... P49137 12791252
    6 1nxk:B (2.7) BS01 STU 2.7.11.1 GO:0000165 ... P49137 12791252
    7 1nxk:C (2.7) BS01 STU 2.7.11.1 GO:0000165 ... P49137 12791252
    8 1nxk:D (2.7) BS01 STU 2.7.11.1 GO:0000165 ... P49137 12791252
    9 1oky:A (2.3) BS01 STU 2.7.11.1 GO:0004672 ... O15530 12892559 MOAD: ic50=6.5nM
    PDBbind: -logKd/Ki=8.19, IC50=6.5nM
    10 1q3d:A (2.2) BS01 STU 2.7.11.1
    2.7.11.26    		 GO:0001837 ... P49841 14529625 MOAD: ic50=15nM
    PDBbind: -logKd/Ki=7.82, IC50=15nM
    11 1q3d:B (2.2) BS01 STU 2.7.11.1
    2.7.11.26    		 GO:0001837 ... P49841 14529625 MOAD: ic50=15nM
    PDBbind: -logKd/Ki=7.82, IC50=15nM
    12 1qpd:A (2.0) BS01 STU 2.7.10.2 GO:0004672 ... P06239 10404594
    13 1qpj:A (2.2) BS01 STU 2.7.10.2 GO:0004672 ... P06239 10404594
    14 1sm2:A (2.3) BS01 STU 2.7.10.2 GO:0004672 ... Q08881 14766749 MOAD: Ki<10nM
    PDBbind: -logKd/Ki=8.00, Ki<10nM
    15 1sm2:B (2.3) BS01 STU 2.7.10.2 GO:0004672 ... Q08881 14766749 MOAD: Ki<10nM
    16 1snu:A (2.5) BS01 STU 2.7.10.2 GO:0004672 ... Q08881 14766749
    17 1snu:B (2.5) BS01 STU 2.7.10.2 GO:0004672 ... Q08881 14766749
    18 1stc:E (2.3) BS02 STU 2.7.11.11 GO:0001669 ... P00517 9438863 MOAD: Ki=8nM
    PDBbind: -logKd/Ki=8.10, Ki=8nM
    19 1u59:A (2.3) BS01 STU 2.7.10.2 GO:0004672 ... P43403 15292186 MOAD: ic50=55.8nM
    PDBbind: -logKd/Ki=7.25, IC50=55.8nM
    20 1wvy:A (2.8) BS01 STU 2.7.11.1 GO:0004672 ... P53355 N/A
    21 1xbc:A (2.0) BS01 STU 2.7.10.2 GO:0004672 ... P43405 15507431 MOAD: ic50=0.012uM
    PDBbind: -logKd/Ki=7.92, IC50=0.012uM
    22 1xjd:A (2.0) BS01 STU 2.7.11.13 GO:0004672 ... Q04759 15364937 MOAD: Ki=0.33nM
    PDBbind: -logKd/Ki=9.48, Ki=0.33nM
    23 1yhs:A (2.15) BS01 STU 2.7.11.1 GO:0004672 ... P11309 15657054 MOAD: ic50=0.01uM
    PDBbind: -logKd/Ki=8.00, IC50=0.01uM
    24 2buj:A (2.6) BS01 STU 2.7.10.2
    2.7.11.1    		 GO:0000978 ... O75716 N/A
    25 2buj:A (2.6) BS02 STU 2.7.10.2
    2.7.11.1    		 GO:0000978 ... O75716 N/A
    26 2buj:B (2.6) BS01 STU 2.7.10.2
    2.7.11.1    		 GO:0000978 ... O75716 N/A
    27 2buj:B (2.6) BS02 STU 2.7.10.2
    2.7.11.1    		 GO:0000978 ... O75716 N/A
    28 2clq:A (2.3) BS01 STU 2.7.11.25 GO:0004672 ... Q99683 17937911
    29 2clq:B (2.3) BS01 STU 2.7.11.25 GO:0004672 ... Q99683 17937911
    30 2dq7:X (2.8) BS01 STU 2.7.10.2 GO:0004672 ... P06241 16782058 PDBbind: -logKd/Ki=8.32, IC50=4.8nM
    31 2gcd:A (2.55) BS01 STU 2.7.11.1 GO:0004672 ... Q9JLS3 16761096 PDBbind: -logKd/Ki=5.52, IC50=3uM
    32 2gcd:B (2.55) BS01 STU 2.7.11.1 GO:0004672 ... Q9JLS3 16761096
    33 2hw7:A (2.71) BS01 STU 2.7.11.1 GO:0004672 ... Q9HBH9 16917500
    34 2nry:A (2.15) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 17161373
    35 2nry:B (2.15) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 17161373
    36 2nry:C (2.15) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 17161373
    37 2nry:D (2.15) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 17161373
    38 2oic:A (2.4) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 17312103 MOAD: ic50=4nM
    PDBbind: -logKd/Ki=8.40, IC50=4nM
    39 2oic:B (2.4) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 17312103 MOAD: ic50=4nM
    40 2oic:C (2.4) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 17312103 MOAD: ic50=4nM
    41 2oic:D (2.4) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 17312103 MOAD: ic50=4nM
    42 2pzy:C (2.9) BS01 STU 2.7.11.1 GO:0004672 ... P49137 17576063
    43 2yn8:A (2.11) BS01 STU 2.7.10.1 GO:0004672 ... P54760 23840071
    44 2yn8:B (2.11) BS01 STU 2.7.10.1 GO:0004672 ... P54760 23840071
    45 2z7r:A (2.0) BS01 STU 2.7.11.1 GO:0004672 ... Q15418 17965187 MOAD: ic50~0.4nM
    PDBbind: -logKd/Ki=9.52, IC50=0.3nM
    46 3a4o:X (3.0) BS01 STU 2.7.10.2 GO:0004672 ... P07948 19857964 PDBbind: -logKd/Ki=8.89, IC50=1.3nM
    47 3a60:A (2.8) BS01 STU 2.7.11.1 GO:0004672 ... P23443 19864428
    48 3a60:B (2.8) BS01 STU 2.7.11.1 GO:0004672 ... P23443 19864428
    49 3a61:A (3.43) BS01 STU 2.7.11.1 GO:0004672 ... P23443 19864428
    50 3a62:A (2.35) BS01 STU 2.7.11.1 GO:0004672 ... P23443 19864428
    51 3bkb:A (1.78) BS01 STU 2.7.10.2 GO:0004672 ... P07332 18775312
    52 3cbl:A (1.75) BS02 STU 2.7.10.2 GO:0004672 ... P07332 18775312
    53 3cbl:A (1.75) BS03 STU 2.7.10.2 GO:0004672 ... P07332 18775312
    54 3cbl:A (1.75) BS04 STU 2.7.10.2 GO:0004672 ... P07332 18775312
    55 3cd3:A (1.98) BS02 STU 2.7.10.2 GO:0004672 ... P07332 18775312
    56 3cd3:A (1.98) BS03 STU 2.7.10.2 GO:0004672 ... P07332 18775312
    57 3cd3:A (1.98) BS04 STU 2.7.10.2 GO:0004672 ... P07332 18775312
    58 3ckx:A (2.7) BS01 STU 2.7.11.1 GO:0004672 ... Q9Y6E0 N/A
    59 3d7t:A (2.899) BS01 STU 2.7.10.2 GO:0004672 ... P41240 18614016
    60 3d7t:B (2.899) BS01 STU 2.7.10.2 GO:0004672 ... P00523 18614016
    61 3fme:A (2.26) BS01 STU 2.7.12.2 GO:0004672 ... P52564 N/A
    62 3hmo:A (2.4) BS01 STU 2.7.12.1 GO:0004672 ... P33981 20099905 MOAD: Kd=30.5nM
    PDBbind: -logKd/Ki=7.52, Kd=30.5nM
    63 3lcs:A (1.95) BS01 STU 2.7.10.1 GO:0004672 ... Q9UM73 20632993
    64 3p86:A (2.496) BS01 STU 2.7.11.1 GO:0004672 ... Q05609 22155294
    65 3ppz:A (2.99) BS01 STU 2.7.11.1 GO:0004672 ... Q05609 22155294
    66 3s95:A (1.65) BS01 STU 2.7.11.1 GO:0004672 ... P53667 N/A
    67 3s95:B (1.65) BS01 STU 2.7.11.1 GO:0004672 ... P53667 N/A
    68 3zew:A (2.5) BS01 STU 2.7.10.1 GO:0004672 ... P54760 24677421
    69 3zew:B (2.5) BS01 STU 2.7.10.1 GO:0004672 ... P54760 24677421
    70 4bf2:A (2.11) BS01 STU 2.7.11.25 GO:0004672 ... Q99683 23776076
    71 4bf2:B (2.11) BS01 STU 2.7.11.25 GO:0004672 ... Q99683 23776076
    72 4c34:A (1.78) BS02 STU 2.7.11.11 GO:0001669 ... P00517 24072592
    73 4cfe:A (3.023) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 24352254
    74 4cfe:C (3.023) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 24352254
    75 4cff:A (3.924) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 24352254
    76 4cff:C (3.924) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 24352254
    77 4cfh:A (3.24) BS02 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... P54645 21399626
    78 4erw:A (2.0) BS01 STU 2.7.11.22 GO:0000082 ... P24941 22893598 PDBbind: -logKd/Ki=8.15, IC50=7nM
    79 4ez7:A (2.49) BS01 STU 2.7.11.22 GO:0000082 ... P24941 22893598
    80 4fr4:A (2.29) BS01 STU 2.7.11.1 GO:0004672 ... Q8WU08 N/A
    81 4fr4:B (2.29) BS01 STU 2.7.11.1 GO:0004672 ... Q8WU08 N/A
    82 4fr4:C (2.29) BS01 STU 2.7.11.1 GO:0004672 ... Q8WU08 N/A
    83 4fr4:D (2.29) BS01 STU 2.7.11.1 GO:0004672 ... Q8WU08 N/A
    84 4fr4:E (2.29) BS01 STU 2.7.11.1 GO:0004672 ... Q8WU08 N/A
    85 4fr4:F (2.29) BS01 STU 2.7.11.1 GO:0004672 ... Q8WU08 N/A
    86 4mvf:A (2.0) BS01 STU 2.7.11.1 GO:0004672 ... O15865 N/A
    87 4qfg:A (3.46) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0000785 ... P54645 25066137
    88 4qfr:A (3.34) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0000785 ... P54645 25066137
    89 4qfs:A (3.55) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0000785 ... P54645 25066137
    90 4qmy:A (1.883) BS01 STU 2.7.11.1 GO:0004672 ... Q9Y6E0 27135311 MOAD: ic50=0.004uM
    PDBbind: -logKd/Ki=8.40, IC50=0.004uM
    91 4rer:A (4.047) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0000785 ... Q13131 25412657
    92 4rew:A (4.58) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0000785 ... Q13131 25412657
    93 4rlo:B (2.527) BS01 STU 2.7.11.1 GO:0004672 ... P23443 25356520
    94 4u97:A (2.65) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 25201411
    95 4u97:B (2.65) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 25201411
    96 4u9a:A (2.8) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 25201411
    97 4u9a:B (2.8) BS01 STU 2.7.11.1 GO:0000287 ... Q9NWZ3 25201411
    98 4yzc:A (2.494) BS01 STU 2.7.11.1
    3.1.26.-    		 GO:0004521 ... O75460 26438213 MOAD: ic50=3nM
    PDBbind: -logKd/Ki=8.52, IC50=3nM
    99 4yzc:B (2.494) BS01 STU 2.7.11.1
    3.1.26.-    		 GO:0004521 ... O75460 26438213 MOAD: ic50=3nM
    100 5e8w:A (1.86) BS01 STU 2.7.11.30 GO:0004672 ... P36897 27139629 PDBbind: -logKd/Ki=4.39, IC50=41uM
    101 5e8x:A (1.45) BS01 STU 2.7.11.30 GO:0004672 ... P36897 27139629
    102 5e8y:A (2.05) BS01 STU 2.7.11.30 GO:0004672 ... P37173 27139629
    103 5ezv:A (2.99) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... P54646
    Q13131    		 26952388
    104 5ezv:C (2.99) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... P54646
    Q13131    		 26952388
    105 5iso:A (2.63) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 N/A
    106 5iso:C (2.63) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 N/A
    107 5kq5:A (3.41) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... P54645 27490827 PDBbind: -logKd/Ki=8.05, Kd=9.0nM
    108 5loh:A (3.1) BS01 STU 2.7.11.1 GO:0004672 ... Q96GX5 27563826 PDBbind: -logKd/Ki=5.04, IC50=9.1uM
    109 5loh:B (3.1) BS01 STU 2.7.11.1 GO:0004672 ... Q96GX5 27563826
    110 5ng2:A (2.8) BS01 STU 2.7.10.2
    2.7.11.1    		 GO:0004672 ... O43353 28545134
    111 5ng2:B (2.8) BS01 STU 2.7.10.2
    2.7.11.1    		 GO:0004672 ... O43353 28545134
    112 5oor:A (1.9) BS01 STU 2.7.11.1 GO:0000077 ... O14757 29023112
    113 5t5t:A (3.46) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... P54645 28289077
    114 5ufu:A (3.45) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... P54645 28467931
    115 5ved:A (2.301) BS01 STU 2.7.11.1 GO:0004672 ... O96013 28993291
    116 5wnl:A (2.5) BS01 STU 2.7.11.1 GO:0004672 ... Q9ERK0 29706531
    117 6b1u:A (2.77) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 29657085
    118 6b1u:C (2.77) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 29657085
    119 6b2e:A (3.8) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 29657085
    120 6c9f:A (2.924) BS02 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... Q13131 30478170
    121 6c9g:A (2.7) BS02 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... Q13131 30478170
    122 6c9h:A (2.65) BS02 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... Q13131 30478170
    123 6c9j:A (3.05) BS02 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... Q13131 30478170
    124 6e4t:A (3.4) BS02 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... P54645 30036059
    125 6e4u:A (3.27) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... P54645 30036059
    126 6e4w:A (3.35) BS01 STU 2.7.11.1
    2.7.11.26
    2.7.11.31    		 GO:0004672 ... P54645 30036059
    127 7ako:A (1.8) BS02 STU 2.7.11.1 GO:0000077 ... O14757 33789090
    128 7ako:B (1.8) BS03 STU 2.7.11.1 GO:0000077 ... O14757 33789090
    129 7nvq:A (2.05) BS01 STU 2.7.11.22 GO:0000082 ... P24941 34188616
    130 8bik:A (2.5) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 N/A
    131 8bik:D (2.5) BS01 STU 2.7.11.1
    2.7.11.31    		 GO:0003682 ... P54646 N/A
    132 8e4t:A (1.95) BS01 STU 2.7.10.1 GO:0004672 ... A9VBW0 37310965
    133 8e4t:A (1.95) BS02 STU 2.7.10.1 GO:0004672 ... A9VBW0 37310965
    134 8jpb:G (3.07) BS01 STU 2.7.11.15 GO:0001664 ... P21146 37532940
    135 8jpc:G (3.07) BS02 STU 2.7.11.15 GO:0001664 ... P21146 37532940
    136 8jpd:G (2.81) BS01 STU 2.7.11.15 GO:0001664 ... P21146 37532940
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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