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BioLiP
Download all results in tab-seperated text for 1135 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.
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    # PDB
    (Resolution Å)
    Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1bgv:A (1.9) BS01 GLU 1.4.1.2 GO:0004352 ... P24295 8263917
    2 1dtd:A (1.65) BS02 GLU 3.4.17.15 GO:0004181 ... P48052 10742178
    3 1ewk:A (2.2) BS02 GLU ? GO:0004930 ... P23385 11069170
    4 1ewk:B (2.2) BS02 GLU ? GO:0004930 ... P23385 11069170
    5 1ftj:A (1.9) BS02 GLU ? GO:0015276 ... P19491 11086992 MOAD: ic50=821nM
    PDBbind: -logKd/Ki=6.09, IC50=821nM
    6 1ftj:B (1.9) BS03 GLU ? GO:0015276 ... P19491 11086992 MOAD: ic50=821nM
    7 1ftj:C (1.9) BS02 GLU ? GO:0015276 ... P19491 11086992 MOAD: ic50=821nM
    8 1gde:A (1.8) BS01 GLU 2.6.1.- GO:0003824 ... O59096 11134972
    9 1gde:B (1.8) BS01 GLU 2.6.1.- GO:0003824 ... O59096 11134972
    10 1gpj:A (1.95) BS01 GLU 1.2.1.70 GO:0006779 ... Q9UXR8 11726494
    11 1hfw:A (1.8) BS01 GLU 3.5.1.1 GO:0004067 ... P06608 11341830
    12 1hfw:B (1.8) BS01 GLU 3.5.1.1 GO:0004067 ... P06608 11341830
    13 1hfw:C (1.8) BS01 GLU 3.5.1.1 GO:0004067 ... P06608 11341830
    14 1hfw:D (1.8) BS01 GLU 3.5.1.1 GO:0004067 ... P06608 11341830
    15 1i7q:B (1.95) BS01 GLU 4.1.3.27 GO:0000162 ... P00900 11371633
    16 1i7q:D (1.95) BS01 GLU 4.1.3.27 GO:0000162 ... P00900 11371633
    17 1i9c:B (1.9) BS02 GLU 5.4.99.1 GO:0003824 ... P80077 11592143
    18 1i9c:D (1.9) BS02 GLU 5.4.99.1 GO:0003824 ... P80077 11592143
    19 1ii5:A (1.6) BS01 GLU ? GO:0015276 ... P73797 11518533 MOAD: Kd=240nM
    PDBbind: -logKd/Ki=6.62, Kd=240nM
    20 1isr:A (4.0) BS01 GLU ? GO:0004930 ... P23385 11867751
    21 1j09:A (1.8) BS01 GLU 6.1.1.17 GO:0000049 ... P27000 12554668
    22 1kjp:A (1.6) BS06 GLU 3.4.24.27 GO:0004222 ... P00800 N/A
    23 1lbc:A (1.8) BS02 GLU ? GO:0015276 ... P19491 12015593
    24 1lbc:B (1.8) BS03 GLU ? GO:0015276 ... P19491 12015593
    25 1lbc:C (1.8) BS02 GLU ? GO:0015276 ... P19491 12015593
    26 1mww:C (2.08) BS01 GLU ? N/A O86237 N/A
    27 1o0c:A (2.7) BS02 GLU 6.1.1.18 GO:0000166 ... P00962 12691748
    28 1rxq:D (1.7) BS01 GLU 3.-.-.- GO:0005737 ... O31562 15581359
    29 1s50:A (1.65) BS01 GLU ? GO:0015276 ... P42260 15721240 MOAD: Ki=1.4uM
    PDBbind: -logKd/Ki=7.20, Ki=0.063uM
    30 1s7y:A (1.75) BS01 GLU ? GO:0015276 ... P42260 15721240 MOAD: Ki=1.4uM
    31 1s7y:B (1.75) BS01 GLU ? GO:0015276 ... P42260 15721240
    32 1tkk:A (2.1) BS03 GLU 5.1.1.20 GO:0016853 ... O34508 15301535
    33 1tkk:B (2.1) BS03 GLU 5.1.1.20 GO:0016853 ... O34508 15301535
    34 1tkk:C (2.1) BS03 GLU 5.1.1.20 GO:0016853 ... O34508 15301535
    35 1tkk:D (2.1) BS03 GLU 5.1.1.20 GO:0016853 ... O34508 15301535
    36 1tkk:E (2.1) BS03 GLU 5.1.1.20 GO:0016853 ... O34508 15301535
    37 1tkk:F (2.1) BS03 GLU 5.1.1.20 GO:0016853 ... O34508 15301535
    38 1tkk:G (2.1) BS03 GLU 5.1.1.20 GO:0016853 ... O34508 15301535
    39 1tkk:H (2.1) BS03 GLU 5.1.1.20 GO:0016853 ... O34508 15301535
    40 1txf:A (2.1) BS01 GLU ? GO:0015276 ... P22756 15721240 MOAD: Ki=57.2nM
    41 1us4:A (1.75) BS01 GLU ? N/A P83817 15388932
    42 1us5:A (1.5) BS01 GLU ? N/A P83817 15388932
    43 1xff:A (1.8) BS01 GLU 2.6.1.16 N/A P17169 8805567 MOAD: Ki=15uM
    PDBbind: -logKd/Ki=4.82, Ki=15uM
    44 1xff:B (1.8) BS01 GLU 2.6.1.16 N/A P17169 8805567 MOAD: Ki=15uM
    45 1xov:A (1.8) BS02 GLU 3.5.1.28 GO:0004386 ... Q8W5Y8 17010991
    46 1ycj:A (1.95) BS01 GLU ? GO:0015276 ... P22756 15710405
    47 1ycj:B (1.95) BS01 GLU ? GO:0015276 ... P22756 15710405
    48 1yxw:A (2.2) BS01 GLU 3.4.24.68 GO:0005576 ... P04958 16104015
    49 2a5s:A (1.7) BS01 GLU ? GO:0015276 ... Q00959 16281028 PDBbind: -logKd/Ki=6.70, Ki=0.2uM
    50 2a5t:B (2.0) BS01 GLU ? GO:0015276 ... Q00959 16281028
    51 2bhq:A (1.4) BS01 GLU 1.2.1.88 GO:0000166 ... Q5SI02 16934832
    52 2bhq:B (1.4) BS01 GLU 1.2.1.88 GO:0000166 ... Q5SI02 16934832
    53 2c6g:A (2.2) BS01 GLU 3.4.17.21 GO:0004180 ... Q04609 16467855 PDBbind: -logKd/Ki=3.37, IC50=428uM
    54 2cfo:A (2.45) BS01 GLU 6.1.1.17 GO:0000049 ... Q8DLI5 16876193
    55 2cmo:B (2.65) BS01 GLU ? GO:0015276 ... P19491 16483599
    56 2cuz:A (1.98) BS01 GLU 6.1.1.17 GO:0000049 ... P27000 17161369
    57 2cv0:A (2.4) BS02 GLU 6.1.1.17 GO:0000049 ... P27000 17161369
    58 2cv0:B (2.4) BS02 GLU 6.1.1.17 GO:0000049 ... P27000 17161369
    59 2d32:A (2.4) BS05 GLU 6.3.2.2 GO:0003824 ... P0A6W9 N/A
    60 2d32:B (2.4) BS04 GLU 6.3.2.2 GO:0003824 ... P0A6W9 N/A
    61 2d32:C (2.4) BS04 GLU 6.3.2.2 GO:0003824 ... P0A6W9 N/A
    62 2d32:D (2.4) BS04 GLU 6.3.2.2 GO:0003824 ... P0A6W9 N/A
    63 2d33:A (2.6) BS05 GLU 6.3.2.2 GO:0003824 ... P0A6W9 N/A
    64 2d33:B (2.6) BS04 GLU 6.3.2.2 GO:0003824 ... P0A6W9 N/A
    65 2d33:C (2.6) BS04 GLU 6.3.2.2 GO:0003824 ... P0A6W9 N/A
    66 2d33:D (2.6) BS04 GLU 6.3.2.2 GO:0003824 ... P0A6W9 N/A
    67 2dbx:B (1.7) BS02 GLU 2.3.2.2
    3.4.19.13
    GO:0006751 ... P18956 16618936
    68 2dbx:D (1.7) BS02 GLU 2.3.2.2
    3.4.19.13
    GO:0006751 ... P18956 16618936
    69 2dg5:B (1.6) BS02 GLU 2.3.2.2
    3.4.19.13
    GO:0006751 ... P18956 16618936
    70 2dg5:D (1.6) BS02 GLU 2.3.2.2
    3.4.19.13
    GO:0006751 ... P18956 16618936
    71 2dvz:A (2.3) BS01 GLU ? N/A Q7W0A0 17057341
    72 2e4u:A (2.35) BS01 GLU ? GO:0004930 ... P31422 17360426
    73 2e4u:B (2.35) BS01 GLU ? GO:0004930 ... P31422 17360426
    74 2f36:A (2.11) BS01 GLU ? GO:0015276 ... P22756 16540562
    75 2f36:B (2.11) BS01 GLU ? GO:0015276 ... P22756 16540562
    76 2f36:C (2.11) BS01 GLU ? GO:0015276 ... P22756 16540562
    77 2f36:D (2.11) BS01 GLU ? GO:0015276 ... P22756 16540562
    78 2gfe:A (1.54) BS02 GLU ? GO:0015276 ... P19491 16855092
    79 2gfe:B (1.54) BS03 GLU ? GO:0015276 ... P19491 16855092
    80 2gfe:C (1.54) BS02 GLU ? GO:0015276 ... P19491 16855092
    81 2gwd:A (2.09) BS02 GLU 6.3.2.2 GO:0003824 ... O23736 16766527
    82 2hln:A (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    83 2hln:B (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    84 2hln:C (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    85 2hln:D (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    86 2hln:E (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    87 2hln:F (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    88 2hln:G (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    89 2hln:H (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    90 2hln:I (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    91 2hln:J (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    92 2hln:K (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    93 2hln:L (2.2) BS01 GLU 3.5.1.1 GO:0004067 ... Q7WWK9 18323619
    94 2i0b:A (1.96) BS01 GLU ? GO:0015276 ... P42260 17115050
    95 2i0b:B (1.96) BS01 GLU ? GO:0015276 ... P42260 17115050
    96 2i0b:C (1.96) BS01 GLU ? GO:0015276 ... P42260 17115050
    97 2i0c:A (2.25) BS01 GLU ? GO:0015276 ... P42260 17115050
    98 2i0c:B (2.25) BS01 GLU ? GO:0015276 ... P42260 17115050
    99 2i3v:A (2.4) BS02 GLU ? GO:0015276 ... P19491 17018279 PDBbind: -logKd/Ki=6.55, Ki=282nM
    100 2i3v:B (2.4) BS01 GLU ? GO:0015276 ... P19491 17018279
    101 2i3v:C (2.4) BS02 GLU ? GO:0015276 ... P19491 17018279
    102 2i3v:D (2.4) BS01 GLU ? GO:0015276 ... P19491 17018279
    103 2i3w:A (2.3) BS01 GLU ? GO:0015276 ... P19491 17018279
    104 2i3w:B (2.3) BS01 GLU ? GO:0015276 ... P19491 17018279
    105 2ia4:A (1.5) BS01 GLU ? GO:0030288 ... A0A0H2UXX1 N/A
    106 2ia4:B (1.5) BS01 GLU ? GO:0030288 ... A0A0H2UXX1 N/A
    107 2j5t:A (2.9) BS01 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    108 2j5t:A (2.9) BS02 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    109 2j5t:B (2.9) BS01 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    110 2j5t:C (2.9) BS01 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    111 2j5t:D (2.9) BS01 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    112 2j5t:D (2.9) BS02 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    113 2j5t:E (2.9) BS01 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    114 2j5t:E (2.9) BS02 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    115 2j5t:F (2.9) BS01 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    116 2j5t:F (2.9) BS02 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    117 2j5t:G (2.9) BS01 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    118 2j5t:G (2.9) BS02 GLU 2.7.2.11 GO:0000287 ... P0A7B5 17321544
    119 2jfn:A (1.9) BS01 GLU 5.1.1.3 GO:0005515 ... P22634 17568739
    120 2jfo:A (2.5) BS01 GLU 5.1.1.3 GO:0008360 ... Q836J0 17568739
    121 2lgs:A (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    122 2lgs:B (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    123 2lgs:C (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    124 2lgs:D (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    125 2lgs:E (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    126 2lgs:F (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    127 2lgs:G (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    128 2lgs:H (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    129 2lgs:I (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    130 2lgs:J (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    131 2lgs:K (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    132 2lgs:L (2.8) BS03 GLU 6.3.1.2 GO:0003824 ... P0A1P6 8099447
    133 2p2a:A (2.26) BS01 GLU ? GO:0015276 ... P19491 17455929
    134 2pyy:A (2.1) BS01 GLU ? GO:0015276 ... D0VWX9 18164033 MOAD: Kd=0.000023M
    PDBbind: -logKd/Ki=4.60, Kd=25uM
    135 2pyy:B (2.1) BS01 GLU ? GO:0015276 ... D0VWX9 18164033 MOAD: Kd=0.000023M
    136 2pyy:C (2.1) BS01 GLU ? GO:0015276 ... D0VWX9 18164033 MOAD: Kd=0.000023M
    137 2qm6:B (1.6) BS01 GLU 2.3.2.2
    3.4.19.13
    GO:0006751 ... O25743 17960917
    138 2qm6:D (1.6) BS01 GLU 2.3.2.2
    3.4.19.13
    GO:0006751 ... O25743 17960917
    139 2uxa:A (2.38) BS01 GLU ? GO:0015276 ... P19491 16815334
    140 2uxa:B (2.38) BS01 GLU ? GO:0015276 ... P19491 16815334
    141 2uxa:C (2.38) BS01 GLU ? GO:0015276 ... P19491 16815334
    142 2vha:A (1.0) BS01 GLU ? GO:0030288 ... A0A0H2UXX1 18640128
    143 2vha:B (1.0) BS01 GLU ? GO:0030288 ... A0A0H2UXX1 18640128
    144 2vha:B (1.0) BS02 GLU ? GO:0030288 ... A0A0H2UXX1 18640128
    145 2whh:A (1.69) BS02 GLU 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16
    GO:0004190 ... P04585 19924250
    146 2whh:A (1.69) BS04 GLU 2.7.7.-
    2.7.7.49
    2.7.7.7
    3.1.-.-
    3.1.13.2
    3.1.26.13
    3.4.23.16
    GO:0004190 ... P04585 19924250
    147 2xhd:A (1.8) BS01 GLU ? GO:0015276 ... P42262 20614889
    148 2xhd:B (1.8) BS01 GLU ? GO:0015276 ... P42262 20614889
    149 2xx7:A (2.2) BS01 GLU ? GO:0015276 ... P19491 21128618
    150 2xx7:B (2.2) BS01 GLU ? GO:0015276 ... P19491 21128618
    151 2xx7:C (2.2) BS02 GLU ? GO:0015276 ... P19491 21128618
    152 2xx8:A (1.55) BS01 GLU ? GO:0015276 ... P19491 21128618
    153 2xx8:B (1.55) BS01 GLU ? GO:0015276 ... P19491 21128618
    154 2xx8:C (1.55) BS02 GLU ? GO:0015276 ... P19491 21128618
    155 2xx9:A (1.97) BS01 GLU ? GO:0015276 ... P19491 21128618
    156 2xx9:B (1.97) BS01 GLU ? GO:0015276 ... P19491 21128618
    157 2xx9:C (1.97) BS02 GLU ? GO:0015276 ... P19491 21128618
    158 2xxh:A (1.5) BS01 GLU ? GO:0015276 ... P19491 21128618
    159 2xxh:B (1.5) BS01 GLU ? GO:0015276 ... P19491 21128618
    160 2xxh:C (1.5) BS02 GLU ? GO:0015276 ... P19491 21128618
    161 2xxi:A (1.6) BS01 GLU ? GO:0015276 ... P19491 21128618
    162 2xxi:B (1.6) BS01 GLU ? GO:0015276 ... P19491 21128618
    163 2xxi:C (1.6) BS02 GLU ? GO:0015276 ... P19491 21128618
    164 2xxr:A (1.6) BS01 GLU ? GO:0015276 ... P42260 21414913 PDBbind: -logKd/Ki=6.55, Ki=280nM
    165 2xxr:B (1.6) BS01 GLU ? GO:0015276 ... P42260 21414913
    166 2xxu:A (1.5) BS01 GLU ? GO:0015276 ... P42260 21414913
    167 2xxu:B (1.5) BS01 GLU ? GO:0015276 ... P42260 21414913
    168 2xxw:A (2.3) BS01 GLU ? GO:0015276 ... P42260 21414913 PDBbind: -logKd/Ki=6.41, Ki=390nM
    169 2xxw:B (2.3) BS01 GLU ? GO:0015276 ... P42260 21414913
    170 2xxx:A (2.098) BS01 GLU ? GO:0015276 ... P42260 21414913 PDBbind: -logKd/Ki=6.41, Ki=390nM
    171 2xxx:B (2.098) BS01 GLU ? GO:0015276 ... P42260 21414913
    172 2xxx:C (2.098) BS01 GLU ? GO:0015276 ... P42260 21414913
    173 2xxx:D (2.098) BS01 GLU ? GO:0015276 ... P42260 21414913
    174 2yep:A (2.7) BS01 GLU 2.3.1.35 GO:0004358 ... P0DJQ5 21796301
    175 2yep:B (2.7) BS01 GLU 2.3.1.35 GO:0004358 ... P0DJQ5 21796301
    176 2yep:C (2.7) BS01 GLU 2.3.1.35 GO:0004358 ... P0DJQ5 21796301
    177 2zns:A (2.0) BS01 GLU ? GO:0015276 ... P39086 21893069 PDBbind: -logKd/Ki=6.54, Ki=290nM
    178 3a75:B (1.95) BS01 GLU 2.3.2.2
    3.4.19.13
    GO:0006751 ... P54422 20088880
    179 3a75:D (1.95) BS01 GLU 2.3.2.2
    3.4.19.13
    GO:0006751 ... P54422 20088880
    180 3age:A (2.6) BS01 GLU 3.5.1.2 GO:0004359 ... Q4U1A6 N/A
    181 3age:B (2.6) BS01 GLU 3.5.1.2 GO:0004359 ... Q4U1A6 N/A
    182 3aog:A (2.1) BS01 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    183 3aog:A (2.1) BS02 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    184 3aog:A (2.1) BS03 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    185 3aog:B (2.1) BS01 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    186 3aog:B (2.1) BS02 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    187 3aog:B (2.1) BS03 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    188 3aog:C (2.1) BS01 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    189 3aog:C (2.1) BS02 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    190 3aog:C (2.1) BS03 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    191 3aog:D (2.1) BS01 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    192 3aog:D (2.1) BS02 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    193 3aog:D (2.1) BS03 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    194 3aog:E (2.1) BS01 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    195 3aog:E (2.1) BS02 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    196 3aog:E (2.1) BS03 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    197 3aog:F (2.1) BS01 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    198 3aog:F (2.1) BS02 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    199 3aog:F (2.1) BS03 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A
    200 3aog:G (2.1) BS01 GLU 1.4.1.3 GO:0000166 ... Q72IC1 N/A

    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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