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BioLiP
Download all results in tab-seperated text for 15 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1bm7:A (2.0) BS01 FLF ? GO:0005179 ... P02766 9789022 MOAD: Kd=30nM
    PDBbind: -logKd/Ki=7.52, Kd=30nM
    BindingDB: IC50=2900nM
    2 1bm7:B (2.0) BS01 FLF ? GO:0005179 ... P02766 9789022 MOAD: Kd=30nM
    PDBbind: -logKd/Ki=7.52, Kd=30nM
    BindingDB: IC50=2900nM
    3 1s2c:A (1.8) BS02 FLF 1.1.1.-
    1.1.1.188
    1.1.1.210
    1.1.1.239
    1.1.1.357
    1.1.1.53
    1.1.1.62
    1.1.1.64    		 GO:0001523 ... P42330 14996743 MOAD: Ki~0.14uM
    BindingDB: IC50=51nM, Ki=140nM
    4 1s2c:A (1.8) BS03 FLF 1.1.1.-
    1.1.1.188
    1.1.1.210
    1.1.1.239
    1.1.1.357
    1.1.1.53
    1.1.1.62
    1.1.1.64    		 GO:0001523 ... P42330 14996743 MOAD: Ki~0.14uM
    BindingDB: IC50=51nM, Ki=140nM
    5 2pix:A (2.4) BS02 FLF ? N/A P10275 17911242 PDBbind: -logKd/Ki=4.30, IC50=50uM
    BindingDB: IC50=>50000nM, EC50=67000nM
    6 3ozl:A (1.9) BS01 FLF ? GO:0005179 ... P02766 N/A BindingDB: IC50=2900nM
    7 3ozl:B (1.9) BS01 FLF ? GO:0005179 ... P02766 N/A BindingDB: IC50=2900nM
    8 4i5x:A (2.1) BS01 FLF 1.1.1.300
    1.1.1.54    		 GO:0001523 ... O60218 24100137 MOAD: ic50=0.76uM
    BindingDB: IC50=760nM
    9 5dq8:A (2.305) BS01 FLF ? N/A Q15562 26592798 MOAD: Kd=73uM
    PDBbind: -logKd/Ki=4.14, Kd=73uM
    10 5dq8:B (2.305) BS01 FLF ? N/A Q15562 26592798 MOAD: Kd=73uM
    11 5dq8:B (2.305) BS02 FLF ? N/A Q15562 26592798 MOAD: Kd=73uM
    12 5ikv:A (2.508) BS01 FLF 1.14.99.1 GO:0001516 ... P35354 27226593 BindingDB: IC50=16nM
    13 5ikv:B (2.508) BS01 FLF 1.14.99.1 GO:0001516 ... P35354 27226593 BindingDB: IC50=16nM
    14 8xqr:R (3.2) BS01 FLF N/A GO:0001580 ... Q59310
    Q9NYV8    		 38776963
    15 8xqs:R (3.3) BS01 FLF N/A GO:0001580 ... Q59310
    Q9NYV8    		 38776963
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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