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BioLiP
Download all results in tab-seperated text for 36 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1c6y:A (2.5) BS01 MK1 3.4.24.- GO:0004190 ... O09893 10739910 PDBbind: -logKd/Ki=9.51, Ki=0.31nM
    2 1c6y:B (2.5) BS01 MK1 3.4.24.- GO:0004190 ... O09893 10739910 MOAD: Ki=0.31nM
    PDBbind: -logKd/Ki=9.51, Ki=0.31nM
    3 1hsg:A (2.0) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 7929352 PDBbind: -logKd/Ki=9.42, Ki=0.38nM
    4 1hsg:B (2.0) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 7929352 MOAD: Ki=0.38nM
    PDBbind: -logKd/Ki=9.42, Ki=0.38nM
    5 1hsh:A (1.9) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.47    		 GO:0004190 ... P04584 7929352 MOAD: Ki=2.45nM
    PDBbind: -logKd/Ki=9.42, Ki=0.38nM
    6 1hsh:B (1.9) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.47    		 GO:0004190 ... P04584 7929352 PDBbind: -logKd/Ki=9.42, Ki=0.38nM
    7 1hsh:C (1.9) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.47    		 GO:0004190 ... P04584 7929352 MOAD: Ki=2.45nM
    8 1hsh:D (1.9) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.47    		 GO:0004190 ... P04584 7929352
    9 1k6c:A (2.2) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P35963 11790852 PDBbind: -logKd/Ki=7.48, Kd=33nM
    10 1k6c:B (2.2) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P35963 11790852 MOAD: Kd=33nM
    PDBbind: -logKd/Ki=7.48, Kd=33nM
    11 1sdt:A (1.3) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 15066177 PDBbind: -logKd/Ki=9.27, Ki=540pM
    12 1sdt:B (1.3) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 15066177 MOAD: Ki=540pM
    PDBbind: -logKd/Ki=9.27, Ki=540pM
    13 1sdu:A (1.25) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 15066177 PDBbind: -logKd/Ki=10.07, Ki=86pM
    14 1sdu:B (1.25) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 15066177 MOAD: Ki=86pM
    PDBbind: -logKd/Ki=10.07, Ki=86pM
    15 1sdv:A (1.4) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 15066177 PDBbind: -logKd/Ki=8.74, Ki=1810pM
    16 1sdv:B (1.4) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 15066177 MOAD: Ki=1810pM
    PDBbind: -logKd/Ki=8.74, Ki=1810pM
    17 1sgu:A (1.9) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 15379553 PDBbind: -logKd/Ki=5.37, Ki=4235nM
    18 1sgu:B (1.9) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 15379553 MOAD: Ki=4235nM
    PDBbind: -logKd/Ki=5.37, Ki=4235nM
    19 2avo:A (1.1) BS01 MK1 3.4.23.16 GO:0004190 ... Q7SSI0 16277992 PDBbind: -logKd/Ki=8.85, Ki=1.40nM
    20 2avo:B (1.1) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992 MOAD: Ki=1.4nM
    PDBbind: -logKd/Ki=8.85, Ki=1.40nM
    21 2avs:A (1.1) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992 PDBbind: -logKd/Ki=7.57, Ki=27.0nM
    22 2avs:B (1.1) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992 MOAD: Ki=27nM
    PDBbind: -logKd/Ki=7.57, Ki=27.0nM
    23 2avv:A (1.5) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992 MOAD: Ki=0.55nM
    PDBbind: -logKd/Ki=9.26, Ki=0.55nM
    24 2avv:B (1.5) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992 PDBbind: -logKd/Ki=9.26, Ki=0.55nM
    25 2avv:D (1.5) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992
    26 2avv:E (1.5) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 16277992 MOAD: Ki=0.55nM
    27 2b7z:A (2.2) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 N/A
    28 2b7z:B (2.2) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P03367 N/A
    29 2bpx:A (2.8) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 9757136 PDBbind: -logKd/Ki=9.40, Ki=0.4nM
    30 2bpx:B (2.8) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... P04587 9757136 PDBbind: -logKd/Ki=9.40, Ki=0.4nM
    31 2r5p:A (2.3) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... O12158 18092815 PDBbind: -logKd/Ki=8.48, Ki=3.3nM
    32 2r5p:B (2.3) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... O12158 18092815 MOAD: Ki=3.3nM
    PDBbind: -logKd/Ki=8.48, Ki=3.3nM
    33 2r5p:C (2.3) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... O12158 18092815
    34 2r5p:D (2.3) BS01 MK1 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16    		 GO:0004190 ... O12158 18092815 MOAD: Ki=3.3nM
    35 3wsj:A (2.404) BS01 MK1 ? GO:0004190 ... Q82134 25006983 MOAD: Ki=35uM
    36 3wsj:B (2.404) BS01 MK1 ? GO:0004190 ... Q82134 25006983
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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