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●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

BioLiP
Download all results in tab-seperated text for 147 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 2qeh:A (2.102) BS01 SRO ? GO:0005549 ... Q7PNF2 17928288 MOAD: Kd=2.4nM
    2 2ymd:A (1.96) BS01 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    PDBbind: -logKd/Ki=3.16, Kd=693uM
    3 2ymd:A (1.96) BS02 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    PDBbind: -logKd/Ki=3.16, Kd=693uM
    4 2ymd:B (1.96) BS01 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    PDBbind: -logKd/Ki=3.16, Kd=693uM
    5 2ymd:B (1.96) BS02 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    PDBbind: -logKd/Ki=3.16, Kd=693uM
    6 2ymd:C (1.96) BS01 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    7 2ymd:C (1.96) BS02 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    8 2ymd:D (1.96) BS01 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    9 2ymd:D (1.96) BS02 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    10 2ymd:E (1.96) BS01 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    11 2ymd:E (1.96) BS02 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    12 2ymd:F (1.96) BS01 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    13 2ymd:F (1.96) BS02 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    14 2ymd:G (1.96) BS01 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    15 2ymd:G (1.96) BS02 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    16 2ymd:H (1.96) BS01 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    17 2ymd:H (1.96) BS02 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    18 2ymd:I (1.96) BS01 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    19 2ymd:I (1.96) BS02 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    20 2ymd:J (1.96) BS01 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    21 2ymd:J (1.96) BS02 SRO ? GO:0004888 ... Q8WSF8 23196367 MOAD: Kd=693uM
    22 3adv:A (2.27) BS01 SRO ? GO:0003677 ... P37231 20717101 MOAD: Kd=933uM
    PDBbind: -logKd/Ki=3.03, Kd=933uM
    23 3adv:A (2.27) BS02 SRO ? GO:0003677 ... P37231 20717101 MOAD: Kd=933uM
    PDBbind: -logKd/Ki=3.03, Kd=933uM
    24 3adv:B (2.27) BS01 SRO ? GO:0003677 ... P37231 20717101 MOAD: Kd=933uM
    25 3brn:A (2.0) BS01 SRO ? GO:0030682 ... Q09JR9 18445596 MOAD: Kd<2nM
    PDBbind: -logKd/Ki=8.70, Kd=2nM
    26 3brn:B (2.0) BS01 SRO ? GO:0030682 ... Q09JR9 18445596 MOAD: Kd<2nM
    27 3nk1:X (2.2) BS01 SRO 1.5.3.5 GO:0000166 ... Q93NH4 20006620
    28 3q6k:A (2.52) BS01 SRO ? GO:0005576 ... Q5WPU9 21795673 Manual survey: Kd=4.3nM (21795673)
    PDBbind: -logKd/Ki=8.37, Kd=4.3nM
    29 3q6k:B (2.52) BS01 SRO ? GO:0005576 ... Q5WPU9 21795673 Manual survey: Kd=4.3nM (21795673)
    30 4dtw:A (1.8) BS02 SRO 1.14.14.1
    1.6.2.4    		 GO:0004497 ... P14779 22659321 MOAD: Kd=80uM
    31 4dtw:B (1.8) BS02 SRO 1.14.14.1
    1.6.2.4    		 GO:0004497 ... P14779 22659321 MOAD: Kd=80uM
    32 4due:A (1.7) BS02 SRO 1.14.14.1
    1.6.2.4    		 GO:0004497 ... P14779 22659321 MOAD: Kd=0.7uM
    33 4due:B (1.7) BS02 SRO 1.14.14.1
    1.6.2.4    		 GO:0004497 ... P14779 22659321 MOAD: Kd=0.7uM
    34 4duf:A (1.8) BS02 SRO 1.14.14.1
    1.6.2.4    		 GO:0004497 ... P14779 22659321 MOAD: Kd=3.3uM
    35 4duf:B (1.8) BS02 SRO 1.14.14.1
    1.6.2.4    		 GO:0004497 ... P14779 22659321 MOAD: Kd=3.3uM
    36 4duf:C (1.8) BS02 SRO 1.14.14.1
    1.6.2.4    		 GO:0004497 ... P14779 22659321 MOAD: Kd=3.3uM
    37 4duf:D (1.8) BS02 SRO 1.14.14.1
    1.6.2.4    		 GO:0004497 ... P14779 22659321 MOAD: Kd=3.3uM
    38 6dg7:A (3.32) BS01 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    39 6dg7:A (3.32) BS02 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    40 6dg7:B (3.32) BS01 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    41 6dg7:B (3.32) BS02 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    42 6dg7:C (3.32) BS01 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    43 6dg7:C (3.32) BS02 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    44 6dg7:D (3.32) BS01 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    45 6dg7:D (3.32) BS02 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    46 6dg7:E (3.32) BS01 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    47 6dg8:A (3.89) BS01 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    48 6dg8:A (3.89) BS02 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    49 6dg8:B (3.89) BS01 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    50 6dg8:B (3.89) BS02 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    51 6dg8:C (3.89) BS01 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    52 6dg8:C (3.89) BS02 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    53 6dg8:D (3.89) BS01 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    54 6dg8:D (3.89) BS02 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    55 6dg8:E (3.89) BS01 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    56 6dg8:E (3.89) BS02 SRO ? GO:0004888 ... P23979 30401837 BindingDB: Ki=361nM, EC50=3400nM
    57 6hin:A (4.1) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    58 6hin:A (4.1) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    59 6hin:B (4.1) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    60 6hin:B (4.1) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    61 6hin:C (4.1) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    62 6hin:C (4.1) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    63 6hin:D (4.1) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    64 6hin:D (4.1) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    65 6hin:E (4.1) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    66 6hin:E (4.1) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    67 6hio:A (4.2) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    68 6hio:A (4.2) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    69 6hio:B (4.2) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    70 6hio:B (4.2) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    71 6hio:C (4.2) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    72 6hio:C (4.2) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    73 6hio:D (4.2) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    74 6hio:D (4.2) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    75 6hio:E (4.2) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    76 6hio:E (4.2) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    77 6hiq:A (3.2) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    78 6hiq:A (3.2) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    79 6hiq:B (3.2) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    80 6hiq:C (3.2) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    81 6hiq:D (3.2) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    82 6hiq:E (3.2) BS01 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    83 6hiq:E (3.2) BS02 SRO ? GO:0004888 ... P23979 30401839 BindingDB: Ki=361nM, EC50=3400nM
    84 6khn:A (2.293) BS02 SRO 4.1.1.28 GO:0005737 ... Q6ZJK7 32595985
    85 6khn:B (2.293) BS01 SRO 4.1.1.28 GO:0005737 ... Q6ZJK7 32595985
    86 6y5a:A (2.8) BS01 SRO ? GO:0004888 ... P23979 33594077 BindingDB: Ki=361nM, EC50=3400nM
    87 6y5a:A (2.8) BS02 SRO ? GO:0004888 ... P23979 33594077 BindingDB: Ki=361nM, EC50=3400nM
    88 6y5a:B (2.8) BS01 SRO ? GO:0004888 ... P23979 33594077 BindingDB: Ki=361nM, EC50=3400nM
    89 6y5a:B (2.8) BS02 SRO ? GO:0004888 ... P23979 33594077 BindingDB: Ki=361nM, EC50=3400nM
    90 6y5a:C (2.8) BS01 SRO ? GO:0004888 ... P23979 33594077 BindingDB: Ki=361nM, EC50=3400nM
    91 6y5a:C (2.8) BS02 SRO ? GO:0004888 ... P23979 33594077 BindingDB: Ki=361nM, EC50=3400nM
    92 6y5a:D (2.8) BS01 SRO ? GO:0004888 ... P23979 33594077 BindingDB: Ki=361nM, EC50=3400nM
    93 6y5a:D (2.8) BS02 SRO ? GO:0004888 ... P23979 33594077 BindingDB: Ki=361nM, EC50=3400nM
    94 6y5a:E (2.8) BS01 SRO ? GO:0004888 ... P23979 33594077 BindingDB: Ki=361nM, EC50=3400nM
    95 6y5a:E (2.8) BS02 SRO ? GO:0004888 ... P23979 33594077 BindingDB: Ki=361nM, EC50=3400nM
    96 7bs2:A (1.8) BS02 SRO 3.4.21.4 GO:0004175 ... P00760 34094189
    97 7bs9:A (1.05) BS02 SRO 3.4.21.4 GO:0004175 ... P00760 34094189
    98 7cfp:A (1.6) BS02 SRO ? GO:0000122 ... P61964 34144982
    99 7cfq:A (1.6) BS02 SRO ? GO:0000122 ... P61964 34144982
    100 7dal:B (2.5) BS02 SRO 2.3.1.87 GO:0008080 ... Q5KQI6 33682300
    101 7e2y:R (3.0) BS01 SRO ? GO:0001586 ... P08908
    P0ABE7    		 33762731
    102 7e32:R (2.9) BS01 SRO ? GO:0001586 ... P0ABE7
    P28221    		 33762731
    103 7li9:A (3.9) BS01 SRO ? GO:0016020 ... P31645 34851672
    104 7li9:A (3.9) BS02 SRO ? GO:0016020 ... P31645 34851672
    105 7lia:A (3.3) BS01 SRO ? GO:0016020 ... P31645 34851672
    106 7lia:A (3.3) BS05 SRO ? GO:0016020 ... P31645 34851672
    107 7mgw:A (3.5) BS02 SRO ? GO:0016020 ... P31645 34851672
    108 7mgw:A (3.5) BS03 SRO ? GO:0016020 ... P31645 34851672
    109 7tx8:A (2.51) BS01 SRO ? GO:0005549 ... B6DDQ8 35568118
    110 7tx8:B (2.51) BS01 SRO ? GO:0005549 ... B6DDQ8 35568118
    111 7tx8:C (2.51) BS01 SRO ? GO:0005549 ... B6DDQ8 35568118
    112 7tx8:D (2.51) BS01 SRO ? GO:0005549 ... B6DDQ8 35568118
    113 7wb7:A (1.45) BS01 SRO 3.4.21.4 GO:0004175 ... P00760 35647681
    114 7wc4:A (3.2) BS04 SRO ? GO:0004930 ... P28223 35084960
    115 7xt8:R (3.1) BS04 SRO ? GO:0004930 ... P0ABE7
    Q13639    		 35714614
    116 7xt9:R (3.2) BS04 SRO ? GO:0004930 ... P0ABE7
    Q13639    		 35714614
    117 7xta:R (3.2) BS01 SRO ? GO:0004930 ... P0ABE7
    Q13639    		 35714614
    118 7xtb:R (3.3) BS01 SRO ? GO:0004930 ... P0ABE7
    P50406    		 35714614
    119 7ys6:A (3.0) BS01 SRO ? GO:0004930 ... P50406 36989299
    120 8c20:B (3.5) BS01 SRO N/A N/A P23979 N/A
    121 8c20:D (3.5) BS01 SRO N/A N/A P23979 N/A
    122 8c21:B (3.6) BS01 SRO N/A N/A P23979 N/A
    123 8c21:B (3.6) BS02 SRO N/A N/A P23979 N/A
    124 8c21:C (3.6) BS01 SRO N/A N/A P23979 N/A
    125 8frz:A (2.75) BS01 SRO ? GO:0004888 ... P23979 38177669
    126 8frz:A (2.75) BS02 SRO ? GO:0004888 ... P23979 38177669
    127 8frz:B (2.75) BS01 SRO ? GO:0004888 ... P23979 38177669
    128 8frz:B (2.75) BS02 SRO ? GO:0004888 ... P23979 38177669
    129 8frz:C (2.75) BS01 SRO ? GO:0004888 ... P23979 38177669
    130 8frz:C (2.75) BS02 SRO ? GO:0004888 ... P23979 38177669
    131 8frz:D (2.75) BS01 SRO ? GO:0004888 ... P23979 38177669
    132 8frz:D (2.75) BS02 SRO ? GO:0004888 ... P23979 38177669
    133 8frz:E (2.75) BS01 SRO ? GO:0004888 ... P23979 38177669
    134 8frz:E (2.75) BS02 SRO ? GO:0004888 ... P23979 38177669
    135 8fsb:A (2.75) BS01 SRO ? GO:0004888 ... P23979 38177669
    136 8fsb:B (2.75) BS01 SRO ? GO:0004888 ... P23979 38177669
    137 8fsb:B (2.75) BS02 SRO ? GO:0004888 ... P23979 38177669
    138 8fsb:C (2.75) BS01 SRO ? GO:0004888 ... P23979 38177669
    139 8fsb:D (2.75) BS01 SRO ? GO:0004888 ... P23979 38177669
    140 8fsb:D (2.75) BS02 SRO ? GO:0004888 ... P23979 38177669
    141 8fsb:E (2.75) BS01 SRO ? GO:0004888 ... P23979 38177669
    142 8gdl:A (1.75) BS01 SRO 3.1.3.2 N/A A2IA89 38110569
    143 8gdl:B (1.75) BS01 SRO 3.1.3.2 N/A A2IA89 38110569
    144 8jsw:A (2.84) BS01 SRO ? GO:0016020 ... Q05940 38081299
    145 8t6b:A (3.72) BS01 SRO ? GO:0001975 ... Q05940 37914936
    146 8tgn:A (3.3) BS01 SRO ? GO:0005335 ... P54219 38499039
    147 8wlm:A (3.57) BS01 SRO ? GO:0001975 ... Q05940 N/A
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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