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BioLiP
Download all results in tab-seperated text for 8 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 2h8h:A (2.2) BS01 H8H 2.7.10.2 GO:0000122 ... P12931 17064066 MOAD: ic50=2.7nM
    PDBbind: -logKd/Ki=8.57, IC50=2.7nM
    BindingDB: IC50=2.7nM
    2 4qmx:A (1.882) BS01 H8H 2.7.11.1 GO:0004672 ... Q9Y6E0 27135311 MOAD: ic50=11uM
    PDBbind: -logKd/Ki=4.96, IC50=11uM
    3 5vcx:A (2.7) BS01 H8H 2.7.11.1 GO:0004672 ... Q99640 28792760 PDBbind: -logKd/Ki=5.55, Kd=2817nM
    BindingDB: IC50=418nM, Ki=40nM, Kd=2817nM
    4 5vd3:A (1.8) BS01 H8H 2.7.11.1 GO:0004672 ... Q99640 28792760 MOAD: Kd=2817nM
    PDBbind: -logKd/Ki=5.55, Kd=2817nM
    BindingDB: IC50=418nM, Ki=40nM, Kd=2817nM
    5 6zgc:A (2.67) BS01 H8H 2.7.11.30 GO:0004672 ... Q04771 33705358
    6 6zgc:B (2.67) BS01 H8H 2.7.11.30 GO:0004672 ... Q04771 33705358
    7 6zgc:C (2.67) BS01 H8H 2.7.11.30 GO:0004672 ... Q04771 33705358
    8 6zgc:D (2.67) BS01 H8H 2.7.11.30 GO:0004672 ... Q04771 33705358
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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