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BioLiP
Download all results in tab-seperated text for 14 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1dmt:A (2.1) BS02 RDF 3.4.24.11 GO:0001786 ... P08473 10669592 PDBbind: -logKd/Ki=8.70, IC50=2nM
    BindingDB: IC50=30nM
    2 1tlp:E (2.3) BS01 RDF 3.4.24.27 GO:0004222 ... P00800 3709536 MOAD: Ki=28nM
    PDBbind: -logKd/Ki=7.55, Ki=28nM
    BindingDB: Kd=28nM, IC50=33nM, Ki=28nM
    3 3dbk:A (1.4) BS03 RDF 3.4.24.26 GO:0004222 ... P14756 N/A
    4 3dwb:A (2.38) BS03 RDF 3.4.24.71 GO:0004222 ... P42892 18992253 MOAD: ic50=0.65uM
    PDBbind: -logKd/Ki=6.19, IC50=0.65uM
    BindingDB: IC50=1200nM
    5 3zuk:A (2.6) BS02 RDF 3.4.24.- GO:0004222 ... O53649 21813647 PDBbind: -logKd/Ki=7.46, Ki=35nM
    6 3zuk:B (2.6) BS02 RDF 3.4.24.- GO:0004222 ... O53649 21813647
    7 4b52:A (1.76) BS05 RDF 3.4.24.- GO:0004222 ... E3E6L0 23275160
    8 4b52:A (1.76) BS06 RDF 3.4.24.- GO:0004222 ... E3E6L0 23275160
    9 4b52:B (1.76) BS05 RDF 3.4.24.- GO:0004222 ... E3E6L0 23275160
    10 4cth:A (2.15) BS02 RDF 3.4.24.11 GO:0001786 ... P08473 25089527 BindingDB: IC50=30nM
    11 4zr5:A (2.8016) BS02 RDF 3.4.24.11 GO:0001822 ... P08049 31204686 BindingDB: IC50=6nM
    12 4zr5:B (2.8016) BS02 RDF 3.4.24.11 GO:0001822 ... P08049 31204686 BindingDB: IC50=6nM
    13 6bh8:A (3.85) BS02 RDF 3.4.24.84 GO:0001889 ... O75844 30082509 PDBbind: -logKd/Ki=5.12, IC50=7.6uM
    14 6bh8:B (3.85) BS02 RDF 3.4.24.84 GO:0001889 ... O75844 30082509
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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