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BioLiP
Download all results in tab-seperated text for 18 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 3caj:A (1.8) BS02 EZL 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 18359629 MOAD: Ki=8nM
    PDBbind: -logKd/Ki=8.10, Ki=8nM
    BindingDB: Ki=8nM, IC50=3nM, Kd=0.71nM
    2 3dcw:A (1.5) BS02 EZL 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 19170619 MOAD: Ki<1nM
    PDBbind: -logKd/Ki=9.00, Ki=1nM
    BindingDB: Ki=8nM, IC50=3nM, Kd=0.71nM
    3 3dd0:A (1.48) BS02 EZL 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 19170619 MOAD: Ki<1nM
    PDBbind: -logKd/Ki=9.00, Ki=1nM
    BindingDB: Ki=8nM, IC50=3nM, Kd=0.71nM
    4 3mdz:A (2.32) BS02 EZL 4.2.1.1 GO:0004089 ... P43166 N/A PDBbind: -logKd/Ki=9.10, Ki=0.8nM
    BindingDB: Ki=0.8nM, Kd=0.710000nM
    5 5jn9:A (2.1) BS02 EZL 4.2.1.1 GO:0004089 ... P22748 28975383 PDBbind: -logKd/Ki=7.79, Kd=16.2nM
    BindingDB: Ki=93nM
    6 5jn9:B (2.1) BS02 EZL 4.2.1.1 GO:0004089 ... P22748 28975383 BindingDB: Ki=93nM
    7 5jn9:C (2.1) BS02 EZL 4.2.1.1 GO:0004089 ... P22748 28975383 BindingDB: Ki=93nM
    8 5jn9:D (2.1) BS02 EZL 4.2.1.1 GO:0004089 ... P22748 28975383 BindingDB: Ki=93nM
    9 5tt3:A (2.2) BS02 EZL ? GO:0004089 ... A0A0M3KL20 28002963 MOAD: Ki=193nM
    PDBbind: -logKd/Ki=6.71, Ki=193nM
    10 5tt3:B (2.2) BS02 EZL ? GO:0004089 ... A0A0M3KL20 28002963 MOAD: Ki=193nM
    11 5tt3:C (2.2) BS02 EZL ? GO:0004089 ... A0A0M3KL20 28002963 MOAD: Ki=193nM
    12 5tt3:E (2.2) BS02 EZL ? GO:0004089 ... A0A0M3KL20 28002963 MOAD: Ki=193nM
    13 5tt3:F (2.2) BS02 EZL ? GO:0004089 ... A0A0M3KL20 28002963 MOAD: Ki=193nM
    14 5tt3:G (2.2) BS02 EZL ? GO:0004089 ... A0A0M3KL20 28002963 MOAD: Ki=193nM
    15 5tt3:H (2.2) BS02 EZL ? GO:0004089 ... A0A0M3KL20 28002963 MOAD: Ki=193nM
    16 6bcc:A (1.8) BS02 EZL 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 29429876 BindingDB: Ki=8nM, IC50=3nM, Kd=0.71nM
    17 6mwi:B (1.75) BS02 EZL 4.6.1.12 GO:0008299 ... Q3JRA0 N/A
    18 6ql2:A (1.3) BS02 EZL 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 31481705 MOAD: Kd=1.1nM
    PDBbind: -logKd/Ki=7.77, Kd=17nM
    BindingDB: Ki=8nM, IC50=3nM, Kd=0.71nM
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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