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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

BioLiP
Download all results in tab-seperated text for 111 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1a27:A (1.9) BS01 EST 1.1.1.51
    1.1.1.62    		 GO:0004303 ... P14061 N/A
    2 1a52:A (2.8) BS01 EST ? N/A P03372 9600906 PDBbind: -logKd/Ki=9.86, Ki=0.138nM
    BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    3 1a52:B (2.8) BS01 EST ? N/A P03372 9600906 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    4 1aqu:A (1.6) BS02 EST 2.8.2.4 GO:0004304 ... P49891 9360604
    5 1aqu:B (1.6) BS02 EST 2.8.2.4 GO:0004304 ... P49891 9360604
    6 1e6w:C (1.7) BS02 EST 1.1.1.159
    1.1.1.178
    1.1.1.239
    1.1.1.35
    1.1.1.53
    1.1.1.62    		 GO:0000049 ... O70351 11023795
    7 1ere:A (3.1) BS01 EST ? N/A P03372 9338790 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    8 1ere:B (3.1) BS01 EST ? N/A P03372 9338790 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    9 1ere:C (3.1) BS01 EST ? N/A P03372 9338790 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    10 1ere:D (3.1) BS01 EST ? N/A P03372 9338790 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    11 1ere:E (3.1) BS01 EST ? N/A P03372 9338790 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    12 1ere:F (3.1) BS01 EST ? N/A P03372 9338790 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    13 1fds:A (1.7) BS01 EST 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 8805577
    14 1fdt:A (2.2) BS01 EST 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 8805577
    15 1fdu:A (2.7) BS01 EST 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 9525918
    16 1fdu:B (2.7) BS01 EST 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 9525918
    17 1fdu:C (2.7) BS01 EST 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 9525918
    18 1fdu:D (2.7) BS01 EST 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 9525918
    19 1fdw:A (2.7) BS01 EST 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 9525918
    20 1g50:A (2.9) BS01 EST ? N/A P03372 11437591 PDBbind: -logKd/Ki=6.28, Kd=0.53uM
    BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    21 1g50:B (2.9) BS01 EST ? N/A P03372 11437591 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    22 1g50:C (2.9) BS01 EST ? N/A P03372 11437591 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    23 1gwr:A (2.4) BS02 EST ? N/A P03372 11937504 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    24 1gwr:B (2.4) BS02 EST ? N/A P03372 11937504 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    25 1iol:A (2.3) BS01 EST 1.1.1.51
    1.1.1.62    		 GO:0003824 ... P14061 8756321
    26 1jgl:H (2.15) BS01 EST N/A N/A N/A 11451948 PDBbind: -logKd/Ki=8.70, Kd=2nM
    27 1jgl:L (2.15) BS01 EST ? N/A Q7TS98 11451948 MOAD: Kd=2nM
    PDBbind: -logKd/Ki=8.70, Kd=2nM
    28 1jnn:H (3.2) BS01 EST ? N/A Q99LC4 11812141
    29 1jnn:L (3.2) BS01 EST ? N/A Q7TS98 11812141
    30 1lhu:A (1.8) BS02 EST ? N/A P04278 12065592 PDBbind: -logKd/Ki=8.83, Kd=1.48nM
    BindingDB: IC50=50nM, Kd=1.5nM
    31 1pcg:A (2.7) BS02 EST ? N/A P03372 13679575 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    32 1pcg:B (2.7) BS02 EST ? N/A P03372 13679575 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    33 1qkt:A (2.2) BS01 EST ? N/A P03372 11278577 MOAD: Kd=0.92nM
    PDBbind: -logKd/Ki=9.04, Kd=0.92nM
    BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    34 1qku:A (3.2) BS01 EST ? N/A P03372 11278577 PDBbind: -logKd/Ki=9.59, Kd=0.26nM
    BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    35 1qku:B (3.2) BS01 EST ? N/A P03372 11278577 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    36 1qku:C (3.2) BS01 EST ? N/A P03372 11278577 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    37 2d06:A (2.3) BS02 EST 2.8.2.1 GO:0004062 ... P50225 16221673 MOAD: Ki=83.2uM
    PDBbind: -logKd/Ki=4.08, Ki=83.2uM
    BindingDB: Kd=1200nM
    38 2d06:B (2.3) BS02 EST 2.8.2.1 GO:0004062 ... P50225 16221673 MOAD: Ki=83.2uM
    BindingDB: Kd=1200nM
    39 2j7x:A (2.1) BS02 EST ? N/A Q62986 N/A PDBbind: -logKd/Ki=8.77, IC50=1.7nM
    BindingDB: EC50=0.14nM, IC50=1.7nM
    40 2ocf:A (2.95) BS01 EST ? N/A P03372 11818562 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    41 2yja:B (1.82) BS02 EST ? N/A P03372 21612236 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    42 3oll:A (1.5) BS02 EST ? GO:0003677 ... Q92731 20922740 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    43 3oll:B (1.5) BS02 EST ? GO:0003677 ... Q92731 20922740 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    44 3ols:A (2.2) BS02 EST ? GO:0003677 ... Q92731 20922740 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    45 3ols:B (2.2) BS02 EST ? GO:0003677 ... Q92731 20922740 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    46 3uud:A (1.6) BS02 EST ? N/A P03372 22927406 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    47 3uud:B (1.6) BS02 EST ? N/A P03372 22927406 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    48 4j24:A (2.1) BS02 EST ? GO:0003677 ... Q92731 23437920 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    49 4j24:B (2.1) BS02 EST ? GO:0003677 ... Q92731 23437920 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    50 4j24:C (2.1) BS02 EST ? GO:0003677 ... Q92731 23437920 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    51 4j24:D (2.1) BS02 EST ? GO:0003677 ... Q92731 23437920 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    52 4j26:A (2.3) BS02 EST ? GO:0003677 ... Q92731 23437920 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    53 4j26:B (2.3) BS02 EST ? GO:0003677 ... Q92731 23437920 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    54 4jvl:A (1.943) BS02 EST 2.8.2.4 GO:0004062 ... P49888 23959441
    55 4jvl:B (1.943) BS02 EST 2.8.2.4 GO:0004062 ... P49888 23959441
    56 4pxm:A (1.9) BS02 EST ? N/A P03372 26836308 PDBbind: -logKd/Ki=8.89, Kd=1.3nM
    BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    57 4pxm:B (1.9) BS02 EST ? N/A P03372 26836308 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    58 5dx3:A (2.0903) BS02 EST ? N/A P03372 26928945 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    59 5dx3:B (2.0903) BS02 EST ? N/A P03372 26928945 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    60 5dxb:A (2.08) BS02 EST ? N/A P03372 26928945 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    61 5dxb:B (2.08) BS02 EST ? N/A P03372 26928945 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    62 5dxe:A (1.5) BS02 EST ? N/A P03372 26928945 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    63 5dxe:B (1.5) BS02 EST ? N/A P03372 26928945 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    64 5dxg:A (1.86) BS02 EST ? N/A P03372 26928945 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    65 5dxg:B (1.86) BS02 EST ? N/A P03372 26928945 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    66 5gs4:A (2.4) BS02 EST ? N/A P03372 29045135 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    67 5gtr:A (2.804) BS02 EST ? N/A P03372 29045135 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    68 5hyr:A (2.271) BS02 EST ? N/A P03372 26928945 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    69 5hyr:B (2.271) BS02 EST ? N/A P03372 26928945 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    70 5toa:A (2.5) BS01 EST ? GO:0003677 ... Q92731 28615710 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    71 5toa:B (2.5) BS01 EST ? GO:0003677 ... Q92731 28615710 BindingDB: IC50=1.1nM, Kd=0.5nM, EC50=2.1nM, Ki=0.015nM
    72 5wgd:A (1.8) BS02 EST ? N/A P03372 29725689 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    73 5wgd:B (1.8) BS02 EST ? N/A P03372 29725689 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    74 5wgq:A (2.3) BS02 EST ? N/A P03372 29725689 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    75 5wgq:B (2.3) BS02 EST ? N/A P03372 29725689 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    76 6cbz:A (1.65) BS02 EST ? N/A P03372 29739819 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    77 6cbz:B (1.65) BS02 EST ? N/A P03372 29739819 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    78 6keo:AA (1.7) BS01 EST 2.5.1.18 GO:0003824 ... Q7JYX0 32241910
    79 6keo:BA (1.7) BS01 EST 2.5.1.18 GO:0003824 ... Q7JYX0 32241910
    80 6kep:AA (1.55) BS02 EST 2.5.1.18 GO:0003824 ... Q7JYX0 32241910
    81 6kep:BA (1.55) BS02 EST 2.5.1.18 GO:0003824 ... Q7JYX0 32241910
    82 6oyv:A (3.101) BS01 EST N/A GO:0004497 ... N/A 32156703
    83 6oyv:B (3.101) BS01 EST N/A GO:0004497 ... N/A 32156703
    84 6pit:A (2.25) BS01 EST ? N/A P03372 31523967 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    85 6pit:B (2.25) BS02 EST ? N/A P03372 31523967 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    86 6pyf:A (1.73) BS02 EST ? N/A P04278 31852737 BindingDB: IC50=50nM, Kd=1.5nM
    87 7axi:A (2.15) BS01 EST ? GO:0003677 ... O75469 33361153
    88 7axj:A (2.3) BS02 EST ? GO:0003677 ... O75469 33361153
    89 7axk:A (2.0) BS01 EST ? GO:0003677 ... O75469 33361153
    90 7axl:A (2.5) BS01 EST ? GO:0003677 ... O75469 33361153
    91 7nel:A (1.45) BS02 EST ? N/A P03372 34006920 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    92 7nel:B (1.45) BS02 EST ? N/A P03372 34006920 BindingDB: IC50=1.3nM, Kd=0.2nM, EC50=0.75nM, Ki=0.21nM
    93 8fw0:A (2.37) BS01 EST ? GO:0003677 ... P39897 38326294
    94 8fw0:B (2.37) BS01 EST ? GO:0003677 ... P39897 38326294
    95 8fw0:C (2.37) BS01 EST ? GO:0003677 ... P39897 38326294
    96 8fw0:D (2.37) BS01 EST ? GO:0003677 ... P39897 38326294
    97 8rh4:A (2.52) BS01 EST N/A N/A P24046 N/A
    98 8rh4:A (2.52) BS02 EST N/A N/A P24046 N/A
    99 8rh4:B (2.52) BS01 EST N/A N/A P24046 N/A
    100 8rh4:B (2.52) BS02 EST N/A N/A P24046 N/A
    101 8rh4:C (2.52) BS01 EST N/A N/A P24046 N/A
    102 8rh4:C (2.52) BS02 EST N/A N/A P24046 N/A
    103 8rh4:D (2.52) BS01 EST N/A N/A P24046 N/A
    104 8rh4:D (2.52) BS02 EST N/A N/A P24046 N/A
    105 8rh4:E (2.52) BS01 EST N/A N/A P24046 N/A
    106 8rh4:E (2.52) BS02 EST N/A N/A P24046 N/A
    107 8rh7:A (2.78) BS01 EST N/A N/A P24046 N/A
    108 8rh7:B (2.78) BS01 EST N/A N/A P24046 N/A
    109 8rh7:C (2.78) BS01 EST N/A N/A P24046 N/A
    110 8rh7:D (2.78) BS01 EST N/A N/A P24046 N/A
    111 8rh7:E (2.78) BS01 EST N/A N/A P24046 N/A
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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