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BioLiP
Download all results in tab-seperated text for 36 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1hxw:A (1.8) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P12499 7708670 PDBbind: -logKd/Ki=10.82, Ki=15pM
    2 1hxw:B (1.8) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P12499 7708670 MOAD: Ki=15pM
    PDBbind: -logKd/Ki=10.82, Ki=15pM
    3 1n49:A (2.2) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 12502847
    4 1n49:B (2.2) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 12502847
    5 1n49:C (2.2) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 12502847
    6 1n49:D (2.2) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03369 12502847
    7 1rl8:A (2.0) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 N/A
    8 1rl8:B (2.0) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 N/A
    9 1sh9:A (2.5) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 15379553 PDBbind: -logKd/Ki=6.03, Ki=932nM
    10 1sh9:B (2.5) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 15379553 MOAD: Ki=932nM
    PDBbind: -logKd/Ki=6.03, Ki=932nM
    11 2b60:A (2.2) BS01 RIT ? GO:0004190 ... Q7SMT3 N/A
    12 2b60:B (2.2) BS01 RIT ? GO:0004190 ... Q7SMT3 N/A
    13 3ndw:A (1.14) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 N/A
    14 3ndw:B (1.14) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 N/A
    15 3ndx:A (1.03) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 N/A
    16 3ndx:B (1.03) BS01 RIT 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 N/A
    17 3nxu:A (2.0) BS02 RIT 1.14.14.1
    1.14.14.55
    1.14.14.56
    1.14.14.73    		 GO:0002933 ... P08684 20937904 BindingDB: IC50=100nM, Ki=170nM
    18 3nxu:B (2.0) BS02 RIT 1.14.14.1
    1.14.14.55
    1.14.14.56
    1.14.14.73    		 GO:0002933 ... P08684 20937904 BindingDB: IC50=100nM, Ki=170nM
    19 3prs:A (1.38) BS01 RIT 3.4.23.22 GO:0004190 ... P11838 22213702 PDBbind: -logKd/Ki=7.82, Ki=15nM
    20 3q70:A (1.4) BS01 RIT 3.4.23.24 GO:0004190 ... P0CS83 N/A
    21 3tne:A (2.4) BS01 RIT 3.4.23.24 GO:0004190 ... P32951 22146051 PDBbind: -logKd/Ki=5.72, Ki=1.9uM
    22 3tne:B (2.4) BS01 RIT 3.4.23.24 GO:0004190 ... P32951 22146051
    23 4eyr:A (1.8) BS01 RIT 3.1.26.13 GO:0004190 ... Q000H7 23313846 PDBbind: -logKd/Ki=6.63, IC50=237nM
    24 4eyr:B (1.8) BS01 RIT 3.1.26.13 GO:0004190 ... Q000H7 23313846 MOAD: ic50=237nM
    PDBbind: -logKd/Ki=6.63, IC50=237nM
    25 4njv:A (1.8) BS01 RIT ? GO:0004190 ... Q9J006 24752271
    26 4njv:B (1.8) BS01 RIT ? GO:0004190 ... Q9J006 24752271
    27 4njv:C (1.8) BS01 RIT ? GO:0004190 ... Q9J006 24752271
    28 4njv:D (1.8) BS01 RIT ? GO:0004190 ... Q9J006 24752271
    29 5vc0:A (2.7) BS02 RIT 1.14.14.1
    1.14.14.55
    1.14.14.56
    1.14.14.73    		 GO:0002933 ... P08684 28590129 BindingDB: IC50=100nM, Ki=170nM
    30 5vce:A (2.2) BS02 RIT 1.14.14.1
    1.14.14.55
    1.14.14.56
    1.14.14.73    		 GO:0002933 ... P08684 28590129 BindingDB: IC50=100nM, Ki=170nM
    31 5veu:A (2.91) BS02 RIT 1.14.14.1 GO:0002933 ... P20815 29093019 BindingDB: Ki=120nM
    32 5veu:B (2.91) BS02 RIT 1.14.14.1 GO:0002933 ... P20815 29093019 BindingDB: Ki=120nM
    33 5veu:H (2.91) BS02 RIT 1.14.14.1 GO:0002933 ... P20815 29093019 BindingDB: Ki=120nM
    34 6xcy:A (2.05) BS01 RIT 3.4.23.1 GO:0004190 ... P00791 N/A
    35 7ve0:A (1.9) BS01 RIT 3.4.23.39 GO:0004190 ... Q8I6V3 38304146
    36 7ve0:B (1.9) BS01 RIT 3.4.23.39 GO:0004190 ... Q8I6V3 38304146
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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