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BioLiP
Download all results in tab-seperated text for 23 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1rqj:A (1.95) BS04 RIS 2.5.1.10 GO:0004161 ... P22939 14672944
    2 1rqj:B (1.95) BS04 RIS 2.5.1.10 GO:0004161 ... P22939 14672944
    3 1yhl:A (1.95) BS04 RIS ? GO:0004659 ... Q8WS26 16288456 BindingDB: IC50=27nM
    4 1yq7:A (2.2) BS03 RIS 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A PDBbind: -logKd/Ki=7.09, Ki=82.2nM
    BindingDB: IC50=11nM, Ki=82.2nM
    5 1yv5:A (2.0) BS05 RIS 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 16684881 BindingDB: IC50=11nM, Ki=82.2nM
    6 2o1o:A (2.42) BS03 RIS ? GO:0004161 ... Q5CR09 19101474 MOAD: Ki=0.38nM
    BindingDB: IC50=45.7nM, Ki=0.38nM
    7 2o1o:B (2.42) BS03 RIS ? GO:0004161 ... Q5CR09 19101474 MOAD: Ki=0.38nM
    BindingDB: IC50=45.7nM, Ki=0.38nM
    8 2qis:A (1.8) BS03 RIS 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A BindingDB: IC50=11nM, Ki=82.2nM
    9 4kpd:A (1.96) BS04 RIS 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A BindingDB: IC50=11nM, Ki=82.2nM
    10 4kqs:A (1.97) BS04 RIS 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A BindingDB: IC50=11nM, Ki=82.2nM
    11 4n9u:A (2.11) BS03 RIS 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A BindingDB: IC50=11nM, Ki=82.2nM
    12 4ng6:A (2.35) BS04 RIS 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A BindingDB: IC50=11nM, Ki=82.2nM
    13 4nke:A (1.46) BS03 RIS 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A BindingDB: IC50=11nM, Ki=82.2nM
    14 4nua:A (1.43) BS01 RIS 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A BindingDB: IC50=11nM, Ki=82.2nM
    15 4q23:A (1.98) BS01 RIS 2.5.1.1
    2.5.1.10    		 GO:0004659 ... P14324 N/A BindingDB: IC50=11nM, Ki=82.2nM
    16 4rxd:A (2.0) BS03 RIS ? GO:0004161 ... Q86C09 25815158 MOAD: ic50=300nM
    PDBbind: -logKd/Ki=6.52, IC50=300nM
    17 4rxd:B (2.0) BS03 RIS ? GO:0004161 ... Q86C09 25815158 MOAD: ic50=300nM
    18 4rxd:C (2.0) BS01 RIS ? GO:0004161 ... Q86C09 25815158 MOAD: ic50=300nM
    PDBbind: -logKd/Ki=6.52, IC50=300nM
    19 5cg5:A (1.402) BS03 RIS 2.5.1.1
    2.5.1.10    		 N/A P14324 26314394 BindingDB: IC50=11nM, Ki=82.2nM
    20 5cg6:A (1.7) BS03 RIS 2.5.1.1
    2.5.1.10    		 N/A P14324 26314394 BindingDB: IC50=11nM, Ki=82.2nM
    21 7kj9:A (2.2) BS02 RIS 4.2.3.37 GO:0016829 ... Q9K499 33270439
    22 7kjd:A (1.5) BS02 RIS 4.2.3.37 GO:0016829 ... Q9K499 33270439
    23 8su2:A (1.33) BS01 RIS 4.2.3.37 GO:0016829 ... Q9K499 37449555
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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