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BioLiP
Download all results in tab-seperated text for 29 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 2yg2:A (1.7) BS01 S1P ? N/A O95445 21606363
    2 2yg2:B (1.7) BS01 S1P ? N/A O95445 21606363
    3 3i9g:H (1.9) BS01 S1P N/A N/A N/A 19815502 PDBbind: -logKd/Ki=8.96, Kd=1.1nM
    4 3i9g:L (1.9) BS03 S1P N/A N/A N/A 19815502 MOAD: Kd=1.1nM
    PDBbind: -logKd/Ki=8.96, Kd=1.1nM
    5 5ksi:A (1.8) BS02 S1P ? GO:0004601 ... P69905 29127281
    6 5ksi:A (1.8) BS03 S1P ? GO:0004601 ... P69905 29127281
    7 5ksi:A (1.8) BS04 S1P ? GO:0004601 ... P69905 29127281
    8 5ksi:B (1.8) BS02 S1P ? GO:0004601 ... P68871 29127281
    9 5ksi:C (1.8) BS02 S1P ? GO:0004601 ... P69905 29127281
    10 5ksi:C (1.8) BS03 S1P ? GO:0004601 ... P69905 29127281
    11 5ksi:D (1.8) BS01 S1P ? GO:0004601 ... P68871 29127281
    12 5ksi:D (1.8) BS03 S1P ? GO:0004601 ... P68871 29127281
    13 7c4s:A (3.2) BS01 S1P ? GO:0003376 ... Q99500 34108205 BindingDB: EC50=1.2nM, IC50=0.66nM
    14 7c4s:B (3.2) BS01 S1P ? GO:0003376 ... Q99500 34108205 BindingDB: EC50=1.2nM, IC50=0.66nM
    15 7ew3:R (3.1) BS01 S1P ? GO:0003376 ... Q99500 34545189 BindingDB: EC50=1.2nM, IC50=0.66nM
    16 7lhv:A (2.75) BS01 S1P ? GO:0008271 ... Q9FY46 34294705
    17 7lhv:A (2.75) BS04 S1P ? GO:0008271 ... Q9FY46 34294705
    18 7lhv:A (2.75) BS05 S1P ? GO:0008271 ... Q9FY46 34294705
    19 7lhv:B (2.75) BS01 S1P ? GO:0008271 ... Q9FY46 34294705
    20 7lhv:B (2.75) BS02 S1P ? GO:0008271 ... Q9FY46 34294705
    21 7lhv:B (2.75) BS03 S1P ? GO:0008271 ... Q9FY46 34294705
    22 7t6b:R (3.19) BS01 S1P ? GO:0001664 ... O95136 35353559
    23 7td3:R (3.0) BS01 S1P ? GO:0001525 ... P21453 35136060
    24 7vie:F (2.86) BS01 S1P ? GO:0001525 ... P21453 35412894
    25 7wf7:A (3.4) BS01 S1P ? GO:0001525 ... P21453 34937912 BindingDB: IC50=1.40nM, EC50=4.3nM
    26 7yub:R (3.22) BS01 S1P ? GO:0001782 ... Q8IVW8 38123825
    27 8ex4:A (2.93) BS01 S1P ? GO:0022857 ... Q8IVW8 37224812
    28 8ex6:A (3.54) BS01 S1P ? GO:0022857 ... Q8IVW8 37224812
    29 8jhq:A (3.6) BS01 S1P ? GO:0022857 ... Q8IVW8
    Q9V2J8    		 38123824
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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